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Proceedings of the National Academy of Sciences

0027-8424 · National Academy of Sciences

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Maternal ranging strategies facilitate offspring social play at energetic cost in the most solitary ape

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Phenotypic screening identifies kenpaullone as a prolymphangiogenic compound to improve heart repair following myocardial infarction

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Breaking trait scaling via the evolution and regulation of dimorphic decoupling in ants

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Dopamine suppresses pathological retinal oscillations and enhances the signal-to-noise ratio

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Spatial and single-nucleus transcriptomics reveals the molecular pathology of type 2 diabetes–associated cognitive dysfunction

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NA-CDQuant: Quantitative spectral analysis of nucleic acid structure by circular dichroism spectroscopy

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53BP1 condensates regulate DNA replication progression and completion

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Structural basis for membrane-dependent positive feedback regulation of DOCK11 by activated Cdc42

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Bypass of the canonical biotin synthesis pathway in yeast

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Titin extension explains residual force enhancement in skeletal muscle

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Two D-loop resolution systems enable natural genetic transformation in bacteria

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Cooperation in binary mixtures of active colloids

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An opto-microperfusion neural probe for multiplexed detection of optogenetically evoked neurochemical release dynamics

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Chemoreceptor complexes signal through a protein-ordering and stabilization mechanism

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Selective sparsity–enhanced synchronization in disordered semiconductor laser networks

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Tailored speckle illumination microscopy with enhanced sectioning and image quality

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A receptor-like kinase pair integrates extracellular ATP and salicylic acid signaling to activate plant immunity

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KAT5/TIP60 orchestrates H4K16 and H2A.Z acetylation to drive the gonocyte-to-spermatogonia transition

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Organic imprint: Natural matter dictates crystallization of manganese oxides on hematite

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DNAAF19–RUVBL1/2 complex recruits multiple adaptors to promote dynein arm assembly

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Chronic intermittent heat exposure induces anxiety in female mice via TLR4 upregulation in paraventricular nucleus CRH neurons

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Late-onset preeclampsia is characterized by accelerated placental aging

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Conformational switch of NPC1 epitomizes a lumen-to-membrane alternating access model for nonpolar substrates

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In This Issue

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Ancient DNA challenges to admixture narratives: Insights from Notre-Dame Cemetery (1683–1796) in Colonial Montreal, Canada

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Chronic cigarette smoke exposure induces distinct stem cell states driving genetic driver–specific non–small cell lung cancer subtypes

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Correction for Doughty et al., Compounded effects on wetland greenhouse gas fluxes from climate change and water management along a saline to freshwater gradient

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Correction for Tomek et al., Beyond “non-significant” results: Why and how to test for practical equivalence

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Correction for Chi et al., Urban tree canopy fragmentation and child mortality in low- and middle-income countries

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Untangling microbial diversification in Antarctic soils—One strain at a time

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