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References from Reactive oxygen species‐induced lipid peroxidation mediates Wnt‐dependent lipodystrophy and associated skin fibrosis. Local targets link to admitted publications; unresolved targets remain external evidence.
The roles of dermal white adipose tissue loss in scleroderma skin fibrosis
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2011 · External reference
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Dermal adipocytes protect against invasive Staphylococcus aureus skin infection
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Dermal white adipose tissue: a new component of the thermogenic response
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Adipocyte plasticity in tissue regeneration, repair, and disease
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Scleroderma and the subcutaneous tissue
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Systemic sclerosis in 2016: dermal white adipose tissue implicated in SSc pathogenesis
2017 · External reference
Atgl‐dependent adipocyte lipolysis promotes lipodystrophy and restrains fibrogenic responses during skin fibrosis
10.1016/j.jid.2024.12.022 · 2025 · External reference
Unresolved reference
2011 · External reference
Wnt activation in mature dermal adipocytes leads to lipodystrophy and skin fibrosis via ATGL‐dependent lipolysis
10.1096/fj.202501380r · 2025 · External reference
Lipodystrophy and recovery are mediated by the Wnt/lipogenesis axis during skin fibrosis
2025 · External reference
Mycophenolate mofetil treatment of systemic sclerosis reduces myeloid cell numbers and attenuates the inflammatory gene signature in skin
10.1016/j.jid.2018.01.006 · 2016 · External reference
Metabolic reprogramming of glycolysis and glutamine metabolism are key events in myofibroblast transition in systemic sclerosis pathogenesis
10.1111/jcmm.16013 · 2020 · External reference
Wnt antagonist DKK‐1 levels in systemic sclerosis are lower in skin but not in blood and are regulated by microRNA33a‐3p
10.1111/exd.14136 · 2021 · External reference
Activation of canonical Wnt signalling is required for TGF‐β‐mediated fibrosis
10.1038/ncomms1734 · 2012 · External reference
β‐Catenin is a central mediator of pro‐fibrotic Wnt signaling in systemic sclerosis
10.1136/annrheumdis-2011-200568 · 2012 · External reference
Sustained β‐catenin activity in dermal fibroblasts is sufficient for skin fibrosis
10.1038/jid.2012.155 · 2012 · External reference
Sustained β‐catenin activity in dermal fibroblasts promotes fibrosis by up‐regulating expression of extracellular matrix protein‐coding genes
10.1002/path.4481 · 2015 · External reference
Adipogenesis and WNT signalling
10.1016/j.tem.2008.09.002 · 2009 · External reference
Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis
10.1073/pnas.1000031107 · 2010 · External reference
Wnt signaling regulates mitochondrial physiology and insulin sensitivity
10.1101/gad.1924910 · 2010 · External reference
Reactive oxygen species facilitate translocation of hormone sensitive lipase to the lipid droplet during lipolysis in human differentiated adipocytes
10.1371/journal.pone.0034904 · 2012 · External reference
Signalling mechanisms regulating lipolysis
10.1016/j.cellsig.2005.08.009 · 2006 · External reference
Reactive oxygen species: metabolism, oxidative stress, and signal transduction
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Reactive oxygen species as signaling molecules in cardiovascular differentiation of embryonic stem cells and tumor‐induced angiogenesis
10.1089/ars.2005.7.1423 · 2005 · External reference
Reactive oxygen species as intracellular messengers during cell growth and differentiation
10.1159/000047804 · 2001 · External reference
Cell signaling. H2O2, a necessary evil for cell signaling
2006 · External reference
Effects of hydrogen peroxide on basal and hormone‐stimulated lipolysis in perifused rat fat cells in relation to the mechanism of action of insulin
10.1016/s0021-9258(19)70390-1 · 1980 · External reference
Reactive oxygen species have a causal role in multiple forms of insulin resistance
10.1038/nature04634 · 2006 · External reference
Increased oxidative stress in obesity and its impact on metabolic syndrome
10.1172/jci21625 · 2004 · External reference
Reactive oxygen species and fibrosis: further evidence of a significant liaison
10.1007/s00441-016-2445-3 · 2016 · External reference
NAD(P)H oxidase 4 mediates transforming growth factor‐beta1‐induced differentiation of cardiac fibroblasts into myofibroblasts
10.1161/01.res.0000187457.24338.3d · 2005 · External reference
A reactive oxygen species–mediated loop maintains increased expression of NADPH oxidases 2 and 4 in skin fibroblasts from patients with systemic sclerosis
10.1002/art.39084 · 2015 · External reference
High reactive oxygen species in fibrotic and nonfibrotic skin of patients with diffuse cutaneous systemic sclerosis
10.1016/j.freeradbiomed.2015.07.002 · 2015 · External reference
Oxidative stress‐induced senescence mediates inflammatory and fibrotic phenotypes in fibroblasts from systemic sclerosis patients
10.1093/rheumatology/keab477 · 2021 · External reference
Increased expression of NAPDH oxidase 4 in systemic sclerosis dermal fibroblasts: regulation by transforming growth factor β
10.1002/art.39242 · 2015 · External reference
Oxidative stress induced by reactive oxygen species (ROS) and NADPH oxidase 4 (NOX4) in the pathogenesis of the fibrotic process in systemic sclerosis: a promising therapeutic target
10.3390/jcm10204791 · 2021 · External reference
Skin fibrosis and recovery is dependent on Wnt activation via DPP4
10.1016/j.jid.2021.10.025 · 2022 · External reference
Cardiovascular protection by DPP‐4 inhibitors in preclinical studies: an updated review of molecular mechanisms
10.1007/s00210-022-02279-3 · 2022 · External reference
Uncoupling Protein‐2 mediates DPP‐4 inhibitor‐induced restoration of endothelial function in hypertension through reducing oxidative stress
10.1089/ars.2013.5519 · 2014 · External reference
Redox regulation of lipid mobilization in adipose tissues
10.3390/antiox10071090 · 2021 · External reference
Detection of mitochondria‐generated reactive oxygen species in cells using multiple probes and methods: potentials, pitfalls, and the future
10.1074/jbc.ra118.003044 · 2018 · External reference
Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation
10.1101/gad.14.11.1377 · 2000 · External reference
Conditional and inducible transgene expression in mice through the combinatorial use of Cre‐mediated recombination and tetracycline induction
10.1093/nar/gki559 · 2005 · External reference
A mouse transgenic approach to induce β‐catenin signaling in a temporally controlled manner
10.1007/s11248-010-9466-6 · 2011 · External reference
Characterization of Cre recombinase models for the study of adipose tissue
10.4161/adip.29674 · 2014 · External reference
A global double‐fluorescent Cre reporter mouse
10.1002/dvg.20335 · 2007 · External reference
An integrated encyclopedia of DNA elements in the human genome
10.1038/nature11247 · 2012 · External reference
Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile
10.1136/annrheumdis-2019-215894 · 2020 · External reference
Activation of beta‐catenin‐Tcf signaling in colon cancer by mutations in beta‐catenin or APC
10.1126/science.275.5307.1787 · 1997 · External reference
Surplus fatty acid synthesis increases oxidative stress in adipocytes and induces lipodystrophy
10.1038/s41467-023-44393-7 · 2024 · External reference
Myofibroblasts in murine cutaneous fibrosis originate from adiponectin‐positive intradermal progenitors
10.1002/art.38990 · 2015 · External reference
NAC, NAC, Knockin’ on Heaven's door: interpreting the mechanism of action of N‐acetylcysteine in tumor and immune cells
10.1016/j.redox.2022.102497 · 2022 · External reference
Chemistry and biochemistry of 4‐hydroxynonenal, malonaldehyde and related aldehydes
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A crucial role for Nox 1 in redox‐dependent regulation of Wnt‐β‐catenin signaling
10.1096/fj.11-196360 · 2012 · External reference
Fatty acids as modulators of the cellular production of reactive oxygen species
10.1016/j.freeradbiomed.2008.04.029 · 2008 · External reference
Increased 4‐Hydroxynonenal formation contributes to obesity‐related lipolytic activation in adipocytes
10.1371/journal.pone.0070663 · 2013 · External reference
Oxidative stress promotes fibrosis in systemic sclerosis through stabilization of a kinase‐phosphatase complex
10.1172/jci.insight.155761 · 2022 · External reference
Dual role of DUOX1‐derived reactive oxygen species in melanoma
10.3390/antiox12030708 · 2023 · External reference
Radical oxygen species production induced by advanced oxidation protein products predicts clinical evolution and response to treatment in systemic sclerosis
10.1136/ard.2006.067504 · 2007 · External reference
Oxidative stress in the pathogenesis of systemic scleroderma: an overview
10.1111/jcmm.13630 · 2018 · External reference
Oxidative damage and antioxidative therapy in systemic sclerosis
10.1155/2014/389582 · 2014 · External reference