Research graph
References from Engineering IL ‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy. Local targets link to admitted publications; unresolved targets remain external evidence.
Altered macrophage differentiation and immune dysfunction in tumor development
10.1172/jci31422 · 2007 · External reference
Tumor‐associated macrophages: from mechanisms to therapy
10.1016/j.immuni.2014.06.010 · 2014 · External reference
Dual roles and therapeutic targeting of tumor‐associated macrophages in tumor microenvironments
10.1038/s41392-025-02325-5 · 2025 · External reference
p50 nuclear factor‐κB overexpression in tumor‐associated macrophages inhibits M1 inflammatory responses and antitumor resistance
10.1158/0008-5472.can-06-1867 · 2006 · External reference
NF‐κB, IκB, and IKK: integral components of immune system signaling
10.1007/978-981-13-9367-9_10 · 2019 · External reference
The phosphorylation status of nuclear NF‐κB determines its association with CBP/300 or HDAC‐1
10.1016/s1097-2765(02)00477-x · 2002 · External reference
The NF‐κB p50:p50:HDAC‐1 repressor complex orchestrates transcriptional inhibition of multiple pro‐inflammatory genes
10.1016/j.jhep.2010.03.025 · 2010 · External reference
IκBα functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF‐κB
10.1074/jbc.273.39.25427 · 1998 · External reference
The specificity of innate immune response is enforced by repression of interferon response elements by NF‐κB p50
10.1126/scisignal.2001501 · 2011 · External reference
Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor κB
10.1073/pnas.0809784106 · 2009 · External reference
The p50 subunit of NF‐κB orchestrates dendritic cell lifespan and activation of adaptive immunity
10.1371/journal.pone.0045279 · 2012 · External reference
Absence of host NF‐κB p50 induces murine glioblastoma tumor regression, increases survival, and decreases T cell induction of tumor‐associated macrophage M2 polarization
10.1007/s00262-018-2184-2 · 2018 · External reference
Pro‐tumor steering of cancer inflammation by p50 NF‐κB enhances colorectal cancer progression
10.1158/2326-6066.cir-17-0036 · 2018 · External reference
NF‐κB p50‐deficient immature myeloid cell (p50‐IMC) adoptive transfer slows the growth of murine prostate and pancreatic ductal carcinoma
10.1136/jitc-2019-000244 · 2020 · External reference
Adoptive transfer of immature myeloid cells lacking NF‐κB p50 (p50‐IMC) impedes the growth of MHC‐matched high‐risk neuroblastoma
2021 · External reference
Macrophage‐based cell therapies: the long and winding road
10.1016/j.jconrel.2016.07.018 · 2016 · External reference
Transcriptional regulation by STAT6
10.1007/s12026-011-8205-2 · 2011 · External reference
The transcription factor STAT6 mediates direct repression of inflammatory enhancers and limits activation of alternatively polarized macrophages
10.1016/j.immuni.2017.12.010 · 2018 · External reference
STAT6‐deficient mice have enhanced tumor immunity to primary and metastatic mammary carcinoma
10.4049/jimmunol.165.11.6015 · 2000 · External reference
Targeting the Stat6 pathway in tumor‐associated macrophages reduces tumor growth and metastatic niche formation in breast cancer
10.1096/fj.201700629r · 2018 · External reference
Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24
10.1038/s41467-019-12384-2 · 2019 · External reference
Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis
10.1182/blood-2011-12-397091 · 2012 · External reference
10.1101/060012
10.1101/060012 · External reference
Molecular signatures database (MSigDB) 3.0
10.1093/bioinformatics/btr260 · 2011 · External reference
Hematopoietic stem cells culture, expansion and differentiation: an insight into variable and available media
10.15283/ijsc19157 · 2020 · External reference
Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells
10.1126/science.1191536 · 2010 · External reference
Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self‐renewal
10.1126/science.1256337 · 2014 · External reference
Lysine‐specific demethylase 1A restricts ex vivo propagation of human HSCs and is a target of UM171
10.1182/blood.2020005827 · 2020 · External reference
UM171 preserves epigenetic marks that are reduced in ex vivo culture of human HSCs via potentiation of the CLR3‐KBTBD4 complex
10.1016/j.stem.2020.12.002 · 2021 · External reference
Optimized sgRNA design to maximize activity and minimize off‐target effects of CRISPR‐Cas9
10.1038/nbt.3437 · 2016 · External reference
CHOPCHOP v3: expanding the CRISPR web toolbox beyond genome editing
10.1093/nar/gkz365 · 2019 · External reference
Predictable and precise template‐free editing of pathogenic variants
10.1038/s41586-018-0686-x · 2018 · External reference
Anti‐CD47 antibody–mediated phagocytosis of cancer by macrophages primes an effective antitumor T‐cell response
10.1073/pnas.1305569110 · 2013 · External reference
Stat6 cooperates with Sp1 in controlling breast cancer cell proliferation by modulating the expression of p21(Cip1/WAF1) and p27 (Kip1)
10.1007/s13402-012-0115-3 · 2013 · External reference
ARHGAP24 inhibits cell proliferation and cell cycle progression and induces apoptosis of lung cancer via a STAT6‐WWP2‐p27 axis
10.1093/carcin/bgz144 · 2020 · External reference
Leveraging a comprehensive unbiased RNAseq database to characterize human monocyte derived macrophage gene expression profiles within commonly employed in vitro polarization methods
10.1038/s41598-024-78000-6 · 2024 · External reference
PSMA antibody, humanized PSMA.CAR10.3, or Cetuximab increases prostate cancer localization of NF‐κB p50‐deficient immature myeloid cells (p50‐IMC) and phagocytosis by their macrophage progeny
10.1007/s00262-024-03939-4 · 2025 · External reference
IL‐4 blockade alters the tumor microenvironment and augments the response to cancer immunotherapy in a mouse model
10.1007/s00262-017-2043-6 · 2017 · External reference
CXCR3‐mediated T‐cell chemotaxis involves ZAP‐70 and is regulated by signalling through the T‐cell receptor
10.1111/j.1365-2567.2006.02534.x · 2007 · External reference
