Research graph
References from Tetrahedral Framework Nucleic Acid‐Based Small RNA Delivery: Prospects and Challenges in Bone and Cartilage Regeneration. Local targets link to admitted publications; unresolved targets remain external evidence.
Articular Fibrocartilage—Why Does Hyaline Cartilage Fail to Repair?
10.1016/j.addr.2018.12.015 · 2019 · External reference
Unlike Bone, Cartilage Regeneration Remains Elusive
10.1126/science.1222454 · 2012 · External reference
The Decisive Early Phase of Bone Regeneration
10.1038/s41584-022-00887-0 · 2023 · External reference
Acute and Stress‐Related Injuries of Bone and Cartilage: Pertinent Anatomy, Basic Biomechanics, and Imaging Perspective
10.1148/radiol.16142305 · 2016 · External reference
Engineering Bone/Cartilage Organoids: Strategy, Progress, and Application
10.1038/s41413-024-00376-y · 2024 · External reference
Recent Strategies and Advances in Hydrogel‐Based Delivery Platforms for Bone Regeneration
10.1007/s40820-024-01557-4 · 2024 · External reference
Biomaterials Targeting Senescent Cells for Bone Regeneration: State‐of‐the‐Art and Future Perspectives
10.1016/j.bioactmat.2025.09.002 · 2025 · External reference
Surgical and Tissue Engineering Strategies for Articular Cartilage and Meniscus Repair
10.1038/s41584-019-0255-1 · 2019 · External reference
Failure of Cartilage Regeneration: Emerging Hypotheses and Related Therapeutic Strategies
10.1038/s41584-023-00979-5 · 2023 · External reference
Small Noncoding RNAs in Knee Osteoarthritis: the Role of MicroRNAs and tRNA‐Derived Fragments
10.3390/ijms22115711 · 2021 · External reference
Dual siRNA‐Loaded Cell Membrane Functionalized Matrix Facilitates Bone Regeneration With Angiogenesis and Neurogenesis
10.1002/smll.202307062 · 2024 · External reference
MicroRNA Profiling: Approaches and Considerations
10.1038/nrg3198 · 2012 · External reference
Both microRNA‐455‐5p and ‐3p Repress Hypoxia‐Inducible Factor‐2α Expression and Coordinately Regulate Cartilage Homeostasis
10.1038/s41467-021-24460-7 · 2021 · External reference
RNA‐Based Scaffolds for Bone Regeneration: Application and Mechanisms of mRNA, miRNA and siRNA
10.7150/thno.42640 · 2020 · External reference
The Role of microRNAs in the Osteogenic and Chondrogenic Differentiation of Mesenchymal Stem Cells and Bone Pathologies
10.7150/thno.55664 · 2021 · External reference
Cell‐Free 3D Scaffold With Two‐Stage Delivery of miRNA‐26a to Regenerate Critical‐Sized Bone Defects
10.1038/ncomms10376 · 2016 · External reference
A ROS‐Responsive Hydrogel Encapsulated With Matrix Metalloproteinase‐13 siRNA Nanocarriers to Attenuate Osteoarthritis Progression
10.1186/s12951-024-03046-7 · 2025 · External reference
Synergistic Inhibition of Endochondral Bone Formation by Silencing Hif1α and Runx2 in Trauma‐Induced Heterotopic Ossification
10.1038/mt.2011.101 · 2011 · External reference
Hydrogels for RNA Delivery
10.1038/s41563-023-01472-w · 2023 · External reference
Gene‐ and RNAi‐Activated Scaffolds for Bone Tissue Engineering: Current Progress and Future Directions
10.1016/j.addr.2021.05.009 · 2021 · External reference
Stimuli‐Responsive Nanotechnology for RNA Delivery
10.1002/advs.202303597 · 2023 · External reference
Nanodelivery of Nucleic Acids
10.1038/s43586-022-00104-y · 2022 · External reference
Protein‐Based Delivery Systems for RNA Delivery
10.1016/j.jconrel.2023.09.032 · 2023 · External reference
Non‐Viral Vectors for RNA Delivery
10.1016/j.jconrel.2022.01.008 · 2022 · External reference
A Perspective of Lipid Nanoparticles for RNA Delivery
10.1002/exp.20230147 · 2024 · External reference
Advances in Biological Applications of Self‐Assembled DNA Tetrahedral Nanostructures
10.1016/j.mattod.2018.08.002 · 2019 · External reference
Tetrahedral Framework Nucleic Acids: Nanokeys Unlocking a New Era of Precision Biomedicine
10.1016/j.jare.2025.10.052 · 2025 · External reference
Design, Fabrication and Applications of Tetrahedral DNA Nanostructure‐Based Multifunctional Complexes in Drug Delivery and Biomedical Treatment
10.1038/s41596-020-0355-z · 2020 · External reference
Prospects and Challenges of Dynamic DNA Nanostructures in Biomedical Applications
10.1038/s41413-022-00212-1 · 2022 · External reference
A Bioswitchable Delivery System for microRNA Therapeutics Based on a Tetrahedral DNA Nanostructure
10.1038/s41596-024-01050-7 · 2025 · External reference
Tetrahedral Framework Nucleic Acids‐based Delivery of microRNA‐155 Inhibits Choroidal Neovascularization by Regulating the Polarization of Macrophages
10.1016/j.bioactmat.2021.11.031 · 2022 · External reference
A Dynamic DNA Tetrahedron Framework for Active Targeting
10.1038/s41596-022-00791-7 · 2023 · External reference
Tetrahedral DNA Nanostructure: A Potential Promoter for Cartilage Tissue Regeneration via Regulating Chondrocyte Phenotype and Proliferation
10.1002/smll.201602770 · 2017 · External reference
Tetrahedral Framework Nucleic Acid Promotes the Treatment of Bisphosphonate‐Related Osteonecrosis of the Jaws by Promoting Angiogenesis and M2 Polarization
10.1021/acsami.0c13839 · 2020 · External reference
Tetrahedral Framework Nucleic Acids Promote the Biological Functions and Related Mechanism of Synovium‐Derived Mesenchymal Stem Cells and Show Improved Articular Cartilage Regeneration Activity In Situ
10.1016/j.bioactmat.2021.07.028 · 2022 · External reference
Nucleic Acid Based Tetrahedral Framework DNA Nanostructures for Fibrotic Diseases Therapy
10.1016/j.apmt.2020.100725 · 2020 · External reference
Research Advances of Tetrahedral Framework Nucleic Acid‐Based Systems in Biomedicine
10.1016/j.cclet.2024.109591 · 2024 · External reference
Potential Applications of Multifunctional Tetrahedral Framework Nucleic Acids in Bone Tissue Engineering
10.1002/smll.202411930 · 2025 · External reference
Transcutaneous Immunotherapy for RNAi: a Cascade‐Responsive Decomposable Nanocomplex Based on Polyphenol‐Mediated Framework Nucleic Acid in Psoriasis
10.1002/advs.202303706 · 2023 · External reference
Bioswitchable Delivery of microRNA by Framework Nucleic Acids: Application to Bone Regeneration
10.1002/smll.202104359 · 2021 · External reference
Framework Nucleic Acid‐Based Selective Cell Catcher for Endogenous Stem Cell Recruitment
10.1002/adma.202406118 · 2024 · External reference
Tetrahedral Framework Nucleic Acids: Rational Structural Design and Structure‐Property Relationships for Biomedical Applications
10.1016/j.matdes.2026.116072 · 2026 · External reference
Tetrahedral Framework Nucleic Acids Delivery of Pirfenidone for Anti‐Inflammatory and Antioxidative Effects to Treat Idiopathic Pulmonary Fibrosis
10.1021/acsnano.4c06598 · 2024 · External reference
Framework Nucleic Acid‐Based and Neutrophil‐Based Nanoplatform Loading Baicalin With Targeted Drug Delivery for Anti‐Inflammation Treatment
10.1021/acsnano.4c12917 · 2025 · External reference
Biological Effect of Differently Sized Tetrahedral Framework Nucleic Acids: Endocytosis, Proliferation, Migration, and Biodistribution
10.1021/acsami.1c20657 · 2021 · External reference
Tetrahedral Framework Nucleic Acid‐Loaded Retinoic Acid Promotes Osteosarcoma Stem Cell Clearance
10.1021/acsami.4c14440 · 2024 · External reference
Enzyme‐Responsive Nanoparachute for Targeted miRNA Delivery: A Protective Strategy Against Acute Liver and Kidney Injury
10.1002/advs.202411210 · 2025 · External reference
Framework Nucleic Acid Nanomaterials for Central Nervous System Therapies: Design for Barrier Penetration, Targeted Delivery, Cellular Uptake, and Endosomal Escape
10.1021/acsnano.5c03945 · 2025 · External reference
Progress in Biomedical Applications of Tetrahedral Framework Nucleic Acid‐Based Functional Systems
10.1021/acsami.0c13806 · 2020 · External reference
Exploration and Insights Into the Cellular Internalization and Intracellular Fate of Amphiphilic Polymeric Nanocarriers
10.1016/j.apsb.2021.02.019 · 2021 · External reference
Biotin Receptor‐Mediated Intracellular Delivery of Synthetic Polypeptide‐Protein Complexes
10.1016/j.jconrel.2023.03.051 · 2023 · External reference
Tetrahedral Framework Nucleic Acids Enhance the Chondrogenic Potential of Human Umbilical Cord Mesenchymal Stem Cells via the PI3K/AKT Axis
10.1093/rb/rbad085 · 2023 · External reference
Effect of Tetrahedral Framework Nucleic Acids on the Reconstruction of Tendon‐to‐Bone Injuries after Rotator Cuff Tears
10.1111/cpr.13605 · 2024 · External reference
Preventive Effect of Tetrahedral Framework Nucleic Acids on Bisphosphonate‐Related Osteonecrosis of the Jaw
10.1039/d0nr03731a · 2020 · External reference
Tetrahedral Framework Nucleic Acids' Role in Facilitating Chronic Diabetic Wound Repair via the Endoplasmic Reticulum‐Mitochondrial Pathway
10.1016/j.nantod.2024.102252 · 2024 · External reference
Proteomic Exploration of Endocytosis of Framework Nucleic Acids
10.1002/smll.202100837 · 2021 · External reference
Strategies and Mechanisms for Endosomal Escape of Therapeutic Nucleic Acids
10.1016/j.cbpa.2024.102506 · 2024 · External reference
Current Understanding and Translational Prospects of Tetrahedral Framework Nucleic Acids
10.1021/jacsau.4c01170 · 2025 · External reference
A Transdermal Drug Delivery System Based on Nucleic Acid Nanomaterials for Skin Photodamage Treatment
10.1002/adfm.202303580 · 2023 · External reference
Tetrahedral Framework Nucleic Acid Loaded With Glabridin: A Transdermal Delivery System Applicated to Anti‐Hyperpigmentation
10.1111/cpr.13495 · 2023 · External reference
Framework Nucleic Acids as Programmable Carrier for Transdermal Drug Delivery
10.1038/s41467-019-09029-9 · 2019 · External reference
Cartilage‐Penetrating Framework Nucleic Acid Nanoparticles Ameliorate Osteoarthritis by Promoting Drug Delivery and Chondrocyte Uptake
10.1002/advs.202502661 · 2025 · External reference
Tetrahedral Framework Nucleic Acids Promote Corneal Epithelial Wound Healing In Vitro and In Vivo
10.1002/smll.201901907 · 2019 · External reference
Advancements in Engineering Tetrahedral Framework Nucleic Acids for Biomedical Innovations
10.1002/smtd.202401360 · 2025 · External reference
Tetrahedral Framework Nucleic Acids for Improving Wound Healing
10.1186/s12951-024-02365-z · 2024 · External reference
Tetrahedral Framework Nucleic Acid Carrying Angiogenic Peptide Prevents Bisphosphonate‐Related Osteonecrosis of the Jaw by Promoting Angiogenesis
10.1038/s41368-022-00171-7 · 2022 · External reference
Tetrahedral Framework Nucleic Acids Promote the Proliferation and Differentiation Potential of Diabetic Bone Marrow Mesenchymal Stem Cell
2024 · External reference
Tetrahedral Framework Nucleic Acid Inhibits Chondrocyte Apoptosis and Oxidative Stress Through Activation of Autophagy
10.1021/acsami.0c17307 · 2020 · External reference
Tetrahedral Framework Nucleic Acids Prevent Retina Ischemia‐Reperfusion Injury From Oxidative Stress via Activating the Akt/Nrf2 Pathway
10.1039/c9nr07171g · 2019 · External reference
Tetrahedral Framework Nucleic Acids Act as Antioxidants in Acute Kidney Injury Treatment
10.1016/j.cej.2020.127426 · 2020 · External reference
Flexible Delivering Potential of Oligonucleotides Reconstructed DNA Tetrahedron
10.1002/smll.202502485 · 2025 · External reference
Angiogenic Aptamer‐Modified Tetrahedral Framework Nucleic Acid Promotes Angiogenesis In Vitro and In Vivo
10.1021/acsami.1c08565 · 2021 · External reference
pH‐ and miRNA‐Responsive DNA‐Tetrahedra/Metal–Organic Framework Conjugates: Functional Sense‐and‐Treat Carriers
10.1021/acsnano.0c09996 · 2021 · External reference
Unveiling the Potential of Tetrahedral DNA Frameworks in Clinical Medicine: Mechanisms, Advances, and Future Perspectives
10.1002/smll.202410162 · 2025 · External reference
Diamond‐Inspired DNA Hydrogel Based on Tetrahedral Framework Nucleic Acids for Burn Wound Healing
2025 · External reference
Lipid Nanoparticles (LNPs) for In Vivo RNA Delivery and Their Breakthrough Technology for Future Applications
10.1016/j.addr.2023.114990 · 2023 · External reference
Acid‐Degradable Lipid Nanoparticles Enhance the Delivery of mRNA
10.1038/s41565-024-01765-4 · 2024 · External reference
Effect of Tetrahedral DNA Nanostructures on Osteogenic Differentiation of Mesenchymal Stem Cells via Activation of the Wnt/β‐Catenin Signaling Pathway
10.1016/j.nano.2017.02.011 · 2017 · External reference
Tetrahedral Framework Nucleic Acids Enhance Osteogenic Differentiation and Prevent Apoptosis for Dental Follicle Stem Cell Therapy in Diabetic Bone Repair
10.1016/j.cclet.2024.110241 · 2025 · External reference
Biomaterials and Nanomedicine for Bone Regeneration: Progress and Future Prospects
10.1002/exp.20210011 · 2021 · External reference
Exosome‐Functionalized Magnesium‐Organic Framework‐Based Scaffolds With Osteogenic, Angiogenic and Anti‐Inflammatory Properties for Accelerated Bone Regeneration
10.1016/j.bioactmat.2022.02.012 · 2022 · External reference
Tetrahedral Framework Nucleic Acids Improve the Effectiveness of Adipose‐Derived Mesenchymal Stem Cells in the Repair of Acute Liver Failure
10.1016/j.mtnano.2024.100454 · 2024 · External reference
The Protective Effect of Tetrahedral Framework Nucleic Acids on Periodontium Under Inflammatory Conditions
10.1016/j.bioactmat.2020.11.018 · 2021 · External reference
Effect of Tetrahedral DNA Nanostructures on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells
10.1111/cpr.12566 · 2019 · External reference
Effects of Tetrahedral DNA Nanostructures on the Treatment of Osteoporosis
10.1111/cpr.13625 · 2024 · External reference
Heterogeneous DNA Hydrogel Loaded With Apt02 Modified Tetrahedral Framework Nucleic Acid Accelerated Critical‐Size Bone Defect Repair
10.1016/j.bioactmat.2024.01.009 · 2024 · External reference
Ageing and the Pathogenesis of Osteoarthritis
10.1038/nrrheum.2016.65 · 2016 · External reference
Osteoarthritis
10.1016/s0140-6736(24)02322-5 · 2025 · External reference
Epidemiology of Posttraumatic Osteoarthritis
10.4085/1062-6050-51.5.08 · 2017 · External reference
Modulation of Chondrocyte Motility by Tetrahedral DNA Nanostructures
10.1111/cpr.12368 · 2017 · External reference
Advanced Cell Therapies for Articular Cartilage Regeneration
10.1016/j.tibtech.2014.11.003 · 2015 · External reference
Endogenous Cell Recruitment Strategy for Articular Cartilage Regeneration
10.1016/j.actbio.2020.07.008 · 2020 · External reference
Tetrahedral Framework Nucleic Acids as a Promising Vehicle for Small Molecule Drugs of Traditional Chinese Medicine: Application to Disease Prevention and Treatment
10.1186/s12951-026-04538-4 · 2026 · External reference
Tetrahedral Framework Nucleic Acid‐Based Delivery of microRNA‐29b: A Precision Nanotherapeutic Strategy for Oral Submucous Fibrosis
10.1016/j.cej.2025.163736 · 2025 · External reference
The Neuroprotective Effect of MicroRNA‐22‐3p Modified Tetrahedral Framework Nucleic Acids on Damaged Retinal Neurons via TrkB/BDNF Signaling Pathway
10.1002/adfm.202104141 · 2021 · External reference
A Lysosome‐Activated Tetrahedral Nanobox for Encapsulated siRNA Delivery
10.1002/adma.202201731 · 2022 · External reference
BACE1 Aptamer‐Modified Tetrahedral Framework Nucleic Acid to Treat Alzheimer's Disease in an APP‐PS1 Animal Model
10.1021/acsami.2c14626 · 2022 · External reference
Tetrahedral Framework Nucleic Acids/Hyaluronic Acid‐Methacrylic Anhydride Hybrid Hydrogel With Antimicrobial and Anti‐Inflammatory Properties for Infected Wound Healing
10.1038/s41368-024-00290-3 · 2024 · External reference
Bioswitchable Intracellular Delivery of Small Activating RNA by Tetrahedral Framework Nucleic Acid: Application to p21‐Mediated Anti‐Tumor Therapy
10.1016/j.jconrel.2025.114488 · 2026 · External reference
Tetrahedral Framework Nucleic Acids Connected With MicroRNA‐126 Mimics for Applications in Vascular Inflammation, Remodeling, and Homeostasis
10.1021/acsami.1c23869 · 2022 · External reference
A Multifunctional miRNA Delivery System Based on Tetrahedral Framework Nucleic Acids for Regulating Inflammatory Periodontal Ligament Stem Cells and Attenuating Periodontitis Bone Loss
10.1021/acsami.4c17195 · 2025 · External reference
Amelioration of Osteoarthritis via Tetrahedral Framework Nucleic Acids Delivering Microrna‐124 for Cartilage Regeneration
10.1002/adfm.202305558 · 2023 · External reference
Tetrahedral Framework Nucleic Acid Loaded miR‐23b Inhibits Synovial Inflammation and Cartilage Matrix Degradation in the Treatment of Rheumatoid Arthritis
10.1002/adfm.202310749 · 2023 · External reference
Nano MiRNA‐Functionating Tetrahedral Framework Nucleic Acid for Cartilage‐Targeted Ferritinophagy Modulation to Attenuate Temporomandibular Joint Osteoarthritis
10.1002/smsc.202500267 · 2026 · External reference
A Novel Bioswitchable miRNA Mimic Delivery System: Therapeutic Strategies Upgraded From Tetrahedral Framework Nucleic Acid System for Fibrotic Disease Treatment and Pyroptosis Pathway Inhibition
10.1002/advs.202305622 · 2024 · External reference
A Tetrahedral Framework DNA‐Based Bioswitchable miR‐150 Delivery System for Sepsis
10.1021/acsami.4c14928 · 2024 · External reference
Construction of Nucleic Acid Aptamer‐Functionalized DNA Hydrogels and Their Application in Biomedicine
10.1016/j.mattod.2025.05.024 · 2025 · External reference
Robust and Smart Polypeptide‐Based Nanomedicines for Targeted Tumor Therapy
10.1016/j.addr.2020.10.019 · 2020 · External reference
TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition
2026 · External reference
DNA Tetrahedron Functionalized Microneedles Blocking IL‐6 to Promote Skin Wound Healing
10.1021/acsami.5c07913 · 2025 · External reference
Enhanced Penetrability of a Tetrahedral Framework Nucleic Acid by Modification With iRGD for DOX‐Targeted Delivery to Triple‐Negative Breast Cancer
10.1021/acsami.1c07297 · 2021 · External reference
Bone Targeted Nano‐Drug and Nano‐Delivery
10.1038/s41413-024-00356-2 · 2024 · External reference
Hydrogel Beads‐Based Nanocomposites in Novel Drug Delivery Platforms: Recent Trends and Developments
10.1016/j.cis.2020.102316 · 2021 · External reference
BBPs‐Functionalized Tetrahedral Framework Nucleic Acid Hydrogel Scaffold Captures Endogenous BMP‐2 to Promote Bone Regeneration
10.1016/j.biomaterials.2025.123194 · 2025 · External reference
Tetrahedral Framework Nucleic Acid Composite Hydrogel Loaded With Naringin for Full Alveolar Bone Regeneration
10.1021/acsami.5c10290 · 2025 · External reference
Human Mesenchymal Stem Cell Derived Exosomes Enhance Cell‐Free Bone Regeneration by Altering Their miRNAs Profiles
10.1002/advs.202001334 · 2020 · External reference
Global MicroRNA Profiling in Human Bone Marrow Skeletal—Stromal or Mesenchymal–Stem Cells Identified Candidates for Bone Regeneration
10.1016/j.ymthe.2017.11.018 · 2018 · External reference
The Widespread Regulation of microRNA Biogenesis, Function and Decay
10.1038/nrg2843 · 2010 · External reference
Epigenomic and microRNA‐Mediated Regulation in Cartilage Development, Homeostasis, and Osteoarthritis
10.1016/j.molmed.2011.11.005 · 2012 · External reference
Roles for miRNAs in Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells
10.1186/s13287-019-1309-7 · 2019 · External reference
Bone Marrow Mesenchymal Stem Cells Derived Exosomal miRNAs Can Modulate Diabetic Bone‐Fat Imbalance
10.3389/fendo.2023.1149168 · 2023 · External reference
miRNA‐21 Promotes Osteogenesis via the PTEN/PI3K/Akt/HIF‐1α Pathway and Enhances Bone Regeneration in Critical Size Defects
10.1186/s13287-019-1168-2 · 2019 · External reference
Promotion Effects of miR‐375 on the Osteogenic Differentiation of Human Adipose‐Derived Mesenchymal Stem Cells
10.1016/j.stemcr.2017.01.028 · 2017 · External reference
Bone‐Targeting Delivery of Platelet Lysate Exosomes Ameliorates Glucocorticoid‐Induced Osteoporosis by Enhancing Bone‐Vessel Coupling
10.1186/s12951-022-01400-1 · 2022 · External reference
Type H Blood Vessels in Bone Modeling and Remodeling
10.7150/thno.34126 · 2020 · External reference
MicroRNA‐378 Promotes Osteogenesis‐Angiogenesis Coupling in BMMSCs for Potential Bone Regeneration
10.1155/2018/8402390 · 2018 · External reference
The Promotion of Bone Regeneration through Positive Regulation of Angiogenic–Osteogenic Coupling Using microRNA‐26a
10.1016/j.biomaterials.2013.03.052 · 2013 · External reference
Therapeutic siRNA: State of the Art
10.1038/s41392-020-0207-x · 2020 · External reference
Engineering Functional Inorganic–Organic Hybrid Systems: Advances in siRNA Therapeutics
10.1039/c7cs00479f · 2018 · External reference
Pyroptotic‐Spatiotemporally Selective Delivery of siRNA Against Pyroptosis and Autoimmune Diseases
10.1002/adma.202407115 · 2024 · External reference
siRNA Goes after Diseases of the Bone
10.1016/j.omtn.2023.102051 · 2023 · External reference
Implications of siRNA Therapy in Bone Health: Silencing Communicates
10.3390/biomedicines12010090 · 2024 · External reference
siAkt2‐Loaded Nanoparticles Reprogramming Macrophages to M2 Phenotype for Effective Bone Defect Repair
10.1002/adma.202410507 · 2026 · External reference
Selective Local Delivery of RANK siRNA to Bone Phagocytes Using Bone Augmentation Biomaterials
10.1016/j.biomaterials.2012.07.039 · 2012 · External reference
Anabolic Bone Formation via a Site‐Specific Bone‐Targeting Delivery System by Interfering With Semaphorin 4D Expression
10.1002/jbmr.2322 · 2015 · External reference
A Small Interfering RNA Targeting Lnk Accelerates Bone Fracture Healing With Early Neovascularization
10.1038/labinvest.2013.93 · 2013 · External reference
Tetrahedral DNA Framework‐Based Spherical Nucleic Acids for Efficient siRNA Delivery
10.1002/anie.202416988 · 2025 · External reference
Improved Antiviral Activity of Classical Swine Fever Virus‐Targeted siRNA by Tetrahedral Framework Nucleic Acid‐Enhanced Delivery
10.1021/acsami.1c08143 · 2021 · External reference
Tetrahedral Framework Nucleic Acids Based Small Interfering RNA Targeting Receptor for Advanced Glycation End Products for Diabetic Complications Treatment
10.1021/acsnano.3c06999 · 2023 · External reference
A Bioswitchable siRNA Delivery System: RNAi Therapy Based on Tetrahedral Framework Nucleic Acids for Bone Defect Repair
10.1039/d4nr04105d · 2024 · External reference
tsRNA Modifications: An Emerging Layer of Biological Regulation in Disease
10.1016/j.jare.2024.09.010 · 2025 · External reference
tRNA‐Derived Small RNAs in Disease Immunity
10.7150/thno.102650 · 2025 · External reference
Targeting MT‐tsRNA IDDMT With Nanoparticles to Annulus Fibrosus: a Novel Therapeutic Approach for Intervertebral Disc Degeneration
2025 · External reference
M1 Macrophage‐Derived Extracellular Vesicle Containing tsRNA‐5006c Promotes Osteogenic Differentiation of Aortic Valve Interstitial Cells through Regulating Mitophagy
10.7717/peerj.14307 · 2022 · External reference
Osteogenic Effect of tsRNA‐10277‐Loaded Exosome Derived From Bone Mesenchymal Stem Cells on Steroid‐Induced Osteonecrosis of the Femoral Head
10.2147/dddt.s258024 · 2020 · External reference
tRNA‐Derived Small RNA Changes in Bone Marrow Stem Cells Under Hypoxia and Osteogenic Conduction
10.1111/joor.13566 · 2023 · External reference
MiR‐26a‐Tetrahedral Framework Nucleic Acids Mediated Osteogenesis of Adipose‐Derived Mesenchymal Stem Cells
10.1111/cpr.13272 · 2022 · External reference
MicroRNA‐29c‐Tetrahedral Framework Nucleic Acids: Towards Osteogenic Differentiation of Mesenchymal Stem Cells and Bone Regeneration in Critical‐Sized Calvarial Defects
10.1111/cpr.13624 · 2024 · External reference
Delivery of MiR335‐5p‐Pendant Tetrahedron DNA Nanostructures Using an Injectable Heparin Lithium Hydrogel for Challenging Bone Defects in Steroid‐Associated Osteonecrosis
10.1002/adhm.202101412 · 2022 · External reference
Stem Cells Recruited From Multifunctional Tetrahedral Framework Nucleic Acids Induce Vascularized Osteogenesis to Repair Bone Defects
10.1002/adfm.202421993 · 2025 · External reference
DNA Tetrahedron Delivering miR‐21‐5p Promotes Senescent Bone Defects Repair Through Synergistic Regulation of Osteogenesis and Angiogenesis
10.1002/adhm.202401275 · 2024 · External reference
Functionalized DNA Nanomaterials Targeting Toll‐Like Receptor 4 Prevent Bisphosphonate‐Related Osteonecrosis of the Jaw via Regulating Mitochondrial Homeostasis in Macrophages
10.1002/adfm.202213401 · 2023 · External reference
Gene‐Activating Framework Nucleic Acid‐Targeted Upregulating Sirtuin‐1 to Modulate Osteoimmune Microenvironment for Diabetic Osteoporosis Therapeutics
10.1021/acsnano.4c08727 · 2024 · External reference
Targeted Inhibition of P. gingivalis OMV‐Derived TsRNA by Tetrahedral Framework Nucleic Acids Promotes Periodontal Regeneration
10.1186/s12951-025-03983-x · 2026 · External reference
A Baicalin‐Loaded Coaxial Nanofiber Scaffold Regulated Inflammation and Osteoclast Differentiation for Vascularized Bone Regeneration
10.1016/j.bioactmat.2021.06.028 · 2022 · External reference
Ion‐Engineered Microcryogels via Osteogenesis‐Angiogenesis Coupling and Inflammation Reversing Augment Vascularized Bone Regeneration
10.1002/adfm.202400745 · 2024 · External reference
Efficient Delivery of siRNA via Tetrahedral Framework Nucleic Acids: Inflammation Attenuation and Matrix Regeneration in Temporomandibular Joint Osteoarthritis
10.1021/acsami.4c11089 · 2024 · External reference
Tetrahedral Framework Nucleic Acids in the Prevention and Treatment of Skin and Mucosal Diseases: Advances and Prospects
10.1016/j.cclet.2025.111728 · 2026 · External reference
RNA Sequencing Data Integration Reveals an miRNA Interactome of Osteoarthritis Cartilage
10.1136/annrheumdis-2018-213882 · 2019 · External reference
The Role of MicroRNAs in the Pathophysiology of Osteoarthritis
10.3390/ijms25126352 · 2024 · External reference
Intra‐Articular Injection of microRNA‐140 (miRNA‐140) Alleviates Osteoarthritis (OA) Progression by Modulating Extracellular Matrix (ECM) Homeostasis in Rats
10.1016/j.joca.2017.06.002 · 2017 · External reference
Self‐Healing Hyaluronic Acid‐Based Hydrogel With miRNA140‐5p Loaded MON‐PEI Nanoparticles for Chondrocyte Regeneration: Schiff Base Self‐Assembly Approach
10.1002/advs.202406479 · 2025 · External reference
Diagnosis and Treatment of Hip and Knee Osteoarthritis
10.1001/jama.2020.22171 · 2021 · External reference
Osteoarthritis: Pathogenic Signaling Pathways and Therapeutic Targets
10.1038/s41392-023-01330-w · 2023 · External reference
miR‐146a Facilitates Osteoarthritis by Regulating Cartilage Homeostasis via Targeting Camk2d and Ppp3r2
10.1038/cddis.2017.146 · 2017 · External reference
MicroRNA‐155 as a Proinflammatory Regulator in Clinical and Experimental Arthritis
10.1073/pnas.1019536108 · 2011 · External reference
MicroRNA‐34a Affects Chondrocyte Apoptosis and Proliferation by Targeting the SIRT1/p53 Signaling Pathway During the Pathogenesis of Osteoarthritis
10.3892/ijmm.2016.2618 · 2016 · External reference
microRNA‐140 Targets RALA and Regulates Chondrogenic Differentiation of Human Mesenchymal Stem Cells by Translational Enhancement of SOX9 and ACAN
10.1089/scd.2013.0209 · 2014 · External reference
MicroRNA‐140 Expression During Chondrogenic Differentiation of Equine Cord Blood‐Derived Mesenchymal Stromal Cells
10.1089/scd.2012.0411 · 2013 · External reference
Chondrogenic Primed Extracellular Vesicles Activate miR‐455/SOX11/FOXO Axis for Cartilage Regeneration and Osteoarthritis Treatment
10.1038/s41536-022-00250-7 · 2022 · External reference
Targeting FAP‐Positive Chondrocytes in Osteoarthritis: A Novel Lipid Nanoparticle siRNA Approach to Mitigate Cartilage Degeneration
10.1186/s12951-024-02946-y · 2024 · External reference
Rejuvenating Hyaline Cartilage With Senescence‐Targeting Si‐ADAM19 Delivery for Osteoarthritis Therapy
10.1002/advs.202414419 · 2025 · External reference
Engineered Hydrogels for siRNA Delivery: From Smart Design to Therapeutic Impact
10.1016/j.cej.2025.171852 · 2026 · External reference
Rekindling RNAi Therapy: Materials Design Requirements for In Vivo siRNA Delivery
10.1002/adma.201903637 · 2019 · External reference
In Vivo Therapeutic Efficacy of TNFα Silencing by Folate‐PEG‐Chitosan‐DEAE/siRNA Nanoparticles in Arthritic Mice
10.2147/ijn.s146942 · 2018 · External reference
Surface Functionalization of Exosomes for Chondrocyte‐Targeted siRNA Delivery and Cartilage Regeneration
10.1016/j.jconrel.2024.04.009 · 2024 · External reference
MMP13‐Targeted siRNA‐Loaded Micelles for Diagnosis and Treatment of Posttraumatic Osteoarthritis
10.1016/j.bioactmat.2024.04.010 · 2024 · External reference
DNA Origami‐Based CD44‐Targeted Therapy Silences Stat3 Enhances Cartilage Regeneration and Alleviates Osteoarthritis Progression
2025 · External reference
Understanding tsRNAs: From Classification to Disease Mechanisms
10.1016/j.isci.2025.112614 · 2025 · External reference
Bone Mesenchymal Stromal Cell‐Derived Extracellular Vesicles Protect Articular Cartilage Through Regulating tRF‐Gln‐TTG‐019/UBL3
10.1155/mi/2705953 · 2025 · External reference
tRNA‐Derived Fragments (tRFs) Regulate Post‐Transcriptional Gene Expression via AGO‐Dependent Mechanism in IL‐1β Stimulated Chondrocytes
10.1016/j.joca.2020.04.014 · 2020 · External reference
WYRGRL‐Functionalized Tetrahedral DNA Integrates ROS Scavenging and miR‐26b‐5p Delivery for Cartilage‐Specific Osteoarthritis Treatment
10.1016/j.cej.2025.170673 · 2025 · External reference
Antilipotoxic Framework Nucleic Acid‐Loaded Injectable Hydrogel Microspheres for the Targeted Delivery of miR‐34a‐5p Inhibitors to Attenuate Dietary Fat‐Associated Osteoarthritis
10.1016/j.cej.2025.168281 · 2025 · External reference
A Tetrahedral Framework Nucleic Acids‐Based Gene Therapeutic Nanococktail Alleviates Cartilage Damage and Protects Against Osteoarthritis Progression
10.1016/j.cej.2024.155189 · 2024 · External reference
A Novel Mesenchymal Stem Cell‐Targeting Dual‐miRNA Delivery System Based on Aptamer‐Functionalized Tetrahedral Framework Nucleic Acids: Application to Endogenous Regeneration of Articular Cartilage
10.1016/j.bioactmat.2024.08.008 · 2024 · External reference
Harnessing Nucleic Acids Nanotechnology for Bone/Cartilage Regeneration
10.1002/smll.202301996 · 2023 · External reference
3D Printing of Scaffolds for Articular Cartilage/Osteochondral Regeneration: Design, Performance, and Applications
10.1016/j.cej.2025.165273 · 2025 · External reference
Anabolic Indices of Matrix Proteins Identify Regenerative Small RNA Intrinsic to Human Cartilage
10.1126/sciadv.adu8440 · 2025 · External reference