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References from Epithelial SLC25A20 Deficiency Drives Immunosuppressive Neutrophil Remodeling via ARG1 Palmitoylation to Promote Colorectal Cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
Cancer statistics
2023 · External reference
Changing epidemiology of colorectal cancer — birth cohort effects and emerging risk factors
10.1038/s41575-023-00841-9 · 2024 · External reference
Colorectal cancer statistics
2020 · External reference
Innate Immune Cells: Key Players of Orchestra in Modulating Tumor Microenvironment (TME)
10.1016/j.heliyon.2024.e27480 · 2024 · External reference
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
10.1016/j.ccell.2023.02.016 · 2023 · External reference
Hallmarks of cancer: The next generation
10.1016/j.cell.2011.02.013 · 2011 · External reference
Neutrophils in cancer: Neutral no more
10.1038/nrc.2016.52 · 2016 · External reference
Neutrophil diversity and plasticity in tumour progression and therapy
10.1038/s41568-020-0281-y · 2020 · External reference
Liver tumour immune microenvironment subtypes and neutrophil heterogeneity
10.1038/s41586-022-05400-x · 2022 · External reference
Polarization of Tumor‐Associated Neutrophil Phenotype by TGF‐β: “N1” versus “N2” TAN
10.1016/j.ccr.2009.06.017 · 2009 · External reference
N1 versus N2 and PMN‐MDSC: A critical appraisal of current concepts on tumor‐associated neutrophils and new directions for human oncology
10.1111/imr.13176 · 2023 · External reference
Single‐cell integration and multi‐modal profiling reveals phenotypes and spatial organization of neutrophils in colorectal cancer
10.1016/j.ccell.2025.12.003 · 2026 · External reference
Tissue‐specific reprogramming leads to angiogenic neutrophil specialization and tumor vascularization in colorectal cancer
10.1172/jci174545 · 2024 · External reference
The prognostic landscape of genes and infiltrating immune cells across human cancers
10.1038/nm.3909 · 2015 · External reference
Neutrophils Alter DNA Repair Landscape to Impact Survival and Shape Distinct Therapeutic Phenotypes of Colorectal Cancer
10.1053/j.gastro.2021.03.027 · 2021 · External reference
Cancer cell metabolic plasticity in migration and metastasis
10.1007/s10585-021-10102-1 · 2021 · External reference
The role of lipids in cancer progression and metastasis
10.1016/j.cmet.2022.09.023 · 2022 · External reference
Lipid metabolism in cancer: New perspectives and emerging mechanisms
10.1016/j.devcel.2021.04.013 · 2021 · External reference
CPT1A‐mediated Fat Oxidation, Mechanisms, and Therapeutic Potential
10.1210/endocr/bqz046 · 2020 · External reference
SCD1/FADS2 fatty acid desaturases equipoise lipid metabolic activity and redox‐driven ferroptosis in ascites‐derived ovarian cancer cells
10.7150/thno.70194 · 2022 · External reference
Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia
10.1038/nm.4093 · 2016 · External reference
Acylcarnitines
10.2337/db12-0466 · 2013 · External reference
Down‐regulation of SLC25A20 promotes hepatocellular carcinoma growth and metastasis through suppression of fatty‐acid oxidation
10.1038/s41419-021-03648-1 · 2021 · External reference
Fatty Acid Metabolism and Cancer
10.1007/978-3-030-51652-9_16 · 2021 · External reference
CPT2 downregulation adapts HCC to lipid‐rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity
10.1136/gutjnl-2017-315193 · 2018 · External reference
Deregulation of MicroRNAs mediated control of carnitine cycle in prostate cancer: Molecular basis and pathophysiological consequences
10.1038/onc.2017.216 · 2017 · External reference
Metabolic Pathway Signatures Associated with Urinary Metabolite Biomarkers Differentiate Bladder Cancer Patients From Healthy Controls
10.3349/ymj.2016.57.4.865 · 2016 · External reference
Intake of Red and Processed Meat, Use of Non‐Steroid Anti‐Inflammatory Drugs, Genetic Variants and Risk of Colorectal Cancer: A Prospective Study of the Danish “Diet, Cancer and Health” Cohort
10.3390/ijms20051121 · 2019 · External reference
Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases
10.3390/ijms23073636 · 2022 · External reference
Neutrophil to lymphocyte ratio may be predict of mortality in all conditions
10.1038/bjc.2013.598 · 2013 · External reference
Dynamics and functions of lipid droplets
10.1038/s41580-018-0085-z · 2019 · External reference
CD36‐mediated metabolic crosstalk between tumor cells and macrophages affects liver metastasis
10.1038/s41467-022-33349-y · 2022 · External reference
Lipophagy‐derived fatty acids undergo extracellular efflux via lysosomal exocytosis
10.1080/15548627.2020.1728097 · 2021 · External reference
The small chemical vacuolin‐1 inhibits Ca2+‐dependent lysosomal exocytosis but not cell resealing
10.1038/sj.embor.7400243 · 2004 · External reference
Vanpouille‐Box C. Cancer cell metabolism and antitumour immunity
10.1038/s41577-024-01026-4 · 2024 · External reference
Fatty acids as modulators of neutrophil recruitment, function and survival
10.1016/j.ejphar.2015.03.098 · 2016 · External reference
Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds
10.1073/pnas.75.5.2458 · 1978 · External reference
Protein post‐translational modifications in the regulation of cancer hallmarks
10.1038/s41417-022-00464-3 · 2023 · External reference
Moonlighting functions of metabolic enzymes and metabolites in cancer
10.1016/j.molcel.2021.08.031 · 2021 · External reference
Lipid‐induced S‐palmitoylation as a Vital Regulator of Cell Signaling and Disease Development
10.7150/ijbs.64046 · 2021 · External reference
In vitro reconstitution of substrate S‐acylation by the zDHHC family of protein acyltransferases
10.1098/rsob.210390 · 2022 · External reference
Lipid metabolism reprogramming and its potential targets in cancer
10.1186/s40880-018-0301-4 · 2018 · External reference
Metabolic regulation of cell growth and proliferation
10.1038/s41580-019-0123-5 · 2019 · External reference
Theoretical framework and emerging challenges of lipid metabolism in cancer
10.1016/j.semcancer.2024.12.002 · 2025 · External reference
Cellular fatty acid metabolism and cancer
10.1016/j.cmet.2013.05.017 · 2013 · External reference
Loss of SLC25A20 in Pancreatic Adenocarcinoma Reversed the Tumor‐Promoting Effects of a High‐Fat Diet
10.7150/thno.114912 · 2025 · External reference
Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress
10.1016/j.cmet.2020.06.002 · 2020 · External reference
Cancer metabolism: Looking forward
10.1038/s41568-021-00378-6 · 2021 · External reference
The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells
10.1038/s41467-017-00910-z · 2017 · External reference
Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?
10.3389/fphys.2018.00113 · 2018 · External reference
Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response
10.1038/s41556-019-0298-1 · 2019 · External reference
A STAT3 palmitoylation cycle promotes TH17 differentiation and colitis
10.1038/s41586-020-2799-2 · 2020 · External reference
Protein S‐palmitoylation in immunity
10.1098/rsob.200411 · 2021 · External reference
Clinical Relevance and Suppressive Capacity of Human Myeloid‐Derived Suppressor Cell Subsets
10.1158/1078-0432.ccr-17-3726 · 2018 · External reference
Metabolism, metabolites, and macrophages in cancer
10.1186/s13045-023-01478-6 · 2023 · External reference
Myeloid Cell‐Derived Arginase in Cancer Immune Response
10.3389/fimmu.2020.00938 · 2020 · External reference
Versatile roles of k63‐linked ubiquitin chains in trafficking
10.3390/cells3041027 · 2014 · External reference
Mechanisms and functions of protein S‐acylation
10.1038/s41580-024-00700-8 · 2024 · External reference
Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity
10.1158/0008-5472.can-03-3645 · 2004 · External reference
Approaches to Measuring the Activity of Major Lipolytic and Lipogenic Enzymes In Vitro and Ex Vivo
10.3390/ijms231911093 · 2022 · External reference
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
10.1038/nature25492 · 2018 · External reference
SLC25A21 downregulation promotes KRAS‐mutant colorectal cancer progression by increasing glutamine anaplerosis
10.1172/jci.insight.167874 · 2023 · External reference
Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non‐small cell lung cancer
2018 · External reference
Metabolic role of fatty acid binding protein 7 in mediating triple‐negative breast cancer cell death via PPAR‐α signaling
10.1194/jlr.m092379 · 2019 · External reference
Quantitative Determination of Plasma C8–C26 Total Fatty Acids for the Biochemical Diagnosis of Nutritional and Metabolic Disorders
10.1006/mgme.2001.3170 · 2001 · External reference
