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References from A Combination of Alleles in LMOD2 and a lncRNA is Strongly Associated With Myxomatous Mitral Valve Disease in Cavalier King Charles Spaniels. Local targets link to admitted publications; unresolved targets remain external evidence.
Disruption of Cardiac Thin Filament Assembly Arising From a Mutation in LMOD2: A Novel Mechanism of Neonatal Dilated Cardiomyopathy
10.1126/sciadv.aax2066 · 2019 · External reference
The Genetic Consequences of Dog Breed Formation‐Accumulation of Deleterious Genetic Variation and Fixation of Mutations Associated With Myxomatous Mitral Valve Disease in Cavalier King Charles Spaniels
10.1371/journal.pgen.1009726 · 2021 · External reference
Breeding Restrictions Decrease the Prevalence of Myxomatous Mitral Valve Disease in Cavalier King Charles Spaniels Over an 8‐ to 10‐Year Period
10.1111/jvim.13663 · 2016 · External reference
Crystal Structure of Leiomodin 2 in Complex With Actin: A Structural and Functional Reexamination
10.1016/j.bpj.2017.07.007 · 2017 · External reference
Trimmomatic: A Flexible Trimmer for Illumina Sequence Data
10.1093/bioinformatics/btu170 · 2014 · External reference
Chronic Valvular Disease (Endocardiosis) in Dogs
1977 · External reference
Heart Disease as a Cause of Death in Insured Swedish Dogs Younger Than 10 Years of Age
10.1111/j.1939-1676.2006.tb01803.x · 2006 · External reference
Glycosaminoglycan Profiles of Myxomatous Mitral Leaflets and Chordae Parallel the Severity of Mechanical Alterations
10.1016/s0735-1097(03)00626-0 · 2003 · External reference
Early Death of 2 Siblings Related to Mutations in LMOD2, a Recently Discovered Cause of Neonatal Dilated Cardiomyopathy
10.1016/j.cjco.2021.07.017 · 2021 · External reference
Chronic Valvular Disease in the Cavalier King Charles Spaniel in Sweden
1992 · External reference
Overview of the Muscle Cytoskeleton
10.1002/j.2040-4603.2017.tb00766.x · 2017 · External reference
A Comprehensive Biomedical Variant Catalogue Based on Whole Genome Sequences of 582 Dogs and Eight Wolves
10.1111/age.12834 · 2019 · External reference
ACVIM Consensus Guidelines for the Diagnosis and Treatment of Myxomatous Mitral Valve Disease in Dogs
10.1111/jvim.15488 · 2019 · External reference
Nebulin and Lmod2 Are Critical for Specifying Thin‐Filament Length in Skeletal Muscle
10.1126/sciadv.abc1992 · 2020 · External reference
Systolic Murmur: Its Clinical Significance
10.1001/jama.1933.02740310020005 · 1933 · External reference
Fast and Accurate Short Read Alignment With Burrows‐Wheeler Transform
10.1093/bioinformatics/btp324 · 2009 · External reference
Evaluation of the Swedish Breeding Program for Cavalier King Charles Spaniels
10.1186/1751-0147-52-54 · 2010 · External reference
Identification of 2 Loci Associated With Development of Myxomatous Mitral Valve Disease in Cavalier King Charles Spaniels
10.1093/jhered/esr041 · 2011 · External reference
The Genome Analysis Toolkit: A MapReduce Framework for Analyzing Next‐Generation DNA Sequencing Data
10.1101/gr.107524.110 · 2010 · External reference
Genetic Variants at the Nebulette Locus Are Associated With Myxomatous Mitral Valve Disease Severity in Cavalier King Charles Spaniels
10.3390/genes13122292 · 2022 · External reference
Non‐Coding RNAs in Disease: From Mechanisms to Therapeutics
10.1038/s41576-023-00662-1 · 2024 · External reference
Comparative Pathology of Human and Canine Myxomatous Mitral Valve Degeneration: 5HT and TGF‐β Mechanisms
10.1016/j.carpath.2019.107196 · 2020 · External reference
Unresolved reference
External reference
Knockout of Lmod2 Results in Shorter Thin Filaments Followed by Dilated Cardiomyopathy and Juvenile Lethality
10.1073/pnas.1508273112 · 2015 · External reference
Mitral Valve Prolapse in the Dog: A Model of Mitral Valve Prolapse in Man
10.1016/s0008-6363(00)00113-9 · 2000 · External reference
PLINK: A Tool Set for Whole‐Genome Association and Population‐Based Linkage Analyses
10.1086/519795 · 2007 · External reference
Mitral Regurgitation Severity and Left Ventricular Systolic Dimension Predict Survival in Young Cavalier King Charles Spaniels
10.1111/jvim.14759 · 2017 · External reference
Whole‐Exome Sequencing Identifies Homozygote Nonsense Variants in LMOD2 Gene Causing Infantile Dilated Cardiomyopathy
10.3390/cells12111455 · 2023 · External reference
Unresolved reference
External reference
Degenerative Valvular Disease in the Cavalier King Charles Spaniel: Results of the UK Breed Scheme 1991–2010
10.1111/jvim.14619 · 2017 · External reference
Regression Shrinkage and Selection via the Lasso
10.1111/j.2517-6161.1996.tb02080.x · 2018 · External reference
Leiomodin Creates a Leaky Cap at the Pointed End of Actin‐Thin Filaments
10.1371/journal.pbio.3000848 · 2020 · External reference
Leiomodin‐2 Is an Antagonist of Tropomodulin‐1 at the Pointed End of the Thin Filaments in Cardiac Muscle
10.1242/jcs.071837 · 2010 · External reference
10.1101/2020.07.02.185108
10.1101/2020.07.02.185108 · External reference
The Functions of Long Non‐Coding RNA (lncRNA) H19 in the Heart
10.1016/j.hlc.2021.10.022 · 2022 · External reference
