Research graph
References from Integrative Multi‐Omics Analysis Identifies Candidate <scp>MicroRNA</scp> Regulatory Networks Associated With High‐Altitude Adaptation in Tibetan Pigs. Local targets link to admitted publications; unresolved targets remain external evidence.
miRDeep*: An Integrated Application Tool for miRNA Identification From RNA Sequencing Data
10.1093/nar/gks1187 · 2013 · External reference
Recent Insights Into Plant miRNA Biogenesis: Multiple Layers of miRNA Level Regulation
10.3390/plants12020342 · 2023 · External reference
Exosomes From Human Induced Pluripotent Stem Cells‐Derived Keratinocytes Accelerate Burn Wound Healing Through miR‐762 Mediated Promotion of Keratinocytes and Endothelial Cells Migration
2022 · External reference
KOBAS‐i: Intelligent Prioritization and Exploratory Visualization of Biological Functions for Gene Enrichment Analysis
10.1093/nar/gkab447 · 2021 · External reference
Fastp: An Ultra‐Fast All‐in‐One FASTQ Preprocessor
10.1093/bioinformatics/bty560 · 2018 · External reference
Twelve Years of SAMtools and BCFtools
10.1093/gigascience/giab008 · 2021 · External reference
Exosome miR‐155 Derived From Gastric Carcinoma Promotes Angiogenesis by Targeting the c‐MYB/VEGF Axis of Endothelial Cells
10.1016/j.omtn.2020.01.024 · 2020 · External reference
Downregulation of EPAS1 and EGLN1 mRNA Expression Associated With High‐Altitude Adaptive Genetic Variants in Sherpa Highlanders
10.1111/ahg.70034 · 2026 · External reference
Single‐Cell RNA‐Seq and Bulk‐Seq Identify RAB17 as a Potential Regulator of Angiogenesis by Human Dermal Microvascular Endothelial Cells in Diabetic Foot Ulcers
10.1093/burnst/tkad020 · 2023 · External reference
High Altitude Adaptation in Livestock and Poultry: Exploring Morphological, Physiological, Biochemical and Omic Insights: A Review
2025 · External reference
A Pleiotropic Hypoxia‐Sensitive EPAS1 Enhancer Is Disrupted by Adaptive Alleles in Tibetans
10.1126/sciadv.ade1942 · 2022 · External reference
Hypoxic Lung Adenocarcinoma‐Derived Exosomal miR‐1290 Induces M2 Macrophage Polarization by Targeting SOCS3
10.1002/cam4.5954 · 2023 · External reference
Male Yaks Adapt to Heat Stress With Enhancement of Immunomodulation, Anti‐Oxidation, and Blood Oxygen Delivery
10.1016/j.jtherbio.2024.103879 · 2024 · External reference
Graph‐Based Genome Alignment and Genotyping With HISAT2 and HISAT‐Genotype
10.1038/s41587-019-0201-4 · 2019 · External reference
Erythrocyte‐Derived microRNAs: Emerging Players in Cardiovascular and Metabolic Disease
10.1161/atvbaha.123.319027 · 2023 · External reference
The Many Faces of Dicer: The Complexity of the Mechanisms Regulating Dicer Gene Expression and Enzyme Activities
10.1093/nar/gkv328 · 2015 · External reference
Integrative Genomic, Transcriptomic and Epigenomic Analysis Reveals Cis‐Regulatory Contributions to High‐Altitude Adaptation in Tibetan Pigs
10.1093/molbev/msaf169 · 2025 · External reference
Fast Gapped‐Read Alignment With Bowtie 2
10.1038/nmeth.1923 · 2012 · External reference
Detecting Mitochondrial Signatures of Selection in Wild Tibetan Pigs and Domesticated Pigs
10.3109/19401736.2014.913169 · 2016 · External reference
The Associations and Roles of microRNA Single‐Nucleotide Polymorphisms in Cervical Cancer
10.7150/ijms.57990 · 2021 · External reference
Hypoxic Stress Promotes Astrocyte Infiltration‐Like Growth via HIF‐1alpha/GDNF/LOXL2 Axis
10.1016/j.bbadis.2025.167702 · 2025 · External reference
miR‐30a‐5p Attenuates Hypoxia/Reoxygenation‐Induced Cardiomyocyte Apoptosis by Regulating PTEN Protein Expression and Activating PI3K/Akt Signaling Pathway
10.1186/s12872-024-03900-4 · 2024 · External reference
featureCounts: An Efficient General Purpose Program for Assigning Sequence Reads to Genomic Features
10.1093/bioinformatics/btt656 · 2014 · External reference
Climate Suitability Assessment on the Qinghai‐Tibet Plateau
10.1016/j.scitotenv.2021.151653 · 2022 · External reference
Comparison Study of Morphology and Vascular Casts Between Plateau‐Type Tibetan Sheep and Low‐Altitude Small‐Tailed Han Sheep Testes
10.1111/ahe.12822 · 2022 · External reference
Gene Regulation in Animal miRNA Biogenesis
10.2217/epi-2022-0214 · 2022 · External reference
Integrative Small and Long RNA Omics Analysis of Human Healing and Nonhealing Wounds Discovers Cooperating microRNAs as Therapeutic Targets
10.7554/elife.80322 · 2022 · External reference
Moderated Estimation of Fold Change and Dispersion for RNA‐Seq Data With DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
Inventory and Frequency of Retrogressive Thaw Slumps in Permafrost Region of the Qinghai–Tibet Plateau
10.1029/2022gl099829 · 2022 · External reference
Recent Selection and Introgression Facilitated High‐Altitude Adaptation in Cattle
10.1016/j.scib.2024.05.030 · 2024 · External reference
Evolutionary Origin of Species Diversity on the Qinghai–Tibet Plateau
10.1111/jse.12809 · 2021 · External reference
Clinical Implications of miRNAs in Erythropoiesis, Anemia, and Other Hematological Disorders
10.1007/s11033-024-09981-w · 2024 · External reference
The Transcription Factor EPAS‐1/Hypoxia‐Inducible Factor 2α Plays an Important Role in Vascular Remodeling
10.1073/pnas.140087397 · 2000 · External reference
Biogenesis and Mechanisms of microRNA‐Mediated Gene Regulation
10.1002/bit.28029 · 2022 · External reference
Comparative Analysis of miRNA Expression Profiles of Yak Milk‐Derived Exosomes at Different Altitudes
10.3390/ani15010087 · 2025 · External reference
Human Adaptation to High Altitude: A Review of Convergence Between Genomic and Proteomic Signatures
10.1186/s40246-022-00395-y · 2022 · External reference
miRNAs Target Databases: Developmental Methods and Target Identification Techniques With Functional Annotations
10.1007/s00018-017-2469-1 · 2017 · External reference
Molecular Mechanisms of Dicer: Endonuclease and Enzymatic Activity
10.1042/bcj20160759 · 2017 · External reference
Life Ascending: Mechanism and Process in Physiological Adaptation to High‐Altitude Hypoxia
10.1146/annurev-ecolsys-110218-025014 · 2019 · External reference
The STRING Database in 2021: Customizable Protein‐Protein Networks, and Functional Characterization of User‐Uploaded Gene/Measurement Sets
10.1093/nar/gkaa1074 · 2021 · External reference
Identification of a miRNA‐mRNA Regulatory Networks in Placental Tissue Associated With Tibetan High Altitude Adaptation
10.3389/fgene.2021.671119 · 2021 · External reference
Hypoxia: Adapting to High Altitude by Mutating EPAS‐1, the Gene Encoding HIF‐2α
10.1089/ham.2010.1099 · 2011 · External reference
miR‐144/451 in Hematopoiesis and Beyond
10.1186/s41544-019-0035-8 · 2019 · External reference
Whole‐Genome Analysis Reveals Distinct Adaptation Signatures to Diverse Environments in Chinese Domestic Pigs
10.1186/s40104-024-01053-0 · 2024 · External reference
Terrain Gradient Variations in the Ecosystem Services Value of the Qinghai‐Tibet Plateau, China
10.1016/j.gecco.2022.e02008 · 2022 · External reference
The Qinghai‐Tibetan Plateau: How High Do Tibetans Live?
10.1089/152702901753397054 · 2001 · External reference
Expression and Variations in EPAS1 Associated With Oxygen Metabolism in Sheep
10.3390/genes13101871 · 2022 · External reference
Analysis of Genetic Evolutionary Differences Among Four Tibetan Pig Populations in China
10.1016/j.ygeno.2024.110950 · 2024 · External reference
Characterization of circRNA‐miRNA‐mRNA Networks Regulating Oxygen Utilization in Type II Alveolar Epithelial Cells of Tibetan Pigs
10.3389/fmolb.2022.854250 · 2022 · External reference
Genetic Adaptations of the Tibetan Pig to High‐Altitude Hypoxia on the Qinghai‐Tibet Plateau
10.3390/ijms252011303 · 2024 · External reference
MicroRNA‐126 Affects Cell Apoptosis, Proliferation, Cell Cycle and Modulates VEGF/TGF‐Beta Levels in Pulmonary Artery Endothelial Cells
2019 · External reference
Physiological and Genetic Basis of High‐Altitude Indigenous Animals' Adaptation to Hypoxic Environments
10.3390/ani14203031 · 2024 · External reference
Biogenesis and Mechanisms of microRNA‐Mediated Gene Regulation
10.1002/bit.28029 · ExternalCitation · doi-reference
Hypoxic Lung Adenocarcinoma‐Derived Exosomal miR‐1290 Induces M2 Macrophage Polarization by Targeting SOCS3
10.1002/cam4.5954 · ExternalCitation · doi-reference
miRNAs Target Databases: Developmental Methods and Target Identification Techniques With Functional Annotations
10.1007/s00018-017-2469-1 · ExternalCitation · doi-reference
Clinical Implications of miRNAs in Erythropoiesis, Anemia, and Other Hematological Disorders
10.1007/s11033-024-09981-w · ExternalCitation · doi-reference
Hypoxic Stress Promotes Astrocyte Infiltration‐Like Growth via HIF‐1alpha/GDNF/LOXL2 Axis
10.1016/j.bbadis.2025.167702 · ExternalCitation · doi-reference
Terrain Gradient Variations in the Ecosystem Services Value of the Qinghai‐Tibet Plateau, China
10.1016/j.gecco.2022.e02008 · ExternalCitation · doi-reference
Male Yaks Adapt to Heat Stress With Enhancement of Immunomodulation, Anti‐Oxidation, and Blood Oxygen Delivery
10.1016/j.jtherbio.2024.103879 · ExternalCitation · doi-reference
Exosome miR‐155 Derived From Gastric Carcinoma Promotes Angiogenesis by Targeting the c‐MYB/VEGF Axis of Endothelial Cells
10.1016/j.omtn.2020.01.024 · ExternalCitation · doi-reference
Recent Selection and Introgression Facilitated High‐Altitude Adaptation in Cattle
10.1016/j.scib.2024.05.030 · ExternalCitation · doi-reference
Climate Suitability Assessment on the Qinghai‐Tibet Plateau
10.1016/j.scitotenv.2021.151653 · ExternalCitation · doi-reference
Analysis of Genetic Evolutionary Differences Among Four Tibetan Pig Populations in China
10.1016/j.ygeno.2024.110950 · ExternalCitation · doi-reference
Inventory and Frequency of Retrogressive Thaw Slumps in Permafrost Region of the Qinghai–Tibet Plateau
10.1029/2022gl099829 · ExternalCitation · doi-reference
Fast Gapped‐Read Alignment With Bowtie 2
10.1038/nmeth.1923 · ExternalCitation · doi-reference
Graph‐Based Genome Alignment and Genotyping With HISAT2 and HISAT‐Genotype
10.1038/s41587-019-0201-4 · ExternalCitation · doi-reference
Molecular Mechanisms of Dicer: Endonuclease and Enzymatic Activity
10.1042/bcj20160759 · ExternalCitation · doi-reference
The Transcription Factor EPAS‐1/Hypoxia‐Inducible Factor 2α Plays an Important Role in Vascular Remodeling
10.1073/pnas.140087397 · ExternalCitation · doi-reference
The Qinghai‐Tibetan Plateau: How High Do Tibetans Live?
10.1089/152702901753397054 · ExternalCitation · doi-reference
Hypoxia: Adapting to High Altitude by Mutating EPAS‐1, the Gene Encoding HIF‐2α
10.1089/ham.2010.1099 · ExternalCitation · doi-reference
featureCounts: An Efficient General Purpose Program for Assigning Sequence Reads to Genomic Features
10.1093/bioinformatics/btt656 · ExternalCitation · doi-reference
Fastp: An Ultra‐Fast All‐in‐One FASTQ Preprocessor
10.1093/bioinformatics/bty560 · ExternalCitation · doi-reference
Single‐Cell RNA‐Seq and Bulk‐Seq Identify RAB17 as a Potential Regulator of Angiogenesis by Human Dermal Microvascular Endothelial Cells in Diabetic Foot Ulcers
10.1093/burnst/tkad020 · ExternalCitation · doi-reference
Twelve Years of SAMtools and BCFtools
10.1093/gigascience/giab008 · ExternalCitation · doi-reference
Integrative Genomic, Transcriptomic and Epigenomic Analysis Reveals Cis‐Regulatory Contributions to High‐Altitude Adaptation in Tibetan Pigs
10.1093/molbev/msaf169 · ExternalCitation · doi-reference
The STRING Database in 2021: Customizable Protein‐Protein Networks, and Functional Characterization of User‐Uploaded Gene/Measurement Sets
10.1093/nar/gkaa1074 · ExternalCitation · doi-reference
KOBAS‐i: Intelligent Prioritization and Exploratory Visualization of Biological Functions for Gene Enrichment Analysis
10.1093/nar/gkab447 · ExternalCitation · doi-reference
miRDeep*: An Integrated Application Tool for miRNA Identification From RNA Sequencing Data
10.1093/nar/gks1187 · ExternalCitation · doi-reference
The Many Faces of Dicer: The Complexity of the Mechanisms Regulating Dicer Gene Expression and Enzyme Activities
10.1093/nar/gkv328 · ExternalCitation · doi-reference
Comparison Study of Morphology and Vascular Casts Between Plateau‐Type Tibetan Sheep and Low‐Altitude Small‐Tailed Han Sheep Testes
10.1111/ahe.12822 · ExternalCitation · doi-reference
Downregulation of EPAS1 and EGLN1 mRNA Expression Associated With High‐Altitude Adaptive Genetic Variants in Sherpa Highlanders
10.1111/ahg.70034 · ExternalCitation · doi-reference
Evolutionary Origin of Species Diversity on the Qinghai–Tibet Plateau
10.1111/jse.12809 · ExternalCitation · doi-reference
A Pleiotropic Hypoxia‐Sensitive EPAS1 Enhancer Is Disrupted by Adaptive Alleles in Tibetans
10.1126/sciadv.ade1942 · ExternalCitation · doi-reference
Life Ascending: Mechanism and Process in Physiological Adaptation to High‐Altitude Hypoxia
10.1146/annurev-ecolsys-110218-025014 · ExternalCitation · doi-reference
Erythrocyte‐Derived microRNAs: Emerging Players in Cardiovascular and Metabolic Disease
10.1161/atvbaha.123.319027 · ExternalCitation · doi-reference
miR‐30a‐5p Attenuates Hypoxia/Reoxygenation‐Induced Cardiomyocyte Apoptosis by Regulating PTEN Protein Expression and Activating PI3K/Akt Signaling Pathway
10.1186/s12872-024-03900-4 · ExternalCitation · doi-reference
Moderated Estimation of Fold Change and Dispersion for RNA‐Seq Data With DESeq2
10.1186/s13059-014-0550-8 · ExternalCitation · doi-reference
Whole‐Genome Analysis Reveals Distinct Adaptation Signatures to Diverse Environments in Chinese Domestic Pigs
10.1186/s40104-024-01053-0 · ExternalCitation · doi-reference
Human Adaptation to High Altitude: A Review of Convergence Between Genomic and Proteomic Signatures
10.1186/s40246-022-00395-y · ExternalCitation · doi-reference
miR‐144/451 in Hematopoiesis and Beyond
10.1186/s41544-019-0035-8 · ExternalCitation · doi-reference
Gene Regulation in Animal miRNA Biogenesis
10.2217/epi-2022-0214 · ExternalCitation · doi-reference
Detecting Mitochondrial Signatures of Selection in Wild Tibetan Pigs and Domesticated Pigs
10.3109/19401736.2014.913169 · ExternalCitation · doi-reference
Identification of a miRNA‐mRNA Regulatory Networks in Placental Tissue Associated With Tibetan High Altitude Adaptation
10.3389/fgene.2021.671119 · ExternalCitation · doi-reference
Characterization of circRNA‐miRNA‐mRNA Networks Regulating Oxygen Utilization in Type II Alveolar Epithelial Cells of Tibetan Pigs
10.3389/fmolb.2022.854250 · ExternalCitation · doi-reference
Physiological and Genetic Basis of High‐Altitude Indigenous Animals' Adaptation to Hypoxic Environments
10.3390/ani14203031 · ExternalCitation · doi-reference
Comparative Analysis of miRNA Expression Profiles of Yak Milk‐Derived Exosomes at Different Altitudes
10.3390/ani15010087 · ExternalCitation · doi-reference
Expression and Variations in EPAS1 Associated With Oxygen Metabolism in Sheep
10.3390/genes13101871 · ExternalCitation · doi-reference
Genetic Adaptations of the Tibetan Pig to High‐Altitude Hypoxia on the Qinghai‐Tibet Plateau
10.3390/ijms252011303 · ExternalCitation · doi-reference
Recent Insights Into Plant miRNA Biogenesis: Multiple Layers of miRNA Level Regulation
10.3390/plants12020342 · ExternalCitation · doi-reference
The Associations and Roles of microRNA Single‐Nucleotide Polymorphisms in Cervical Cancer
10.7150/ijms.57990 · ExternalCitation · doi-reference
Integrative Small and Long RNA Omics Analysis of Human Healing and Nonhealing Wounds Discovers Cooperating microRNAs as Therapeutic Targets
10.7554/elife.80322 · ExternalCitation · doi-reference
