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References from Serum Chitotriosidase Links to Activated Glia at Chronic Active Lesion Rims in Multiple Sclerosis Brain. Local targets link to admitted publications; unresolved targets remain external evidence.
The role of glial cells in multiple sclerosis disease progression
10.1038/s41582-022-00624-x · 2022 · External reference
Chronic active lesions in multiple sclerosis: classification, terminology, and clinical significance
10.1177/17562864241306684 · 2024 · External reference
Serum glial fibrillary acidic protein compared with neurofilament light chain as a biomarker for disease progression in multiple sclerosis
10.1001/jamaneurol.2022.5250 · 2023 · External reference
Serum neurofilament light chain for individual prognostication of disease activity in people with multiple sclerosis: a retrospective modelling and validation study
10.1016/s1474-4422(22)00009-6 · 2022 · External reference
GFAP and NfL as predictors of disease progression and relapse activity in fingolimod‐treated multiple sclerosis
10.1093/brain/awaf433 · 2025 · External reference
Chitinases and immunity: ancestral molecules with new functions
10.1016/j.imbio.2015.11.014 · 2016 · External reference
Chitinases and chitinase‐like proteins as biomarkers in neurologic disorders
10.1212/nxi.0000000000000921 · 2020 · External reference
CHIT1 at diagnosis predicts faster disability progression and reflects early microglial activation in multiple sclerosis
10.1038/s41467-024-49312-y · 2024 · External reference
Gene expression profiling of multiple sclerosis pathology identifies early patterns of demyelination surrounding chronic active lesions
10.3389/fimmu.2017.01810 · 2017 · External reference
CHIT1 at diagnosis reflects long‐term multiple sclerosis disease activity
10.1002/ana.25691 · 2020 · External reference
Cerebrospinal fluid chitinase‐3‐like 2 and chitotriosidase are potential prognostic biomarkers in early multiple sclerosis
10.1111/ene.12960 · 2016 · External reference
Plasma chitotriosidase activity in multiple sclerosis
10.1016/j.clim.2008.12.004 · 2009 · External reference
Intrathecal chitotriosidase and the outcome of multiple sclerosis
10.1177/1352458506070614 · 2006 · External reference
Chitinase effects on immune cell response in neuromyelitis optica and multiple sclerosis
10.1177/1352458510392619 · 2011 · External reference
Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria
10.1016/s1474-4422(17)30470-2 · 2018 · External reference
Insights into disseminated MS brain pathology with multimodal diffusion tensor and PET imaging
10.1212/nxi.0000000000000691 · 2020 · External reference
Imaging chronic active lesions in multiple sclerosis: a consensus statement
10.1093/brain/awae013 · 2024 · External reference
Carimas: an extensive medical imaging data processing tool for research
10.1007/s10278-023-00812-1 · 2023 · External reference
Microglial activation, white matter tract damage, and disability in MS
10.1212/nxi.0000000000000443 · 2018 · External reference
Phenotyping of multiple sclerosis lesions according to innate immune cell activation using 18 kDa translocator protein‐PET
10.1093/braincomms/fcab301 · 2022 · External reference
Reference and target region modeling of [11C]‐(R)‐PK11195 brain studies
2007 · External reference
Optimization of supervised cluster analysis for extracting reference tissue input curves in (R)‐[(11)C]PK11195 brain PET studies
10.1038/jcbfm.2012.59 · 2012 · External reference
Broad rim lesions are a new pathological and imaging biomarker for rapid disease progression in multiple sclerosis
10.1038/s41591-025-03625-7 · 2025 · External reference
Unresolved reference
1977 · External reference
Human CHIT1 gene distribution: new data from Mediterranean and European populations
10.1007/s10038-006-0086-1 · 2007 · External reference
Spatially‐restricted inflammation‐induced senescent‐like glia in multiple sclerosis and patient‐derived organoids
10.1038/s41467-025-63371-9 · 2025 · External reference
SPOTlight: seeded NMF regression to deconvolute spatial transcriptomics spots with single‐cell transcriptomes
10.1093/nar/gkab043 · 2021 · External reference
A lymphocyte–microglia–astrocyte axis in chronic active multiple sclerosis
10.1038/s41586-021-03892-7 · 2021 · External reference
Nebulosa recovers single‐cell gene expression signals by kernel density estimation
10.1093/bioinformatics/btab003 · 2021 · External reference
Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis
10.1038/s41467-019-14118-w · 2020 · External reference
snRNA‐seq stratifies multiple sclerosis patients into distinct white matter glial responses
10.1016/j.neuron.2024.11.016 · 2025 · External reference
Limma powers differential expression analyses for RNA‐sequencing and microarray studies
10.1093/nar/gkv007 · 2015 · External reference
Lesion stage‐dependent causes for impaired remyelination in MS
10.1007/s00401-020-02189-9 · 2020 · External reference
TSPO‐detectable chronic active lesions predict disease progression in multiple sclerosis
10.1212/nxi.0000000000200133 · 2023 · External reference
Effect of interferon‐γ, interleukin‐10, lipopolysaccharide and tumor necrosis factor‐α on chitotriosidase synthesis in human macrophages
10.1515/cclm.2005.088 · 2005 · External reference
Modulation of chitotriosidase during macrophage differentiation
10.1007/s12013-012-9471-x · 2013 · External reference
Predictors of risk of secondary progression in multiple sclerosis
10.1177/17562864251357276 · 2025 · External reference
Cerebrospinal fluid biomarkers as a measure of disease activity and treatment efficacy in relapsing‐remitting multiple sclerosis
10.1111/jnc.13881 · 2017 · External reference
Microglia: unique and common features with other tissue macrophages
10.1007/s00401-014-1267-1 · 2014 · External reference
Plasma CHI3L1 associates with brain volume loss and glial activation in multiple sclerosis
10.1136/jnnp-2025-336063 · 2025 · External reference
Association of serum neurofilament light with microglial activation in multiple sclerosis
10.1136/jnnp-2023-331051 · 2023 · External reference
Serum glial fibrillary acid protein associates with TSPO‐expressing lesions in multiple sclerosis brain
10.1177/17562864251352998 · 2025 · External reference
CX3CR1+/UCHL1+ microglial extracellular vesicles in blood: a potential biomarker for multiple sclerosis
10.1186/s12974-024-03243-z · 2024 · External reference
Different neuroinflammatory profile in amyotrophic lateral sclerosis and frontotemporal dementia is linked to the clinical phase
10.1136/jnnp-2018-318868 · 2019 · External reference
Immunopathology of multiple sclerosis
10.1038/nri3871 · 2015 · External reference
The human chitotriosidase gene: Nature of inherited enzyme deficiency
10.1074/jbc.273.40.25680 · 1998 · External reference