Research graph
References from Iterative Optimization of Photoactivatable BRD4 Degraders for Aging‐Amplified Immunotherapy in Patient‐Derived Lung Cancer Organoids. Local targets link to admitted publications; unresolved targets remain external evidence.
Targeted Protein Degradation for Cancer Therapy
10.1038/s41568-025-00817-8 · 2025 · External reference
Proteolysis‐Targeting Drug Delivery System (ProDDS): Integrating Targeted Protein Degradation Concepts Into Formulation Design
10.1039/d4cs00411f · 2024 · External reference
Unconventional PROTACs for Targeted Protein Degradation in Cancer Therapy
10.1002/anie.202507702 · 2025 · External reference
Checkpoint Nano‐PROTACs for Activatable Cancer Photo‐Immunotherapy
10.1002/adma.202208553 · 2023 · External reference
Chemical Proteomics Identifies RBBP7 as a New E3 Ligase Supporting Targeted Protein Degradation
10.1002/anie.202508538 · 2025 · External reference
Optical Control of Targeted Protein Degradation
10.1016/j.chembiol.2021.05.010 · 2021 · External reference
Sonodynamic Nano‐LYTACs Reverse Tumor Immunosuppressive Microenvironment for Cancer Immunotherapy
10.1021/jacs.4c13022 · 2024 · External reference
Covalently Engineered Nanobody Chimeras for Targeted Membrane Protein Degradation
10.1021/jacs.1c08521 · 2021 · External reference
Targeted Protein Degradation via the Autophagy‐Lysosome System: AUTOTAC (AUTOphagy‐TArgeting Chimera)
10.1080/15548627.2022.2091338 · 2022 · External reference
Advances in Peptide‐Based Chimeric Strategies for Targeted Protein Degradation
10.1021/acs.jmedchem.5c02379 · 2025 · External reference
Opportunities and Challenges of Protein‐Based Targeted Protein Degradation
10.1039/d3sc02361c · 2023 · External reference
Chasing Molecular Glue Degraders: Screening Approaches
10.1039/d2cs00197g · 2022 · External reference
A New Drug Design for Chemical Biology With Many Challenges in Drug Discovery
10.1016/j.drudis.2022.103395 · 2023 · External reference
Photoinduced Synergism of Ferroptosis/Pyroptosis/Oncosis by an O2‐Independent Photocatalyst for Enhanced Tumor Immunotherapy
10.1021/jacs.4c17268 · 2025 · External reference
Metal‐Based Photosensitizers as Inducers of Regulated Cell Death Mechanisms
10.1021/acs.chemrev.3c00161 · 2023 · External reference
Screening π‐Extended Ruthenium(II) Complexes for the Photoinduced Oxidative Modulation of Amyloid‐β Peptide Aggregation
10.1021/acs.inorgchem.5c04609 · 2026 · External reference
A BRD4‐Targeting Photothermal Agent for Controlled Protein Degradation
10.1002/anie.202403258 · 2024 · External reference
Near‐Infrared‐Activated Anticancer Platinum(IV) Complexes Directly Photooxidize Biomolecules in an Oxygen‐Independent Manner
10.1038/s41557-023-01242-w · 2023 · External reference
PHOTACs Enable Optical Control of Protein Degradation
10.1126/sciadv.aay5064 · 2020 · External reference
Reversible Spatiotemporal Control of Induced Protein Degradation by Bistable PhotoPROTACs
10.1021/acscentsci.9b00713 · 2019 · External reference
Photocontrolled Trimethoprim PROTACs Targeting the eDHFR Protein Tag
10.1038/s41467-025-67527-5 · 2026 · External reference
Light‐Induced Control of Protein Destruction by Opto‐PROTAC
10.1126/sciadv.aay5154 · 2020 · External reference
Stimuli‐Responsive PROTACs for Controlled Protein Degradation
10.1002/anie.202306824 · 2023 · External reference
Two‐Photon Photodegradation of E3 Ubiquitin Ligase Cereblon by a Ru(II) Complex: Inducing Ferroptosis in Cisplatin‐Resistant Tumor Cells
10.1021/acs.jmedchem.4c00545 · 2024 · External reference
Light‐Activated Metal‐Dependent Protein Degradation: A Heterobifunctional Ruthenium(II) Photosensitizer Targeting New Delhi Metallo‐β‐lactamase 1
10.1021/jacs.5c12405 · 2025 · External reference
PDTAC: Targeted Photodegradation of GPX4 Triggers Ferroptosis and Potent Antitumor Immunity
10.1021/acs.jmedchem.2c00855 · 2022 · External reference
Human Disease Models in Drug Development
10.1038/s44222-023-00063-3 · 2023 · External reference
Patient‐Derived Organoids in Human Cancer: A Platform for Fundamental Research and Precision Medicine
10.1186/s43556-023-00165-9 · 2024 · External reference
Photoactivatable Cyclometalated Ir(III) Compound Penetrates the Blood‐Brain Barrier in 3D Spheroidal and Advanced 3D Organoid Models of Inherently Resistant and Aggressive Brain Tumors
10.1021/acsptsci.5c00145 · 2025 · External reference
Generation of N‐Heterocyclic Carbene (NHC) Gold–Selenolato Complexes as Potent Anticancer Agents: Distinct Synthetic Routes and Evaluation in 2D and 3D Cancer Models
10.1039/d5sc04490a · 2025 · External reference
Iridium(III) Carbene Complexes as Potent Girdin Inhibitors against Metastatic Cancers
10.1073/pnas.2316615121 · 2024 · External reference
Patient‐Derived Immunocompetent Tumor Organoids: A Platform for Chemotherapy Evaluation in the Context of T‐cell Recognition
10.1002/anie.202317613 · 2024 · External reference
Vitamin C Inhibits ACSL4 to Alleviate Ferro‐Aging in Primates
10.1016/j.cmet.2026.02.010 · 2026 · External reference
Peptide Inhibitor Targeting the Extraterminal Domain in BRD4 Potently Suppresses Breast Cancer both in Vitro and in Vivo
10.1021/acs.jmedchem.4c00141 · 2024 · External reference
Two‐Photon Mediated Cancer Therapy: A Comprehensive Review on Two‐Photon Photodynamic Therapy and Two‐Photon‐Activated Therapeutic Delivery Systems
10.1002/adfm.202408594 · 2024 · External reference
BRD4 Protein as a Target for Lung Cancer and Hematological Cancer Therapy: A Review
10.2174/0113894501269090231012090351 · 2023 · External reference
In‐vitro Safety Assessment of Ultrasmall Gold Nanoparticles for Preclinical Drug Delivery Applications
10.2174/2210303113666230622123933 · 2023 · External reference
Targeting Drugs to Tumours Using Cell Membrane‐Coated Nanoparticles
10.1038/s41571-022-00699-x · 2022 · External reference
Thin to Thick, Short to Long: Spectral Properties of Gold Nanorods by Theoretical Modeling
10.1021/jp4078344 · 2013 · External reference
A Novel Class of Ruthenium‐Based Photosensitizers Effectively Kills in Vitro Cancer Vells and in Vivo Tumors
10.1039/c4pp00438h · 2015 · External reference
Stromal Induction of BRD4 Phosphorylation Results in Chromatin Remodeling and BET Inhibitor Resistance in Colorectal Cancer
10.1038/s41467-021-24687-4 · 2021 · External reference
Implication of Ferroptosis in Aging
10.1038/s41420-021-00553-6 · 2021 · External reference
Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species
10.1002/advs.202416559 · 2025 · External reference
A Ruthenium(II) Complex Inhibits BRD4 for Synergistic Seno‐ and Chemo‐Immunotherapy in Cisplatin‐Resistant Tumor Cells
10.1002/anie.202505689 · 2025 · External reference
Loss of BRD4 Induces Cell Senescence in HSC/HPCs by Deregulating Histone H3 Clipping
10.15252/embr.202357032 · 2023 · External reference
Organoid Cultures as Preclinical Models of Non–Small Cell Lung Cancer
10.1158/1078-0432.ccr-19-1376 · 2020 · External reference
Tumor Organoid–T‐Cell Coculture Systems
10.1038/s41596-019-0232-9 · 2020 · External reference
