Research graph
References from Functionalized Benzisoxazoles: Recent Developments in Diversified Synthetic Strategies and Cytotoxic Potential. Local targets link to admitted publications; unresolved targets remain external evidence.
An Insight Into the Medicinal Perspective of Synthetic Analogs of Imidazole
10.1016/j.molstruc.2021.129982 · 2021 · External reference
Applications of Bridgehead Heterocycles in Drug Design and Medicinal Chemistry
10.1007/s41061-025-00502-2 · 2025 · External reference
Click Chemistry: An Overview and Recent Updates in Medicinal Chemistry Attributes of Click‐Derived Heterocycles
10.1007/s11030-025-11110-z · 2025 · External reference
Design, Synthesis, and in Vitro Antitumor Activity of New 1,4‐Diarylimidazole‐2‐Ones and Their 2‐Thione Analogues
10.1016/j.bmcl.2007.12.023 · 2008 · External reference
The Pharmacology of Indomethacin
10.1111/head.12769 · 2016 · External reference
Design, Synthesis, Anticancer Evaluation, and Molecular Modelling Studies of Novel Tolmetin Derivatives as Potential VEGFR‐2 Inhibitors and Apoptosis Inducers
10.1080/14756366.2021.1901089 · 2021 · External reference
Nitrofurantoin Revisited: A Systematic Review and Meta‐Analysis of Controlled Trials
10.1093/jac/dkv147 · 2015 · External reference
Recent Highlights on Molecular Hybrids Potentially Useful in Central Nervous System Disorders
10.2174/1389557517666161111110121 · 2017 · External reference
10.1007/978-981-16-8399-2_10
10.1007/978-981-16-8399-2_10 · 2022 · External reference
Synthesis of Some Fluorescent Dyes Based on Stilbene Derivatives With Various Substituents and Their Effects on the Absorption Maxima
10.3390/app13095543 · 2023 · External reference
Ratiometric Sensing of Nerve Agent Mimic DCP Through In Situ Benzisoxazole Formation
10.1016/j.dyepig.2019.107585 · 2019 · External reference
Unresolved reference
2016 · External reference
Research Progress of Benzothiazole and Benzoxazole Derivatives in the Discovery of Agricultural Chemicals
10.3390/ijms241310807 · 2023 · External reference
Development of Benzobisoxazole‐Based Novel Conjugated Polymers for Organic Thin‐Film Transistors
10.3390/polym15051156 · 2023 · External reference
Benzisoxazole: A Privileged Scaffold for Medicinal Chemistry
10.1039/c7md00449d · 2017 · External reference
Solution‐Phase Synthesis of a Diverse Library of Benzisoxazoles Utilizing the [3+2] Cycloaddition of In Situ‐Generated Nitrile Oxides and Arynes
10.1021/co300159g · 2013 · External reference
Benzoisoxazoles as Privileged Scaffolds in the Design and Synthesis of N‐Containing Molecules: A Recent Update
10.1002/ejoc.202401021 · 2025 · External reference
Recent Advances in Chemistry and Therapeutic Potential of Functionalized Quinoline Motifs—A Review
10.1039/d2ra02896d · 2022 · External reference
Mechanistic Characterization of Zeolite‐Catalyzed Aromatic Electrophilic Substitution at Realistic Operating Conditions
10.1021/jacsau.1c00544 · 2022 · External reference
Isoxazole → Benzisoxazole Rearrangement Promoted Cascade Reactions Affording Stereodefined Polycycles
10.1021/ol0272848 · 2003 · External reference
10.2174/1568026616666160506145700
10.2174/1568026616666160506145700 · 2016 · External reference
Heterocycles in Drugs and Drug Discovery
10.1007/s10593-012-0960-z · 2012 · External reference
Pharmacological Evaluation of Bioisosterically Replaced and Triazole‐Tethered Derivatives for Anticancer Therapy
10.2174/0115734064320533240903062533 · 2025 · External reference
Bioisosterism: A Useful Strategy for Molecular Modification and Drug Design
10.2174/0929867053363540 · 2005 · External reference
C‐to‐N Atom Swapping and Skeletal Editing in Indoles and Benzofurans
10.1038/s41586-025-09019-6 · 2025 · External reference
2(3H)‐Benzoxazolone and Bioisosters as ‘Privileged Scaffold’ in the Design of Pharmacological Probes
10.2174/0929867053507388 · 2005 · External reference
New Cholinesterase Inhibitors: Synthesis and Structure–Activity Relationship Studies of 1,2‐Benzisoxazole Series and Novel Imidazolyl‐d2‐Isoxazolines
10.1002/poc.936 · 2005 · External reference
Synthesis of Novel 6‐Fluoro‐3‐(4‐Piperidinyl)‐1,2‐Benzisoxazole Derivatives as Antiproliferative Agents: A Structure–Activity Relationship Study
10.1007/s10637-008-9205-5 · 2009 · External reference
Synthesis of New Naphthoisoxazole Amide Derivatives and Study of Their Biological Evaluations
10.1007/s00044-014-0961-9 · 2014 · External reference
The Knoevenagel Reactions of Pregnenolone With Cyanomethylene Reagents: Synthesis of Thiophene, Thieno[2,3‐b]Pyridine, Thieno[3,2‐d]Isoxazole Derivatives of Pregnenolone and Their In Vitro Cytotoxicity Towards Tumor and Normal Cell Lines
10.1016/j.steroids.2013.08.007 · 2013 · External reference
Unresolved reference
2022 · External reference
Exploring the Benzazoles Derivatives as Pharmacophores for AChE, BACE1, and as Anti‐Aβ Aggregation to Find Multitarget Compounds Against Alzheimer's Disease
10.3390/molecules29194780 · 2024 · External reference
Design and Synthesis of (5‐Amino‐1, 2, 4‐Triazin‐6‐yl)(2‐(Benzo[d] Isoxazol‐3‐yl) Pyrrolidin‐1‐yl)Methanone Derivatives as Sodium Channel Blocker and Anticonvulsant Agents
10.3109/14756366.2013.815177 · 2014 · External reference
Inhibition of Protein Glycation by Urea and Thiourea Derivatives of Glycine/Proline Conjugated Benzisoxazole Analogue – Synthesis and Structure–Activity Studies
10.1016/j.ejmech.2012.12.029 · 2013 · External reference
Unresolved reference
2009 · External reference
Unresolved reference
2016 · External reference
10.3390/ijms22052329
10.3390/ijms22052329 · 2021 · External reference
A Review on 1,2,4‐Triazoles as Scaffold for Various Pharmacological Activities: Review Article
10.69613/aewrja40 · 2025 · External reference
Synthesis and Anti‐HIV Activity of New Alkenyldiarylmethane (ADAM) Non‐Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) Incorporating Benzoxazolone and Benzisoxazole Rings
10.1016/j.bmc.2005.11.014 · 2006 · External reference
Synthesis of 6‐Halo‐1,2‐Benzisoxazoles, Chromeno‐6,7‐Isoxazoles and Chromeno‐6,7‐Oxazoles
10.1080/00304940109356601 · 2001 · External reference
New Synthetic Benzisoxazole Derivatives as Antimicrobial, Antioxidant and Anti‐Inflammatory Agents
10.5155/eurjchem.4.4.402-407.864 · 2013 · External reference
The Isoxazole Ring and Its N‐Oxide: A Privileged Core Structure in Neuropsychiatric Therapeutics
10.1002/cmdc.201700023 · 2017 · External reference
1,2‐Benzisoxazole Phosphorodiamidates as Novel Anticancer Prodrugs Requiring Bioreductive Activation
10.1021/jm020581y · 2003 · External reference
Anti‐Cancer Activity of Novel Dibenzo[b,f]Azepine Tethered Isoxazoline Derivatives
10.1186/1472-6769-12-5 · 2012 · External reference
10.1177/20451253241280046
10.1177/20451253241280046 · 2024 · External reference
Paliperidone for Schizophrenia
10.2146/ajhp070261 · 2008 · External reference
Risperidone Decreases Expression of Serotonin Receptor‐2A (5‐HT2A) and Serotonin Transporter (SERT) But Not Dopamine Receptors and Dopamine Transporter (DAT) in PBMCs From Patients With Schizophrenia
10.3390/ph17020167 · 2024 · External reference
Neuropharmacological Effect of Risperidone: From Chemistry to Medicine
10.1016/j.cbi.2022.110296 · 2023 · External reference
Zonisamide: Chemistry, Mechanism of Action, and Pharmacokinetics
10.1016/j.seizure.2004.04.016 · 2004 · External reference
Introduction to Zonisamide
10.1016/j.eplepsyres.2005.11.004 · 2006 · External reference
Unresolved reference
2024 · External reference
Clinical Pharmacology and Mechanism of Action of Zonisamide
10.1097/wnf.0b013e3180413d7d · 2007 · External reference
10.1177/10600280241308287
10.1177/10600280241308287 · 2025 · External reference
10.2147/ce.s114094
10.2147/ce.s114094 · 2016 · External reference
Extended Radioligand Binding Profile of Iloperidone: A Broad Spectrum Dopamine/Serotonin/Norepinephrine Receptor Antagonist for the Management of Psychotic Disorders
10.1016/s0893-133x(01)00285-8 · 2001 · External reference
Unresolved reference
2009 · External reference
Iloperidone: A New Drug for the Treatment of Schizophrenia
10.2146/ajhp100079 · 2011 · External reference
ADN‐1184 a Monoaminergic Ligand With 5‐HT6/7 Receptor Antagonist Activity: Pharmacological Profile and Potential Therapeutic Utility
10.1111/bph.12509 · 2014 · External reference
Susceptibility of Neisseria Gonorrhoeae to Zoliflodacin and Quinolones in Hyogo Prefecture, Japan
10.3390/pathogens14080831 · 2025 · External reference
10.1016/j.jalz.2011.05.1875
10.1016/j.jalz.2011.05.1875 · 2011 · External reference
Recent Advances in the Synthesis and Reactivity of Isothiazoles
10.1002/adsc.201900072 · 2019 · External reference
Recent Advances in the Synthesis of Benzothiazole and Its Derivatives
10.2174/1385272826666211229144446 · 2022 · External reference
TfOH‐Promoted Decyanative Cyclization Toward the Synthesis of 2,1‐Benzisoxazoles
10.1021/acs.joc.1c00091 · 2021 · External reference
Rapid and High‐Yield Electrosynthesis of Benzisoxazole and Some Derivatives
10.1002/celc.201801321 · 2019 · External reference
10.1002/slct.202003570
10.1002/slct.202003570 · 2020 · External reference
Nanocatalyst‐Fe3O4@SiO2 Mediated Efficient Isoxazole Cyclization and Bulk Synthesis
2022 · External reference
Microwave‐Promoted Syntheses of Fluoren‐9‐Ones and Benzisoxazoles
10.1007/s11164-014-1882-4 · 2015 · External reference
Oxazole and Isoxazole‐Containing Pharmaceuticals: Targets, Pharmacological Activities, and Their SAR Studies
10.1039/d4md00777h · 2025 · External reference
Unresolved reference
2024 · External reference
Ambient Reductive Synthesis of N‐Heterocyclic Compounds Over Cellulose‐Derived Carbon Supported Pt Nanocatalyst Under H2 atmosphere
10.1039/d0gc01177k · 2020 · External reference
Synthesis of 2,1‐Benzoisoxazole‐Containing 1,2,3‐Triazoles Through Copper‐Catalyzed Three‐Component Domino Reactions of o‐Bromoacetophenones, Aldehydes, and Sodium Azide
10.1021/acs.joc.9b02865 · 2020 · External reference
10.1002/slct.202501122
10.1002/slct.202501122 · 2026 · External reference
The Anthranil Core as a π‐Conjugated Bridge in the Synthesis of Molecular Photosensitizers
10.1021/acs.joc.5c00389 · 2025 · External reference
Substrate Controlled Synthesis of Benzisoxazole and Benzisothiazole Derivatives via PhI(OAc)2‑Mediated Oxidation Followed by Intramolecular Oxidative O–N/S–N Bond Formation
10.1021/acs.joc.5b02276 · 2015 · External reference
Synthesis of 3‐Substituted 2,1‐Benzisoxazoles by the Oxidative Cyclization of 2‐Aminoacylbenzenes With Oxone
10.1055/s-0035-1561471 · 2016 · External reference
Preparation of Anthranils via Chemo Selective Oxidative Radical Cyclization of 3‐(2‐Azidoaryl) Substituted Propargyl Alcohols
10.1039/d0cc07919g · 2021 · External reference
Synthesis of 2,1‐Benzisoxazole‐3(1H)‐Ones by Base‐Mediated Photochemical N–O Bond‐Forming Cyclization of 2‐Azidobenzoic Acids
10.3762/bjoc.12.86 · 2016 · External reference
Simple and Scalable Electrochemical Synthesis of 2,1‐Benzisoxazoles and Quinoline N‐Oxides
10.1039/c9cc06054e · 2019 · External reference
Simple and Versatile Electrochemical Synthesis of Highly Substituted 2,1‐Benzisoxazoles
10.1039/d4ob01875c · 2025 · External reference
General Synthesis of 2,1‐Benzisoxazoles (Anthranils) From Nitroarenes and Benzylic C–H Acids in Aprotic Media Promoted by Combination of Strong Bases and Silylating Agents
10.1007/s11030-015-9627-x · 2015 · External reference
A Direct Synthesis of 3‐Acylanthranils via a One‐Pot Oxidation and Electrophilic Halogen‐Induced Annulation From 2‐Alkynylanilines
10.1002/ajoc.202500366 · 2025 · External reference
Heavy‐Atom Tunneling Through Crossing Potential Energy Surfaces: Cyclization of a Triplet 2‐Formylarylnitrene to a Singlet 2,1‐Benzisoxazole
10.1002/anie.202006640 · 2020 · External reference
A Synthetic Route to Novel 3‐Substituted‐2,1‐Benzisoxazoles From 5‐(2‐Nitrobenzylidene)(Thio)Barbiturates
10.1016/j.crci.2017.10.002 · 2017 · External reference
A New Mechanism for Selective Recognition of Cyanide in Organic and Aqueous Solution
10.1002/ejoc.202000342 · 2020 · External reference
Metal‐Free Synthesis of Anthranils by PhIO Mediated Heterocyclization of Ortho‐Carbonyl Anilines
10.1002/ejoc.202100756 · 2021 · External reference
Spontaneous Low‐Temperature Conversion of Ortho‐Azidocarbonyl Compounds to 2,1‐benzisoxazoles
2024 · External reference
Targeting Akt as Strategy to Kill Cancer Cells Using 3‐Substituted 5‐Anilinobenzo[c]isoxazolequinones: A Preliminary Study
10.1016/j.biopha.2017.10.108 · 2018 · External reference
Synthesis of 1,2‐Benzisoxazole Tethered 1,2,3‐Triazoles That Exhibit Anticancer Activity in Acute Myeloid Leukemia Cell Lines by Inhibiting Histone Deacetylases, and Inducing p21 and Tubulin Acetylation
10.1016/j.bmc.2015.07.069 · 2015 · External reference
10.1016/j.bbrep.2025.102074
10.1016/j.bbrep.2025.102074 · 2025 · External reference
Chemodivergent C‐to‐N Atom Swap From Benzofurans to Benzisoxazoles and Benzoxazoles
10.1039/d5sc02032h · 2025 · External reference
Microwave‐Assisted Facile Synthesis of 1,2‐Benzisoxazoles, Isoxazoloquinolines, and Isothiazoloquinolines in [BMIM(SO2Cl)][OTs] Ionic Liquid as a Recyclable System
10.1134/s1070363224611943 · 2025 · External reference
Photocatalyzed Nitrene Insertion Into C–O Bonds: Access to Benzisoxazoline‐3‐Ones
10.1021/acs.orglett.5c04188 · 2025 · External reference
A Novel PPh3 Mediated One‐Pot Method for Synthesis of 3‐Aryl or Alkyl 1,2‐Benzisoxazoles
10.1021/acs.orglett.7b00563 · 2017 · External reference
10.1021/acs.orglett.5c05009
10.1021/acs.orglett.5c05009 · 2026 · External reference
10.1016/j.cclet.2022.107778
10.1016/j.cclet.2022.107778 · 2023 · External reference
Utility of Nitrogen Extrusion of Azido Complexes for the Synthesis of Nitriles, Benzoxazoles, and Benzisoxazoles
10.1021/acs.joc.5b01305 · 2015 · External reference
N‐[3‐(Chloromethyl)‐1,2‐Benzisoxazol‐5‐Yl]Acetamide
10.3390/m1389 · 2022 · External reference
Strain‐Driven [3+2] Cycloaddition of Triazine 1‐Oxides With Arynes/Cyclooctyne: Access to Benzisoxazoles/Cyclooctene‐Fused Isoxazoles
10.1002/ejoc.202400424 · 2024 · External reference
Phenolate‐Induced N−O Bond Formation versus Tiemann‐Type Rearrangement for the Synthesis of 3‐Aminobenzisoxazoles and 2‐Aminobenzoxazoles
10.1002/open.202200252 · 2022 · External reference
Benzo[d]Isoxazole Derivatives as Hypoxia‐Inducible Factor (HIF)‐1α Inhibitors
10.1021/acsmedchemlett.2c00308 · 2022 · External reference
Substitutional Diversity‐Oriented Synthesis and In Vitro Anticancer Activity of Framework‐Integrated Estradiol‐Benzisoxazole Chimeras
10.3390/molecules27217456 · 2022 · External reference
Multistep Synthesis and In Vitro Anticancer Evaluation of 2‐Pyrazolyl‐Estradiol Derivatives, Pyrazolocoumarin‐Estradiol Hybrids and Analogous Compounds
10.3390/molecules25184039 · 2020 · External reference
Carboxylic Acid Directed C–H Arylation of Azulene
10.1021/acs.orglett.0c01576 · 2020 · External reference
A Simple and Effective Method for Chemoselective Esterification of Phenolic Acids
10.1081/scc-200046532 · 2005 · External reference
Rational Design of Novel Benzisoxazole Derivatives With Acetylcholinesterase Inhibitory and Serotoninergic 5‐HT4 Receptors Activities for the Treatment of Alzheimer's Disease
10.1038/s41598-020-59805-7 · 2020 · External reference
Synthesis of New Benzisoxazole Derivatives and Their Antimicrobial, Antioxidant and Anti‐Inflammatory Activities
10.5155/eurjchem.5.1.91-95.866 · 2014 · External reference
Synthesis of Elastin Based Peptides Conjugated to Benzisoxazole as a New Class of Potent Antimicrobials—A Novel Approach to Enhance Biocompatibility
10.1016/j.ejmech.2010.12.005 · 2011 · External reference
Synthesis and Characterization of Novel 6‐Fluoro‐4‐Piperidinyl‐1,2‐Benzisoxazole Amides and 6‐Fluoro‐Chroman‐2‐Carboxamides: Antimicrobial Studies
10.1016/j.bmc.2005.01.026 · 2005 · External reference
New 3‐Benzisothiazolyl and 3‐Benzisoxazolylpiperazine Derivatives With Atypical Antipsychotic Binding Profile
10.1016/s0223-5234(02)01391-0 · 2002 · External reference
Synthesis and Biological Investigation of Coumarin Piperazine (Piperidine) Derivatives as Potential Multireceptor Atypical Antipsychotics
10.1021/jm400408r · 2013 · External reference
Design and Synthesis of New of 3‐(Benzo[d]isoxazol‐3‐yl)‐1‐Substituted Pyrrolidine‐2, 5‐Dione Derivatives as Anticonvulsants
10.1016/j.ejmech.2014.07.016 · 2014 · External reference
Synthesis and Biological Evaluation of Piperidine‐Substituted Triazine Derivatives as HIV‐1 Non‐Nucleoside Reverse Transcriptase Inhibitors
10.1016/j.ejmech.2012.02.019 · 2012 · External reference
Synthesis and Biological Evaluation of 1‐(isoxazol‐5‐ylmethylaminoethyl)‐4‐phenyl Tetrahydropyridine and Piperidine Derivatives as Potent T‐Type Calcium Channel Blockers With Antinociceptive Effect in a Neuropathic Pain Model
10.1016/j.ejmech.2013.12.056 · 2014 · External reference
Synthesis and Screening of Pro‐Apoptotic and Angio‐Inhibitory Activity of Novel Benzisoxazole Derivatives Both In Vitro and In Vivo
10.2174/1871520619666190114170621 · 2019 · External reference
Seeking Potent Anti‐Tubercular Agents: Design, Synthesis, Anti‐Tubercular Activity and Docking Study of Various ((Triazoles/Indole)‐Piperazin‐1‐yl/1,4‐Diazepan‐1‐yl)benzo[d]isoxazole Derivatives
10.1016/j.bmcl.2016.03.059 · 2016 · External reference
1,2‐Benzisoxazole‐3‐Acetamide Derivatives as Dual Agents for DPP‐IV Inhibition and Anticancer Activity
10.1080/00397911.2018.1508723 · 2018 · External reference
Discovery of a Novel Lead Compound Targeting BRD4 BD2 With a Di‐Phenyl Ether Fragment: Synthesis, Molecular Docking and Drug‐Likeness Studies
10.1007/s12039-025-02386-7 · 2025 · External reference
10.1002/slct.202502445
10.1002/slct.202502445 · 2025 · External reference
Heterocyclic Compounds: Importance in Anticancer Drug Discovery
10.2174/1871520622666220404082648 · 2022 · External reference
Synthesis of Potent and Selective Inhibitors of Candida Albicans N‐Myristoyltransferase Based on the Benzothiazole Structure
10.1016/j.bmc.2005.01.033 · 2005 · External reference
Novel O‐Acylated (E)‐3‐Aryl‐6,7‐Dihydrobenzisoxazol‐4(5H)‐one Oximes Targeting HSP90‐HER2 Axis in Breast Cancer Cells
10.1016/j.bmc.2021.116521 · 2022 · External reference
Design, Synthesis and Anti‐Diabetic Activity of Chromen‐2‐One Derivatives
10.1016/j.arabjc.2016.11.011 · 2019 · External reference
Design and Synthesis of Sulfonamide Derivatives of Pyrrolidine and Piperidine as Anti‐Diabetic Agents
10.1016/j.ejmech.2014.11.041 · 2015 · External reference
Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6
10.1021/jm8002894 · 2008 · External reference
Domain‐Selective Small‐Molecule Inhibitor of Histone Deacetylase 6 (HDAC6)‐Mediated Tubulin Deacetylation
10.1073/pnas.0430973100 · 2003 · External reference
Synthesis, In Silico Analysis, Anticancer Activity and Photophysical Properties of Novel Benzisoxazoles
10.1016/j.molstruc.2025.144538 · 2025 · External reference
Synthesis, Computational Studies and Evaluation of Benzisoxazole Tethered 1,2,4‐Triazoles as Anticancer and Antimicrobial Agents
10.1016/j.molstruc.2024.138070 · 2024 · External reference
Design, Synthesis and Anticancer Activity of Functionalized Spiro‐Quinolines With Barbituric and Thiobarbituric Acids
10.1007/s00044-015-1408-7 · 2015 · External reference
Synthesis, Biological Evaluation, and Computational Studies of 6‐Fluoro‐3‐(Piperidin‐4‐yl)‐1,2‐Benzisoxazole Sulfonamide Conjugates
10.1080/10406638.2023.2247117 · 2024 · External reference
Synthesis, Anticancer and Molecular Docking Studies of New Class of Benzoisoxazolyl‐Piperidinyl‐1, 2, 3‐Triazoles
10.1016/j.jksus.2020.09.012 · 2020 · External reference
HDAC and NF‐κB Mediated Cytotoxicity Induced by Novel N‐Chloro β‐Lactams and Benzisoxazole Derivatives
10.1016/j.cbi.2016.01.010 · 2016 · External reference
