Research graph
References from Dual DHFR and DNA Gyrase Inhibitory Potency of Some Novel Pyridine Hybrids Linked to Pyrazolo[1,5‐ a ]Pyrimidine Units: Antibacterial Screening and SAR Study. Local targets link to admitted publications; unresolved targets remain external evidence.
Structure‐Based Molecular Hybridization Design and Synthesis of Keap1‐Nrf2 Inhibitors for Anti‐Inflammatory Treatment
10.1016/j.bioorg.2025.108350 · 2025 · External reference
Synthesis and Antibacterial Activity of Some New Pyrazoles Incorporating Benzimidazole or Indole Moiety
10.1016/j.molstruc.2026.145308 · 2026 · External reference
Molecular Hybridization: A Powerful Tool for Multitarget Drug Discovery
10.1080/17460441.2024.2322990 · 2024 · External reference
Indane‐1,3‐Dione as a Versatile Intermediate for the Synthesis of 4‐Azafluorenones
10.2174/0113852728385966250513110724 · 2025 · External reference
Applying Molecular Hybridization to Design a New Class of Pyrazolo[3,4‐D]Pyrimidines as Src Inhibitors Active in Hepatocellular Carcinoma
10.1016/j.ejmech.2024.116929 · 2024 · External reference
Synthesis and In Vitro Screening of Methicillin‐Resistant Staphylococcus aureus Inhibitory Activity of New Bis(Benzimidazole‐1,3,4‐Oxadiazole) Hybrids Linked by Different Spacers
10.1002/slct.202506229 · 2026 · External reference
Navigating Antimicrobials and Combating Antimicrobial Resistance: Challenges, Impacts, and Strategies for Global Action
2025 · External reference
Antibiotic Resistance
10.1016/j.mpmed.2017.07.006 · 2017 · External reference
Microwave Assisted Three Component One‐Pot Synthesis of Bis(Aminoazolo[1,5‐A]Pyrimidines) and Bis(Aminoazino[1,2‐A]Benzimidazoles) Bearing Thiazole Moiety
10.1002/slct.201902828 · 2019 · External reference
An Overview of the Global Alarming Increase of Multiple Drug Resistant: A Major Challenge in Clinical Diagnosis
10.2174/1871526523666230725103902 · 2024 · External reference
Current Status and Recent Trends in Innovative Tactics and the One Health Approach to Address the Challenge of Methicillin‐Resistant Staphylococcus aureus Infections: A Comprehensive Review
10.1007/s44337-025-00300-1 · 2025 · External reference
Dual Anti‐Cancer and Anti‐Inflammatory Activity of Some New Benzofuran‐Thiazole Hybrids With Promising COX‐2 Inhibitory Potency: Cell Cycle Arrest, Apoptosis, and Safety Study
10.1002/ardp.70293 · 2026 · External reference
Unveiling the Hidden Regulators: The Impact of lncRNAs on Zoonoses
10.3390/ijms25063539 · 2024 · External reference
New Chromene‐Based 1‐Aryl‐1H‐Pyrazole‐3‐Carboxylate Hybrids Linked to 1,3,4‐Oxadiazole and/or Arene Units With Potential Bacterial and DNA Gyrase Inhibitory Potency
10.1080/00397911.2026.2675325 · 2026 · External reference
Mrsa Inhibitory Activity of New Bis(Benzimidazole‐1,3,4‐Oxadiazole) Hybrids Linked to Different Spacers: Synthesis and In Vitro Screening
10.1016/j.molstruc.2025.145043 · 2026 · External reference
3‐Aminopyrazolo[3,4‐b]Pyridine: Effective Precursor for Barium Hydroxide‐Mediated Three Components Synthesis of New Mono‐ and Bis(Pyrimidines) With Potential Cytotoxic Activity
10.1002/cbdv.202100500 · 2022 · External reference
New Thieno[2,3‐b]Pyridine‐Fused Pyrimidin‐4(3H)‐Ones as Potential Thymidylate Synthase Inhibitors: Synthesis, Sar, In Vitro and In Silico Study
10.1016/j.molstruc.2023.135236 · 2023 · External reference
New Bis(Pyrazolo[3,4‐b]Pyridines) and Bis(Thieno[2,3‐b]Pyridines) as Potential Acetylcholinesterase Inhibitors: Synthesis, In Vitro and SwissADME Prediction Study
10.1007/s13738-022-02614-8 · 2022 · External reference
New Piperazine‐Based Bis(Thieno[2,3‐b]Pyridine) and Bis(Pyrazolo[3,4‐b]Pyridine) Hybrids Linked to Benzofuran Units: Synthesis and In Vitro Screening of Potential Acetylcholinesterase Inhibitors
10.1080/00397911.2022.2056853 · 2022 · External reference
Synthesis, Characterization, and Antimicrobial Evaluation of Novel Thiohydrazonates and Pyrazolo[3,4‐b]Pyridines
10.1080/10406638.2019.1631194 · 2021 · External reference
New Bis(Thieno[2,3‐b]Pyridine) Hybrids Linked to Arene Units as Potential Bacterial Biofilm and MRSA Inhibitors
10.1139/cjc-2022-0236 · 2023 · External reference
Synthesis, Characterization, Antibacterial Evaluation, 2D‐QSAR Modeling and Molecular Docking Studies for Benzocaine Derivatives
10.1007/s11030-020-10138-7 · 2021 · External reference
Synthesis, Characterization, and In Vitro Antibacterial Activity of Some New Pyridinone and Pyrazole Derivatives With Some In Silico Adme and Molecular Modeling Study
10.1007/s13738-022-02575-y · 2022 · External reference
Synthesis of New 2‐Pyridinone and 2‐Iminochromene Derivatives Bearing Biologically Active Pyrrole Moiety as Expected Antibacterial and Antifungal Agents
10.1080/10406638.2023.2254892 · 2024 · External reference
Synthesis and Antioxidant Assay of New Nicotinonitrile Analogues Clubbed Thiazole, Pyrazole and/or Pyridine Ring Systems
10.1002/jhet.3820 · 2020 · External reference
Discovery and Optimization of 2‐Pyridones as Dual H‐DHFR/EGFRTK Inhibitors With Immunomodulatory Potential; Design, Synthesis, Anti‐Proliferative Activity, and Apoptosis Inducer
10.1016/j.ejmech.2025.117751 · 2025 · External reference
Synthesis of Novel Cyano‐Acetic Acid Hydrazide Derivatives as Precursor for Generation of Dihydropyridine and Pyrrole as Anticancer Agents: Multi‐Target Recognition, In Vitro and In Silico Studies
10.1016/j.molstruc.2025.141501 · 2025 · External reference
Synthesis of Novel 1‐Pyrazolylpyridin‐2‐Ones as Potential Anti‐Inflammatory and Analgesic Agents
10.1002/ardp.200600197 · 2007 · External reference
Challenging Breast Cancer Through Novel Sulfonamide–Pyridine Hybrids: Design, Synthesis, Carbonic Anhydrase IX Inhibition and Induction of Apoptosis
10.4155/fmc-2022-0197 · 2023 · External reference
Development of Non‐Acidic 4‐Methylbenzenesulfonate‐Based Aldose Reductase Inhibitors; Design, Synthesis, Biological Evaluation and In‐Silico Studies
10.1016/j.bioorg.2024.107666 · 2024 · External reference
Potential Role of PIM1 Inhibition in the Treatment of SARS‐CoV‐2 Infection
10.1186/s43141-023-00520-x · 2023 · External reference
Aminopyridone‐Linked Benzimidazoles: A Fragment‐Based Drug Design for the Development of CDK9 Inhibitors
10.4155/fmc-2023-0139 · 2023 · External reference
Sulfaguanidine Hybrid With Some New Pyridine‐2‐One Derivatives: Design, Synthesis, and Antimicrobial Activity Against Multidrug‐Resistant Bacteria as Dual DNA Gyrase and DHFR Inhibitors
10.3390/antibiotics10020162 · 2021 · External reference
10.1002/ardp.202200040
10.1002/ardp.202200040 · External reference
An Efficient and Ecofriendly Synthesis of Highly Functionalized Pyridones via a One‐Pot Three‐Component Reaction
10.1039/c8ra05690k · 2018 · External reference
Synthesis and Cytotoxic Effect of Some Novel 1,2‐Dihydropyridin‐3‐Carbonitrile and Nicotinonitrile Derivatives
10.3390/molecules21010030 · 2015 · External reference
Hantzsch Reaction: The Important Key for Pyridine/Dihydropyridine Synthesis
10.1080/00397911.2024.2377738 · 2024 · External reference
Design, Green Synthesis, and Quorum Sensing Quenching Potential of Novel 2‐Oxo‐Pyridines Containing a Thiophene/Furan Scaffold and Targeting a Las R Gene on P. aeruginosa
10.1039/d3ra04230h · 2023 · External reference
Bis(α‐Cyanoacetamides): Versatile Intermediates for the Synthesis of Diverse Heterocyclic and Macrocyclic Molecular Systems
10.2174/0113852728367861250110001856 · 2025 · External reference
Formal [4+2] Annulation of β‐Aminoacrylamides and Malononitrile: A Synthetic Route to Substituted Pyridin‐2(1H)‐Ones
10.1007/s12039-025-02360-3 · 2025 · External reference
Molecular Structures and In Silico Molecular Docking of New Pyrazine‐Based Heterocycles as Antibacterial Agents
10.1186/s13065-025-01535-w · 2025 · External reference
Synthesis and Antibacterial Assay of Some New Pyrenyl Pyridine Candidates
10.1134/s1070363219020245 · 2019 · External reference
One‐Pot Two‐Step Catalytic Synthesis of 6‐amino‐2‐Pyridone‐3,5‐Dicarbonitriles Enabling Anti‐Cancer Bioactivity
10.1039/d2ra03579k · 2022 · External reference
L‐Proline Catalyzed One‐Pot Synthesis of Polysubstituted Pyridine System Incorporating Benzothiazole Moiety via Sustainable Sonochemical Approach
10.1039/c8ra07013j · 2018 · External reference
A Novel Synthesis of Highly Functionalized Pyridines by a One‐Pot, Three‐Component Tandem Reaction of Aldehydes, Malononitrile and N‐Alkyl‐2‐Cyanoacetamides Under Microwave Irradiation
10.3390/molecules23030619 · 2018 · External reference
Ionic Liquids in the Aza‐Michael Reaction: From Early Imidazolium Salts to Bio‐Based Catalytic Media
10.3390/molecules31040628 · 2026 · External reference
Green Synthesis of Pyridine and Their Fused System: Harnessing the Catalytic Power of Ionic Liquids for Sustainable and Efficient Multicomponent Reaction
10.2174/0113852728331797240903101654 · 2025 · External reference
Supported Choline Hydroxide (Ionic Liquid) on Mesoporous Silica as Heterogeneous Catalyst for Knoevenagel Condensation Reactions
10.1016/j.micromeso.2017.12.024 · 2018 · External reference
Solvent in Solute System for the Synthesis of Highly Substituted Pyridine by Using Choline Hydroxide and Water
10.1080/10406638.2018.1485713 · 2020 · External reference
Synthesis of New Phenothiazine‐Pyrazolo[1,5‐a]Pyrimidine Hybrids With Promising Antibacterial Activity
10.1080/00397911.2026.2667477 · 2026 · External reference
Potential MRSA Inhibitory Activity of Some New Benzofuran‐Pyrazolo[1,5‐a]Pyrimidine Hybrids Attached to Arene Units via Methylene or Azo Linkage
10.1080/00397911.2024.2409875 · 2024 · External reference
New Pyrazolo[1,5‐a]Pyrimidine‐Fused Chromeno[2,3‐b]Pyridine Hybrids Linked to 4,6‐Diarylnicotinonitrile Units: Synthesis, Antibacterial Screening and SAR Study
10.1080/00397911.2025.2599470 · 2025 · External reference
New Thiazole‐Based Pyrazolo[1,5‐a]Pyrimidine Hybrids: One‐Pot Synthesis of Potential MRSA and VRE Inhibitors
10.1080/00397911.2025.2475901 · 2025 · External reference
Synthesis of New Bis(Pyrazolo[1,5‐a]Pyrimidines) Linked to Different Spacers With Potential MurB Inhibitory Activity Utilizing 1H‐Pyrazole‐3,5‐Diamines
10.1080/00397911.2024.2428653 · 2025 · External reference
Synthesis of Pyrazole Encompassing 2‐Pyridone Derivatives as Antibacterial Agents
10.1016/j.bmcl.2013.02.077 · 2013 · External reference
Synthesis, Antibacterial and Antitubercular Activities of Benzimidazole Bearing Substituted 2‐Pyridone Motifs
10.1016/j.ejmech.2014.06.004 · 2014 · External reference
Synthesis, In Silico Study and Antibacterial Evaluation of New Cyanopyridine Based Scaffold
10.1080/10406638.2021.2019800 · 2023 · External reference
Synthesis and Antimicrobial Activity of Some New Thiazole, Thiophene and Pyrazole Derivatives Containing Benzothiazole Moiety
10.1016/j.ejmech.2010.05.018 · 2010 · External reference
Development of Pyrazole and Pyrazolopyrimidine Derivatives as Promising Anti‐MRSA Agents Targeting Penicillin‐Binding Protein (PBP2a) and mecA Gene
10.1016/j.bioorg.2025.108977 · 2025 · External reference
MRSA Inhibitory Activity of Some New Pyrazolo[1,5‐a]Pyrimidines Linked to Arene and/or Furan or Thiophene Units
10.1002/cbdv.202402031 · 2025 · External reference
Synthesis of New Pyrazolo[1,5‐a]Pyrimidines as Potential Antibacterial Agents: In Vitro and In Silico Study
10.1002/slct.202300487 · 2023 · External reference
Novel Macrocyclic Bis(Schiff Bases) Incorporating Fused Pyrazolo[1,5‐a]Pyrimidine Units: Metal‐Free Synthesis, Antibacterial Screening, Biofilm Inhibitory Activity, and SAR Study
10.1016/j.molstruc.2025.144647 · 2026 · External reference
Furan‐Based 1H‐Pyrazole‐3,5‐Diamine: Regioselective Synthesis of New Mono‐ and Bis(Pyrazolo[1,5‐a]Pyrimidines), DFT‐Based NMR Prediction, Antibacterial Screening, and SAR Study
10.1007/s13738-026-03342-z · 2026 · External reference
Annulated and Spiro‐Molecular Systems From Cycloheptane‐Based β‐Ketoesters: Synthesis, Reactivity, and Biological Applications
10.1016/j.molstruc.2024.141274 · 2025 · External reference
Indane‐1,3‐Dione: Versatile Precursor for the Microwave‐Assisted Synthesis of Annulated and Spiro‐Molecular Systems
10.1080/00397911.2025.2492703 · 2025 · External reference
The Reactions of Benzylmalononitriles With Hydrazine and Hydroxylamine. Synthesis of Pyrazoles, Isoxazoles, and Pyrazolo[1,5‐a]Pyrimidine Derivatives
10.1055/s-1987-27831 · 1987 · External reference
Antibacterial Activity and DNA Gyrase Inhibitory Potency of Some Novel Pyrazolo[1,5‐a]Pyrimidine‐Based Thiazolidin‐4‐One Hybrids Linked to Aryl Units
10.1080/00397911.2026.2634260 · 2026 · External reference
Discovery of an EGFR Tyrosine Kinase Inhibitor From Ilex Latifolia in Breast Cancer Therapy
10.1016/j.bmcl.2019.04.009 · 2019 · External reference
Discovery of Novel Aminobutanoic Acid‐Based ASCT2 Inhibitors for the Treatment of Non‐Small‐Cell Lung Cancer
10.1021/acs.jmedchem.3c01093 · 2024 · External reference
Design, Synthesis, Antibacterial Evaluation, and Computational Studies of Hybrid Oxothiazolidin‐1,2,4‐Triazole Scaffolds
10.1002/ardp.202000473 · 2021 · External reference
NMI‐SO2Cl2‐Mediated Amide Bond Formation: Facile Synthesis of Some Dihydrotriazolopyrimidine Amide Derivatives as Potential Anti‐Inflammatory and Anti‐Tubercular Agents
10.3390/ph17050548 · 2024 · External reference
Synthesis, Antimicrobial and Cytotoxic Activities of Some Novel Thiazole Clubbed 1,3,4‐Oxadiazoles
10.1016/j.ejmech.2013.06.029 · 2013 · External reference
Influence of Lipophilicity on the Antibacterial Activity of Polymyxin Derivatives and on Their Ability to Act as Potentiators of Rifampicin
10.1021/acsinfecdis.0c00917 · 2021 · External reference
Lipophilicity as a Central Component of Drug‐Like Properties of Chalchones and Flavonoid Derivatives
10.3390/molecules24081505 · 2019 · External reference
Synthesis, Physicochemical Properties and Antimicrobial Activity of Some New Benzimidazole Derivatives
10.1016/j.ejmech.2009.04.037 · 2009 · External reference
Treatment of MRSA Infection: Where Are We?
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Synthesis and Antibacterial Evaluation of Some Pyrimidine Hybrids as Potential MRSA Inhibitors
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Potential of Nanocarrier‐Mediated Delivery of Vancomycin for MRSA Infections
10.1080/17425247.2025.2459756 · 2025 · External reference
New Pyrido[3’,2’:4,5]Thieno[3,2‐d]Pyrimidin‐4(3H)‐One Hybrids Linked to Arene Units: Synthesis of Potential MRSA, VRE and COX‐2 Inhibitors,
10.1139/cjc-2021-0121 · 2021 · External reference
Biofilm Producing Methicillin‐Resistant Staphylococcus aureus (MRSA) Infections in Humans: Clinical Implications and Management
10.3390/pathogens13010076 · 2024 · External reference
New Thieno[2,3‐b]Pyridine‐Fused [1,2,4]Triazolo[4,3‐a]Pyrimidinone Hybrids as Potential Mrsa and VRE Inhibitors
10.1016/j.mencom.2021.04.029 · 2021 · External reference
Chromene‐Based Enaminones: Versatile Precursors for the Synthesis of New 1‐Phenyl‐1H‐Pyrazole‐3‐Carboxylate Hybrids With Potential MRSA Inhibitory Potency
10.1080/00397911.2026.2621793 · 2026 · External reference
Antibacterial, Anti‐Biofilm, and Anti‐DNA Gyrase Potency of Novel Diphenyl Ether‐Linked Bis(Thiazolidin‐4‐Ones): Synthesis, In Vitro Screening, SAR, and Molecular Modeling Study
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N‐Phenyl−4,5‐Dibromopyrrolamides and N‐Phenylindolamides as ATP Competitive DNA Gyrase B Inhibitors: Design, Synthesis, and Evaluation
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Chemical Space of Escherichia coli Dihydrofolate Reductase Inhibitors: New Approaches for Discovering Novel Drugs for Old Bugs
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New Imidazolone Derivatives Comprising a Benzoate or Sulfonamide Moiety as Anti‐Inflammatory and Antibacterial Inhibitors: Design, Synthesis, Selective COX‐2, DHFR and Molecular‐Modeling Study
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Synthesis and In Vitro Screening of Some New Thiazolone‐Based Schiff Bases as Potential MurB Inhibitors
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Pyrazolo[5,1‐b]Quinazolines and Their Bis‐Analogues Linked to Different Spacers: Regioselective Synthesis, Antibacterial Screening and SwissADME Prediction Study
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