Research graph
References from Molecular Control of Replication Fork Speed: dNTP Availability, Phosphorylation, PARylation, and UFMylation. Local targets link to admitted publications; unresolved targets remain external evidence.
Fast and Efficient DNA Replication With Purified Human Proteins
10.1038/s41586-022-04759-1 · 2022 · External reference
Regulated Eukaryotic DNA Replication Origin Firing With Purified Proteins
10.1038/nature14285 · 2015 · External reference
How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication
10.1016/j.molcel.2016.11.017 · 2017 · External reference
Pif1‐Family Helicases Support Fork Convergence During DNA Replication Termination in Eukaryotes
10.1016/j.molcel.2019.01.040 · 2019 · External reference
The CMG DNA Helicase and the Core Replisome
10.1016/j.sbi.2023.102612 · 2023 · External reference
The Initiation of Eukaryotic DNA Replication
10.1146/annurev-biochem-072321-110228 · 2022 · External reference
Dynamic Molecular Combing: Stretching the Whole human Genome for High‐Resolution Studies
10.1126/science.277.5331.1518 · 1997 · External reference
Replicon Clusters are Stable Units of Chromosome Structure: Evidence That Nuclear Organization Contributes to the Efficient Activation and Propagation of S Phase in human Cells
10.1083/jcb.140.6.1285 · 1998 · External reference
DNA Fiber Assay for the Analysis of DNA Replication Progression in Human Pluripotent Stem Cells
10.1002/cpsc.115 · 2020 · External reference
Monitoring and Quantifying Replication Fork Dynamics With High‐Throughput Methods
10.1038/s42003-024-06412-1 · 2024 · External reference
Quantifying DNA Replication Speeds in Single Cells by scEdU‐seq
10.1038/s41592-024-02308-4 · 2024 · External reference
Effects of Acute Versus Chronic Hypoxia on DNA Damage Responses and Genomic Instability
10.1158/0008-5472.can-09-2715 · 2010 · External reference
dNTP Pools Determine Fork Progression and Origin Usage Under Replication Stress
10.1038/emboj.2011.470 · 2012 · External reference
Redox‐Sensitive Alteration of Replisome Architecture Safeguards Genome Integrity
10.1126/science.aao3172 · 2017 · External reference
cGAS Suppresses Genomic Instability as a Decelerator of Replication Forks
10.1126/sciadv.abb8941 · 2020 · External reference
Developmental Differences in Genome Replication Program and Origin Activation
10.1093/nar/gkaa1124 · 2020 · External reference
Genome‐Wide Control of Heterochromatin Replication by the Telomere Capping Protein TRF2
10.1016/j.molcel.2018.03.036 · 2018 · External reference
Sources, Resolution and Physiological Relevance of R‐Loops and RNA‐DNA Hybrids
10.1038/s41580-022-00474-x · 2022 · External reference
The DNA Replication Program is Altered at the FMR1 Locus in Fragile X Embryonic Stem Cells
10.1016/j.molcel.2013.10.029 · 2014 · External reference
The Mechanism of Replication Stalling and Recovery Within Repetitive DNA
10.1038/s41467-022-31657-x · 2022 · External reference
Unprocessed Genomic Uracil as a Source of DNA Replication Stress in Cancer Cells
10.1016/j.molcel.2024.04.004 · 2024 · External reference
Uracil‐induced Replication Stress Drives Mutations, Genome Instability, Anti‐Cancer Treatment Efficacy, and Resistance
10.1016/j.molcel.2025.04.015 · 2025 · External reference
CDK‐Independent and PCNA‐Dependent Functions of p21 in DNA Replication
10.3390/genes11060593 · 2020 · External reference
Endogenous p21 Levels Protect Genomic Stability by Suppressing both Excess and Restrained Nascent DNA Syntheses
10.1126/sciadv.adw4618 · 2025 · External reference
SLFN11 Blocks Stressed Replication Forks Independently of ATR
10.1016/j.molcel.2018.01.012 · 2018 · External reference
Chk1 promotes Replication Fork Progression by Controlling Replication Initiation
10.1073/pnas.1005031107 · 2010 · External reference
A High‐Resolution, Nanopore‐Based Artificial Intelligence Assay for DNA Replication Stress in Human Cancer Cells
10.1038/s41467-025-63168-w · 2025 · External reference
High Speed of Fork Progression Induces DNA Replication Stress and Genomic Instability
10.1038/s41586-018-0261-5 · 2018 · External reference
ATR‐Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross‐Links
10.1016/j.celrep.2018.08.019 · 2018 · External reference
PCNA‐Mediated Stabilization of E3 Ligase RFWD3 at the Replication Fork is Essential for DNA Replication
10.1073/pnas.1814521115 · 2018 · External reference
USP7 is a SUMO Deubiquitinase Essential for DNA Replication
10.1038/nsmb.3185 · 2016 · External reference
SUMO2 conjugation of PCNA Facilitates Chromatin Remodeling to Resolve Transcription‐Replication Conflicts
10.1038/s41467-018-05236-y · 2018 · External reference
MCM5 UFMylation Regulates Replication Origin Firing and Fork Progression
2025 · External reference
Interferon‐Stimulated Gene 15 Accelerates Replication Fork Progression Inducing Chromosomal Breakage
10.1083/jcb.202002175 · 2020 · External reference
Interferon Restores Replication Fork Stability and Cell Viability in BRCA‐defective Cells via ISG15
10.1038/s41467-023-41801-w · 2023 · External reference
PARP1 Auto‐Modification Promotes Faithful Okazaki Fragment Processing and Limits Replication Fork Speed
10.1016/j.molcel.2025.09.006 · 2025 · External reference
Dynamic De Novo Heterochromatin Assembly and Disassembly at Replication Forks Ensures Fork Stability
10.1038/s41556-023-01167-z · 2023 · External reference
Embryonic Genome Instability Upon DNA Replication Timing Program Emergence
10.1038/s41586-024-07841-y · 2024 · External reference
DNA Replication in Early Mammalian Embryos is Patterned, Predisposing Lamina‐Associated Regions to Fragility
10.1038/s41467-024-49565-7 · 2024 · External reference
Spi‐1/PU.1 Oncogene Accelerates DNA Replication Fork Elongation and Promotes Genetic Instability in the Absence of DNA Breakage
10.1158/0008-5472.can-09-4691 · 2010 · External reference
AMBRA1 Regulates Cyclin D to Guard S‐Phase Entry and Genomic Integrity
10.1038/s41586-021-03422-5 · 2021 · External reference
Sonic Hedgehog Accelerates DNA Replication to Cause Replication Stress Promoting Cancer Initiation in Medulloblastoma
10.1038/s43018-020-0094-7 · 2020 · External reference
A Homologous Recombination Defect Affects Replication‐Fork Progression in Mammalian Cells
10.1242/jcs.010330 · 2008 · External reference
Combined Inhibition of Rad51 and Wee1 Enhances Cell Killing in HNSCC Through Induction of Apoptosis Associated With Excessive DNA Damage and Replication Stress
10.1158/1535-7163.mct-20-0252 · 2021 · External reference
RAD51 is a Druggable Target That Sustains Replication Fork Progression Upon DNA Replication Stress
2022 · External reference
Replication Fork Velocities at Adjacent Replication Origins are Coordinately Modified During DNA Replication in Human Cells
10.1091/mbc.e06-08-0689 · 2007 · External reference
Equilibrium Between Nascent and Parental MCM Proteins Protects Replicating Genomes
10.1038/s41586-020-2842-3 · 2020 · External reference
An Extending ATR‐CHK1 Circuitry: The Replication Stress Response and Beyond
10.1016/j.gde.2021.07.003 · 2021 · External reference
DNA Damage Response as a Candidate Anti‐Cancer Barrier in Early Human Tumorigenesis
10.1038/nature03482 · 2005 · External reference
Activation of the DNA Damage Checkpoint and Genomic Instability in Human Precancerous Lesions
10.1038/nature03485 · 2005 · External reference
Oncogene‐Induced Senescence is a DNA Damage Response Triggered by DNA Hyper‐Replication
10.1038/nature05327 · 2006 · External reference
Oncogene‐Induced Senescence is Part of the Tumorigenesis Barrier Imposed by DNA Damage Checkpoints
10.1038/nature05268 · 2006 · External reference
Hallmarks of DNA Replication Stress
10.1016/j.molcel.2022.05.004 · 2022 · External reference
Nucleotide Imbalance Decouples Cell Growth From Cell Proliferation
10.1038/s41556-022-00965-1 · 2022 · External reference
A Sensitive Assay for dNTPs Based on Long Synthetic Oligonucleotides, EvaGreen Dye and Inhibitor‐Resistant High‐fidelity DNA Polymerase
10.1093/nar/gkaa516 · 2020 · External reference
DNA Replication Stress as a Hallmark of Cancer
10.1146/annurev-pathol-012414-040424 · 2015 · External reference
TP53 Mutations in Human Cancer: Database Reassessment and Prospects for the Next Decade
10.1002/humu.22552 · 2014 · External reference
Genomic and Molecular Landscape of DNA Damage Repair Deficiency Across the Cancer Genome Atlas
10.1016/j.celrep.2018.03.076 · 2018 · External reference
Mechanistic Cross‐Talk Between DNA/RNA Polymerase Enzyme Kinetics and Nucleotide Substrate Availability in Cells: Implications for Polymerase Inhibitor Discovery
10.1074/jbc.rev120.013746 · 2020 · External reference
Ribonucleotide Reductases: Structure, Chemistry, and Metabolism Suggest New Therapeutic Targets
10.1146/annurev-biochem-013118-111843 · 2020 · External reference
Highly Mutagenic and Severely Imbalanced dNTP Pools can Escape Detection by the S‐phase Checkpoint
10.1093/nar/gkq128 · 2010 · External reference
A Suppressor of Two Essential Checkpoint Genes Identifies a Novel Protein That Negatively Affects dNTP Pools
10.1016/s1097-2765(00)80277-4 · 1998 · External reference
The Dun1 Checkpoint Kinase Phosphorylates and Regulates the Ribonucleotide Reductase Inhibitor Sml1
10.1073/pnas.062502299 · 2002 · External reference
Survival of DNA Damage in Yeast Directly Depends on Increased dNTP Levels Allowed by Relaxed Feedback Inhibition of Ribonucleotide Reductase
10.1016/s0092-8674(03)00075-8 · 2003 · External reference
Acetylation Regulates Ribonucleotide Reductase Activity and Cancer Cell Growth
10.1038/s41467-019-11214-9 · 2019 · External reference
Bcl2 Induces DNA Replication Stress by Inhibiting Ribonucleotide Reductase
10.1158/0008-5472.can-13-1536-t · 2014 · External reference
Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development
10.1016/j.cell.2011.03.044 · 2011 · External reference
Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene‐Induced Senescence
10.1016/j.celrep.2013.03.004 · 2013 · External reference
Depletion of Deoxyribonucleotide Pools Is an Endogenous Source of DNA Damage in Cells Undergoing Oncogene‐Induced Senescence
10.1016/j.ajpath.2012.09.011 · 2013 · External reference
Spontaneous Spinal Epidural Hematoma in a 7‐Year‐Old Girl. Diagnostic Value of Magnetic Resonance Imaging
10.1016/s0303-8467(89)80038-1 · 1989 · External reference
Myc and Ras Oncogenes Engage Different Energy Metabolism Programs and Evoke Distinct Patterns of Oxidative and DNA Replication Stress
10.1016/j.molonc.2014.11.001 · 2015 · External reference
Cancer Cells Tune the Signaling Pathways to Empower De Novo Synthesis of Nucleotides
10.3390/cancers11050688 · 2019 · External reference
A Clinically Operational Method for Three‐Dimensional Dose Calculations
10.1088/0031-9155/30/3/002 · 1985 · External reference
Replication Stress is a Potent Driver of Functional Decline in Ageing Haematopoietic Stem Cells
10.1038/nature13619 · 2014 · External reference
Helicase Activation and Establishment of Replication Forks at Chromosomal Origins of Replication
10.1101/cshperspect.a010371 · 2013 · External reference
DDK: The Outsourced Kinase of Chromosome Maintenance
2022 · External reference
Checking on DNA Damage in S Phase
10.1038/nrm1493 · 2004 · External reference
p53‐Deficient Cells Rely on ATM‐ and ATR‐Mediated Checkpoint Signaling Through the p38MAPK/MK2 Pathway for Survival After DNA Damage
10.1016/j.ccr.2006.11.024 · 2007 · External reference
Death Through a Tragedy: Mitotic Catastrophe
10.1038/cdd.2008.47 · 2008 · External reference
DNA Damage and Replication Stress Checkpoints
10.1146/annurev-biochem-072324-031915 · 2025 · External reference
The Dominant Role of Proofreading Exonuclease Activity of Replicative Polymerase Epsilon in Cellular Tolerance to Cytarabine (Ara‐C)
10.18632/oncotarget.16508 · 2017 · External reference
Mechanism of Cytarabine‐Induced Neurotoxicity
10.1038/s41586-025-09210-9 · 2025 · External reference
Targeting DNA Damage Response and Repair to Enhance Therapeutic Index in Cisplatin‐Based Cancer Treatment
10.3390/ijms22158199 · 2021 · External reference
Human Topoisomerases and Their Roles in Genome Stability and Organization
10.1038/s41580-022-00452-3 · 2022 · External reference
New Life of Topoisomerase I Inhibitors as Antibody‐Drug Conjugate Warheads
10.1158/1078-0432.ccr-22-3640 · 2023 · External reference
BMN 673, a Novel and Highly Potent PARP1/2 Inhibitor for the Treatment of human Cancers With DNA Repair Deficiency
10.1158/1078-0432.ccr-13-1391 · 2013 · External reference
Stereospecific PARP Trapping by BMN 673 and Comparison With Olaparib and Rucaparib
10.1158/1535-7163.mct-13-0803 · 2014 · External reference
Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
10.1158/0008-5472.can-12-2753 · 2012 · External reference
Discovery of 5‐4‐[(7‐Ethyl‐6‐oxo‐5,6‐dihydro‐1,5‐naphthyridin‐3‐yl)Methyl]Piperazin‐1‐yl‐N‐methylpyridine‐2‐carboxamide (AZD5305): A PARP1‐DNA Trapper With High Selectivity for PARP1 Over PARP2 and Other PARPs
10.1021/acs.jmedchem.1c01012 · 2021 · External reference
BRCAness, DNA Gaps, and Gain and Loss of PARP Inhibitor‐Induced Synthetic Lethality
10.1172/jci181062 · 2024 · External reference
Temozolomide in the Era of Precision Medicine
10.1158/0008-5472.can-16-2983 · 2017 · External reference
Temozolomide and Other Alkylating Agents in Glioblastoma Therapy
10.3390/biomedicines7030069 · 2019 · External reference
dUTPase Inhibition Augments Replication Defects of 5‐Fluorouracil
10.18632/oncotarget.15785 · 2017 · External reference
Review of 5‐FU Resistance Mechanisms in Colorectal Cancer: Clinical Significance of Attenuated on‐Target Effects
10.20517/cdr.2022.136 · 2023 · External reference
Nanoliposomal Irinotecan With Fluorouracil and Folinic Acid in Metastatic Pancreatic Cancer After Previous Gemcitabine‐based Therapy (NAPOLI‐1): A Global, Randomised, Open‐label, Phase 3 Trial
10.1016/s0140-6736(15)00986-1 · 2016 · External reference
BRCA2 and RAD51 Promote Double‐Strand Break Formation and Cell Death in Response to Gemcitabine
10.1158/1535-7163.mct-13-0862 · 2014 · External reference
DNA Damage Kinase Signaling: Checkpoint and Repair at 30 Years
2019 · External reference
The Essential Kinase ATR: Ensuring Faithful Duplication of a Challenging Genome
10.1038/nrm.2017.67 · 2017 · External reference
ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA
10.1016/j.cell.2013.10.043 · 2013 · External reference
The DNA Replication Checkpoint Prevents PCNA/RFC Depletion to Protect Forks From HLTF‐Induced Collapse in Human Cells
10.1016/j.molcel.2025.06.002 · 2025 · External reference
The Need for Speed: Drivers and Consequences of Accelerated Replication Forks
10.1038/s42003-025-08905-z · 2025 · External reference
Poly(ADP‐ribose) Polymerase Inhibition: Past, Present and Future
10.1038/s41573-020-0076-6 · 2020 · External reference
Targeting DNA Damage Response Pathways in Cancer
10.1038/s41568-022-00535-5 · 2023 · External reference
Endogenous DNA Damage as a Source of Genomic Instability in
10.1016/j.cell.2017.01.002 · 2017 · External reference
DNA Single‐Strand Break Repair and Human Genetic Disease
10.1016/j.tcb.2022.04.010 · 2022 · External reference
Overlapping Roles for PARP1 and PARP2 in the Recruitment of Endogenous XRCC1 and PNKP Into Oxidized Chromatin
2017 · External reference
The Importance of Poly(ADP‐Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments During DNA Replication
10.1016/j.molcel.2018.06.004 · 2018 · External reference
Redundant but Essential Functions of PARP1 and PARP2 in DNA Ligase I‐independent DNA Replication
10.1093/nar/gkae672 · 2024 · External reference
FANCD2 maintains Replication Fork Stability During Misincorporation of the DNA Demethylation Products 5‐hydroxymethyl‐2'‐deoxycytidine and 5‐hydroxymethyl‐2'‐deoxyuridine
10.1038/s41419-022-04952-0 · 2022 · External reference
PARP1 Recruits DNA Translocases to Restrain DNA Replication and Facilitate DNA Repair
10.1371/journal.pgen.1010545 · 2022 · External reference
PARP‐1 Ensures Regulation of Replication Fork Progression by Homologous Recombination on Damaged DNA
10.1083/jcb.200806068 · 2008 · External reference
DNA Polymerase Alpha‐Primase Facilitates PARP Inhibitor‐Induced Fork Acceleration and Protects BRCA1‐Deficient Cells Against ssDNA Gaps
10.1038/s41467-024-51667-1 · 2024 · External reference
Replication Gaps are a Key Determinant of PARP Inhibitor Synthetic Lethality With BRCA Deficiency
10.1016/j.molcel.2021.06.011 · 2021 · External reference
Loss of Nuclear DNA Ligase III Reverts PARP Inhibitor Resistance in BRCA1/53BP1 Double‐Deficient Cells by Exposing ssDNA Gaps
10.1016/j.molcel.2021.09.005 · 2021 · External reference
Preclinical Characterization of AZD5305, a Next‐Generation, Highly Selective PARP1 Inhibitor and Trapper
10.1158/1078-0432.ccr-22-0301 · 2022 · External reference
Rad51‐Mediated Replication Fork Reversal is a Global Response to Genotoxic Treatments in Human Cells
10.1083/jcb.201406099 · 2015 · External reference
NASP Modulates Histone Turnover to Drive PARP Inhibitor Resistance
10.1038/s41586-025-09414-z · 2025 · External reference
Timeless Interacts With PARP‐1 to Promote Homologous Recombination Repair
10.1016/j.molcel.2015.07.031 · 2015 · External reference
TIMELESS Forms a Complex With PARP1 Distinct From Its Complex With TIPIN and Plays a Role in the DNA Damage Response
10.1016/j.celrep.2015.09.017 · 2015 · External reference
Topoisomerase I Poisoning Results in PARP‐Mediated Replication Fork Reversal
10.1038/nsmb.2258 · 2012 · External reference
Replication Fork Reversal: Players and Guardians
10.1016/j.molcel.2017.11.022 · 2017 · External reference
The Plasticity of DNA Replication Forks in Response to Clinically Relevant Genotoxic Stress
10.1038/s41580-020-0257-5 · 2020 · External reference
Mechanisms of Damage Tolerance and Repair During DNA Replication
10.1093/nar/gkab101 · 2021 · External reference
Human RECQ1 Promotes Restart of Replication Forks Reversed by DNA Topoisomerase I Inhibition
10.1038/nsmb.2501 · 2013 · External reference
Mre11‐Dependent Degradation of Stalled DNA Replication Forks is Prevented by BRCA2 and PARP1
10.1158/0008-5472.can-11-3417 · 2012 · External reference
CARM1 Regulates Replication Fork Speed and Stress Response by Stimulating PARP1
10.1016/j.molcel.2020.12.010 · 2021 · External reference
Mechanisms and Regulation of Replication Fork Reversal
10.1016/j.dnarep.2024.103731 · 2024 · External reference
ATR Inhibitors VE‐821 and VX‐970 Sensitize Cancer Cells to Topoisomerase i Inhibitors by Disabling DNA Replication Initiation and Fork Elongation Responses
10.1158/0008-5472.can-13-3369 · 2014 · External reference
The Proofreading Exonuclease of Leading‐Strand DNA Polymerase Epsilon Prevents Replication Fork Collapse at Broken Template Strands
10.1093/nar/gkad999 · 2023 · External reference
PARP Inhibition Impedes the Maturation of Nascent DNA Strands During DNA Replication
10.1038/s41594-022-00747-1 · 2022 · External reference
Replication Gaps Underlie BRCA Deficiency and Therapy Response
10.1158/0008-5472.can-20-1602 · 2021 · External reference
The TIMELESS and PARP1 Interaction Suppresses Replication‐Associated DNA Gap Accumulation
10.1093/nar/gkae445 · 2024 · External reference
Schlafen 11 Further Sensitizes BRCA‐Deficient Cells to PARP Inhibitors Through Single‐Strand DNA Gap Accumulation Behind Replication Forks
10.1038/s41388-024-03094-1 · 2024 · External reference
Ubiquitinated‐PCNA Protects Replication Forks From DNA2‐Mediated Degradation by Regulating Okazaki Fragment Maturation and Chromatin Assembly
10.1038/s41467-020-16096-w · 2020 · External reference
HPF1‐Dependent PARP Activation Promotes LIG3‐XRCC1‐Mediated Backup Pathway of Okazaki Fragment Ligation
10.1093/nar/gkab269 · 2021 · External reference
Regulation of Replication Fork Speed: Mechanisms and Impact on Genomic Stability
10.1016/j.dnarep.2019.102654 · 2019 · External reference
Multi‐Step Processing of Replication Stress‐Derived Nascent Strand DNA Gaps by MRE11 and EXO1 Nucleases
10.1038/s41467-023-42011-0 · 2023 · External reference
A Genetic Map of the Response to DNA Damage in Human Cells
10.1016/j.cell.2020.05.040 · 2020 · External reference
Ctf18‐RFC and DNA Pol Ε Form a Stable Leading Strand Polymerase/Clamp Loader Complex Required for Normal and Perturbed DNA Replication
10.1093/nar/gkaa541 · 2020 · External reference
CTF18‐RFC Contributes to Cellular Tolerance Against Chain‐Terminating Nucleoside Analogs (CTNAs) in Cooperation With Proofreading Exonuclease Activity of DNA Polymerase Epsilon
10.1016/j.dnarep.2023.103503 · 2023 · External reference
Checkpoint‐Mediated DNA Polymerase Epsilon Exonuclease Activity Curbing Counteracts Resection‐Driven Fork Collapse
10.1016/j.molcel.2021.04.006 · 2021 · External reference
Mechanisms Controlling Replication Fork Stalling and Collapse at Topoisomerase 1 Cleavage Complexes
10.1016/j.molcel.2024.08.004 · 2024 · External reference
Fork Pausing Complex Engages Topoisomerases at the Replisome
10.1101/gad.331868.119 · 2020 · External reference
Structure and Repair of Replication‐Coupled DNA Breaks
10.1126/science.ado3867 · 2024 · External reference
Deciphering the Fate of Replication‐Induced DNA Double‐Strand Breaks
10.1016/j.molcel.2024.12.006 · 2025 · External reference
Specific Killing of BRCA2‐Deficient Tumours With Inhibitors of Poly(ADP‐ribose) Polymerase
10.1038/nature03443 · 2005 · External reference
Targeting the DNA Repair Defect in BRCA Mutant Cells as a Therapeutic Strategy
10.1038/nature03445 · 2005 · External reference
The UFM1 System: Working Principles, Cellular Functions, and Pathophysiology
10.1016/j.molcel.2023.11.034 · 2024 · External reference
Ufm1‐Specific Ligase Ufl1 Regulates Endoplasmic Reticulum Homeostasis and Protects Against Heart Failure
2018 · External reference
Mechanistic Insights Into the Roles of the UFM1 E3 Ligase Complex in Ufmylation and Ribosome‐Associated Protein Quality Control
10.1126/sciadv.adh3635 · 2023 · External reference
Ufmylation on UFBP1 Alleviates Non‐Alcoholic Fatty Liver Disease by Modulating Hepatic Endoplasmic Reticulum Stress
10.1038/s41419-023-06095-2 · 2023 · External reference
The UFM1 E3 Ligase Recognizes and Releases 60S Ribosomes From ER Translocons
10.1038/s41586-024-07093-w · 2024 · External reference
UFM1 E3 ligase Promotes Recycling of 60S Ribosomal Subunits From the ER
10.1038/s41586-024-07073-0 · 2024 · External reference
UFMylation Maintains Tumour Suppressor p53 Stability by Antagonizing Its Ubiquitination
10.1038/s41556-020-0559-z · 2020 · External reference
The Ufmylation Modification of Ribosomal Protein L10 in the Development of Pancreatic Adenocarcinoma
10.1038/s41419-023-05877-y · 2023 · External reference
UFL1 promotes Histone H4 Ufmylation and ATM Activation
10.1038/s41467-019-09175-0 · 2019 · External reference
MRE11 UFMylation Promotes ATM Activation
10.1093/nar/gkz110 · 2019 · External reference
Dynamic Recruitment of UFM1‐specific Peptidase 2 to the DNA Double‐Strand Breaks Regulated by WIP1
10.1007/s42764-022-00076-z · 2022 · External reference
Defining a Cancer Dependency Map
10.1016/j.cell.2017.06.010 · 2017 · External reference
The Present and Future of the Cancer Dependency Map
10.1038/s41568-024-00763-x · 2025 · External reference
The Human Pre‐Replication Complex is an Open Complex
10.1016/j.cell.2022.12.008 · 2023 · External reference
Chemoproteomic Screening of Covalent Ligands Reveals UBA5 as a Novel Pancreatic Cancer Target
10.1021/acschembio.7b00020 · 2017 · External reference
A Conserved Mechanism for Regulating Replisome Disassembly in Eukaryotes
10.1038/s41586-021-04145-3 · 2021 · External reference
Structure of a Human Replisome Shows the Organisation and Interactions of a DNA Replication Machine
10.15252/embj.2021108819 · 2021 · External reference
CryoEM Structures of Human CMG‐ATPgammaS‐DNA and CMG‐AND‐1 Complexes
10.1093/nar/gkaa429 · 2020 · External reference
Congenital Diseases of DNA Replication: Clinical Phenotypes and Molecular Mechanisms
10.3390/ijms22020911 · 2021 · External reference
Inherited GINS1 Deficiency Underlies Growth Retardation Along With Neutropenia and NK Cell Deficiency
10.1172/jci90727 · 2017 · External reference
In Silico Protein Interaction Screening Uncovers DONSON's Role in Replication Initiation
10.1126/science.adi3448 · 2023 · External reference
DNSN‐1 Recruits GINS for CMG Helicase Assembly During DNA Replication Initiation in Caenorhabditis elegans
10.1126/science.adi4932 · 2023 · External reference
Mutations in DONSON Disrupt Replication Fork Stability and Cause Microcephalic Dwarfism
10.1038/ng.3790 · 2017 · External reference
The Ufm1‐Activating Enzyme Uba5 is Indispensable for Erythroid Differentiation in Mice
10.1038/ncomms1182 · 2011 · External reference
RCAD/Ufl1, a Ufm1 E3 Ligase, is Essential for Hematopoietic Stem Cell Function and Murine Hematopoiesis
10.1038/cdd.2015.51 · 2015 · External reference
The Embryonic Origins of Erythropoiesis in Mammals
10.1182/blood-2012-01-153486 · 2012 · External reference
Biallelic Variants in UBA5 Reveal That Disruption of the UFM1 Cascade Can Result in Early‐Onset Encephalopathy
10.1016/j.ajhg.2016.06.030 · 2016 · External reference
UBA5 Mutations Cause a New Form of Autosomal Recessive Cerebellar Ataxia
10.1371/journal.pone.0149039 · 2016 · External reference
Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin‐Like Modifier Pathway to Severe Infantile‐Onset Encephalopathy
10.1016/j.ajhg.2016.06.020 · 2016 · External reference
UFM1 Founder Mutation in the Roma Population Causes Recessive Variant of H‐ABC
10.1212/wnl.0000000000004578 · 2017 · External reference
Biallelic UFM1 and UFC1 Mutations Expand the Essential Role of Ufmylation in Brain Development
10.1093/brain/awy135 · 2018 · External reference
Mechanisms and Pathways of Growth Failure in Primordial Dwarfism
10.1101/gad.169037 · 2011 · External reference
The Expanding Genetic and Clinical Landscape Associated With Meier‐Gorlin Syndrome
10.1038/s41431-023-01359-z · 2023 · External reference
A Mouse Model of ATR‐Seckel Shows Embryonic Replicative Stress and Accelerated Aging
10.1038/ng.420 · 2009 · External reference
Mutations in ORC1, Encoding the Largest Subunit of the Origin Recognition Complex, Cause Microcephalic Primordial Dwarfism Resembling Meier‐Gorlin Syndrome
10.1038/ng.776 · 2011 · External reference
Maintaining Genome Stability in the Nervous System
10.1038/nn.3537 · 2013 · External reference
Stems Cells and the Pathways to Aging and Cancer
10.1016/j.cell.2008.01.036 · 2008 · External reference
