Research graph
References from GlycoMAC: A Multiscale Metabolic‐Glycosylation Framework for Predicting Glycosylation Across Conditions in Mammalian Cell Cultures. Local targets link to admitted publications; unresolved targets remain external evidence.
Effects of Nutrient Levels and Average Culture pH on the Glycosylation Pattern of Camelid‐Humanized Monoclonal Antibody
10.1016/j.jbiotec.2014.05.024 · 2014 · External reference
Metabolic Flux Analysis of CHO Cells at Growth and Non‐Growth Phases Using Isotopic Tracers and Mass Spectrometry
10.1016/j.ymben.2011.07.002 · 2011 · External reference
Towards Dynamic Metabolic Flux Analysis in CHO Cell Cultures
10.1002/biot.201100052 · 2012 · External reference
Neutralization of pH in the Golgi Apparatus Causes Redistribution of Glycosyltransferases and Changes in the O‐Glycosylation of Mucins
10.1093/glycob/11.8.633 · 2001 · External reference
The Choice of Mammalian Cell Host and Possibilities for Glycosylation Engineering
10.1016/j.copbio.2014.06.010 · 2014 · External reference
Microevolutionary Dynamics of Eccdna in Chinese Hamster Ovary Cells Grown in Fed‐Batch Cultures under Control and Lactate‐Stressed Conditions
10.1038/s41598-023-27962-0 · 2023 · External reference
Cell‐and Tissue‐Specific Glycosylation Pathways Informed by Single‐Cell Transcriptomics
10.1093/nargab/lqae169 · 2024 · External reference
Metabolic Profiling of Cho Cells During the Production of Biotherapeutics
10.3390/cells11121929 · 2022 · External reference
Amino Acid and Manganese Supplementation Modulates the Glycosylation State of Erythropoietin in a CHO Culture System
10.1002/bit.21141 · 2007 · External reference
Expression Systems for Therapeutic Glycoprotein Production
10.1016/j.copbio.2009.10.008 · 2009 · External reference
Spent Media Analysis With an Integrated CE‐MS Analyzer of Chinese Hamster Ovary Cells Grown in an Ammonia‐Stressed Parallel Microbioreactor Platform
10.12665/j19oa.elliott · 2020 · External reference
Dynamic Multiscale Metabolic Network Modeling of Chinese Hamster Ovary Cell Metabolism Integrating N‐Linked Glycosylation in Industrial Biopharmaceutical Manufacturing
10.1002/bit.27578 · 2021 · External reference
The N‐Glycosylation Processing Potential of the Mammalian Golgi Apparatus
10.3389/fcell.2019.00157 · 2019 · External reference
High‐End pH‐Controlled Delivery of Glucose Effectively Suppresses Lactate Accumulation in CHO Fed‐Batch Cultures
10.1002/bit.23072 · 2011 · External reference
Ammonium Alters N‐Glycan Structures of Recombinant TNFR‐IgG: Degradative Versus Biosynthetic Mechanisms
10.1002/(sici)1097-0290(20000620)68:6<637::aid-bit6>3.0.co;2-c · 2000 · External reference
The Chemical Langevin Equation
10.1063/1.481811 · 2000 · External reference
Modulation of Antibody Galactosylation Through Feeding of Uridine, Manganese Chloride, and Galactose
10.1002/bit.23075 · 2011 · External reference
Temporal Galactose‐Manganese Feeding in Fed‐Batch and Perfusion Bioreactors Modulates UDP‐Galactose Pools for Enhanced Mab Glycosylation Homogeneity
10.1002/bit.28999 · 2025 · External reference
PID Controls: The Forgotten Bioprocess Parameters
10.1007/s43938-022-00008-z · 2022 · External reference
Optimal and Consistent Protein Glycosylation in Mammalian Cell Culture
10.1093/glycob/cwp079 · 2009 · External reference
Systems Analysis of N‐Glycan Processing in Mammalian Cells
10.1371/journal.pone.0000713 · 2007 · External reference
Quantitative Intracellular Flux Modeling and Applications in Biotherapeutic Development and Production Using CHO Cell Cultures
10.1002/bit.26384 · 2017 · External reference
Evaluating the Impact of Cell Culture Process Parameters on Monoclonal Antibody N‐Glycosylation
10.1016/j.jbiotec.2014.08.026 · 2014 · External reference
pH Excursions Impact CHO Cell Culture Performance and Antibody N‐Linked Glycosylation
10.1007/s00449-018-1996-y · 2018 · External reference
A Quantitative and Mechanistic Model for Monoclonal Antibody Glycosylation as a Function of Nutrient Availability During Cell Culture
10.1186/1753-6561-7-s6-o10 · 2013 · External reference
A Dynamic Mathematical Model for Monoclonal Antibody N‐Linked Glycosylation and Nucleotide Sugar Donor Transport Within a Maturing Golgi Apparatus
10.1002/btpr.688 · 2011 · External reference
Modulation and Modeling of Monoclonal Antibody N‐Linked Glycosylation in Mammalian Cell Perfusion Reactors
10.1002/bit.26315 · 2017 · External reference
Dynamic pH Profiles Drive Higher Cell‐Specific and Volumetric Productivity
10.1002/btpr.70080 · 2026 · External reference
Influence of Intracellular Nucleotide and Nucleotide Sugar Contents on Recombinant Interferon‐γ $\gamma $ Glycosylation During Batch and Fed‐Batch Cultures of CHO Cells
10.1002/bit.21816 · 2008 · External reference
Golgi pH Elevation Due to Loss of V‐ATPase Subunit v0a2 Function Correlates With Tissue‐Specific Glycosylation Changes and Globozoospermia
10.1007/s00018-024-05506-7 · 2024 · External reference
CHOGlycoNET: Comprehensive Glycosylation Reaction Network for CHO Cells
10.1016/j.ymben.2022.12.009 · 2023 · External reference
Model‐Based Optimization of Antibody Galactosylation in CHO Cell Culture
10.1002/bit.26960 · 2019 · External reference
Model‐Based Analysis of N‐Glycosylation in Chinese Hamster Ovary Cells
10.1371/journal.pone.0175376 · 2017 · External reference
A Mathematical Model of N‐Linked Glycosylation
10.1002/bit.20645 · 2005 · External reference
Uncertainty Propagation for Deterministic Models of Biochemical Networks Using Moment Equations and the Extended Kalman Filter
10.1098/rsif.2021.0331 · 2021 · External reference
Kinetic Modeling of Mammalian Cell Culture Bioprocessing: The Quest to Advance Biomanufacturing
10.1002/biot.201700229 · 2018 · External reference
Therapeutic Glycoprotein Production in Mammalian Cells
10.1016/j.jbiotec.2017.04.028 · 2017 · External reference
Glycan Profiles of FDA‐Approved Therapeutic Antibodies: Insights From Regulatory Submissions
10.1208/s12248-026-01207-0 · 2026 · External reference
Adaptive Nonlinear Model Predictive Control of Monoclonal Antibody Glycosylation in Cho Cell Culture
10.1016/j.conengprac.2025.106731 · 2026 · External reference
Quasi‐Steady‐State Approach for Efficient Multiscale Simulation and Optimization of Mab Glycosylation in Cho Cell Culture
10.1016/j.ces.2025.122162 · 2025 · External reference
New Developments in Online Our Monitoring and Its Application to Animal Cell Cultures
10.1007/s00253-019-09989-4 · 2019 · External reference
Quantification of the Dynamics of Population Heterogeneities in CHO Cultures With Stably Integrated Fluorescent Markers
10.1007/s00216-020-02401-5 · 2020 · External reference
on Metabolic Shift to Lactate Consumption in Fed‐Batch Culture of Mammalian Cells
10.1016/j.ymben.2011.12.006 · 2012 · External reference
Effects of Buffering Conditions and Culture pH on Production Rates and Glycosylation of Clinical Phase I Anti‐Melanoma Mouse IgG3 Monoclonal Antibody R24
10.1002/bit.10673 · 2003 · External reference
Effects of Cell Culture Conditions on Antibody N‐Linked Glycosylation—What Affects High Mannose 5 Glycoform
10.1002/bit.23200 · 2011 · External reference
Oxygen Uptake Rate Soft‐Sensing via Dynamic K L a Computation: Cell Volume and Metabolic Transition Prediction in Mammalian Bioprocesses
10.3389/fbioe.2019.00195 · 2019 · External reference
Scalable and Flexible Inference Framework for Stochastic Dynamic Single‐Cell Models
10.1371/journal.pcbi.1010082 · 2022 · External reference
Intraclonal Protein Expression Heterogeneity in Recombinant CHO Cells
10.1371/journal.pone.0008432 · 2009 · External reference
Hybrid Deep Modeling of a CHO‐K1 Fed‐Batch Process: Combining First‐Principles With Deep Neural Networks
10.3389/fbioe.2023.1237963 · 2023 · External reference
Controlling the Glycosylation Profile in mAbs Using Time‐Dependent Media Supplementation
10.3390/antib7010001 · 2017 · External reference
Fc Glycans of Therapeutic Antibodies as Critical Quality Attributes
10.1093/glycob/cwv065 · 2015 · External reference
Elevated Golgi pH Impairs Terminal N‐Glycosylation by Inducing Mislocalization of Golgi Glycosyltransferases
10.1002/jcp.21744 · 2009 · External reference
Elevated Golgi pH in Breast and Colorectal Cancer Cells Correlates With the Expression of Oncofetal Carbohydrate T‐Antigen
10.1002/jcp.20653 · 2006 · External reference
A Single Dynamic Metabolic Model Can Describe mAb Producing CHO Cell Batch and Fed‐Batch Cultures on Different Culture Media
10.1371/journal.pone.0136815 · 2015 · External reference
Approximation and Inference Methods for Stochastic Biochemical Kinetics—A Tutorial Review
10.1088/1751-8121/aa54d9 · 2017 · External reference
Combined in Silico Modeling and Metabolomics Analysis to Characterize Fed‐Batch CHO Cell Culture
10.1002/bit.24445 · 2012 · External reference
Mechanistic Modeling and Applications for CHO Cell Culture Development and Production
10.1016/j.coche.2018.08.010 · 2018 · External reference
A Mathematical and Computational Approach for Integrating the Major Sources of Cell Population Heterogeneity
10.1016/j.jtbi.2010.06.002 · 2010 · External reference
Dissecting N‐Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed‐Batch Cultures Using Time Course Omics Analyses
10.1016/j.isci.2019.01.006 · 2019 · External reference
Transient Ammonia Stress on Chinese Hamster Ovary (CHO) Cells Yield Alterations to Alanine Metabolism and IgG Glycosylation Profiles
10.1002/biot.202100098 · 2021 · External reference
What CHO Is Made Of: Variations in the Biomass Composition of Chinese Hamster Ovary Cell Lines
10.1016/j.ymben.2020.06.002 · 2020 · External reference
Sources, Propagation and Consequences of Stochasticity in Cellular Growth
10.1038/s41467-018-06912-9 · 2018 · External reference
A Mathematical Model of N‐Linked Glycoform Biosynthesis
10.1002/(sici)1097-0290(19970920)55:6<890::aid-bit7>3.0.co;2-b · 1997 · External reference
Controlling the Time Evolution of mAb N‐Linked Glycosylation, Part I: Microbioreactor Experiments
10.1002/btpr.2305 · 2016 · External reference
Controlling the Time Evolution of mAb N‐Linked Glycosylation‐Part II: Model‐Based Predictions
10.1002/btpr.2315 · 2016 · External reference
Multi‐Scale Hybrid Modeling to Predict Cell Culture Process With Metabolic Phase Transitions
10.1002/bit.70205 · 2026 · External reference
Simulation and Inference Algorithms for Stochastic Biochemical Reaction Networks: From Basic Concepts to State‐of‐the‐Art
10.1098/rsif.2018.0943 · 2019 · External reference
Production of Recombinant Protein Therapeutics in Cultivated Mammalian Cells
10.1038/nbt1026 · 2004 · External reference
Progress in Fed‐Batch Culture for Recombinant Protein Production in CHO Cells
10.1007/s00253-022-12342-x · 2023 · External reference
Effects of Ammonia on CHO Cell Growth, Erythropoietin Production, and Glycosylation
10.1002/(sici)1097-0290(20000520)68:4<370::aid-bit2>3.0.co;2-k · 2000 · External reference
