Research graph
References from Development and application of a mechanistic model for protein <scp>A</scp> resolution of a bispecific antibody for process characterization and optimization. Local targets link to admitted publications; unresolved targets remain external evidence.
Bispecific antibodies in oncology
10.1038/d41573-022-00040-2 · 2022 · External reference
Safety and preliminary antitumor activity of the anti‐PD‐1 monoclonal antibody REGN2810 alone or in combination with REGN1979, an anti‐CD20 x anti‐CD3 bispecific antibody, in patients with B‐lymphoid malignancies
2017 · External reference
Tumor‐targeted CD28 bispecific antibodies enahnce the antitumor efficacy of PD‐1 immunotherapy
10.1126/scitranslmed.aba2325 · 2020 · External reference
Bispecific antibody process development: assembly and purification of knob and hole bispecific antibodies
10.1002/btpr.2590 · 2018 · External reference
Production of bispecific antibodies in “knobs‐into‐holes” using a cell‐free expression system
10.4161/19420862.2015.989013 · 2015 · External reference
Improved assembly of bispecific antibodies from knob and hole half‐antibodies
10.1002/btpr.2130 · 2015 · External reference
A novel, native‐format bispecific antibody triggering T‐cell killing of B‐cells is robustly active in mouse tumor models and cynomolgus monkeys
10.1038/srep17943 · 2016 · External reference
Development of purification processes for fully human bispecific antibodies based upon modification of protein a binding avidity
10.1080/19420862.2016.1160192 · 2016 · External reference
Development of a novel affinity chromatography resin for platform purification of bispecific antibodies with modified protein a binding avidity
10.1002/btpr.2622 · 2018 · External reference
An overview of mechanistic modeling of liquid chromatography
10.1080/10826068.2019.1615504 · 2019 · External reference
Integration and digitalization in the manufacturing of therapeutic proteins
10.1016/j.ces.2021.117159 · 2022 · External reference
Rational and systematic protein purification process development: the next generation
10.1016/j.tibtech.2009.09.002 · 2009 · External reference
Current state of implementation of in silico tools in the biopharmaceutical industry ‐ proceedings of the 5th modeling workshop
10.1002/bit.28768 · 2024 · External reference
Steric mass‐action ion exchange: displacement profiles and induced salt gradients
10.1002/aic.690381212 · 1992 · External reference
Straightforward method for calibration of mechanistic cation exchange chromatography models for industrial applications
10.1002/btpr.2984 · 2020 · External reference
Combined Yamamoto approach for simultaneous estimation of adsorption isotherm and kinetic parameters in ion‐exchange chromatography
10.1016/j.chroma.2015.08.025 · 2015 · External reference
Adsorption of colloidal proteins in ion‐exchange chromatography under consideration of charge regulation
10.1016/j.chroma.2019.460608 · 2020 · External reference
Protein adsorption on ion exchange adsorbers: a comparison of a stoichiometric and non‐stoichimoetric modeling approach
10.1016/j.chroma.2021.462397 · 2021 · External reference
Water on hydrophobic surfaces: mechanistic modeling of hydrophobic interaction chromatography
10.1016/j.chroma.2016.07.085 · 2016 · External reference
Mechanistic modeling of hydrophobic interaction chromatography for monoclonal antibody purification: process optimization in the quality by design paradigm
2017 · External reference
Model‐based analysis of a hydrophobic interaction chromatography for antibody‐drug conjugate purificcation
10.1016/j.chroma.2025.465916 · 2025 · External reference
Modeling of hydrophobic interaction chromatography for the separation of antibody‐drug conjugates and its application towards quality by design
10.1016/j.jbiotec.2020.04.018 · 2020 · External reference
Standardized method for mechanistic modeling of multimodal anion exchange chromatography in flow through operation
10.1016/j.chroma.2023.463789 · 2023 · External reference
Isotherm model discrimination for multimodal chromatography using mechanistic models derived from high‐throughput batch isotherm data
10.1016/j.chroma.2023.463878 · 2023 · External reference
Mechanistic modeling, simulation, and optimization of mixed‐mode chromatography for an antibody polishing step
10.1002/btpr.3316 · 2023 · External reference
Model‐based process development of continuous chromatography for antibody capture: a case study with twin‐column system
10.1016/j.chroma.2020.460936 · 2020 · External reference
An affinity complex titration isotherm for mechanistic modeling in protein a chromatography
10.1002/bit.29035 · 2025 · External reference
Predictive scaling of fiber‐based protein a capture chromatography using mechanistic modeling
10.1002/bit.28434 · External reference
Predictive mechanistic modeling of loading and elution in protein a chromatography
10.1016/j.chroma.2023.464558 · 2024 · External reference
Good modeling practice for industrial chromatography: mechanistic modeling of ion exchange chromatography for a bispecific antibody
10.1016/j.compchemeng.2019.106532 · 2019 · External reference
In silico optimization of a challenging bispecific antibody chromatography step
10.1002/btpr.3531 · 2025 · External reference
Modeling of bispecific antibody elution in mixed‐mode cation‐exchange chromatography
10.1002/jssc.201700313 · 2017 · External reference
10.1002/3527603484
10.1002/3527603484 · 2005 · External reference
Unresolved reference
2006 · External reference
Elution relationships to model affinity chromatography using a general rate model
10.1002/jmr.2223 · 2012 · External reference
A review of the thermodynamics of protein association to ligands, protein adsorption, and adsorption isotherms
10.1002/ceat.200800082 · 2008 · External reference
Prot‐a capture model ‐ from batch to continuous
2019 · External reference
Analysis of complex protein elution behavior in preparative ion exchange processes using a colloidal particle adsorption model
10.1016/j.chroma.2021.462439 · 2021 · External reference
Unresolved reference
2008 · External reference
UV adsoprtion‐based inverse modeling of protein chromatography
10.1002/elsc.201400247 · 2016 · External reference
Unresolved reference
External reference
SUNDIALS: suite of nonlinear and differential/algebraic equation solvers
10.1145/1089014.1089020 · 2005 · External reference
A systematic approach for estimating colloidal particle adsorption model parameters
10.1016/j.chroma.2024.465512 · 2025 · External reference
Mechanistic modeling of ion‐exchange process chromatography of charge variants of monoclonal antibody products
10.1016/j.chroma.2015.11.062 · 2015 · External reference
Parameter‐by‐parameter method for steric mass action model of ion exchange chromatography: simplified estimation for steric shielding factor
10.1016/j.chroma.2022.463418 · 2022 · External reference
