Research graph
References from Chemical Biology‐Based Drug Discovery Workflow Highlights Target Identification as a Key Step in Developing a Novel, Potent, and Selective GLUT1 Inhibitor. Local targets link to admitted publications; unresolved targets remain external evidence.
Identification of a Novel ALDH1A3‐Selective Inhibitor by a Chemical Probe with Unrelated Bioactivity: An Approach to Affinity‐Based Drug Target Discovery
10.1111/cbdd.14176 · 2023 · External reference
Target Deconvolution Techniques in Modern Phenotypic Profiling
10.1016/j.cbpa.2012.12.022 · 2013 · External reference
Biochemical Target Isolation for Novices: Affinity‐Based Strategies
10.1016/j.chembiol.2010.05.015 · 2010 · External reference
Target Identification of Small Molecules Based on Chemical Biology Approaches
10.1039/c2mb25468a · 2013 · External reference
Affinity‐Based Target Identification for Bioactive Small Molecules
10.1039/c3md00276d · 2014 · External reference
Identification of a Small Compound Targeting PKM2‐Regulated Signaling Using 2D Gel Electrophoresis‐Based Proteome‐Wide CETSA
10.1016/j.chembiol.2019.11.010 · 2020 · External reference
Splicing Factor SF3b as a Target of the Antitumor Natural Product Pladienolide
10.1038/nchembio.2007.16 · 2007 · External reference
Selective Degradation of Splicing Factor CAPERα by Anticancer Sulfonamides
10.1038/nchembio.2363 · 2017 · External reference
Chemical Proteomics for Drug Discovery Based on Compound‐Immobilized Affinity Chromatography
10.1016/j.jchromb.2006.12.047 · 2007 · External reference
Development of Chemically Stable Solid Phases for the Target Isolation with Reduced Nonspecific Binding Proteins
10.1016/j.bmcl.2005.09.011 · 2006 · External reference
Improvement of Monolithic Solid Material by Utilization of Spacer for Identification of the Target Using Affinity Resins
10.1016/j.bmcl.2009.01.050 · 2009 · External reference
Target Identification of Marine Natural Product Odoamide: Odoamide Induces Apoptotic Cell Death by Targeting ATPase Na+/K+ Transporting Subunit Alpha 1 (ATP1A1)
10.1002/cbic.202400762 · 2025 · External reference
Unresolved reference
External reference
Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success
10.1021/jm901241e · 2009 · External reference
An Integrated Database of Chemosensitivity to 55 Anticancer Drugs and Gene Expression Profiles of 39 Human Cancer Cell Lines
2002 · External reference
Panel of Human Cancer Cell Lines Provides Valuable Database for Drug Discovery and Bioinformatics
10.1007/s00280-003-0649-1 · 2003 · External reference
JFCR39, a Panel of 39 Human Cancer Cell Lines, and Its Application in the Discovery and Development of Anticancer Drugs
10.1016/j.bmc.2012.01.017 · 2012 · External reference
Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY‐876
10.1002/cmdc.201600276 · 2016 · External reference
Crystal Structure of the Human Glucose Transporter GLUT1
10.1038/nature13306 · 2014 · External reference
Glucose Transporter 1 Deficiency in the Idiopathic Generalized Epilepsies
10.1002/ana.23702 · 2012 · External reference
On the Origin of Cancer Cells
10.1126/science.123.3191.309 · 1956 · External reference
Hallmarks of Cancer: New Dimensions
10.1158/2159-8290.cd-21-1059 · 2022 · External reference
Nomenclature of the GLUT/SLC2A Family of Sugar/Polyol Transport Facilitators
10.1152/ajpendo.00407.2001 · 2002 · External reference
The SLC2 (GLUT) Family of Membrane Transporters
10.1016/j.mam.2012.07.001 · 2013 · External reference
Expression of GLUT1 in Pseudopalisaded and Perivascular Tumor Cells Is an Independent Prognostic Factor for Patients With Glioblastomas
10.1093/jnen/nly124 · 2019 · External reference
GLUT1 Inhibition Blocks Growth of RB1‐Positive Triple Negative Breast Cancer
10.1038/s41467-020-18020-8 · 2020 · External reference
Role of Glucose Metabolism Related Gene GLUT1 in the Occurrence and Prognosis of Colorectal Cancer
10.18632/oncotarget.18090 · 2017 · External reference
Identification of a Small‐Molecule Glucose Transporter Inhibitor, Glutipyran, That Inhibits Cancer Cell Growth
10.1021/acschembio.1c00480 · 2021 · External reference
GLUT1 Inhibitor BAY‐876 Induces Apoptosis and Enhances Anti‐Cancer Effects of Bitter Receptor Agonists in Head and Neck Squamous Carcinoma Cells
10.1038/s41420-024-02106-z · 2024 · External reference
GLUT1 Inhibition by BAY‐876 Induces Metabolic Changes and Cell Death in Human Colorectal Cancer Cells
10.1186/s12885-025-14141-9 · 2025 · External reference
Glucose Transporter 1 Inhibitors Induce Autophagy and Synergize with Lenvatinib in Thyroid Cancer Cells
10.1002/hed.27953 · 2025 · External reference
Inhibition of Glucose Transporters and Glutaminase Synergistically Impairs Tumor Cell Growth
10.1016/j.chembiol.2019.06.005 · 2019 · External reference
Phenotypic Drug Discovery: Recent Successes, Lessons Learned and New Directions
10.1038/s41573-022-00472-w · 2022 · External reference
Is Target‐Based Drug Discovery Efficient? Discovery and “Off‐Target” Mechanisms of All Drugs
10.1021/acs.jmedchem.2c01737 · 2023 · External reference
Probing Immunosuppressant Action with a Nonnatural Immunophilin Ligand
10.1126/science.1700475 · 1990 · External reference
Proteome‐Wide Covalent Ligand Discovery in Native Biological Systems
10.1038/nature18002 · 2016 · External reference
Ligand Discovery by Activity‐Based Protein Profiling
10.1016/j.chembiol.2024.08.006 · 2024 · External reference
Improvement of Solid Material for Affinity Resins by Application of Long PEG Spacers to Capture the Whole Target Complex of FK506
10.1016/j.bmcl.2015.05.014 · 2015 · External reference
Antitumor and Antiangiogenic Activities of Lenvatinib in Mouse Xenograft Models of Vascular Endothelial Growth Factor‐Induced Hypervascular Human Hepatocellular Carcinoma
10.1080/07357907.2019.1601209 · 2019 · External reference
Unresolved reference
2018 · External reference
SHELXT – Integrated Space‐Group and Crystal‐Structure Determination
10.1107/s2053273314026370 · 2015 · External reference
Olex2: A Complete Structure Solution, Refinement and Analysis Program
10.1107/s0021889808042726 · 2009 · External reference
Crystal Structure Refinement with SHELXL
2015 · External reference
