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References from Discovery and Characterization of Novel Piperidine Derivatives as Potent Cytochrome P450 17A1 Inhibitors for Prostate Cancer Therapy. Local targets link to admitted publications; unresolved targets remain external evidence.
Cancer Statistics, 2023
2023 · External reference
Prostate Cancer Review: Genetics, Diagnosis, Treatment Options, and Alternative Approaches
10.3390/molecules27175730 · 2022 · External reference
Hormonal Therapy for Prostate Cancer
10.1210/endrev/bnab002 · 2021 · External reference
Androgen Deprivation Therapy: Progress in Understanding Mechanisms of Resistance and Optimizing Androgen Depletion
10.1038/ncpuro1322 · 2009 · External reference
Mechanisms of Resistance in Castration‐Resistant Prostate Cancer (CRPC)
2015 · External reference
Castration‐Resistant Prostate Cancer: From Uncovered Resistance Mechanisms to Current Treatments
10.3390/cancers15205047 · 2023 · External reference
Steroidogenesis in Castration‐Resistant Prostate Cancer
10.1016/j.urolonc.2022.10.018 · 2023 · External reference
Advanced Prostate Cancer: Treatment Advances and Future Directions
10.1016/j.trecan.2020.04.010 · 2020 · External reference
Cytochrome b5 Modulation of 17α Hydroxylase and 17‐20 Lyase (CYP17) Activities in Steroidogenesis
10.1677/joe.1.06375 · 2005 · External reference
Regulation of 17,20 Lyase Activity by Cytochrome b5 and by Serine Phosphorylation of P450c17
10.1074/jbc.m414673200 · 2005 · External reference
Mechanism of the Dual Activities of Human CYP17A1 and Binding to Anti‐Prostate Cancer Drug Abiraterone Revealed by a Novel V366M Mutation Causing 17,20 Lyase Deficiency
10.3390/ph11020037 · 2018 · External reference
The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
10.1210/er.2010-0013 · 2011 · External reference
Adrenal Androgens and Androgen Precursors‐Definition, Synthesis, Regulation and Physiological Actions
10.1002/j.2040-4603.2014.tb00590.x · 2014 · External reference
Steroidogenic Cytochrome P450 17A1 Structure and Function
10.1016/j.mce.2021.111261 · 2021 · External reference
Molecular Pathways: Inhibiting Steroid Biosynthesis in Prostate Cancer
10.1158/1078-0432.ccr-12-0931 · 2013 · External reference
Novel Steroidal Inhibitors of Human Cytochrome P45017α (17α‐Hydroxylase‐C17,20‐lyase): Potential Agents for the Treatment of Prostatic Cancer
10.1021/jm00013a022 · 1995 · External reference
Abiraterone and Increased Survival in Metastatic Prostate Cancer
10.1056/nejmoa1014618 · 2011 · External reference
Phase I Clinical Trial of a Selective Inhibitor of CYP17, Abiraterone Acetate, Confirms That Castration‐Resistant Prostate Cancer Commonly Remains Hormone Driven
10.1200/jco.2007.15.9749 · 2008 · External reference
Specificity of Anti‐Prostate Cancer CYP17A1 Inhibitors on Androgen Biosynthesis
10.1016/j.bbrc.2016.07.019 · 2016 · External reference
CYP17A1 Inhibitor Abiraterone, an Anti‐Prostate Cancer Drug, Also Inhibits the 21‐Hydroxylase Activity of CYP21A2
10.1016/j.jsbmb.2017.09.007 · 2017 · External reference
Conversion of Abiraterone to D4A Drives Anti‐Tumour Activity in Prostate Cancer
10.1038/nature14406 · 2015 · External reference
Redirecting Abiraterone Metabolism to Fine‐Tune Prostate Cancer Anti‐Androgen Therapy
10.1038/nature17954 · 2016 · External reference
Inhibition of AKR1C3 Activation Overcomes Resistance to Abiraterone in Advanced Prostate Cancer
10.1158/1535-7163.mct-16-0186 · 2017 · External reference
CYP17A1 Inhibitor Failure—Lessons for Future Drug Development
10.1038/nrurol.2015.66 · 2015 · External reference
CYP17 Inhibitors—Abiraterone, C17,20‐Lyase Inhibitors and Multi‐Targeting Agents
10.1038/nrurol.2013.274 · 2014 · External reference
Clinical and Biochemical Consequences of CYP17A1 Inhibition with Abiraterone Given with and without Exogenous Glucocorticoids in Castrate Men with Advanced Prostate Cancer
10.1210/jc.2011-2189 · 2012 · External reference
Abiraterone Acetate in Combination with Prednisone in the Treatment of Prostate Cancer: Safety and Efficacy
10.1080/14737140.2020.1785289 · 2020 · External reference
Non‐Steroidal CYP17A1 Inhibitors: Discovery and Assessment
10.1021/acs.jmedchem.3c00442 · 2023 · External reference
Pyridine Indole Hybrids as Novel Potent CYP17A1 Inhibitors
10.1080/14756366.2025.2463014 · 2025 · External reference
Overview of AKR1C3: Inhibitor Achievements and Disease Insights
10.1021/acs.jmedchem.9b02138 · 2020 · External reference
Development of Novel AKR1C3 Inhibitors as New Potential Treatment for Castration‐Resistant Prostate Cancer
10.1021/acs.jmedchem.0c00939 · 2020 · External reference
New Aldo‐Keto Reductase 1C3 (AKR1C3) Inhibitors Based on the Hydroxytriazole Scaffold
10.1016/j.ejmech.2022.114366 · 2022 · External reference
Structure‐Guided Optimization of 3‐Hydroxybenzoisoxazole Derivatives as Inhibitors of Aldo‐Keto Reductase 1C3 (AKR1C3) to Target Prostate Cancer
10.1016/j.ejmech.2024.116193 · 2024 · External reference
AI Based Discovery of a New AKR1C3 Inhibitor for Anticancer Applications
10.1021/acsmedchemlett.4c00150 · 2024 · External reference
SwissADME: A Free Web Tool to Evaluate Pharmacokinetics, Drug‐Likeness and Medicinal Chemistry Friendliness of Small Molecules
10.1038/srep42717 · 2017 · External reference
Experimental and Computational Approaches to Estimate Solubility and Permeability in Drug Discovery and Development Settings
10.1016/j.addr.2012.09.019 · 2012 · External reference
A Knowledge‐Based Approach in Designing Combinatorial or Medicinal Chemistry Libraries for Drug Discovery. 1. A Qualitative and Quantitative Characterization of Known Drug Databases
10.1021/cc9800071 · 1999 · External reference
Prediction of Drug Absorption Using Multivariate Statistics
10.1021/jm000292e · 2000 · External reference
Molecular Properties That Influence the Oral Bioavailability of Drug Candidates
10.1021/jm020017n · 2002 · External reference
Simple Selection Criteria for Drug‐Like Chemical Matter
10.1021/jm015507e · 2001 · External reference
Weighted Averaging Scheme and Local Atomic Descriptor for pKa Prediction Based on Density Functional Theory
10.1021/acs.jcim.7b00537 · 2018 · External reference
Effect of Essential Oil Components on the Activity of Steroidogenic Cytochrome P450
10.3390/biom14020203 · 2024 · External reference
Synthesis and Structure–Activity Relationships of Novel Non‐Steroidal CYP17A1 Inhibitors as Potential Prostate Cancer Agents
10.3390/biom12020165 · 2022 · External reference
Exploring the Potential of Sulfur Moieties in Compounds Inhibiting Steroidogenesis
10.3390/biom13091349 · 2023 · External reference
Parallel Targeted and Non‐Targeted Quantitative Analysis of Steroids in Human Serum and Peritoneal Fluid by Liquid Chromatography High‐Resolution Mass Spectrometry
10.1007/s00216-022-03881-3 · 2022 · External reference
In Vitro Scratch Assay: A Convenient and Inexpensive Method for Analysis of Cell Migration In Vitro
10.1038/nprot.2007.30 · 2007 · External reference
