Research graph
References from Discrepancy in Reported and Observed Monoacylglycerol Lipase Inhibition of Aryl Formyl Piperidine Containing Potent and Highly Selective Monoacylglycerol Lipase Inhibitor. Local targets link to admitted publications; unresolved targets remain external evidence.
2‐Arachidonoylglycerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain
10.1006/bbrc.1995.2437 · 1995 · External reference
Brain Monoglyceride Lipase Participating in Endocannabinoid Inactivation
10.1073/pnas.152334899 · 2002 · External reference
A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2‐Arachidonoylglycerol
10.1016/j.chembiol.2007.11.006 · 2007 · External reference
The Serine Hydrolases MAGL, ABHD6 and ABHD12 as Guardians of 2‐Arachidonoylglycerol Signalling Through Cannabinoid Receptors
10.1111/j.1748-1716.2011.02280.x · 2012 · External reference
Anandamide Amidohydrolase Reacting With 2‐Arachidonoylglycerol, Another Cannabinoid Receptor Ligand
10.1016/s0014-5793(97)01603-7 · 1998 · External reference
Development of a Potent Inhibitor of 2‐Arachidonoylglycerol Hydrolysis With Antinociceptive Activity In Vivo
10.1016/j.bbalip.2008.10.007 · 2009 · External reference
Inhibition of Monoacylglycerol Lipase Attenuates Nonsteroidal Anti‐Inflammatory Drug‐Induced Gastric Hemorrhages in Mice
10.1124/jpet.110.175778 · 2011 · External reference
Increasing Endogenous 2‐Arachidonoylglycerol Levels Counteracts Colitis and Related Systemic Inflammation
10.1096/fj.10-176602 · 2011 · External reference
Inhibition of Monoacylglycerol Lipase Attenuates Vomiting in Suncus Murinus and 2‐Arachidonoyl Glycerol Attenuates Nausea in Rats
10.1111/j.1476-5381.2011.01407.x · 2012 · External reference
Monoacylglycerol Lipase Regulates a Fatty Acid Network That Promotes Cancer Pathogenesis
10.1016/j.cell.2009.11.027 · 2010 · External reference
A Review on Structurally Diversified Synthesized Molecules as Monoacylglycerol Lipase Inhibitors and Their Therapeutic Uses
10.2174/2589977514666220301111457 · 2022 · External reference
Targeting Monoacylglycerol Lipase in Pursuit of Therapies for Neurological and Neurodegenerative Diseases
10.3390/molecules26185668 · 2021 · External reference
Anticancer Potential of Small‐Molecule Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase
10.1002/cmdc.202100120 · 2021 · External reference
Unresolved reference
External reference
Structural Basis for Human Monoglyceride Lipase Inhibition
10.1016/j.jmb.2009.11.060 · 2010 · External reference
Piperazine and Piperidine Triazole Ureas as Ultrapotent and Highly Selective Inhibitors of Monoacylglycerol Lipase
10.1016/j.chembiol.2013.01.012 · 2013 · External reference
Development and Characterization of Endocannabinoid Hydrolases FAAH and MAGL Inhibitors Bearing a Benzotriazol‐1‐Yl Carboxamide Scaffold
10.1016/j.bmc.2012.09.011 · 2012 · External reference
Loratadine Analogues as MAGL Inhibitors
10.1016/j.bmcl.2015.02.037 · 2015 · External reference
Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization
10.1021/acs.jmedchem.3c01278 · 2024 · External reference
Characterization of Tunable Piperidine and Piperazine Carbamates as Inhibitors of Endocannabinoid Hydrolases
10.1021/jm9016976 · 2010 · External reference
Highly Selective Inhibitors of Monoacylglycerol Lipase Bearing a Reactive Group that Is Bioisosteric With Endocannabinoid Substrates
10.1016/j.chembiol.2012.03.009 · 2012 · External reference
Evaluation of NHS Carbamates as a Potent and Selective Class of Endocannabinoid Hydrolase Inhibitors
10.1021/cn400116z · 2013 · External reference
Selective Blockade of the Hydrolysis of the Endocannabinoid 2‐Arachidonoylglycerol Impairs Learning and Memory Performance While Producing Antinociceptive Activity in Rodents
10.1038/srep07642 · 2015 · External reference
Identification of ABX‐1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders
10.1021/acs.jmedchem.8b00951 · 2018 · External reference
Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation
10.1021/acs.jmedchem.8b00070 · 2018 · External reference
Synthesis and Pharmacological Evaluation of 2,4‐Dinitroaryldithiocarbamate Derivatives as Novel Monoacylglycerol Lipase Inhibitors
10.1021/jm3006004 · 2012 · External reference
Crystal Structure of a Soluble Form of Human Monoglyceride Lipase in Complex With an Inhibitor at 1.35 Å Resolution
10.1002/pro.596 · 2011 · External reference
Structural Optimization of 4‐Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors
10.1021/acs.jmedchem.6b01459 · 2016 · External reference
Discovery of 1,5‐Diphenylpyrazole‐3‐Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors
10.1021/acs.jmedchem.7b01845 · 2018 · External reference
Design, Synthesis, and Evaluation of Piperazinyl Pyrrolidin‐2‐Ones as a Novel Series of Reversible Monoacylglycerol Lipase Inhibitors
10.1021/acs.jmedchem.8b00824 · 2018 · External reference
Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor
10.1021/acs.jmedchem.8b01483 · 2019 · External reference
Discovery of Aryl Formyl Piperidine Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase Inhibitors
10.1021/acs.jmedchem.9b02137 · 2020 · External reference
Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation From 3‐Oxo‐3,4‐Dihydro‐2H‐Benzo[b][1,4]Oxazin‐6‐Yl Moiety
10.1021/acs.jmedchem.1c00432 · 2021 · External reference
Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives
10.1021/acs.jmedchem.1c01806 · 2022 · External reference
A Potent and Selective Inhibitor for the Modulation of MAGL Activity in the Neurovasculature
10.1371/journal.pone.0268590 · 2022 · External reference
Structure‐Guided Discovery of Cis‐Hexahydro‐Pyrido‐Oxazinones as Reversible, Drug‐Like Monoacylglycerol Lipase Inhibitors
10.1021/acs.jmedchem.4c01769 · 2024 · External reference
Structure–Activity Relationship Studies of Aryl Sulfoxides as Reversible Monoacylglycerol Lipase Inhibitors
10.1021/acs.jmedchem.4c01037 · 2024 · External reference
Discovery of a Novel Class of Reversible Monoacylglycerol Lipase Inhibitors for Potential Treatment of Depression
10.1016/j.ejmech.2024.116285 · 2024 · External reference
A Reversible and Selective Inhibitor of Monoacylglycerol Lipase Ameliorates Multiple Sclerosis
10.1002/anie.201407807 · 2014 · External reference
Chronic Monoacylglycerol Lipase Blockade Causes Functional Antagonism of the Endocannabinoid System
10.1038/nn.2616 · 2010 · External reference
Molecular Imaging With PET
10.1021/cr0782426 · 2008 · External reference
Molecular Imaging in Drug Development
10.1038/nrd2290 · 2008 · External reference
Synthesis of 11C, 18F, 15O, and 13N Radiolabels for Positron Emission Tomography
10.1002/anie.200800222 · 2008 · External reference
Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development
10.1021/acs.jmedchem.0c01459 · 2021 · External reference
Synthesis and Preclinical Evaluation of Sulfonamidobased [11C‐Carbonyl]‐Carbamates and Ureas for Imaging Monoacylglycerol Lipase
10.7150/thno.15257 · 2016 · External reference
In Vitro and In Vivo Evaluation of 11C‐Labeled Azetidinecarboxylates for Imaging Monoacylglycerol Lipase by PET Imaging Studies
10.1021/acs.jmedchem.7b01400 · 2018 · External reference
Synthesis and Preclinical Evaluation of [11C]MA‐PB‐1 for In Vivo Imaging of Brain Monoacylglycerol Lipase (MAGL)
10.1016/j.ejmech.2017.04.066 · 2017 · External reference
Identification and Development of an Irreversible Monoacylglycerol Lipase (MAGL) Positron Emission Tomography (PET) Radioligand With High Specificity
10.1021/acs.jmedchem.9b00847 · 2019 · External reference
Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a “Tail Switching” Strategy on a Piperazinyl Azetidine Skeleton
10.1021/acs.jmedchem.8b01778 · 2019 · External reference
Development of a Highly‐Specific 18F‐Labeled Irreversible Positron Emission Tomography Tracer for Monoacylglycerol Lipase Mapping
10.1016/j.apsb.2021.01.021 · 2021 · External reference
Design, Synthesis, and Evaluation of 18F‐Labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes
10.1021/acs.jmedchem.9b00936 · 2019 · External reference
Discovery, Synthesis and Evaluation of Novel Reversible Monoacylglycerol Lipase Radioligands Bearing a Morpholine‐3‐One Scaffold
10.1016/j.nucmedbio.2022.02.002 · 2022 · External reference
Multi‐Parameter Optimization: Development of a Morpholin‐3‐One Derivative With an Improved Kinetic Profile for Imaging Monoacylglycerol Lipase in the Brain
10.1016/j.ejmech.2022.114750 · 2022 · External reference
Design, Synthesis, and Evaluation of (4R)‐1‐{3‐[2‐(18F)Fluoro‐4‐Methylpyridin‐3‐Yl]phenyl}‐4‐[4‐(1,3‐Thiazol‐2‐Ylcarbonyl)piperazin‐1‐Yl]pyrrolidin‐2‐One ([18F]T‐401) as a Novel Positron‐Emission Tomography Imaging Agent for Monoacylglycerol Lipase
10.1021/acs.jmedchem.8b01576 · 2019 · External reference
Novel Reversible‐Binding PET Ligands for Imaging Monoacylglycerol Lipase Based on the Piperazinyl Azetidine Scaffold
10.1021/acs.jmedchem.1c00747 · 2021 · External reference
A Novel Monoacylglycerol Lipase‐Targeted 18F‐Labeled Probe for Positron Emission Tomography Imaging of Brown Adipose Tissue in the Energy Network
10.1038/s41401-022-00912-8 · 2022 · External reference
Development of High Brain‐Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging
10.1021/acs.jmedchem.1c01706 · 2022 · External reference
Development of a Novel 18F‐Labeled Reversible‐Binding Radioligand for Imaging Monoacylglycerol Lipase With Positron Emission Tomography
10.1016/j.apsb.2025.05.041 · 2025 · External reference
Biochemical and Pharmacological Characterization of Human α/β‐Hydrolase Domain Containing 6 (ABHD6) and 12 (ABHD12)
10.1194/jlr.m030411 · 2012 · External reference
Optimization of 1,2,5‐Thiadiazole Carbamates as Potent and Selective ABHD6 Inhibitors
10.1002/cmdc.201402453 · 2015 · External reference
Revisiting 1,3,4‐Oxadiazol‐2‐Ones: Utilization in the Development of ABHD6 Inhibitors
10.1016/j.bmc.2015.08.030 · 2015 · External reference
Chiral 1,3,4‐Oxadiazol‐2‐Ones as Highly Selective FAAH Inhibitors
10.1021/jm400923s · 2013 · External reference
Pharmacologic Characterization of JNJ‐42226314, [1‐(4‐Fluorophenyl)indol‐5‐Yl]‐[3‐[4‐(Thiazole‐2‐Carbonyl)Piperazin‐1‐Yl]azetidin‐1‐Yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor
10.1124/jpet.119.262139 · 2020 · External reference
Characterization of Binding Properties of Monoglyceride Lipase Inhibitors by a Versatile Fluorescence‐Based Technique
10.1016/j.ab.2009.12.009 · 2010 · External reference
