Research graph
References from Mitochondrial Metabolic Reprogramming in Glioma: Mechanisms of Tumorigenesis and Implications for Clinical Therapy. Local targets link to admitted publications; unresolved targets remain external evidence.
Primary Brain and Other Central Nervous System Tumors in the United States (2014‐2018): A Summary of the CBTRUS Statistical Report for Clinicians
2022 · External reference
Neural Stem Cells and the Origin of Gliomas
10.1056/nejmra043666 · 2005 · External reference
Glioblastoma and Other Primary Brain Malignancies in Adults: A Review
10.1001/jama.2023.0023 · 2023 · External reference
The 2021 WHO Classification of Tumors of the Central Nervous System: A Summary
10.1093/neuonc/noab106 · 2021 · External reference
Management of Glioblastoma: State of the Art and Future Directions
2020 · External reference
IDH1 Mutation Is Sufficient to Establish the Glioma Hypermethylator Phenotype
10.1038/nature10866 · 2012 · External reference
Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma
10.1056/nejmoa043330 · 2005 · External reference
Malignant Gliomas in Adults
10.1056/nejmra0708126 · 2008 · External reference
Suppressive Immune Microenvironment and CART Therapy for Glioblastoma: Future Prospects and Challenges
10.1016/j.canlet.2024.217185 · 2024 · External reference
Emerging Therapies for Glioblastoma: Current State and Future Directions
10.1186/s13046-022-02349-7 · 2022 · External reference
Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure
10.1016/j.cmet.2013.03.002 · 2013 · External reference
Mitochondria: Dynamic Organelles in Disease, Aging, and Development
10.1016/j.cell.2006.06.010 · 2006 · External reference
Mitochondria and Cancer
10.1038/nrc3365 · 2012 · External reference
Mitochondrial Free Radical Generation, Oxidative Stress, and Aging
10.1016/s0891-5849(00)00317-8 · 2000 · External reference
Optical/Electrochemical Methods for Detecting Mitochondrial Energy Metabolism
10.1039/d0cs01610a · 2022 · External reference
Oxidative Phosphorylation as an Emerging Target in Cancer Therapy
10.1158/1078-0432.ccr-17-3070 · 2018 · External reference
Coupling of Phosphorylation to Electron and Hydrogen Transfer by a Chemi‐Osmotic Type of Mechanism
10.1038/191144a0 · 1961 · External reference
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
10.1126/science.1160809 · 2009 · External reference
Mitochondrial Dynamics in Health and Disease: Mechanisms and Potential Targets
10.1038/s41392-023-01547-9 · 2023 · External reference
Evolution of Mitochondria as Signaling Organelles
10.1016/j.cmet.2015.05.013 · 2015 · External reference
We Need to Talk About the Warburg Effect
10.1038/s42255-020-0172-2 · 2020 · External reference
Hypoxia in the Glioblastoma Microenvironment: Shaping the Phenotype of Cancer Stem‐Like Cells
10.1093/neuonc/now258 · 2017 · External reference
Crossing the Blood‐Brain Barrier: Emerging Therapeutic Strategies for Neurological Disease
10.1016/s1474-4422(24)00476-9 · 2025 · External reference
An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma
10.1016/j.cell.2019.06.024 · 2019 · External reference
Infiltrative and Drug‐Resistant Slow‐Cycling Cells Support Metabolic Heterogeneity in Glioblastoma
10.15252/embj.201798772 · 2018 · External reference
Pathway‐Based Classification of Glioblastoma Uncovers a Mitochondrial Subtype With Therapeutic Vulnerabilities
10.1038/s43018-020-00159-4 · 2021 · External reference
Metabolic State of Glioma Stem Cells and Nontumorigenic Cells
10.1073/pnas.1106704108 · 2011 · External reference
Tumor Glycolysis as a Target for Cancer Therapy: Progress and Prospects
10.1186/1476-4598-12-152 · 2013 · External reference
Targeting Lactate Metabolism for Cancer Therapeutics
10.1172/jci69741 · 2013 · External reference
Targeting OXPHOS and the Electron Transport Chain in Cancer; Molecular and Therapeutic Implications
10.1016/j.semcancer.2022.02.002 · 2022 · External reference
Understanding the Intersections Between Metabolism and Cancer Biology
10.1016/j.cell.2016.12.039 · 2017 · External reference
Metabolic Codependencies in the Tumor Microenvironment
10.1158/2159-8290.cd-20-1211 · 2021 · External reference
Otto Warburg's Contributions to Current Concepts of Cancer Metabolism
10.1038/nrc3038 · 2011 · External reference
Mitochondria and Cancer
10.1016/j.molcel.2016.02.011 · 2016 · External reference
The Pro‐Tumorigenic Effects of Metabolic Alterations in Glioblastoma Including Brain Tumor Initiating Cells
10.1016/j.bbcan.2018.01.004 · 2018 · External reference
Targeting Lactate‐Fueled Respiration Selectively Kills Hypoxic Tumor Cells in Mice
2008 · External reference
Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress
10.1016/j.cmet.2020.06.002 · 2020 · External reference
Deficiency in SLC25A15, a Hypoxia‐Responsive Gene, Promotes Hepatocellular Carcinoma by Reprogramming Glutamine Metabolism
10.1016/j.jhep.2023.10.024 · 2024 · External reference
Cancer‐Associated IDH1 Mutations Produce 2‐Hydroxyglutarate
10.1038/nature08617 · 2009 · External reference
An Integrated Genomic Analysis of Human Glioblastoma Multiforme
10.1126/science.1164382 · 2008 · External reference
Transaminase Inhibition by 2‐Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma
10.1016/j.cell.2018.08.038 · 2018 · External reference
Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
10.1146/annurev-cellbio-092910-154237 · 2011 · External reference
Circular RNA circRNF20 Promotes Breast Cancer Tumorigenesis and Warburg Effect Through miR‐487a/HIF‐1alpha/HK2
10.1038/s41419-020-2336-0 · 2020 · External reference
Unlocking the Potential of HK2 in Cancer Metabolism and Therapeutics
10.2174/0929867326666181213092652 · 2019 · External reference
Overexpression of Isocitrate Dehydrogenase‐1R (1)(3)(2)H Enhances the Proliferation of A172 Glioma Cells via Aerobic Glycolysis
10.3892/mmr.2015.3187 · 2015 · External reference
Regulation of Glucose Metabolism by 6‐Phosphofructo‐2‐Kinase/Fructose‐2,6‐Bisphosphatases in Cancer
10.1016/j.yexmp.2009.01.003 · 2009 · External reference
D‐Amino Acid Oxidase‐Induced Oxidative Stress, 3‐Bromopyruvate and Citrate Inhibit Angiogenesis, Exhibiting Potent Anticancer Effects
10.1007/s10863-012-9455-y · 2012 · External reference
3‐Bromopyruvate Antagonizes Effects of Lactate and Pyruvate, Synergizes With Citrate and Exerts Novel Anti‐Glioma Effects
10.1007/s10863-012-9409-4 · 2012 · External reference
PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis
10.1016/j.cell.2012.07.018 · 2012 · External reference
The Role of Pyruvate Kinase M2 in Cancer Metabolism
10.1111/bpa.12311 · 2015 · External reference
LncRNA LINC00689 Promotes the Growth, Metastasis and Glycolysis of Glioma Cells by Targeting miR‐338‐3p/PKM2 Axis
10.1016/j.biopha.2019.109069 · 2019 · External reference
RSL3 Induced Autophagic Death in Glioma Cells via Causing Glycolysis Dysfunction
10.1016/j.bbrc.2019.08.096 · 2019 · External reference
Mitochondrial PKM2 Regulates Oxidative Stress‐Induced Apoptosis by Stabilizing Bcl2
10.1038/cr.2016.159 · 2017 · External reference
Transformation by the (R)‐Enantiomer of 2‐Hydroxyglutarate Linked to EGLN Activation
10.1038/nature10898 · 2012 · External reference
Screen for IDH1, IDH2, IDH3, D2HGDH and L2HGDH Mutations in Glioblastoma
10.1371/journal.pone.0019868 · 2011 · External reference
Cancer‐Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation
10.1016/j.celrep.2017.05.014 · 2017 · External reference
Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism
10.1093/jnci/djq187 · 2010 · External reference
Targeting Cancer Metabolism
10.1158/1078-0432.ccr-12-2587 · 2012 · External reference
Inhibition of Mitochondria NADH‐Ubiquinone Oxidoreductase (Complex I) Sensitizes the Radioresistant Glioma U87MG Cells to Radiation
10.1016/j.biopha.2020.110460 · 2020 · External reference
Gboxin Is an Oxidative Phosphorylation Inhibitor That Targets Glioblastoma
10.1038/s41586-019-0993-x · 2019 · External reference
Mitochondrial Complex I Activity in Microglia Sustains Neuroinflammation
10.1038/s41586-024-07167-9 · 2024 · External reference
The Pharmacological Regulation of Cellular Mitophagy
10.1038/nchembio.2287 · 2017 · External reference
Targeting DNM1L/DRP1‐FIS1 Axis Inhibits High‐Grade Glioma Progression by Impeding Mitochondrial Respiratory Cristae Remodeling
10.1186/s13046-024-03194-6 · 2024 · External reference
De Novo Pyrimidine Synthesis Is a Targetable Vulnerability in IDH Mutant Glioma
10.1016/j.ccell.2022.07.011 · 2022 · External reference
Vorasidenib in IDH1‐Or IDH2‐Mutant Low‐Grade Glioma
10.1056/nejmoa2304194 · 2023 · External reference
Replication and Transcription of Human Mitochondrial DNA
10.1146/annurev-biochem-052621-092014 · 2024 · External reference
Mitochondrial Proteins: From Biogenesis to Functional Networks
10.1038/s41580-018-0092-0 · 2019 · External reference
HSP60 Chaperone Deficiency Disrupts the Mitochondrial Matrix Proteome and Dysregulates Cholesterol Synthesis
10.1016/j.molmet.2024.102009 · 2024 · External reference
Quantitative High‐Confidence Human Mitochondrial Proteome and Its Dynamics in Cellular Context
10.1016/j.cmet.2021.11.001 · 2021 · External reference
Post‐Translational Modifications on Mitochondrial Metabolic Enzymes in Cancer
10.1016/j.freeradbiomed.2021.12.264 · 2022 · External reference
Nuclear Localization of Mitochondrial TCA Cycle Enzymes Modulates Pluripotency via Histone Acetylation
10.1038/s41467-022-35199-0 · 2022 · External reference
Mechanisms, Regulation and Functions of the Unfolded Protein Response
10.1038/s41580-020-0250-z · 2020 · External reference
Ubiquitination in Disease Pathogenesis and Treatment
10.1038/nm.3739 · 2014 · External reference
Cellular Quality Control by the Ubiquitin‐Proteasome System and Autophagy
10.1126/science.aax3769 · 2019 · External reference
The Mitophagy Pathway and Its Implications in Human Diseases
10.1038/s41392-023-01503-7 · 2023 · External reference
ER Stress and UPR Activation in Glioblastoma: Identification of a Noncanonical PERK Mechanism Regulating GBM Stem Cells Through SOX2 Modulation
10.1038/s41419-019-1934-1 · 2019 · External reference
Regulation and Metabolic Functions of mTORC1 and mTORC2
10.1152/physrev.00026.2020 · 2021 · External reference
Natural Products Targeting the PI3K‐Akt‐mTOR Signaling Pathway in Cancer: A Novel Therapeutic Strategy
10.1016/j.semcancer.2019.12.008 · 2022 · External reference
PI3K/AKT/mTOR Signaling Pathway Activity in IDH‐Mutant Diffuse Glioma and Clinical Implications
10.1093/neuonc/noac064 · 2022 · External reference
The Structural Basis for mTOR Function
10.1016/j.semcdb.2014.09.024 · 2014 · External reference
A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma
10.1016/j.ccell.2017.01.014 · 2017 · External reference
Emerging Role of mTOR in the Response to Cancer Therapeutics
10.1016/j.trecan.2016.03.008 · 2016 · External reference
mTOR Substrate Phosphorylation in Growth Control
10.1016/j.cell.2022.04.013 · 2022 · External reference
Protein Acetylation in Metabolism ‐ Metabolites and Cofactors
10.1038/nrendo.2015.181 · 2016 · External reference
Class I Histone Deacetylases (HDAC1‐3) Are Histone Lysine Delactylases
10.1126/sciadv.abi6696 · 2022 · External reference
Phase I/II Trial of Vorinostat Combined With Temozolomide and Radiation Therapy for Newly Diagnosed Glioblastoma: Results of Alliance N0874/ABTC 02
10.1093/neuonc/nox161 · 2018 · External reference
The Ubiquitin‐Proteasome Pathway in Adult and Pediatric Brain Tumors: Biological Insights and Therapeutic Opportunities
10.1007/s10555-017-9700-2 · 2017 · External reference
Cannabidiol Inhibits Human Glioma by Induction of Lethal Mitophagy Through Activating TRPV4
10.1080/15548627.2021.1885203 · 2021 · External reference
Bortezomib Primes Glioblastoma, Including Glioblastoma Stem Cells, for TRAIL by Increasing tBid Stability and Mitochondrial Apoptosis
10.1158/1078-0432.ccr-11-0075 · 2011 · External reference
PINK1/Parkin‐Mediated Mitophagy Is Dependent on VDAC1 and p62/SQSTM1
10.1038/ncb2012 · 2010 · External reference
The Multifaceted Roles of Fatty Acid Synthesis in Cancer
10.1038/nrc.2016.89 · 2016 · External reference
FAT SIGNALS‐Lipases and Lipolysis in Lipid Metabolism and Signaling
10.1016/j.cmet.2011.12.018 · 2012 · External reference
Mitochondrial Cholesterol and Cancer
10.1016/j.semcancer.2020.07.014 · 2021 · External reference
FASN Is a Biomarker Enriched in Malignant Glioma‐Derived Extracellular Vesicles
10.3390/ijms21061931 · 2020 · External reference
Medium‐Chain Acyl‐CoA Dehydrogenase Protects Mitochondria From Lipid Peroxidation in Glioblastoma
10.1158/2159-8290.cd-20-1437 · 2021 · External reference
Identification of ATP Citrate Lyase as a Positive Regulator of Glycolytic Function in Glioblastomas
10.1002/ijc.24918 · 2010 · External reference
Chemical Inhibition of Acetyl‐CoA Carboxylase Suppresses Self‐Renewal Growth of Cancer Stem Cells
10.18632/oncotarget.2059 · 2014 · External reference
Fatty Acid Synthase Inhibition Engages a Novel Caspase‐2 Regulatory Mechanism to Induce Ovarian Cancer Cell Death
10.1038/onc.2014.271 · 2015 · External reference
Phase II Investigation of TVB‐2640 (Denifanstat) With Bevacizumab in Patients With First Relapse High‐Grade Astrocytoma
10.1158/1078-0432.ccr-22-2807 · 2023 · External reference
Molecular Pathways: Fatty Acid Synthase
10.1158/1078-0432.ccr-15-0126 · 2015 · External reference
The Role of Cardiolipin in Mitochondrial Function and Neurodegenerative Diseases
10.3390/cells13070609 · 2024 · External reference
Effects of siRNA‐Dependent Knock‐Down of Cardiolipin Synthase and Tafazzin on Mitochondria and Proliferation of Glioma Cells
10.1016/j.bbalip.2018.01.003 · 2018 · External reference
Human Atg8‐Cardiolipin Interactions in Mitophagy: Specific Properties of LC3B, GABARAPL2 and GABARAP
10.1080/15548627.2016.1240856 · 2016 · External reference
Nucleotide Metabolism: A Pan‐Cancer Metabolic Dependency
10.1038/s41568-023-00557-7 · 2023 · External reference
The Intersection of Purine and Mitochondrial Metabolism in Cancer
10.3390/cells10102603 · 2021 · External reference
Human de Novo Purine Biosynthesis
10.1080/10409238.2020.1832438 · 2021 · External reference
Nucleotide Metabolism
10.1101/cshperspect.a040592 · 2021 · External reference
De Novo and Salvage Purine Synthesis Pathways Across Tissues and Tumors
10.1016/j.cell.2024.05.011 · 2024 · External reference
Ribonucleotide Synthesis by NME6 Fuels Mitochondrial Gene Expression
10.15252/embj.2022113256 · 2023 · External reference
Purine Metabolism Regulates DNA Repair and Therapy Resistance in Glioblastoma
10.1038/s41467-020-17512-x · 2020 · External reference
DHODH Inhibition Impedes Glioma Stem Cell Proliferation, Induces DNA Damage, and Prolongs Survival in Orthotopic Glioblastoma Xenografts
10.1038/s41388-022-02517-1 · 2022 · External reference
The Pentose Phosphate Pathway in Health and Disease
10.1038/s42255-023-00863-2 · 2023 · External reference
Tyrosine Phosphorylation Activates 6‐Phosphogluconate Dehydrogenase and Promotes Tumor Growth and Radiation Resistance
10.1038/s41467-019-08921-8 · 2019 · External reference
NADPH Homeostasis in Cancer: Functions, Mechanisms and Therapeutic Implications
10.1038/s41392-020-00326-0 · 2020 · External reference
Glioma Grade and Mortality in Relation to Sequence Variation in the Mitochondrial Genome
10.1016/j.cancergen.2025.05.001 · 2025 · External reference
Identification and Functional Prediction of Mitochondrial Complex III and IV Mutations Associated With Glioblastoma
10.1093/neuonc/nov020 · 2015 · External reference
Mitochondrial DNA Copy Number as a Prognostic Marker Is Age‐Dependent in Adult Glioblastoma
2022 · External reference
GAP43‐Dependent Mitochondria Transfer From Astrocytes Enhances Glioblastoma Tumorigenicity
10.1038/s43018-023-00556-5 · 2023 · External reference
Tunneling Nanotubes, TNT, Communicate Glioblastoma With Surrounding Non‐Tumor Astrocytes to Adapt Them to Hypoxic and Metabolic Tumor Conditions
10.1038/s41598-021-93775-8 · 2021 · External reference
A Randomized Phase II Study of Everolimus in Combination With Chemoradiation in Newly Diagnosed Glioblastoma: Results of NRG Oncology RTOG 0913
10.1093/neuonc/nox209 · 2018 · External reference
