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References from Hyperglycemia‐Induced Microglial CTSS Disrupts Blood‐Retinal Barrier Integrity via PAR2 ‐Dependent Downregulation of Endothelial MFSD2A. Local targets link to admitted publications; unresolved targets remain external evidence.
Diabetic Retinopathy
10.1016/s0140-6736(09)62124-3 · 2010 · External reference
The Role of Inflammation in Immune System of Diabetic Retinopathy: Molecular Mechanisms, Pathogenetic Role and Therapeutic Implications
10.3389/fimmu.2022.1055087 · 2022 · External reference
Mfsd2a Overexpression Alleviates Vascular Dysfunction in Diabetic Retinopathy
10.1016/j.phrs.2021.105755 · 2021 · External reference
A Systematic Meta‐Analysis of Genetic Association Studies for Diabetic Retinopathy
10.2337/db09-0059 · 2009 · External reference
Innate Immune Response in Retinal Homeostasis and Inflammatory Disorders
10.1016/j.preteyeres.2019.100778 · 2020 · External reference
Retinal Microglia: Just Bystander or Target for Therapy
10.1016/j.preteyeres.2014.11.004 · 2015 · External reference
Immune Regulation in the Aging Retina
10.1016/j.preteyeres.2018.10.003 · 2019 · External reference
Wnt Signaling Activates MFSD2A to Suppress Vascular Endothelial Transcytosis and Maintain Blood‐Retinal Barrier
10.1126/sciadv.aba7457 · 2020 · External reference
Single‐Cell Transcriptomic Analysis Revealing Changes in Retinal Cell Subpopulation Levels and the Pathways Involved in Diabetic Retinopathy
10.21037/atm-22-1546 · 2022 · External reference
Cathepsin S: Therapeutic, Diagnostic, and Prognostic Potential
10.1515/hsz-2015-0114 · 2015 · External reference
Leading the Invasion: The Role of Cathepsin S in the Tumour Microenvironment
10.1016/j.bbamcr.2020.118781 · 2020 · External reference
Cathepsin S Inhibitor Prevents Autoantigen Presentation and Autoimmunity
10.1172/jci0214682 · 2002 · External reference
Therapeutic Effect of Ultra‐Long‐Lasting Human C‐Peptide Delivery Against Hyperglycemia‐Induced Neovascularization in Diabetic Retinopathy
10.7150/thno.81714 · 2023 · External reference
scFTD‐Seq: Freeze‐Thaw Lysis Based, Portable Approach Toward Highly Distributed Single‐Cell 3′ mRNA Profiling
10.1093/nar/gky1173 · 2019 · External reference
STAR: Ultrafast Universal RNA‐seq Aligner
10.1093/bioinformatics/bts635 · 2013 · External reference
featureCounts: An Efficient General Purpose Program for Assigning Sequence Reads to Genomic Features
10.1093/bioinformatics/btt656 · 2014 · External reference
SCANPY: Large‐Scale Single‐Cell Gene Expression Data Analysis
10.1186/s13059-017-1382-0 · 2018 · External reference
clusterProfiler: An R Package for Comparing Biological Themes Among Gene Clusters
10.1089/omi.2011.0118 · 2012 · External reference
CellPhoneDB: Inferring Cell‐Cell Communication From Combined Expression of Multi‐Subunit Ligand–Receptor Complexes
10.1038/s41596-020-0292-x · 2020 · External reference
Occurrence of Lymphangiogenesis in Peripheral Nerve Autografts Contrasts Schwann Cell‐Induced Apoptosis of Lymphatic Endothelial Cells In Vitro
10.3390/biom12060820 · 2022 · External reference
Cell Type‐Specific Adaptive Signaling Responses to KRASG12C Inhibition
10.1158/1078-0432.ccr-20-3872 · 2021 · External reference
Endothelial Cell Plasticity at the Single‐Cell Level
10.1007/s10456-021-09797-3 · 2021 · External reference
Dysregulated CD200‐CD200R Signaling in Early Diabetes Modulates Microglia‐Mediated Retinopathy
10.1073/pnas.2308214120 · 2023 · External reference
Translocator Protein (18kDa): New Nomenclature for the Peripheral‐Type Benzodiazepine Receptor Based on Its Structure and Molecular Function
10.1016/j.tips.2006.06.005 · 2006 · External reference
The Impact of Oxidative Stress on Blood‐Retinal Barrier Physiology in Age‐Related Macular Degeneration
10.3390/cells10010064 · 2021 · External reference
Photoreceptor Metabolic Reprogramming Provides Survival Advantage in Acute Stress While Causing Chronic Degeneration
10.1038/s41598-017-18098-z · 2017 · External reference
Semaglutide Ameliorates Retinal Vascular Permeability Destruction in Diabetic Retinopathy by AnxA2‐Mediated MMP‐9 Activation and Basement Membrane Remodeling
10.1016/j.biopha.2025.118409 · 2025 · External reference
Wnt Signaling in Inner Blood‐Retinal Barrier Maintenance
10.3390/ijms222111877 · 2021 · External reference
Cathepsins Are Potential Therapeutic Targets in Kidney Disease
10.1016/j.kint.2016.07.034 · 2016 · External reference
Global Prevalence and Major Risk Factors of Diabetic Retinopathy
10.2337/dc11-1909 · 2012 · External reference
The Role of Microglia in Diabetic Retinopathy: Inflammation, Microvasculature Defects and Neurodegeneration
10.3390/ijms19010110 · 2018 · External reference
Glial Reactivity, an Early Feature of Diabetic Retinopathy
2000 · External reference
Fractalkine‐Induced Microglial Vasoregulation Occurs Within the Retina and Is Altered Early in Diabetic Retinopathy
10.1073/pnas.2112561118 · 2021 · External reference
Icariin Alleviates Uveitis by Targeting Peroxiredoxin 3 to Modulate Retinal Microglia M1/M2 Phenotypic Polarization
10.1016/j.redox.2022.102297 · 2022 · External reference
A Combination of Inhibiting Microglia Activity and Remodeling Gut Microenvironment Suppresses the Development and Progression of Experimental Autoimmune Uveitis
10.1016/j.bcp.2020.114108 · 2020 · External reference
Cathepsin S Cleavage of Protease‐Activated Receptor‐2 on Endothelial Cells Promotes Microvascular Diabetes Complications
10.1681/asn.2015020208 · 2016 · External reference
Cathepsin S Knockdown Suppresses Endothelial Inflammation, Angiogenesis, and Complement Protein Activity Under Hyperglycemic Conditions In Vitro by Inhibiting NF‐κB Signaling
10.3390/ijms24065428 · 2023 · External reference
Targeted P2X7/NLRP3 Signaling Pathway Against Inflammation, Apoptosis, and Pyroptosis of Retinal Endothelial Cells in Diabetic Retinopathy
10.1038/s41419-022-04786-w · 2022 · External reference
Increased Intestinal Permeability in Obese Mice: New Evidence in the Pathogenesis of Nonalcoholic Steatohepatitis
10.1152/ajpgi.00024.2006 · 2007 · External reference
Prevention of Leukostasis and Vascular Leakage in Streptozotocin‐Induced Diabetic Retinopathy via Intercellular Adhesion Molecule‐1 Inhibition
10.1073/pnas.96.19.10836 · 1999 · External reference
Gradual Suppression of Transcytosis Governs Functional Blood‐Retinal Barrier Formation
10.1016/j.neuron.2017.02.043 · 2017 · External reference
Mfsd2a‐Based Pharmacological Strategies for Drug Delivery Across the Blood‐Brain Barrier
10.1016/j.phrs.2015.12.024 · 2016 · External reference