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References from Mast Cell–Microglia Crosstalk Drives Aberrant Synaptic Pruning Through PAR ‐2/ MAPK / NF ‐ κB Signaling in Neonatal Hypoxic–Ischemic Encephalopathy. Local targets link to admitted publications; unresolved targets remain external evidence.
Neonatal Encephalopathy and Hypoxic‐Ischemic Encephalopathy: The State of the Art
10.1038/s41390-025-03986-2 · 2025 · External reference
The YAP/SCAP/SREBP1 Pathway in Astrocytes: A Novel Target for Treating Neonatal Hypoxic‐Ischemic Encephalopathy
10.1016/j.pneurobio.2025.102869 · 2025 · External reference
Regulated Cell Death in Hypoxic‐Ischaemic Encephalopathy: Recent Development and Mechanistic Overview
10.1038/s41420-024-02014-2 · 2024 · External reference
Protecting Effects of 4‐Octyl Itaconate on Neonatal Hypoxic‐Ischemic Encephalopathy via Nrf2 Pathway in Astrocytes
10.1186/s12974-024-03121-8 · 2024 · External reference
Mast Cells in Neurodegenerative Disease
10.3389/fncel.2019.00171 · 2019 · External reference
Mast Cell Activation and Microtubule Organization Are Modulated by Miltefosine Through Protein Kinase C Inhibition
10.3389/fimmu.2018.01563 · 2018 · External reference
Meningeal Mast Cell‐T Cell Crosstalk Regulates T Cell Encephalitogenicity
10.1016/j.jaut.2016.06.015 · 2016 · External reference
Inhibition of Mast Cell Tryptase Attenuates Neuroinflammation via PAR‐2/p38/NFκB Pathway Following Asphyxial Cardiac Arrest in Rats
10.1186/s12974-020-01808-2 · 2020 · External reference
The Role of Mast Cells in Autism Spectrum Disorder
10.1016/j.neubiorev.2025.106263 · 2025 · External reference
Focal Brain Inflammation and Autism
10.1186/1742-2094-10-46 · 2013 · External reference
Mast Cell Deficiency Improves Cognition and Enhances Disease‐Associated Microglia in 5XFAD Mice
10.1016/j.celrep.2023.113141 · 2023 · External reference
Glia Maturation Factor and Mast Cell‐Dependent Expression of Inflammatory Mediators and Proteinase Activated Receptor‐2 in Neuroinflammation
10.3233/jad-180786 · 2018 · External reference
Mast Cells Are Early Responders After Hypoxia‐Ischemia in Immature Rat Brain
10.1161/strokeaha.109.549691 · 2009 · External reference
Mast Cells Proliferate in the Peri‐Hippocampal Space During Early Development and Modulate Local and Peripheral Immune Cells
10.1016/j.devcel.2024.11.015 · 2025 · External reference
Mast Cells Mediate Inflammatory Injury and Aggravate Neurological Impairment in Experimental Subarachnoid Hemorrhage Through Microglial PAR‐2 Pathway
10.3389/fncel.2021.710481 · 2021 · External reference
Microglia‐Mediated Synapse Loss in Alzheimer's Disease
10.1523/jneurosci.1136-17.2017 · 2018 · External reference
Complement and Microglia Mediate Early Synapse Loss in Alzheimer Mouse Models
10.1126/science.aad8373 · 2016 · External reference
Microglia Emerge as Central Players in Brain Disease
10.1038/nm.4397 · 2017 · External reference
Mechanisms Governing Activity‐Dependent Synaptic Pruning in the Mammalian CNS
10.1038/s41583-021-00507-y · 2021 · External reference
Microglial Over‐Pruning of Synapses During Development in Autism‐Associated SCN2A‐Deficient Mice and Human Cerebral Organoids
10.1038/s41380-024-02518-4 · 2024 · External reference
Wogonin Mitigates Microglia‐Mediated Synaptic Over‐Pruning and Cognitive Impairment Following Epilepsy
10.1016/j.phymed.2024.156222 · 2024 · External reference
Mast Cell Tryptase Induces Microglia Activation via Protease‐Activated Receptor 2 Signaling
10.1159/000171029 · 2012 · External reference
Bidirectional Interplay Between Microglia and Mast Cells
10.3390/ijms26157556 · 2025 · External reference
Differential Expression and Distinct Roles of Proteinase‐Activated Receptor 2 in Microglia and Neurons in Neonatal Mouse Brain After Hypoxia‐Ischemic Injury
10.1007/s12035-021-02594-5 · 2022 · External reference
Gut Microbiome‐Derived Lipopolysaccharides Aggravate Cognitive Impairment via TLR4‐Mediated Inflammatory Signaling in Neonatal Rats Following Hypoxic‐Ischemic Brain Damage
10.1016/j.bbi.2025.02.029 · 2025 · External reference
Directed Evolution of Adeno‐Associated Virus for Efficient Gene Delivery to Microglia
10.1038/s41592-022-01547-7 · 2022 · External reference
Molecular Mechanisms Underlying Microglial Sensing and Phagocytosis in Synaptic Pruning
10.4103/1673-5374.385854 · 2024 · External reference
Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
10.1126/science.1202529 · 2011 · External reference
Targeting Mast Cell as a Neuroprotective Strategy
10.1080/02699052.2018.1556807 · 2019 · External reference
Suppression of Brain Mast Cells Degranulation Inhibits Microglial Activation and Central Nervous System Inflammation
10.1007/s12035-016-9720-x · 2017 · External reference
Mast Cell Stabilizer Disodium Cromoglycate Improves Long‐Term Cognitive Impairment After General Anesthesia Exposure in Neonatal Mice
10.3389/fnins.2022.990333 · 2022 · External reference
Protracted Downregulation of CX3CR1 on Microglia of Aged Mice After Lipopolysaccharide Challenge
10.1016/j.bbi.2010.05.011 · 2010 · External reference
Focal Ischemia Induces Expression of Protease‐Activated receptor1 (PAR1) and PAR3 on Microglia and Enhances PAR4 Labeling in the Penumbra
10.1016/j.brainres.2005.10.100 · 2006 · External reference
Inhibition of Protease‐Activated Receptor‐2 Activation in Parkinson's Disease Using 1‐Piperidin Propionic Acid
2024 · External reference
Infection of Microglia With Porphyromonas gingivalis Promotes Cell Migration and an Inflammatory Response Through the Gingipain‐Mediated Activation of Protease‐Activated Receptor‐2 in Mice
10.1038/s41598-017-12173-1 · 2017 · External reference
Activation of Protease‐Activated Receptor 2‐Mediated Signaling by Mast Cell Tryptase Modulates Cytokine Production in Primary Cultured Astrocytes
10.1155/2013/140812 · 2013 · External reference
