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References from Metabolomics Analysis Revealed That SXZ Ameliorates Cognitive Impairment in Naturally Aged Rats by Promoting Glutathione Metabolism and Inhibiting the Ferroptosis Pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
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Aging and Rejuvenation of Neural Stem Cells and Their Niches
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Clinical Practice. Mild Cognitive Impairment
10.1056/nejmcp0910237 · 2011 · External reference
Cholinesterase Inhibitors for Mild Cognitive Impairment
2012 · External reference
Screening for Cognitive Impairment in Older Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force
10.1001/jama.2019.22258 · 2020 · External reference
Traditional Chinese Medicine for Alzheimer's Disease: A Systematic Review and Meta‐Analysis
10.1142/s0192415x25500016 · 2025 · External reference
Diosgenin‐Rich Yam Extract Enhances Cognitive Function: A Placebo‐Controlled, Randomized, Double‐Blind, Crossover Study of Healthy Adults
10.3390/nu9101160 · 2017 · External reference
Yam (Dioscorea Pseudojaponica Yamamoto) Ameliorates Cognition Deficit and Attenuates Oxidative Damage in Senescent Mice Induced by D‐Galactose
10.1142/s0192415x09007296 · 2009 · External reference
β‐Sitosterol Treatment Attenuates Cognitive Deficits and Prevents Amyloid Plaque Deposition in Amyloid Protein Precursor/Presenilin 1 Mice
10.4196/kjpp.2020.24.1.39 · 2020 · External reference
Early Postnatal Oleic Acid Administration Enhances Synaptic Development and Cognitive Abilities in the Ts65Dn Mouse Model of Down Syndrome
10.1080/1028415x.2020.1861897 · 2022 · External reference
Study on Anti‐Aging Effects of “ShenXian Zhou” in DunHuang YiFang
2018 · External reference
Dunhuang Shenxian Porridge Alleviates Radiation‐Induced Brain Porridge Alleviates Radiation‐Induced Brain
2025 · External reference
Recent Advances in the Application of Metabolomics for Food Safety Control and Food Quality Analyses
10.1080/10408398.2020.1761287 · 2021 · External reference
Untargeted Metabolomics Strategies‐Challenges and Emerging Directions
10.1007/s13361-016-1469-y · 2016 · External reference
L‐Arginine Metabolism Ameliorates Age‐Related Cognitive Impairment by Amuc_1100‐Mediated Gut Homeostasis Maintaining
10.1111/acel.14081 · 2024 · External reference
Global Metabolic Shifts in Age and Alzheimer's Disease Mouse Brains Pivot at NAD+/NADH Redox Sites
10.3233/jad-190408 · 2019 · External reference
Dose Conversion Among Different Animals and Healthy Volunteers in Pharmacological Study
2004 · External reference
The Preventive Effect of Urinary Trypsin Inhibitor on Postoperative Cognitive Dysfunction, on the Aspect of Behavior, Evaluated by Y‐Maze Test, via Modulation of Microglial Activity
10.3390/ijms25052708 · 2024 · External reference
Establishment of a Valuable Mimic of Alzheimer's Disease in Rat Animal Model by Intracerebroventricular Injection of Composited Amyloid Beta Protein
2018 · External reference
MetaboLights: Open Data Repository for Metabolomics
10.1093/nar/gkad1045 · 2024 · External reference
Ageing as a Risk Factor for Neurodegenerative Disease
10.1038/s41582-019-0244-7 · 2019 · External reference
Advanced Glycation in D‐Galactose Induced Mouse Aging Model
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Mechanisms of Sex Differences in Alzheimer's Disease
10.1016/j.neuron.2024.01.024 · 2024 · External reference
Microglial Senescence Contributes to Female‐Biased Neuroinflammation in the Aging Mouse Hippocampus: Implications for Alzheimer's Disease
10.1186/s12974-023-02870-2 · 2023 · External reference
Oroxylin A, a Flavonoid, Stimulates Adult Neurogenesis in the Hippocampal Dentate Gyrus Region of Mice
10.1007/s11064-010-0235-y · 2010 · External reference
Wogonin Mitigates Microglia‐Mediated Synaptic Over‐Pruning and Cognitive Impairment Following Epilepsy
10.1016/j.phymed.2024.156222 · 2024 · External reference
Microbiome‐Metabolomics Analysis Reveals the Potential Effect of Verbascoside in Alleviating Cognitive Impairment in Db/Db Mice
10.1039/d2fo03110h · 2023 · External reference
GJ‐4 Ameliorates Memory Impairment in Focal Cerebral Ischemia/Reperfusion of Rats via Inhibiting JAK2/STAT1‐Mediated Neuroinflammation
10.1016/j.jep.2020.113491 · 2021 · External reference
Carvacrol Suppresses Learning and Memory Dysfunction and Hippocampal Damages Caused by Chronic Cerebral Hypoperfusion
10.1007/s00210-019-01754-8 · 2020 · External reference
The Age and Genomic Integrity of Neurons After Cortical Stroke in Humans
10.1038/nn.3706 · 2014 · External reference
The Molecular Basis of the Specificity and Cross‐Reactivity of the NeuN Epitope of the Neuron‐Specific Splicing Regulator, Rbfox3
10.1007/s00418-013-1159-9 · 2014 · External reference
Iron and Ferroptosis More Than a Suspect: Beyond the Most Common Mechanisms of Neurodegeneration for New Therapeutic Approaches to Cognitive Decline and Dementia
10.3390/ijms24119637 · 2023 · External reference
TIGAR Alleviates Cognitive Impairment in Rats With Chronic Cerebral Hypoperfusion by Suppressing Oxidative Stress and Pyroptosis
10.62347/nwqs1671 · 2025 · External reference
Protein S‐Thiolation by Glutathionylspermidine (Gsp): The Role of Escherichia coli Gsp synthetASE/Amidase in Redox Regulation
10.1074/jbc.m110.133363 · 2010 · External reference
Coenzyme Q10 Levels Associated With Cognitive Functioning and Executive Function in Older Adults
10.1093/gerona/glac152 · 2023 · External reference
L‐Ornithine vs. L‐Ornithine‐L‐Aspartate as a Treatment for Hyperammonemia‐Induced Encephalopathy in Rats
10.1016/s0168-8278(97)80024-4 · 1997 · External reference
Salidroside Alleviates Cognitive Impairment by Inhibiting Ferroptosis via Activation of the Nrf2/GPX4 Axis in SAMP8 Mice
10.1016/j.phymed.2023.154762 · 2023 · External reference
Ferroptosis and Its Potential Role in the Physiopathology of Parkinson's Disease
10.1016/j.pneurobio.2020.101890 · 2021 · External reference
Ablation of Ferroptosis Regulator Glutathione Peroxidase 4 in Forebrain Neurons Promotes Cognitive Impairment and Neurodegeneration
10.1016/j.redox.2017.01.021 · 2017 · External reference
Vitamin D Improves Cognitive Impairment and Alleviates Ferroptosis via the Nrf2 Signaling Pathway in Aging Mice
10.3390/ijms242015315 · 2023 · External reference
Glutathione
10.1146/annurev.bi.52.070183.003431 · 1983 · External reference
A Reversible Early Oxidized Redox State That Precedes Macromolecular ROS Damage in Aging Nontransgenic and 3xTg‐AD Mouse Neurons
10.1523/jneurosci.6192-11.2012 · 2012 · External reference
Iron Speciation in the Cytosol: An Overview
10.1039/c2dt32149a · 2013 · External reference
Speciation of Iron in Mouse Liver During Development, Iron Deficiency, IRP2 Deletion and Inflammatory Hepatitis
10.1039/c4mt00215f · 2015 · External reference
Tissue‐Variation of Iron Stable Isotopes in Marine Fish Coupled With Speciation Analysis Using X‐Ray Absorption Fine Structure
10.1016/j.scitotenv.2023.163449 · 2023 · External reference
Activation of SAT1 Engages Polyamine Metabolism With p53‐Mediated Ferroptotic Responses
2016 · External reference
Ferroptosis as a p53‐Mediated Activity During Tumour Suppression
10.1038/nature14344 · 2015 · External reference
Unfolded p53 as a Marker of Oxidative Stress in Mild Cognitive Impairment, Alzheimer's and Parkinson's Disease
10.2174/1567205018666211117101216 · 2021 · External reference
Age‐Related p53 SUMOylation Accelerates Senescence and Tau Pathology in Alzheimer's Disease
10.1038/s41418-025-01448-0 · 2025 · External reference
Ferritin Reduction Is Essential for Cerebral Ischemia‐Induced Hippocampal Neuronal Death Through p53/SLC7A11‐Mediated Ferroptosis
10.1016/j.brainres.2020.147216 · 2021 · External reference
Cerebroprotein Hydrolysate‐I Ameliorates Cognitive Dysfunction in APP/PS1 Mice by Inhibiting Ferroptosis via the p53/SAT1/ALOX15 Signalling Pathway
10.1016/j.ejphar.2024.176820 · 2024 · External reference
Insights Into the Novel Function of System xc‐ in Regulated Cell Death
2021 · External reference
Oxyphylla A Ameliorates Cognitive Deficits and Alleviates Neuropathology via the Akt‐GSK3β and Nrf2‐Keap1‐HO‐1 Pathways in Vitro and in Vivo Murine Models of Alzheimer's Disease
10.1016/j.jare.2021.09.002 · 2021 · External reference
Ling‐Gui‐Zhu‐Gan Decoction Protects H9c2 Cells Against H(2)O(2)‐Induced Oxidative Injury via Regulation of the Nrf2/Keap1/HO‐1 Signaling Pathway
10.1155/2020/8860603 · 2020 · External reference
NRF2 Plays a Critical Role in Mitigating Lipid Peroxidation and Ferroptosis
10.1016/j.redox.2019.101107 · 2019 · External reference
Activation of the p62‐Keap1‐NRF2 Pathway Protects Against Ferroptosis in Hepatocellular Carcinoma Cells
10.1002/hep.28251 · 2016 · External reference
Role of Nrf2 in Aging, Alzheimer's and Other Neurodegenerative Diseases
10.1016/j.arr.2022.101756 · 2022 · External reference
Dimethyl Fumarate Improves Cognitive Deficits in Chronic Cerebral Hypoperfusion Rats by Alleviating Inflammation, Oxidative Stress, and Ferroptosis via NRF2/ARE/NF‐κB Signal Pathway
10.1016/j.intimp.2021.107844 · 2021 · External reference
Three‐Dimensional Growth Sensitizes Breast Cancer Cells to Treatment With Ferroptosis‐Promoting Drugs
10.1038/s41419-023-06106-2 · 2023 · External reference