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References from Dihydropyrimidine Dehydrogenase Genotype–Phenotype Correlations in Plasma and Peripheral Blood Mononuclear Cells. Local targets link to admitted publications; unresolved targets remain external evidence.
Toxicity of fluorouracil in patients with advanced colorectal cancer: effect of administration schedule and prognostic factors
10.1200/jco.1998.16.11.3537 · 1998 · External reference
Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first‐line treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III study
10.1200/jco.2001.19.8.2282 · 2001 · External reference
Oral capecitabine vs intravenous 5‐fluorouracil and leucovorin: integrated efficacy data and novel analyses from two large, randomised, phase III trials
10.1038/sj.bjc.6601676 · 2004 · External reference
DPYD variants as predictors of 5‐fluorouracil toxicity in adjuvant colon cancer treatment (NCCTG N0147)
2014 · External reference
Individualized dosing of fluoropyrimidine‐based chemotherapy to prevent severe fluoropyrimidine‐related toxicity: what are the options?
10.1002/cpt.2069 · 2021 · External reference
DPYD genotype‐guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis
10.1016/s1470-2045(18)30686-7 · 2018 · External reference
Known variant DPYD alleles do not explain DPD deficiency in cancer patients
10.1097/00008571-200004000-00002 · 2000 · External reference
Predicting Dihydropyrimidine dehydrogenase deficiency and related 5‐fluorouracil toxicity: opportunities and challenges of DPYD exon sequencing and the role of phenotyping assays
10.3390/ijms232213923 · 2022 · External reference
Quantitative contribution of rs75017182 to Dihydropyrimidine dehydrogenase mRNA splicing and enzyme activity
10.1002/cpt.685 · 2017 · External reference
Clinical pharmacogenetics implementation consortium (CPIC) guideline for Dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing: 2017 update
10.1002/cpt.911 · 2018 · External reference
DPYD genotyping recommendations: a joint consensus recommendation of the Association for Molecular Pathology, American College of Medical Genetics and Genomics, clinical pharmacogenetics implementation consortium, College of American Pathologists, Dutch pharmacogenetics working Group of the Royal Dutch Pharmacists Association, European Society for Pharmacogenomics and Personalized Therapy, pharmacogenomics knowledgebase, and Pharmacogene variation consortium
10.1016/j.jmoldx.2024.05.015 · 2024 · External reference
Studies on fluorinated pyrimidines. IX. The degradation of 5‐fluorouracil‐6‐C14
10.1016/s0021-9258(18)69542-0 · 1960 · External reference
Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5‐fluorouracil chemotherapy
1993 · External reference
Profound variation in dihydropyrimidine dehydrogenase activity in human blood cells: major implications for the detection of partly deficient patients
10.1038/sj.bjc.6690097 · 1999 · External reference
5‐fluorouracil‐related severe toxicity: a comparison of different methods for the pretherapeutic detection of dihydropyrimidine dehydrogenase deficiency
10.1016/j.canlet.2006.09.006 · 2007 · External reference
Link between dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cells and liver
1996 · External reference
Application of simple chromatographic methods for the diagnosis of defects in pyrimidine degradation
10.1093/clinchem/39.3.380 · 1993 · External reference
Predicting 5‐fluorouracil toxicity: DPD genotype and 5,6‐dihydrouracil:uracil ratio
10.2217/pgs.14.126 · 2014 · External reference
Quantitative impact of pre‐analytical process on plasma uracil when testing for dihydropyrimidine dehydrogenase deficiency
10.1111/bcp.15536 · 2023 · External reference
The Mayo Clinic biobank: a building block for individualized medicine
10.1016/j.mayocp.2013.06.006 · 2013 · External reference
Haplotype structure defines effects of common DPYD variants c.85T > C (rs1801265) and c.496A > G (rs2297595) on dihydropyrimidine dehydrogenase activity: implication for 5‐fluorouracil toxicity
10.1111/bcp.14742 · 2021 · External reference
Novel deleterious Dihydropyrimidine dehydrogenase variants may contribute to 5‐fluorouracil sensitivity in an east African population
10.1002/cpt.531 · 2017 · External reference
Discovering novel germline genetic variants linked to severe fluoropyrimidine‐related toxicity in‐ and outside DPYD
10.1186/s13073-024-01354-z · 2024 · External reference
pTrimmer: an efficient tool to trim primers of multiplex deep sequencing data
10.1186/s12859-019-2854-x · 2019 · External reference
Graph‐based genome alignment and genotyping with HISAT2 and HISAT‐genotype
10.1038/s41587-019-0201-4 · 2019 · External reference
10.1101/201178
10.1101/201178 · External reference
A genomic mutational constraint map using variation in 76,156 human genomes
10.1038/s41586-023-06045-0 · 2024 · External reference
Comparative functional analysis of DPYD variants of potential clinical relevance to dihydropyrimidine dehydrogenase activity
10.1158/0008-5472.can-13-2482 · 2014 · External reference
Gene‐specific variant classifier (DPYD‐Varifier) to identify deleterious alleles of Dihydropyrimidine dehydrogenase
10.1002/cpt.1020 · 2018 · External reference
Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5‐iodouracil. Implications for mechanism of inhibition and electron transfer
10.1074/jbc.m111877200 · 2002 · External reference
Fluoropyrimidine‐associated toxicity and DPYD variants c.85T>C, c.496A>G, and c.1236G>a: impact of haplotype
10.1007/s00280-022-04491-7 · 2023 · External reference
Age and sex are independent predictors of 5‐fluorouracil toxicity. Analysis of a large scale phase III trial
10.1002/1097-0142(19950101)75:1<11::aid-cncr2820750104>3.0.co;2-n · 1995 · External reference
Women experience greater toxicity with fluorouracil‐based chemotherapy for colorectal cancer
10.1200/jco.2002.20.6.1491 · 2002 · External reference
Differences in toxicity between men and women treated with 5‐fluorouracil therapy for colorectal carcinoma
10.1002/cncr.20878 · 2005 · External reference
The value of dihydrouracil/uracil plasma ratios in predicting 5‐fluorouracil‐related toxicity in colorectal cancer patients
10.1177/147323001003800413 · 2010 · External reference
Can we identify patients carrying targeted deleterious DPYD variants with plasma uracil and dihydrouracil? A GPCO‐RNPGx retrospective analysis
10.1515/cclm-2024-0317 · 2024 · External reference
Pretreatment serum uracil concentration as a predictor of severe and fatal fluoropyrimidine‐associated toxicity
10.1038/bjc.2017.94 · 2017 · External reference
Unresolved reference
External reference
Phenotypic and clinical implications of variants in the dihydropyrimidine dehydrogenase gene
10.1016/j.bbadis.2016.01.009 · 2016 · External reference
Unresolved reference
External reference
Dose‐individualisation of fluoropyrimidines based on pre‐treatment serum uracil levels: the Alpe2U study
10.1016/j.ejca.2025.115483 · 2025 · External reference
A comprehensive population‐based study comparing the phenotype and genotype in a pretherapeutic screen of dihydropyrimidine dehydrogenase deficiency
10.1038/s41416-020-0962-z · 2020 · External reference
A DPYD variant (Y186C) in individuals of african ancestry is associated with reduced DPD enzyme activity
10.1038/clpt.2013.69 · 2013 · External reference
Haematological and non‐haematological toxicity after 5‐fluorouracil and leucovorin in patients with advanced colorectal cancer is significantly associated with gender, increasing age and cycle number. Tomudex international study group
10.1016/s0959-8049(98)00259-7 · 1998 · External reference
Sex differences in fluorouracil‐induced stomatitis
10.1200/jco.2000.18.2.412 · 2000 · External reference
Severe toxicity related to the 5‐fluorouracil/leucovorin combination (the Mayo Clinic regimen): a prospective study in colorectal cancer patients
10.1097/01.coc.0000017526.55135.6d · 2003 · External reference
Effects of gender on capecitabine toxicity in colorectal cancer
10.1177/1078155215587345 · 2016 · External reference
Influence of sex and age on fluorouracil clearance
10.1200/jco.1992.10.7.1171 · 1992 · External reference
Relative importance of dose, body surface area, sex, and age for 5‐fluorouracil clearance
1991 · External reference
Gender‐specific elimination of continuous‐infusional 5‐fluorouracil in patients with gastrointestinal malignancies: results from a prospective population pharmacokinetic study
10.1007/s00280-012-2018-4 · 2013 · External reference