Research graph
References from Bioactive peptides in cancer and inflammation: Mechanisms, model systems and clinical translation. Local targets link to admitted publications; unresolved targets remain external evidence.
Anti‐cancer natural products and their bioactive compounds inducing ER stress‐mediated apoptosis: a review
10.3390/nu10081021 · 2018 · External reference
Role of bioactive peptides derived from food proteins in programmed cell death to treat inflammatory diseases and cancer
10.1080/10408398.2021.1992606 · 2023 · External reference
Anti‐cancer peptides: status and future prospects
10.3390/molecules28031148 · 2023 · External reference
Antimicrobial/anticancer peptides: bioactive molecules and therapeutic agents
10.2217/imt-2020-0312 · 2021 · External reference
Bioactive peptides and proteins for tissue repair: microenvironment modulation, rational delivery, and clinical potential
10.1186/s40779-024-00576-x · 2024 · External reference
In silico peptide design: methods, resources, and role of AI
10.1002/psc.70063 · 2025 · External reference
Bioactive peptides: an alternative therapeutic approach for cancer management
10.3389/fimmu.2024.1310443 · 2024 · External reference
Cationic amphiphilic peptides with cancer‐selective toxicity
10.1016/j.ejphar.2009.08.043 · 2009 · External reference
The current landscape of the antimicrobial peptide melittin and its therapeutic potential
10.3389/fimmu.2024.1326033 · 2024 · External reference
Mechanism of anticancer activity of buforin IIb, a histone H2A‐derived peptide
10.1016/j.canlet.2008.05.041 · 2008 · External reference
Enhancement of the cancer targeting specificity of buforin IIb by fusion with an anionic peptide via a matrix metalloproteinases‐cleavable linker
10.1016/j.peptides.2011.02.010 · 2011 · External reference
Anticancer potential of antimicrobial peptides: focus on buforins
10.3390/polym16060728 · 2024 · External reference
Mode‐of‐action of antimicrobial peptides: membrane disruption vs. intracellular mechanisms
10.3389/fmedt.2020.610997 · 2020 · External reference
Bioactive cationic peptides as potential agents for breast cancer treatment
10.1042/bsr20211218c · 2021 · External reference
Anticancer peptide: physicochemical property, functional aspect and trend in clinical application
10.3892/ijo.2020.5099 · 2020 · External reference
Antimicrobial peptide WK‐13‐3D promotes apoptosis, autophagy, and ubiquitination in triple‐negative breast cancer via binding immunoglobulin protein (BiP)
10.1016/j.cbi.2025.111530 · 2025 · External reference
Bioactive peptides from food science to pharmaceutical industries: their mechanism of action, potential role in cancer treatment and available resources
10.1016/j.heliyon.2024.e40563 · 2024 · External reference
p28 bacterial peptide, as an anticancer agent
10.3389/fonc.2020.01303 · 2020 · External reference
Antimicrobial peptides and their applications in biomedical sector
10.3390/antibiotics10091094 · 2021 · External reference
Current research status of anti‐cancer peptides: mechanism of action, production, and clinical applications
10.1016/j.biopha.2023.114996 · 2023 · External reference
MAPK signaling pathway‐targeted marine compounds in cancer therapy
10.1007/s00432-020-03460-y · 2021 · External reference
A complex role for calcium signaling in colorectal cancer development and progression
10.1158/1541-7786.mcr-19-0429 · 2019 · External reference
Aberrant calcium signalling downstream of mutations in TP53 and the PI3K/AKT pathway genes promotes disease progression and therapy resistance in triple negative breast cancer
10.20517/cdr.2022.41 · 2022 · External reference
NFAT signaling dysregulation in cancer: emerging roles in cancer stem cells
10.1016/j.biopha.2023.115167 · 2023 · External reference
Novel compounds target aberrant calcium signaling in the treatment of relapsed high‐risk neuroblastoma
10.3390/ijms26073180 · 2025 · External reference
Isolation and identification of anti‐colorectal cancer peptides from walnut proteins and associated in silico analysis
10.1016/j.jff.2023.105952 · 2024 · External reference
Antimicrobial peptide 17BIPHE2 inhibits the proliferation of lung cancer cells in vitro and in vivo by regulating the ERK signaling pathway
10.3892/ol.2021.12762 · 2021 · External reference
Polyphyllin II induces protective autophagy and apoptosis via inhibiting PI3K/AKT/mTOR and STAT3 signaling in colorectal cancer cells
10.3390/ijms231911890 · 2022 · External reference
Combination of berberine and NVP‐BEZ235 inhibits metastasis of triple‐negative breast cancer MDA‐MB‐231 cell line
10.1016/j.bbrc.2025.152473 · 2025 · External reference
Pentapeptide AYP from Isochrysis zhanjiangensis exhibits antiangiogenic activity in HT1080 cells and HUVECs by suppressing migration and invasion in vitro
10.1021/acs.jafc.2c02813 · 2022 · External reference
Anti‐angiogenic effect of Bryopsis plumosa‐derived peptide via aquaporin 3 in non‐small cell lung cancer
10.3892/ijo.2024.5711 · 2024 · External reference
Generation of bioactive peptides from Porphyridium sp. and assessment of their potential for use in the prevention of hypertension, inflammation and pain
10.3390/md21080422 · 2023 · External reference
F2 peptide fraction of Androctonus crassicauda scorpion venom: inducing M2 to M1 macrophage polarization and inhibiting colon carcinoma cell proliferation and migration
2025 · External reference
Lunasin as a promising plant‐derived peptide for cancer therapy
10.3390/ijms23179548 · 2022 · External reference
Study of alloferon, a novel immunomodulatory antimicrobial peptide (AMP), and its analogues
10.3389/fphar.2024.1359261 · 2024 · External reference
Thymopentin enhances antitumor immunity through thymic rejuvenation and T cell functional reprogramming
10.3390/biomedicines13102494 · 2025 · External reference
Chlorotoxin‐directed CAR T cells for specific and effective targeting of glioblastoma
10.1126/scitranslmed.aaw2672 · 2020 · External reference
Immunogenic cell death inducer peptides: a new approach for cancer therapy, current status and future perspectives
10.1016/j.biopha.2023.114503 · 2023 · External reference
Bioactive peptide nanodrugs based on supramolecular assembly for boosting immunogenic cell death‐induced cancer immunotherapy
10.1002/smtd.202201708 · 2023 · External reference
The potential of food protein‐derived bioactive peptides against chronic intestinal inflammation
2020 · External reference
Dermaseptin B2 bioactive gene's potential for anticancer and anti‐proliferative effect is linked to the regulation of the BAX/BBC3/AKT pathway
10.1007/s12032-024-02384-8 · 2024 · External reference
The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: a comprehensive review
10.1016/j.biopha.2020.110917 · 2021 · External reference
Interaction of a short antimicrobial peptide on charged lipid bilayer: a case study on aurein 1.2 peptide
10.1016/j.bbadva.2022.100045 · 2022 · External reference
Design, synthesis, and biological evaluation of new analogs of aurein 1.2 containing non‐proteinogenic amino acids
10.3390/molecules30092050 · 2025 · External reference
Characterization of tachyplesin peptides and their cyclized analogues to improve antimicrobial and anticancer properties
10.3390/ijms20174184 · 2019 · External reference
Tachyplesin induces apoptosis in non‐small cell lung cancer cells and enhances the chemosensitivity of A549/DDP cells to cisplatin by activating Fas and necroptosis pathway
10.1111/cbdd.13810 · 2021 · External reference
A tetrameric peptide derived from bovine lactoferricin exhibits specific cytotoxic effects against oral squamous‐cell carcinoma cell lines
2015 · External reference
Antibacterial synthetic peptides derived from bovine lactoferricin exhibit cytotoxic effect against MDA‐MB‐468 and MDA‐MB‐231 breast cancer cell lines
10.3390/molecules22101641 · 2017 · External reference
Caerin 1.1/1.9 enhances antitumour immunity by activating the IFN‐α response signalling pathway of tumour macrophages
10.3390/cancers14235785 · 2022 · External reference
Caerin 1.1 and 1.9 peptides induce acute caspase 3/GSDME‐mediated pyroptosis in epithelial cancer cells
10.1038/s41598-025-96438-0 · 2025 · External reference
Antitumor activity of Tigerinin‐1: necroptosis mediates toxicity in A549 cells
10.1016/j.bbagen.2022.130182 · 2022 · External reference
Temporin A and Bombinin H2 antimicrobial peptides exhibit selective cytotoxicity to lung cancer cells
2020 · External reference
Antimicrobial and antitumor properties of anuran peptide temporin‐SHf induce apoptosis in A549 lung cancer cells
10.1007/s00726-023-03373-3 · 2024 · External reference
Synthesis and biological studies of new temporin a analogs containing unnatural amino acids in position 7
10.3390/pharmaceutics16060716 · 2024 · External reference
Antimicrobial peptides as anticancer agents: functional properties and biological activities
10.3390/molecules25122850 · 2020 · External reference
Bee venom and its peptide component melittin suppress growth and migration of melanoma cells via inhibition of PI3K/AKT/mTOR and MAPK pathways
10.3390/molecules24050929 · 2019 · External reference
Honeybee venom and melittin suppress growth factor receptor activation in HER2‐enriched and triple‐negative breast cancer
10.1038/s41698-020-00129-0 · 2020 · External reference
Effect of dimerization of a β‐turn antimicrobial peptide, PST13‐RK, on antimicrobial activity and mammalian cell toxicity
10.1007/s10529-008-9848-5 · 2009 · External reference
Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin
10.1016/j.bbamem.2020.183228 · 2020 · External reference
Antibacterial and anticancer activities of pleurocidin‐amide, a potent marine antimicrobial peptide derived from winter flounder, Pleuronectes americanus
10.3390/md20080519 · 2022 · External reference
BMAP‐27 peptide reduces proliferation and increases apoptosis in primary and metastatic colon cancer cell lines
10.1007/s10989-023-10572-9 · 2023 · External reference
Effective topical treatment of subcutaneous murine B16F10‐Nex2 melanoma by the antimicrobial peptide gomesin
10.1593/neo.07885 · 2008 · External reference
Gomesin inhibits melanoma growth by manipulating key signaling cascades that control cell death and proliferation
10.1016/j.toxicon.2018.11.327 · 2019 · External reference
Cytotoxic effect of hepcidin (TH1‐5) on human breast cancer cell line (MCF7)
2015 · External reference
Fish‐derived hepcidins in cancer treatment: a scoping review
10.1186/s43088-025-00599-w · 2025 · External reference
Mastoparan is a membranolytic anti‐cancer peptide that works synergistically with gemcitabine in a mouse model of mammary carcinoma
10.1016/j.bbamem.2016.09.021 · 2016 · External reference
Gramicidin A induces metabolic dysfunction and energy depletion leading to cell death in renal cell carcinoma cells
10.1158/1535-7163.mct-13-0445 · 2013 · External reference
Gramicidin, a bactericidal antibiotic, is an antiproliferative agent for ovarian cancer cells
10.3390/medicina59122059 · 2023 · External reference
Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus
10.1074/jbc.ra120.012627 · 2020 · External reference
Characterization and evaluation of cytotoxic and antimicrobial activities of cyclotides from Viola japonica
10.1038/s41598-024-60246-9 · 2024 · External reference
Design and biological evaluation of novel BF‐30 analogs for the treatment of malignant melanoma
10.7150/jca.47549 · 2020 · External reference
Anticancer activities of natural antimicrobial peptides from animals
10.3389/fmicb.2023.1321386 · 2024 · External reference
The first Brevinin‐1 antimicrobial peptide with LPS‐neutralizing and anti‐inflammatory activities in vitro and in vivo
10.3389/fmicb.2023.1102576 · 2023 · External reference
Recent advances in the therapeutic potential of cathelicidins
10.3389/fmicb.2024.1405760 · 2024 · External reference
Effect of hydrophobicity on the anticancer activity of fatty‐acyl‐conjugated CM4 in breast cancer cells
10.1021/acsomega.0c02093 · 2020 · External reference
Antimicrobial peptides mediate apoptosis by changing mitochondrial membrane permeability
10.3390/ijms232112732 · 2022 · External reference
Structural pores not required: antimicrobial peptides induce ion permeabilization of lipid membranes through transient water channels
10.1073/pnas.2517944122 · 2025 · External reference
Pharmacodynamics and clinical implications of the main bioactive peptides: a review
10.3390/nutraceuticals2040030 · 2022 · External reference
Bioactive milk peptides: an updated comprehensive overview and database
10.1080/10408398.2023.2240396 · 2024 · External reference
Anti‐cancer immunotherapies targeting telomerase
10.3390/cancers12082260 · 2020 · External reference
Humanization of immunodeficient animals for the modeling of transplantation, graft versus host disease, and regenerative medicine
10.1097/tp.0000000000003177 · 2020 · External reference
The human cathelicidin peptide LL‐37 inhibits pancreatic cancer growth by suppressing autophagy and reprogramming of the tumor immune microenvironment
10.3389/fphar.2022.906625 · 2022 · External reference
Biophysical characterization of LTX‐315 anticancer peptide interactions with model membrane platforms: effect of membrane surface charge
10.3390/ijms231810558 · 2022 · External reference
Acceleration of infectious disease drug discovery and development using a humanized model of drug metabolism
10.1073/pnas.2315069121 · 2024 · External reference
Bioactive peptides from microalgae: focus on anti‐cancer and immunomodulating activity
10.1111/ppl.13472 · 2021 · External reference
Zebrafish (Danio rerio) as a model system for diseases in biological studies
10.56557/upjoz/2025/v46i104967 · 2025 · External reference
The effect of LL37 antimicrobial peptide on FOXE1 and lncRNA PTCSC 2 genes expression in colorectal cancer (CRC) and normal cells
10.31557/apjcp.2022.23.10.3437 · 2022 · External reference
Efficacy of marine biomolecules on angiogenesis by targeting hypoxia inducible factor/vascular endothelial growth factor signaling in zebrafish model
10.1002/jbt.22954 · 2022 · External reference
A Novel anticancer peptide derived from Bryopsis plumosa regulates proliferation and invasion in non‐small cell lung cancer cells
10.3390/md21120607 · 2023 · External reference
Application of zebrafish as a model for anti‐cancer activity evaluation and toxicity testing of natural products
10.3390/ph16060827 · 2023 · External reference
Bioactivity of marine‐derived peptides and proteins: a review
10.3390/md23040157 · 2025 · External reference
Visualizing engrafted human cancer and therapy responses in immunodeficient zebrafish
10.1016/j.cell.2019.04.004 · 2019 · External reference
Cytochrome P450‐dependent biotransformation capacities in embryonic, juvenile and adult stages of zebrafish (Danio rerio)—a state‐of‐the‐art review
10.1007/s00204-021-03071-7 · 2021 · External reference
Single‐cell imaging of human cancer xenografts using adult immunodeficient zebrafish
10.1038/s41596-020-0372-y · 2020 · External reference
Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials
10.1038/s41573-021-00210-8 · 2021 · External reference
Exploring experimental models of colorectal cancer: a critical appraisal from 2D cell systems to organoids, humanized mouse avatars, organ‐on‐chip, CRISPR engineering, and AI‐driven platforms—challenges and opportunities for translational precision oncology
10.3390/cancers17132163 · 2025 · External reference
The effect of bacterial peptide p28 on viability and apoptosis status of p53‐null HeLa cells
10.15171/apb.2019.078 · 2019 · External reference
The antimicrobial peptide cathelicidin exerts immunomodulatory effects via scavenger receptors
10.3390/ijms24010875 · 2023 · External reference
In vivo detection of human TRPV6‐rich tumors with anti‐cancer peptides derived from soricidin
10.1371/journal.pone.0058866 · 2013 · External reference
First‐in‐human phase I study of SOR‐C13, a TRPV6 calcium channel inhibitor, in patients with advanced solid tumors
10.1007/s10637-017-0438-z · 2017 · External reference
GPA peptide inhibits NLRP3 inflammasome activation to ameliorate colitis through AMPK pathway
10.18632/aging.103825 · 2020 · External reference
A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes
10.7554/elife.59683 · 2021 · External reference
Nrf2‐activating bioactive peptides exert anti‐inflammatory activity through inhibition of the NF‐κB pathway
10.3390/ijms23084382 · 2022 · External reference
Advances in the application and mechanism of bioactive peptides in the treatment of inflammation
10.3389/fimmu.2024.1413179 · 2024 · External reference
Aloin suppresses lipopolysaccharide‑induced inflammation by inhibiting JAK1‑STAT1/3 activation and ROS production in RAW264. 7 cells
2018 · External reference
Soybean bioactive peptides and their functional properties
10.3390/nu10091211 · 2018 · External reference
Triggering of cancer cell cycle arrest by a novel scorpion venom‐derived peptide—Gonearrestide
10.1111/jcmm.13745 · 2018 · External reference
Anticancer bioactive peptide (ACBP) inhibits gastric cancer cells by upregulating growth arrest and DNA damage‐inducible gene 45A (GADD45A)
10.1007/s13277-014-2272-7 · 2014 · External reference
Preventive effect of peptides derived from fermented milk on chronic stress‐induced brain damage and intestinal dysfunction in mice
10.3168/jds.2023-23320 · 2023 · External reference
Human β‐defensin 3 has immunosuppressive activity in vitro and in vivo
10.1002/eji.200940041 · 2010 · External reference
PMAP‐37: a versatile cathelicidin for neutralizing bacteria and viruses
10.1016/j.micpath.2025.107568 · 2025 · External reference
The protective role of chicken cathelicidin‐1 against Streptococcus suis serotype 2 in vitro and in vivo
10.1186/s13567-023-01199-1 · 2023 · External reference
Structure and function of papiliocin with antimicrobial and anti‐inflammatory activities isolated from the swallowtail butterfly, Papilio xuthus
10.1074/jbc.m111.269225 · 2011 · External reference
Molecular mechanism underlying the TLR4 antagonistic and antiseptic activities of papiliocin, an insect innate immune response molecule
10.1073/pnas.2115669119 · 2022 · External reference
Antimicrobial peptide temporin‐1CEa isolated from frog skin secretions inhibits the proinflammatory response in lipopolysaccharide‐stimulated RAW264. 7 murine macrophages through the MyD88‐dependent signaling pathway
10.1016/j.molimm.2021.01.007 · 2021 · External reference
Effects of frog skin peptide temporin‐1CEa and its analogs on ox‐LDL induced macrophage‐derived foam cells
10.3389/fphar.2023.1139532 · 2023 · External reference
Temporin‐1CEa and its analog LK2 (6) A (L) confer neuroprotective effects in Parkinson's disease model by attenuating neuroinflammation via the NF‐κB and MAPK signaling pathways
10.1007/s11481-025-10241-2 · 2025 · External reference
10.1128/spectrum.01494-22
10.1128/spectrum.01494-22 · External reference
An amphipathic peptide combats multidrug‐resistant Staphylococcus aureus and biofilms
10.1038/s42003-024-07216-z · 2024 · External reference
Characterization of the first antimicrobial peptide from Sea Seal with potent therapeutic effect in septic mice
10.1016/j.bcp.2025.116891 · 2025 · External reference
An antimicrobial peptide as a potential therapy for bacterial pneumonia that alleviates antimicrobial resistance
10.1038/s41467-025-65449-w · 2025 · External reference
Modulatory effects of acidic pH and membrane potential on the adsorption of pH‐sensitive peptides to anionic lipid membrane
10.3390/membranes11050307 · 2021 · External reference
Biophysics of pH‐driven membrane insertion: a review of the phlip peptide
10.1021/acs.jpcb.5c00225 · 2025 · External reference
Tumor microenvironment pH‐sensitive peptidomimetics for targeted anticancer drug delivery
10.1021/acs.biochem.4c00657 · 2025 · External reference
Effect of bioactive peptides on gut microbiota and their relations to human health
10.3390/foods13121853 · 2024 · External reference
Exploring the potential of antioxidants from fruits and vegetables and strategies for their recovery
10.1016/j.ifset.2022.102974 · 2022 · External reference
Roles of dietary bioactive peptides in redox balance and metabolic disorders
10.1155/2021/5582245 · 2021 · External reference
Bioactive peptides and metabolic health: a mechanistic review of the impact on insulin sensitivity, lipid profiles, and inflammation
10.1016/j.afres.2025.101056 · 2025 · External reference
Bioactive peptides from fermented foods: production approaches, sources, and potential health benefits
10.3390/foods13213369 · 2024 · External reference
Therapeutic effects of blue mussel‐derived peptides (PIISVYWK and FSVVPSPK) on non‐alcoholic fatty liver disease by modulating lipid metabolism and inflammation in high‐fat diet‐induced mice
10.1016/j.tice.2024.102630 · 2024 · External reference
Asiaticoside exerts neuroprotection through targeting NLRP3 inflammasome activation
10.1016/j.phymed.2024.155494 · 2024 · External reference
Anti‐inflammatory, anti‐oxidative and anti‐apoptotic effects of thymol and 24‐epibrassinolide in zebrafish larvae
10.3390/antiox12061297 · 2023 · External reference
Suppression of lipopolysaccharide‐induced inflammatory and oxidative response by 5‐aminolevulinic acid in RAW 264.7 macrophages and zebrafish larvae
10.4062/biomolther.2021.030 · 2021 · External reference
Antimicrobial peptide biological activity, delivery systems and clinical translation status and challenges
10.1186/s12967-025-06321-9 · 2025 · External reference
Basics and recent advances in peptide and protein drug delivery
10.4155/tde.13.104 · 2013 · External reference
Recent developments in protein and peptide parenteral delivery approaches
10.4155/tde.14.5 · 2014 · External reference
Protease‐resistant peptides for targeting and intracellular delivery of therapeutics
10.3390/pharmaceutics13122065 · 2021 · External reference
On the immunogenic properties of retro‐inverso peptides. Total retro‐inversion of T‐cell epitopes causes a loss of binding to MHC II molecules
10.1016/s0161-5890(97)00004-7 · 1997 · External reference
10.1371/journal.pone.0080390
10.1371/journal.pone.0080390 · External reference
Polymyxin and lipopeptide antibiotics: membrane‐targeting drugs of last resort
10.1099/mic.0.001136 · 2022 · External reference
Antimicrobial activity and stability to proteolysis of small linear cationic peptides with D‐amino acid substitutions
10.1111/j.1348-0421.2002.tb02759.x · 2002 · External reference
Polysialic acids: potential in improving the stability and pharmacokinetics of proteins and other therapeutics
10.1007/pl00000676 · 2000 · External reference
Site‐specific enzymatic polysialylation of therapeutic proteins using bacterial enzymes
10.1073/pnas.1019266108 · 2011 · External reference
Therapeutic peptides: current applications and future directions
10.1038/s41392-022-00904-4 · 2022 · External reference
Barriers and strategies for oral peptide and protein therapeutics delivery: update on clinical advances
10.3390/pharmaceutics17040397 · 2025 · External reference
Peptides as a platform for targeted therapeutics for cancer: peptide–drug conjugates (PDCs)
10.1039/d0cs00556h · 2021 · External reference
Antimicrobial peptides and their druggability, bio‐safety, stability, and resistance
2024 · External reference
Current status of the application of antimicrobial peptides and their conjugated derivatives
10.3390/molecules30153070 · 2025 · External reference
Overcoming delivery challenges of antimicrobial peptides for clinical translation: from nanocarriers to molecular modifications
10.1016/j.drup.2025.101289 · 2025 · External reference
Therapeutic peptides: chemical strategies fortify peptides for enhanced disease treatment efficacy
10.1007/s00726-025-03454-5 · 2025 · External reference
Balancing act of the intestinal antimicrobial proteins on gut microbiota and health
10.1007/s12275-024-00122-3 · 2024 · External reference
Lessons learned from clinical trials using antimicrobial peptides (AMPs)
10.3389/fmicb.2021.616979 · 2021 · External reference
How does an anti‐cancer peptide passively permeate the plasma membrane of a cancer cell and not a normal cell?
10.1021/acs.jpcb.5c00680 · 2025 · External reference
Protein and peptide in cancer research: from biomarker to biotherapeutics
10.3390/cancers17183031 · 2025 · External reference
Peptide‐based nanoparticle for tumor therapy
10.3390/biomedicines13061415 · 2025 · External reference
Advance in peptide‐based drug development: delivery platforms, therapeutics and vaccines
10.1038/s41392-024-02107-5 · 2025 · External reference
Unlocking the potential of tumor‐targeting peptides in precision oncology
10.32604/or.2025.062197 · 2025 · External reference
Beyond efficacy: ensuring safety in peptide therapeutics through immunogenicity assessment
10.1002/psc.70016 · 2025 · External reference
Treatment‐induced and pre‐existing anti‐peg antibodies: prevalence, clinical implications, and future perspectives
10.1016/j.xphs.2023.11.001 · 2024 · External reference
Identification of a mast‐cell‐specific receptor crucial for pseudo‐allergic drug reactions
10.1038/nature14022 · 2015 · External reference
Complex in vitro model: a transformative model in drug development and precision medicine
10.1111/cts.13695 · 2024 · External reference
Computational approaches streamlining drug discovery
10.1038/s41586-023-05905-z · 2023 · External reference
The FoldX web server: an online force field
10.1093/nar/gki387 · 2005 · External reference
A deep learning framework (CreoPep) for target‐specific design and optimization of conotoxin peptides
10.1038/s42004-025-01885-5 · 2026 · External reference
Peptide design through binding interface mimicry with PepMimic
2025 · External reference
PepINVENT: generative peptide design beyond natural amino acids
10.1039/d4sc07642g · 2025 · External reference
Nanocarrier system: an emerging strategy for bioactive peptide delivery
10.3389/fnut.2022.1050647 · 2022 · External reference
Improve stability of bioactive peptides by enzymatic modular synthesis of peptides with O‐linked sialyl Lewis x
10.1021/acscatal.1c00955 · 2021 · External reference
Formulation, characterisation and evaluation of the antihypertensive peptides, isoleucine‐proline‐proline and leucine‐lysine‐proline in chitosan nanoparticles coated with zein for oral drug delivery
10.3390/ijms231911160 · 2022 · External reference
Encapsulation of selenium‐containing peptides in xanthan gum‐lysozyme nanoparticles as a powerful gastrointestinal delivery system
10.1016/j.foodres.2022.111351 · 2022 · External reference
Engineering bispecific peptides for precision immunotherapy and beyond
10.3390/ijms262010082 · 2025 · External reference
Recent Advancement, mechanisms of action and applications of tumor‐targeting peptides
10.15419/4sem5685 · 2025 · External reference
Azurin‐based peptide p28 disrupts p53–HDM2 interactions: insights from in silico studies
10.1039/d5cp02358k · 2026 · External reference
In situ bioconjugation of synthetic peptides onto universal chimeric antigen receptor T cells for targeted cancer immunotherapies
10.1021/acsnano.4c16824 · 2025 · External reference
Structural changes in peptide‐Scfv bispecific cars impact T cell effector function against acute myeloid leukemia
10.1182/blood-2022-169508 · 2022 · External reference
Human β‐defensin 3 has immunosuppressive activity in vitro and in vivo
10.1002/eji.200940041 · ExternalCitation · doi-reference
Efficacy of marine biomolecules on angiogenesis by targeting hypoxia inducible factor/vascular endothelial growth factor signaling in zebrafish model
10.1002/jbt.22954 · ExternalCitation · doi-reference
Beyond efficacy: ensuring safety in peptide therapeutics through immunogenicity assessment
10.1002/psc.70016 · ExternalCitation · doi-reference
In silico peptide design: methods, resources, and role of AI
10.1002/psc.70063 · ExternalCitation · doi-reference
Bioactive peptide nanodrugs based on supramolecular assembly for boosting immunogenic cell death‐induced cancer immunotherapy
10.1002/smtd.202201708 · ExternalCitation · doi-reference
Polysialic acids: potential in improving the stability and pharmacokinetics of proteins and other therapeutics
10.1007/pl00000676 · ExternalCitation · doi-reference
Cytochrome P450‐dependent biotransformation capacities in embryonic, juvenile and adult stages of zebrafish (Danio rerio)—a state‐of‐the‐art review
10.1007/s00204-021-03071-7 · ExternalCitation · doi-reference
MAPK signaling pathway‐targeted marine compounds in cancer therapy
10.1007/s00432-020-03460-y · ExternalCitation · doi-reference
Antimicrobial and antitumor properties of anuran peptide temporin‐SHf induce apoptosis in A549 lung cancer cells
10.1007/s00726-023-03373-3 · ExternalCitation · doi-reference
Therapeutic peptides: chemical strategies fortify peptides for enhanced disease treatment efficacy
10.1007/s00726-025-03454-5 · ExternalCitation · doi-reference
Effect of dimerization of a β‐turn antimicrobial peptide, PST13‐RK, on antimicrobial activity and mammalian cell toxicity
10.1007/s10529-008-9848-5 · ExternalCitation · doi-reference
First‐in‐human phase I study of SOR‐C13, a TRPV6 calcium channel inhibitor, in patients with advanced solid tumors
10.1007/s10637-017-0438-z · ExternalCitation · doi-reference
BMAP‐27 peptide reduces proliferation and increases apoptosis in primary and metastatic colon cancer cell lines
10.1007/s10989-023-10572-9 · ExternalCitation · doi-reference
Temporin‐1CEa and its analog LK2 (6) A (L) confer neuroprotective effects in Parkinson's disease model by attenuating neuroinflammation via the NF‐κB and MAPK signaling pathways
10.1007/s11481-025-10241-2 · ExternalCitation · doi-reference
Dermaseptin B2 bioactive gene's potential for anticancer and anti‐proliferative effect is linked to the regulation of the BAX/BBC3/AKT pathway
10.1007/s12032-024-02384-8 · ExternalCitation · doi-reference
Balancing act of the intestinal antimicrobial proteins on gut microbiota and health
10.1007/s12275-024-00122-3 · ExternalCitation · doi-reference
Anticancer bioactive peptide (ACBP) inhibits gastric cancer cells by upregulating growth arrest and DNA damage‐inducible gene 45A (GADD45A)
10.1007/s13277-014-2272-7 · ExternalCitation · doi-reference
Bioactive peptides and metabolic health: a mechanistic review of the impact on insulin sensitivity, lipid profiles, and inflammation
10.1016/j.afres.2025.101056 · ExternalCitation · doi-reference
Interaction of a short antimicrobial peptide on charged lipid bilayer: a case study on aurein 1.2 peptide
10.1016/j.bbadva.2022.100045 · ExternalCitation · doi-reference
Antitumor activity of Tigerinin‐1: necroptosis mediates toxicity in A549 cells
10.1016/j.bbagen.2022.130182 · ExternalCitation · doi-reference
Mastoparan is a membranolytic anti‐cancer peptide that works synergistically with gemcitabine in a mouse model of mammary carcinoma
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Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin
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