Research graph
References from Maternal and Postnatal Effects of Poly I:C‐Induced Intrauterine Inflammation and Rytvela, a Non‐Competitive IL‐1R Antagonist, in the Pregnant Spiny Mouse. Local targets link to admitted publications; unresolved targets remain external evidence.
Maternal Immune Activation by Poly (I: C) Induces Expression of Cytokines IL‐1β and IL‐13, Chemokine MCP‐1 and Colony Stimulating Factor VEGF in Fetal Mouse Brain
10.1186/1742-2094-9-83 · 2012 · External reference
Maternal Immune Activation by Poly I:C Induces Expression of Cytokines IL‐1β and IL‐13, Chemokine MCP‐1 and Colony Stimulating Factor VEGF in Fetal Mouse Brain
10.1186/1742-2094-9-83 · 2012 · External reference
The Different Effects of LPS and Poly I: C Prenatal Immune Challenges on the Behavior, Development and Inflammatory Responses in Pregnant Mice and Their Offspring
10.1016/j.bbi.2013.12.016 · 2014 · External reference
Prenatal Infection as a Risk Factor for Schizophrenia
10.1093/schbul/sbj052 · 2006 · External reference
Serologic Evidence of Prenatal Influenza in the Etiology of Schizophrenia
10.1001/archpsyc.61.8.774 · 2004 · External reference
Nonaffective Psychosis After Prenatal Exposure to Rubella
10.1176/appi.ajp.157.3.438 · 2000 · External reference
Maternal Exposure to Toxoplasmosis and Risk of Schizophrenia in Adult Offspring
10.1176/appi.ajp.162.4.767 · 2005 · External reference
Maternal Exposure to respiratory Infections and Adult Schizophrenia Spectrum Disorders: a Prospective Birth Cohort Study
10.1093/oxfordjournals.schbul.a033453 · 2000 · External reference
A Comparative Study of Prenatal Development in the Olfactory Bulb, Neocortex and Hippocampal Region of the Precocial Mouse Acomys cahirinus and Rat
10.1016/0165-3806(89)90055-2 · 1989 · External reference
The Precocial Mouse, Acomys cahirinus
10.3758/bf03327252 · 1990 · External reference
A Comprehensive Approach to Modeling Maternal Immune Activation in Rodents
10.3389/fnins.2022.1071976 · 2022 · External reference
Inhibition of Interleukin‐1 Signaling Protects Against Group B Streptococcus‐Induced Preterm Birth and Fetal Loss in Mice
10.1016/j.jri.2025.104520 · 2025 · External reference
Critical Regulation of Early Th17 Cell Differentiation by Interleukin‐1 Signaling
10.1016/j.immuni.2009.02.007 · 2009 · External reference
Production of IL‐1beta and IL‐1Ra as Risk Factors for Susceptibility and Progression of Relapse‐Onset Multiple Sclerosis
10.1016/s0165-5728(02)00056-5 · 2002 · External reference
Toll‐Like Receptors: The Swiss Army Knife of Immunity and Vaccine Development
10.1038/cti.2016.22 · 2016 · External reference
Optimising Reliability of Mouse Performance in Behavioural Testing: The Major Role of Non‐Aversive Handling
10.1038/srep44999 · 2017 · External reference
Pharmacodynamic Characterization of Rytvela, a Novel Allosteric Anti‐Inflammatory Therapeutic, to Prevent Preterm Birth and Improve Fetal and Neonatal Outcomes
10.1016/j.ajog.2022.10.007 · 2023 · External reference
Maternal Immune Activation by Poly I: C as a Preclinical Model for Neurodevelopmental Disorders: A Focus on Autism and Schizophrenia
10.1016/j.neubiorev.2020.04.012 · 2020 · External reference
The Biology and Husbandry of the African Spiny Mouse (Acomys cahirinus) and the Research Uses of a Laboratory Colony
2016 · External reference
Poly (dI· dC)‐Induced Toll‐Like Receptor 3 (TLR3)‐Mediated Activation of NFκB and MAP Kinase Is Through an Interleukin‐1 Receptor‐Associated Kinase (IRAK)‐Independent Pathway Employing the Signaling Components TLR3‐TRAF6‐TAK1‐TAB2‐PKR
10.1074/jbc.m300562200 · 2003 · External reference
The Role of Brain Interleukin‐1 in Stress‐Enhanced Fear Learning
10.1038/npp.2014.317 · 2015 · External reference
Interleukin‐1: An Important Target for Perinatal Neuroprotection?
10.4103/1673-5374.341044 · 2023 · External reference
Global, Regional, and National Causes of Child Mortality: An Updated Systematic Analysis for 2010 With Time Trends Since 2000
10.1016/s0140-6736(12)60560-1 · 2012 · External reference
Novel Object Recognition Test for the Investigation of Learning and Memory in Mice
2017 · External reference
Poly I:C‐Induced Maternal Immune Activation Causes Schizophrenia‐Like Memory and Prepulse Inhibition Deficits in the Offspring by Upregulating IL‐6
10.1016/j.brainresbull.2026.111848 · 2026 · External reference
Antenatal Suppression of IL‐1 Protects Against Inflammation‐induced Fetal Injury and Improves Neonatal and Developmental Outcomes in Mice
10.4049/jimmunol.1601600 · 2017 · External reference
Novel Noncompetitive IL‐1 Receptor–Biased Ligand Prevents Infection‐ and Inflammation‐Induced Preterm Birth
10.4049/jimmunol.1500758 · 2015 · External reference
At the Crux of Maternal Immune Activation: Viruses, Microglia, Microbes, and IL‐17A
10.1111/imr.13125 · 2022 · External reference
Prenatal Poly(I:C) Exposure, Rather Than Altered Maternal Care, Causes Offspring Behavioural and Cognitive Deficits in a Rat Model of Neurodevelopmental Disorders
10.1016/j.bbi.2025.06.005 · 2025 · External reference
Interleukin‐1 and Ischemic Brain Injury in the Newborn: Development of a Small Molecule Inhibitor of IL‐1 Receptor
10.1053/j.semperi.2008.07.001 · 2008 · External reference
Development of a Novel Noncompetitive Antagonist of IL‐1 Receptor
10.4049/jimmunol.180.10.6977 · 2008 · External reference
Understanding the Behavioural Phenotype of the Precocial Spiny Mouse
10.1016/j.bbr.2014.08.035 · 2014 · External reference
Prenatal Exposure to the Viral Mimetic Poly I: C Alters Fetal Brain Cytokine Expression and Postnatal Behaviour
10.1159/000362205 · 2014 · External reference
Cytokines and the Neurodevelopmental Basis of Mental Illness
10.3389/fnins.2013.00180 · 2013 · External reference
Behaviour and Hippocampus‐Specific Changes in Spiny Mouse Neonates After Treatment of the Mother With the Viral‐Mimetic Poly I: C at Mid‐Pregnancy
10.1016/j.bbi.2012.08.011 · 2012 · External reference
Clinical Chorioamnionitis at Term IV: The Maternal Plasma Cytokine Profile
2016 · External reference
Exploratory Rearing: A Context‐ and Stress‐Sensitive Behavior Recorded in the Open‐Field Test
10.1080/10253890.2018.1438405 · 2018 · External reference
Prenatal Poly I: C Challenge Affects Behaviors and Neurotransmission via Elevated Neuroinflammation Responses in Female Juvenile Rats
10.1093/ijnp/pyab087 · 2022 · External reference
Interleukin‐1 Receptor Antagonists Partially Inhibited Histological Injury but Not Tissue Inflammation in a Sheep Model of Pregnancy
10.1007/s43032-024-01781-8 · 2025 · External reference
Direct Administration of the Non‐Competitive Interleukin‐1 Receptor Antagonist Rytvela Transiently Reduced Intrauterine Inflammation in an Extremely Preterm Sheep Model of Chorioamnionitis
10.1371/journal.pone.0257847 · 2021 · External reference
The Enhanced Production of Placental Interleukin‐1 During Labor and Intrauterine Infection
10.1016/0002-9378(91)90241-i · 1991 · External reference
The Long‐Term Behavioural Effects of Maternal Creatine Supplementation in a Spiny Mouse Model of Birth Asphyxia
2025 · External reference
TRIF‐Dependent TLR Signaling, Its Functions in Host Defense and Inflammation, and Its Potential as a Therapeutic Target
10.1189/jlb.2ri1115-531r · 2016 · External reference
Automated Measurement of Mouse Freezing Behavior and Its Use for Quantitative Trait Locus Analysis of Contextual Fear Conditioning in (BALB/cJ × C57BL/6J)F2 Mice
10.1101/lm.5.4.391 · 1998 · External reference
The Use of the Elevated Plus Maze as an Assay of Anxiety‐Related Behavior in Rodents
10.1038/nprot.2007.44 · 2007 · External reference
Viral Infections During Pregnancy: The Big Challenge Threatening Maternal and Fetal Health
10.1097/fm9.0000000000000133 · 2022 · External reference
