Research graph
References from Kv3.1 activation suppresses provoked and spontaneous seizures in a mouse Dravet syndrome model. Local targets link to admitted publications; unresolved targets remain external evidence.
Synaptic vesicle glycoprotein 2A knockout in parvalbumin and somatostatin interneurons drives seizures in the postnatal mouse brain
10.1523/jneurosci.1169-24.2024 · 2025 · External reference
A comparison of the antiepileptogenic efficacy of two rationally chosen multitargeted drug combinations in a rat model of posttraumatic epilepsy
10.1016/j.expneurol.2024.114962 · 2024 · External reference
Disruption of KCC2 in parvalbumin‐positive interneurons is associated with a decreased seizure threshold and a progressive loss of parvalbumin‐positive interneurons
10.3389/fnmol.2021.807090 · 2021 · External reference
Increase in seizure susceptibility after repetitive concussion results from oxidative stress, parvalbumin‐positive interneuron dysfunction and biphasic increases in glutamate/GABA ratio
10.1093/cercor/bhaa157 · 2020 · External reference
Parvalbumin interneuron impairment causes synaptic transmission deficits and seizures in SCN8A developmental and epileptic encephalopathy
10.1172/jci.insight.181005 · 2024 · External reference
Chemogenetic recruitment of specific interneurons suppresses seizure activity
10.3389/fncel.2018.00293 · 2018 · External reference
Activation of hypoactive parvalbumin‐positive fast‐spiking interneurons restores dentate inhibition to reduce electrographic seizures in the mouse intrahippocampal kainate model of temporal lobe epilepsy
10.1016/j.nbd.2024.106737 · 2024 · External reference
Chemogenetic activation of feed‐forward inhibitory parvalbumin‐expressing interneurons in the Cortico‐Thalamocortical network during absence seizures
10.3389/fncel.2021.688905 · 2021 · External reference
From genotype to phenotype in Dravet disease
10.1016/j.seizure.2016.10.014 · 2017 · External reference
Preferential inactivation of Scn1a in parvalbumin interneurons increases seizure susceptibility
10.1016/j.nbd.2012.08.012 · 2013 · External reference
Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure‐associated sudden death in a mouse model of Dravet syndrome
10.1093/hmg/ddt331 · 2013 · External reference
Nav1.1 localizes to axons of parvalbumin‐positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation
10.1523/jneurosci.5270-06.2007 · 2007 · External reference
K(+) channel expression distinguishes subpopulations of parvalbumin‐ and somatostatin‐containing neocortical interneurons
10.1523/jneurosci.19-21-09332.1999 · 1999 · External reference
Parvalbumin role in epilepsy and psychiatric comorbidities: from mechanism to intervention
10.3389/fnint.2022.765324 · 2022 · External reference
Contributions of Kv3 channels to neuronal excitability
10.1111/j.1749-6632.1999.tb11295.x · 1999 · External reference
Brain structure. Cell types in the mouse cortex and hippocampus revealed by single‐cell RNA‐seq
10.1126/science.aaa1934 · 2015 · External reference
Targeted therapy improves cellular dysfunction, ataxia, and seizure susceptibility in a model of a progressive myoclonus epilepsy
10.1016/j.xcrm.2023.101389 · 2024 · External reference
Encephalopathies with KCNC1 variants: genotype‐phenotype‐functional correlations
10.1002/acn3.50822 · 2019 · External reference
A recurrent de novo mutation in KCNC1 causes progressive myoclonus epilepsy
10.1038/ng.3144 · 2015 · External reference
Ion dynamics during seizures
10.3389/fncel.2015.00419 · 2015 · External reference
Mapping genetic modifiers of survival in a mouse model of Dravet syndrome
10.1111/gbb.12099 · 2014 · External reference
PTZ‐induced seizures in mice require a revised Racine scale
10.1016/j.yebeh.2019.02.029 · 2019 · External reference
Depressed glutamate transporter 1 expression in a mouse model of Dravet syndrome
10.1002/acn3.51851 · 2023 · External reference
Exploration of group II metabotropic glutamate receptor modulation in mouse models of Rett syndrome and MECP2 duplication syndrome
10.1016/j.neuropharm.2022.109022 · 2022 · External reference
N‐acetylcysteine treatment mitigates loss of cortical parvalbumin‐positive interneuron and perineuronal net integrity resulting from persistent oxidative stress in a rat TBI model
10.1093/cercor/bhac327 · 2023 · External reference
Ceftriaxone treatment preserves cortical inhibitory interneuron function via transient salvage of GLT‐1 in a rat traumatic brain injury model
10.1093/cercor/bhy328 · 2019 · External reference
Trajectory of parvalbumin cell impairment and loss of cortical inhibition in traumatic brain injury
10.1093/cercor/bhw318 · 2017 · External reference
A behavioral screen for heat‐induced seizures in mouse models of epilepsy
2021 · External reference
Temperature‐ and age‐dependent seizures in a mouse model of severe myoclonic epilepsy in infancy
10.1073/pnas.0813330106 · 2009 · External reference
Effect of anticonvulsants on seizures developing in the course of daily administration of pentetrazol to rats
10.1016/0014-2999(77)90086-3 · 1977 · External reference
Kv3 channels: voltage‐gated K+ channels designed for high‐frequency repetitive firing
10.1016/s0166-2236(00)01892-0 · 2001 · External reference
Pharmacological rescue of mutated K(v)3.1 ion‐channel linked to progressive myoclonus epilepsies
10.1016/j.ejphar.2018.06.015 · 2018 · External reference
Ankyrin‐R regulates fast‐spiking interneuron excitability through perineuronal nets and Kv3.1b K(+) channels
10.7554/elife.66491 · 2021 · External reference
Myoclonus epilepsy and ataxia due to potassium channel mutation (MEAK) is caused by heterozygous KCNC1 mutations
2016 · External reference
K(v)3.1/K(v)3.2 channel positive modulators enable faster activating kinetics and increase firing frequency in fast‐spiking GABAergic interneurons
10.1016/j.neuropharm.2017.02.024 · 2017 · External reference
Impaired excitability of fast‐spiking neurons in a novel mouse model of KCNC1 epileptic encephalopathy
10.7554/elife.103784 · 2026 · External reference
Perineuronal net dynamics in the pathophysiology of epilepsy
10.1177/15357597211018688 · 2021 · External reference
Mechanism of activity‐dependent downregulation of the neuron‐specific K‐Cl cotransporter KCC2
10.1523/jneurosci.5265-03.2004 · 2004 · External reference
Casein kinase 2 determines the voltage dependence of the Kv3.1 channel in auditory neurons and transfected cells
10.1523/jneurosci.21-04-01160.2001 · 2001 · External reference
Subunit specific altered expression and activity of casein kinase 2 in the brain tissues resected from mesial temporal lobe epilepsy with hippocampal sclerosis patients & rodent temporal lobe epilepsy model
10.1016/j.neuroscience.2025.03.001 · 2025 · External reference
Seizure‐induced oxidative stress in temporal lobe epilepsy
10.1155/2015/745613 · 2015 · External reference
Oxidative stress‐related cellular aging causes dysfunction of the Kv3.1/KCNC1 channel reverted by melatonin
10.1111/acel.14185 · 2024 · External reference
Parvalbumin interneuron dysfunction in neurological disorders: focus on epilepsy and Alzheimer's disease
10.3390/ijms25105549 · 2024 · External reference
Plasticity during sleep is linked to specific regulation of cortical circuit activity
10.3389/fncir.2017.00065 · 2017 · External reference
Life‐span characterization of epilepsy and comorbidities in Dravet syndrome mice carrying a targeted deletion of exon 1 of the Scn1a gene
10.1016/j.expneurol.2022.114090 · 2022 · External reference
Altered sleep regulation in a mouse model of SCN1A‐derived genetic epilepsy with febrile seizures plus (GEFS+)
10.1111/epi.12060 · 2013 · External reference
Modulators of Kv3 potassium channels rescue the auditory function of fragile X mice
10.1523/jneurosci.0839-18.2019 · 2019 · External reference
The effects of AUT00206, a novel Kv3.1/3.2 potassium channel modulator, on task‐based reward system activation: a test of mechanism in schizophrenia
10.1007/s00213-022-06216-3 · 2022 · External reference
Antimanic efficacy of a novel Kv3 Potassium Channel modulator
10.1038/npp.2017.155 · 2018 · External reference
A novel modulator of Kv3 potassium channels regulates the firing of parvalbumin‐positive cortical interneurons
10.1124/jpet.115.225748 · 2015 · External reference
