Research graph
References from Gastrodia elata Polysaccharide Attenuates Aging by Modulating Oxidative Stress, Inflammation, and Gut Microbiota. Local targets link to admitted publications; unresolved targets remain external evidence.
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Lactobacillus paracasei LP18 Ameliorated Inflammation and Intestinal Barrier Dysfunction in Severe Acute Pancreatitis via Gut Microbiota‐Mediated Regulation of Butyrate Metabolism
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Centenary of the Death of Elie Metchnikoff: A Visionary and an Outstanding Team Leader
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Mitigation of Ischemia/Reperfusion Injury via Selenium Nanoparticles: Suppression of STAT1 to Inhibit Cardiomyocyte Oxidative Stress and Inflammation
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Preparation, Characterization and Anti‐Ageing Activity of Gastrodia elata Blume Polysaccharide
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Physicochemical Properties, Antioxidant Activity and Immunological Effects In Vitro of Polysaccharides From Schisandra sphenanthera and Schisandra chinensis
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Molecular Mechanisms Underlying Apple Extract Ameliorates Depression‐Incident Cognitive Dysfunction Based on Network Pharmacology
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A Gastrodia elata Polysaccharide for Restoring Intestinal Immunocompromise
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Intestinal Stem Cells: Guardians of Homeostasis in Health and Aging Amid Environmental Challenges
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Age‐Related Loss of Intestinal Barrier Integrity Plays an Integral Role in Thymic Involution and T Cell Ageing
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Intestinal Interoceptive Dysfunction Drives Age‐Associated Cognitive Decline
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Towards a Better Understanding of the Relationships Between the Structure and Antitumor Activity of Gastrodia elata Polysaccharides by Asymmetrical Flow Field‐Flow Fractionation
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Gut Microbiome and Health: Mechanistic Insights
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NF‐κB and AMPK‐Nrf2 Pathways Support the Protective Effect of Polysaccharides From Polygonatum cyrtonema Hua in Lipopolysaccharide‐Induced Acute Lung Injury
10.1016/j.jep.2022.115153 · 2022 · External reference
Gastrodia elata Polysaccharide Alleviates Parkinson's Disease via Inhibiting Apoptotic and Inflammatory Signaling Pathways and Modulating the Gut Microbiota
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Longevity Leap: Mind the Healthspan Gap
10.1038/s41536-021-00169-5 · 2021 · External reference
Traditional Uses, Phytochemistry, Pharmacology, Applications, and Quality Control of Gastrodia elata Blume: A Comprehensive Review
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Oxidative Stress, Inflammation, and Vascular Aging in Hypertension
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Parkinson's Disease and the Gut‐Brain Connection: Unveiling Pathways, Mechanisms and Promising Therapies
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Gastrodiae Rhizoma Attenuates Brain Aging via Promoting Neuritogenesis and Neurodifferentiation
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Age‐Related Alterations in Gut Homeostasis Are Microbiota Dependent
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Supplementing Glycine and N‐Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial
10.1093/gerona/glac135 · 2023 · External reference
Pharmacodynamic Components and Molecular Mechanism of Gastrodia elata Blume in Treating Hypertension: Absorbed Components, Network Pharmacology Analysis, Molecular Docking and In Vivo Experimental Verification
10.1016/j.jep.2025.119583 · 2025 · External reference
Lactobacillus casei Improve Anti‐Tuberculosis Drugs‐Induced Intestinal Adverse Reactions in Rat by Modulating Gut Microbiota and Short‐Chain Fatty Acids
10.3390/nu14081668 · 2022 · External reference
Gastrodia elata‐Derived Parishin Extracts Attenuate Aging by Modulating Oxidative Stress, Inflammation, Apoptosis, and Metabolism
10.1002/fsn3.71737 · 2026 · External reference
Nuclear microRNA‐Mediated Transcriptional Control Determines Adult Microglial Homeostasis and Brain Function
10.1016/j.celrep.2024.113964 · 2024 · External reference
Breviscapine Exerts Neuroprotective Effects Through Multiple Mechanisms in APP/PS1 Transgenic Mice
10.1007/s11010-020-03698-7 · 2020 · External reference
1,3‐ and 1,4‐Linked Polysaccharides Uptake in Intestinal Cells Relies on Clathrin/Dynamin 1/Rab5‐Dependent Endocytosis
10.1038/s41467-026-68542-w · 2026 · External reference
Effect of Water‐Soluble Polysaccharides From Morchella esculenta on High‐Fat Diet‐Induced Obese Mice: Changes in Gut Microbiota and Metabolic Functions
10.1039/d3fo00574g · 2023 · External reference
A Comprehensive Pharmacology Study Reveals the Molecular Mechanisms Underlying the Antidepressant Effects of Gastrodiae Rhizoma
10.1016/j.phymed.2025.156761 · 2025 · External reference
Hallmarks of Aging: An Expanding Universe
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10.1016/j.crfs.2023.100459 · 2023 · External reference
Ganoderic Acids Alleviate Neuroinflammation by Targeting Myeloid Differentiation Factor 2 for Ischemic Stroke Therapy
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The Antioxidant, Antibacterial and Infected Wound Healing Effects of Dioscorea opposita Polysaccharide‐Zinc Oxide Nanocomposites
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Gut Microbiota Remodeling Improves Natural Aging‐Related Disorders Through Akkermansia muciniphila and Its Derived Acetic Acid
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BBB‐Permeable, Neuroprotective, and Neurotrophic Polysaccharide, Midi‐GAGR
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Gastrodia elata and Epilepsy: Rationale and Therapeutic Potential
10.1016/j.phymed.2016.09.001 · 2016 · External reference
Alterations in Oxidative, Inflammatory and Apoptotic Events in Short‐Lived and Long‐Lived Mice Testes
10.18632/aging.100875 · 2016 · External reference
Reducing Senescent Cell Burden in Aging and Disease
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Protective Effects of Sesamol on Systemic Oxidative Stress‐Induced Cognitive Impairments via Regulation of Nrf2/Keap1 Pathway
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Spontaneous DNA Damage to the Nuclear Genome Promotes Senescence, Redox Imbalance and Aging
10.1016/j.redox.2018.04.007 · 2018 · External reference
Multivariate Genome‐Wide Analysis of Aging‐Related Traits Identifies Novel Loci and New Drug Targets for Healthy Aging
10.1038/s43587-023-00455-5 · 2023 · External reference
Alzheimer's Disease Pathogenic Mechanisms: Linking Redox Homeostasis and Mitochondria‐Associated Metabolic Pathways Through Nuclear Factor Erythroid 2‐Related Factor 2 (Nrf2)
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Intestinal Barrier Dysfunction: An Evolutionarily Conserved Hallmark of Aging
10.1242/dmm.049969 · 2023 · External reference
Healthy Ageing in Older Adults With Cardiovascular Disease
10.1093/eurheartj/ehaf231 · 2025 · External reference
ROS‐Induced Ribosome Impairment Underlies ZAKα‐Mediated Metabolic Decline in Obesity and Aging
10.1126/science.adf3208 · 2023 · External reference
Inhibitory Effect of Ent‐Sauchinone on Amyloidogenesis via Inhibition of STAT3‐Mediated NF‐κB Activation in Cultured Astrocytes and Microglial BV‐2 Cells
10.1186/1742-2094-11-118 · 2014 · External reference
10.14336/ad.2025.1201
10.14336/ad.2025.1201 · External reference
Charting Human Cellular Senescence in Aging and Disease
10.1016/j.cell.2026.05.028 · 2026 · External reference
Growth Differentiation Factor 11 Alleviates Oxidative Stress‐Induced Senescence of Endothelial Progenitor Cells via Activating Autophagy
10.1186/s13287-024-03975-y · 2024 · External reference
Structural Characterization and Antioxidant Activity of Alkali‐Extracted Polysaccharides From Quinoa
10.1016/j.foodhyd.2020.106392 · 2021 · External reference
Recent Advances in the Anti‐Aging Effects of Natural Polysaccharides: Sources, Structural Characterization, Action Mechanisms and Structure‐Activity Relationships
10.1016/j.tifs.2025.105000 · 2025 · External reference
The Gut Microbiome and Ageing Trajectories: Mechanisms and Clinical Implications
10.1038/s41574-026-01236-x · 2026 · External reference
Oxidative Stress and Mitochondrial Dysfunction in Neurodegenerative Diseases
10.1016/j.neuroscience.2006.10.056 · 2007 · External reference
Akkermansia muciniphila ‐Derived SCFAs Improve the Depression‐Like Behaviors of Mice by Inhibiting Neuroinflammation
10.1016/j.phrs.2025.107938 · 2025 · External reference
Ultrasound‐Assisted Extraction of Polysaccharide From Spent Lentinus edodes Substrate: Process Optimization, Precipitation, Structural Characterization and Antioxidant Activity
10.1016/j.ijbiomac.2021.09.174 · 2021 · External reference
Ginger Processing Remodels the Metabolome Profile of Gastrodia elata and Potentiates Its Neuroprotective Effects
10.1016/j.phymed.2025.157469 · 2025 · External reference
Multifunctional Gastrodia elata Polysaccharide‐Based Triple‐Network Hydrogel Promotes Staphylococcus aureus Infected Diabetes Wound
10.1016/j.carbpol.2025.123983 · 2025 · External reference
Low‐Molecular‐Weight Heparin Ameliorates Intestinal Barrier Dysfunction in Aged Male Rats via Protection of Tight Junction Proteins
10.1007/s10522-024-10118-6 · 2024 · External reference
Gastrodin Regulates the TLR4/TRAF6/NF‐κB Pathway to Reduce Neuroinflammation and Microglial Activation in an AD Model
10.1016/j.phymed.2024.155518 · 2024 · External reference
Integrative Single‐Cell Metabolomics and Phenotypic Profiling Reveals Metabolic Heterogeneity of Cellular Oxidation and Senescence
10.1038/s41467-025-57992-3 · 2025 · External reference
Gastrodia elata Polysaccharide Alleviates Depression via Gut Microbiota Modulation and Keap1‐Nrf2/BDNF‐TrkB Pathway Activation
10.1016/j.ijbiomac.2025.144630 · 2025 · External reference
Inhibition of IL‐11 Signalling Extends Mammalian Healthspan and Lifespan
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Gut Microbiome Pattern Reflects Healthy Ageing and Predicts Survival in Humans
10.1038/s42255-021-00348-0 · 2021 · External reference
Unresolved reference
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Therapeutic Efficacy and Underlying Mechanisms of Gastrodia elata Polysaccharides on Dextran Sulfate Sodium‐Induced Inflammatory Bowel Disease in Mice: Modulation of the Gut Microbiota and Improvement of Metabolic Disorders
10.1016/j.ijbiomac.2023.125919 · 2023 · External reference
From Nature to Clinic: Lessons From Successfully Marketed Polysaccharide Drugs
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The Flavonoid Procyanidin C1 Has Senotherapeutic Activity and Increases Lifespan in Mice
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The Role of Akkermansia muciniphila in the Regulation of Inflammatory Bowel Disease: Intestinal Immunity and Metabolism
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Progress in Understanding Oxidative Stress, Aging, and Aging‐Related Diseases
10.3390/antiox13040394 · 2024 · External reference
Study on the Structure Characterization and Moisturizing Effect of Tremella Polysaccharide Fermented From GCMCC5.39
10.1016/j.fshw.2021.04.009 · 2021 · External reference
Protective Effect of Gastrodia elata Polysaccharide GEP‐2 Against Oxidative Stress in Intestinal Epithelial NCM460 Cells
10.3390/ijms27062655 · 2026 · External reference
Direct Economic Burden Attributable to Age‐Related Diseases in China: An Econometric Modelling Study
10.7189/jogh.13.04042 · 2023 · External reference
Structural Characteristics, Anticoagulant and Antithrombotic Mechanism of a Novel Polysaccharide From Rosa chinensis Flos
10.1016/j.fshw.2022.07.042 · 2023 · External reference
Short‐Chain Fatty Acids Alleviated Fluoride‐Induced Neuroinflammation via the Gut‐Brain Axis in Rats
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Mechanisms for the Biological Activity of Gastrodia elata Blume and Its Constituents: A Comprehensive Review on Sedative‐Hypnotic, and Antidepressant Properties
10.1016/j.phymed.2023.155251 · 2024 · External reference
Effect of Hydrophobic Property on Antibacterial Activities of Green Tea Polysaccharide Conjugates Against Escherichia coli
10.1016/j.ijbiomac.2023.126583 · 2023 · External reference
Gastrodin Reduces Aβ Brain Levels in an Alzheimer's Disease Mouse Model by Inhibiting P‐Glycoprotein Ubiquitination
10.1016/j.phymed.2024.156229 · 2024 · External reference
Effect and Mechanism of Chinese Medicine on Inhibiting the Senescence of Mesenchymal Stem Cells
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