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References from Spatial Transcriptomic Profiling Reveals a Fibroblast‐Associated Extracellular Matrix Niche in KRAS G12C ‐Mutant Lung Adenocarcinoma Primary Tumors From Patients With Metastasis. Local targets link to admitted publications; unresolved targets remain external evidence.
KRAS G12C in Advanced NSCLC: Prevalence, Co‐Mutations, and Testing
10.1016/j.lungcan.2023.107293 · 2023 · External reference
Sotorasib for Lung Cancers With KRAS p.G12C Mutation
10.1056/nejmoa2103695 · 2021 · External reference
Adagrasib in Non‐Small‐Cell Lung Cancer Harboring a KRASG12C Mutation
10.1056/nejmoa2204619 · 2022 · External reference
The Role of Tumor Microenvironment in Cancer Metastasis: Molecular Mechanisms and Therapeutic Opportunities
10.3390/cancers13092053 · 2021 · External reference
The Evolving Tumor Microenvironment: From Cancer Initiation to Metastatic Outgrowth
10.1016/j.ccell.2023.02.016 · 2023 · External reference
Visualization and Analysis of Gene Expression in Tissue Sections by Spatial Transcriptomics
10.1126/science.aaf2403 · 2016 · External reference
High‐Resolution Single‐Cell Atlas Reveals Diversity and Plasticity of Tissue‐Resident Neutrophils in Non‐Small Cell Lung Cancer
10.1016/j.ccell.2022.10.008 · 2022 · External reference
Concepts of Extracellular Matrix Remodelling in Tumour Progression and Metastasis
10.1038/s41467-020-18794-x · 2020 · External reference
Extracellular Matrices and Cancer‐Associated Fibroblasts: Targets for Cancer Diagnosis and Therapy?
10.3390/cancers13143466 · 2021 · External reference
Single‐Cell and Spatial Transcriptomics Reveal POSTN+ Cancer‐Associated Fibroblasts Correlated With Immune Suppression and Tumour Progression in Non‐Small Cell Lung Cancer
10.1002/ctm2.1515 · 2023 · External reference
Unresolved reference
External reference
Spatial Reconstruction of Single‐Cell Gene Expression Data
10.1038/nbt.3192 · 2015 · External reference
Comprehensive Integration of Single‐Cell Data
10.1016/j.cell.2019.05.031 · 2019 · External reference
Robust Decomposition of Cell Type Mixtures in Spatial Transcriptomics
10.1038/s41587-021-00830-w · 2022 · External reference
Gene Ontology: Tool for the Unification of Biology. The Gene Ontology Consortium
10.1038/75556 · 2000 · External reference
clusterProfiler: An R Package for Comparing Biological Themes Among Gene Clusters
10.1089/omi.2011.0118 · 2012 · External reference
Pre‐Metastatic Niche: Formation, Characteristics and Therapeutic Implication
10.1038/s41392-024-01937-7 · 2024 · External reference
Tumor Metastasis: Mechanistic Insights and Therapeutic Interventions
2021 · External reference
Spatial Transcriptomics in Lung Cancer and Pulmonary Diseases: A Comprehensive Review
10.3390/cancers17121912 · 2025 · External reference
The Extracellular Matrix as Hallmark of Cancer and Metastasis: From Biomechanics to Therapeutic Targets
10.1126/scitranslmed.adg3840 · 2024 · External reference
Modulating Extracellular Matrix Stiffness: A Strategic Approach to Boost Cancer Immunotherapy
10.1038/s41419-024-06697-4 · 2024 · External reference
Cancer‐Associated Fibroblasts Expressing Fibroblast Activation Protein and Podoplanin in Non‐Small Cell Lung Cancer Predict Poor Clinical Outcome
10.1038/s41416-024-02671-1 · 2024 · External reference
Matrix Proteoglycans in Tumor Inflammation and Immunity
10.1152/ajpcell.00023.2022 · 2022 · External reference
Versican in Nonsmall Cell Lung Cancer: Relation to Hyaluronan, Clinicopathologic Factors, and Prognosis
10.1016/j.humpath.2004.10.010 · 2005 · External reference
TGF‐β1 Dominates Stromal Fibroblast‐Mediated EMT via the FAP/VCAN Axis in Bladder Cancer Cells
10.1186/s12967-023-04303-3 · 2023 · External reference
Resveratrol Suppresses Growth and VCAN Expression in a Cancer‐Associated Fibroblast‐Breast Cancer Hybrid Organoid
10.1016/j.intimp.2025.114451 · 2025 · External reference
Spatial Omics: Applications and Utility in Profiling the Tumor Microenvironment
10.1007/s10555-025-10304-z · 2025 · External reference
Versican Associates With Tumor Immune Phenotype and Limits T‐Cell Trafficking via Chondroitin Sulfate
10.1158/2767-9764.crc-23-0548 · 2024 · External reference
PoweREST: Statistical Power Estimation for Spatial Transcriptomics Experiments to Detect Differentially Expressed Genes Between Two Conditions
10.1371/journal.pcbi.1013293 · 2025 · External reference
