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References from Causal Associations Between Plasma Metabolites and Stroke Risk Identified by Mendelian Randomization. Local targets link to admitted publications; unresolved targets remain external evidence.
The Global Burden of Stroke
10.1177/17474930231181677 · 2023 · External reference
Increasing Burden of Stroke in China: A Systematic Review and Meta‐Analysis of Prevalence, Incidence, Mortality, and Case Fatality
10.1177/17474930221135983 · 2023 · External reference
Metabolomics and Metabolites in Ischemic Stroke
10.1515/revneuro-2021-0048 · 2022 · External reference
Emerging Applications of Metabolomics in Drug Discovery and Precision Medicine
10.1038/nrd.2016.32 · 2016 · External reference
Acupuncture for Ischemic Stroke: Where Are We Now?
10.1097/hm9.0000000000000094 · 2024 · External reference
10.1007/978-1-4939-2377-9
10.1007/978-1-4939-2377-9 · 2015 · External reference
Metabolomics of Ischemic Stroke: Insights Into Risk Prediction and Mechanisms
10.1007/s11011-022-01011-7 · 2022 · External reference
Comparative Targeted Metabolomics of Ischemic Stroke: Thrombi and Serum Profiling for the Identification of Stroke‐Related Metabolites
2024 · External reference
Blood Biomarkers for Stroke Diagnosis and Management
10.1007/s12017-019-08530-0 · 2019 · External reference
Data Dredging, Bias, or Confounding
10.1136/bmj.325.7378.1437 · 2002 · External reference
Mendelian Randomization: Concepts and Scope
10.1101/cshperspect.a040501 · 2022 · External reference
Whole‐Genome Sequencing Identifies Common‐To‐Rare Variants Associated With Human Blood Metabolites
10.1038/ng.3809 · 2017 · External reference
Heritability Estimates for 361 Blood Metabolites Across 40 Genome‐Wide Association Studies
10.1038/s41467-019-13770-6 · 2020 · External reference
‘Mendelian Randomization’: An Approach for Exploring Causal Relations in Epidemiology
10.1016/j.puhe.2016.12.033 · 2017 · External reference
Commentary: The Concept of ‘Mendelian Randomization’
10.1093/ije/dyh048 · 2004 · External reference
Gut Microbiota in Combination With Blood Metabolites Reveals Characteristics of the Disease Cluster of Coronary Artery Disease and Cognitive Impairment: A Mendelian Randomization Study
10.3389/fimmu.2023.1308002 · 2023 · External reference
Causal Effects of Serum Metabolites on Amyotrophic Lateral Sclerosis: A Mendelian Randomization Study
10.1016/j.pnpbp.2019.109771 · 2020 · External reference
Triangulating Evidence From Longitudinal and Mendelian Randomization Studies of Metabolomic Biomarkers for Type 2 Diabetes
10.1038/s41598-021-85684-7 · 2021 · External reference
Causal Relationships Between Gut Metabolites and Alzheimer's Disease: A Bidirectional Mendelian Randomization Study
2021 · External reference
Causal Effects of Genetically Determined Metabolites on Cancers Included Lung, Breast, Ovarian Cancer, and Glioma: A Mendelian Randomization Study
10.21037/tlcr-22-34 · 2022 · External reference
Causal Relationship Between Blood Metabolites and Risk of Five Infections: A Mendelian Randomization Study
10.1186/s12879-023-08662-6 · 2023 · External reference
Mendelian Randomization: Genetic Anchors for Causal Inference in Epidemiological Studies
10.1093/hmg/ddu328 · 2014 · External reference
Association Between Human Blood Metabolome and the Risk of Breast Cancer
10.1186/s13058-023-01609-4 · 2023 · External reference
Assessing the Causal Effects of Human Serum Metabolites on 5 Major Psychiatric Disorders
10.1093/schbul/sbz138 · 2020 · External reference
Causal Relationship Between Obesity, Leptin, and Brain Structure and Functional Connectivity: Evidence Based on Bidirectional and Mediation Mendelian Randomisation Analyses
10.1186/s12986-026-01081-9 · 2026 · External reference
Dissecting Immune Cell Ferroptosis via Single‐Cell Multi‐Omics Identifies RPL8 as a Potential Therapeutic Target for Depression
10.1096/fj.202600636r · 2026 · External reference
Power and Instrument Strength Requirements for Mendelian Randomization Studies Using Multiple Genetic Variants
10.1093/ije/dyq151 · 2011 · External reference
Investigating the Relationship Between Depression and Breast Cancer: Observational and Genetic Analyses
10.1186/s12916-023-02876-w · 2023 · External reference
PhenoScanner V2: An Expanded Tool for Searching Human Genotype–Phenotype Associations
10.1093/bioinformatics/btz469 · 2019 · External reference
Emerging Risk Factors for Stroke: What Have We Learned From Mendelian Randomization Studies?
10.1161/strokeaha.115.010646 · 2016 · External reference
Genomic Atlas of the Plasma Metabolome Prioritizes Metabolites Implicated in Human Diseases
10.1038/s41588-022-01270-1 · 2023 · External reference
Multiancestry Genome‐Wide Association Study of 520,000 Subjects Identifies 32 Loci Associated With Stroke and Stroke Subtypes
10.1038/s41588-018-0058-3 · 2018 · External reference
Classification of Subtypes of Ischemic Stroke: History of the Trial of Org 10 172 in Acute Stroke Treatment Classification
10.1161/strokeaha.114.007773 · 2015 · External reference
A Global Reference for Human Genetic Variation
10.1038/nature15393 · 2015 · External reference
Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data
10.1002/gepi.21758 · 2013 · External reference
Efficient Design for Mendelian Randomization Studies: Subsample and 2‐Sample Instrumental Variable Estimators
10.1093/aje/kwt084 · 2013 · External reference
Interpreting Findings From Mendelian Randomization Using the MR‐Egger Method
10.1007/s10654-017-0255-x · 2017 · External reference
Detection of Widespread Horizontal Pleiotropy in Causal Relationships Inferred From Mendelian Randomization Between Complex Traits and Diseases
10.1038/s41588-018-0099-7 · 2018 · External reference
A Robust and Efficient Method for Mendelian Randomization With Hundreds of Genetic Variants
10.1038/s41467-019-14156-4 · 2020 · External reference
Cochran's Q Test Was Useful to Assess Heterogeneity in Likelihood Ratios in Studies of Diagnostic Accuracy
10.1016/j.jclinepi.2014.09.005 · 2015 · External reference
A Comparison of Robust Mendelian Randomization Methods Using Summary Data
10.1002/gepi.22295 · 2020 · External reference
DNA Methylation Regulates CDK5R1 and NRBP1 to Exert Effects on Alcohol Dependence: Insights From Mendelian Randomization
10.1111/adb.70162 · 2026 · External reference
Orienting the Causal Relationship Between Imprecisely Measured Traits Using GWAS Summary Data
10.1371/journal.pgen.1007081 · 2017 · External reference
Calculating Statistical Power in Mendelian Randomization Studies
10.1093/ije/dyt179 · 2013 · External reference
Distinguishing Genetic Correlation From Causation Across 52 Diseases and Complex Traits
10.1038/s41588-018-0255-0 · 2018 · External reference
The Blood Exposome and Its Role in Discovering Causes of Disease
10.1289/ehp.1308015 · 2014 · External reference
Circulating Metabolites Differentiate Acute Ischemic Stroke From Stroke Mimics
10.1002/ana.25859 · 2020 · External reference
Metabolomics and Lipidomics of Ischemic Stroke
10.1016/bs.acc.2018.02.002 · 2018 · External reference
Application of Metabolomics to the Discovery of Biomarkers for Ischemic Stroke in the Murine Model: A Comparison With the Clinical Results
10.1007/s12035-021-02535-2 · 2021 · External reference
Signaling Pathways Involved in Ischemic Stroke: Molecular Mechanisms and Therapeutic Interventions
10.1038/s41392-022-01064-1 · 2022 · External reference
Prognostic Value of Dehydroepiandrosterone‐Sulfate and Other Parameters of Adrenal Function in Acute Ischemic Stroke
10.1371/journal.pone.0063224 · 2013 · External reference
Low Dehydroepiandrosterone Sulfate Is Associated With Increased Risk of Ischemic Stroke Among Women
10.1161/strokeaha.111.000485 · 2013 · External reference
Single‐Cell RNA Transcriptomics and Multi‐Omics Analyses Reveal the Clinical Effects of Acupuncture on Methadone Reduction
2025 · External reference
Potential Metabolite Biomarkers for Acute Versus Chronic Stage of Ischemic Stroke: A Pilot Study
10.1016/j.jstrokecerebrovasdis.2019.104618 · 2020 · External reference
Targeted Metabolomics Reveals Serum Changes of Amino Acids in Mild to Moderate Ischemic Stroke and Stroke Mimics
10.3389/fneur.2023.1153193 · 2023 · External reference
Amino Acid Biosignature in Plasma Among Ischemic Stroke Subtypes
10.1155/2019/8480468 · 2019 · External reference
Biomarker for Ischemic Stroke Using Metabolome: A Clinician Perspective
10.5853/jos.2018.03454 · 2019 · External reference
Searching for Metabolic Markers of Stroke in Human Plasma via NMR Analysis
10.3390/ijms242216173 · 2023 · External reference
Copeptin: A Novel, Independent Prognostic Marker in Patients With Ischemic Stroke
10.1002/ana.21783 · 2009 · External reference
Hypothalamic–Pituitary–Adrenal Axis Response to the Severity of Illness in Non‐Critically Ill Patients: Does Relative Corticosteroid Insufficiency Exist?
10.1530/eje-09-0883 · 2010 · External reference
Stroke and Neuroinflamation: Role of Sexual Hormones
10.2174/138161282210160304112834 · 2016 · External reference
Poststroke Inflammasome Expression and Regulation in the Peri‐Infarct Area by Gonadal Steroids After Transient Focal Ischemia in the Rat Brain
10.1159/000439435 · 2016 · External reference
Effects of Steroid Hormones on Vascular Functions
10.1002/jemt.10246 · 2003 · External reference
Bile Acids and Bile Acid Derivatives: Use in Drug Delivery Systems and as Therapeutic Agents
10.1080/17425247.2016.1178233 · 2016 · External reference
The Biochemistry and Physiology of Long‐Chain Dicarboxylic Acid Metabolism
10.1042/bcj20230041 · 2023 · External reference
Fatty Acid Transporting Proteins: Roles in Brain Development, Aging, and Stroke
10.1016/j.plefa.2017.04.004 · 2018 · External reference
Carnitine and Its Derivatives in Cardiovascular Disease
10.1016/s0033-0620(97)80037-0 · 1997 · External reference
Unresolved reference
1999 · External reference
Altered Asparagine and Glutamate Homeostasis Precede Coronary Artery Disease and Type 2 Diabetes
10.1210/jc.2018-00546 · 2018 · External reference
A Novel Preliminary Metabolomic Panel for IHD Diagnostics and Pathogenesis
10.1038/s41598-024-53215-9 · 2024 · External reference
Assessing the Causal Effect of Genetically Predicted Metabolites and Metabolic Pathways on Stroke
10.1186/s12967-023-04677-4 · 2023 · External reference
