Research graph
References from Rotenone‐Induced Cytotoxicity in Human Umbilical Vein Endothelial Cells (HUVECs): Involvement of Oxidative Stress, Mitochondrial Dysfunction, and Intrinsic Apoptosis. Local targets link to admitted publications; unresolved targets remain external evidence.
From Imbalance to Impairment: The Central Role of Reactive Oxygen Species in Oxidative Stress‐Induced Disorders and Therapeutic Exploration
10.3389/fphar.2023.1269581 · 2023 · External reference
Trans‐Resveratrol Protects Ischemic PC12 Cells by Inhibiting the Hypoxia Associated Transcription Factors and Increasing the Levels of Antioxidant Defense Enzymes
10.1021/cn300143m · 2013 · External reference
Exploring the Interplay of Antioxidants, Inflammation, and Oxidative Stress: Mechanisms, Therapeutic Potential, and Clinical Implications
10.3390/diseases13090309 · 2025 · External reference
Hepatoprotective Effect of D‐Carvone Against Rotenone‐Induced Liver Toxicity in Swiss Albino Mice
10.1186/s41936-026-00543-z · 2026 · External reference
Rotenone‐Induced Cellular Dysfunction in Human Blood Platelets: Unraveling Calcium Dysregulation, Mitochondrial Impairment, Oxidative Stress, and Apoptosis
10.1016/j.toxlet.2025.111804 · 2025 · External reference
Human Umbilical Vein Endothelial Cells (HUVECs) in Pharmacology and Toxicology: A Review
10.1002/jat.4885 · 2025 · External reference
The Use of Human Umbilical Vein Endothelial Cells (HUVECs) as an In Vitro Model to Assess the Toxicity of Nanoparticles to Endothelium: A Review
10.1002/jat.3470 · 2017 · External reference
Rotenone‐Induced Oxidative Stress in THP‐1 Cells: Biphasic Effects of Baicalin
10.1007/s11033-022-08060-2 · 2023 · External reference
Cytotoxicity of Mitochondrial Complex I Inhibitor Rotenone: A Complex Interplay of Cell Death Pathways
2022 · External reference
Functional Role of p21 During the Cellular Response to Stress
2018 · External reference
Mechanisms of ER Stress‐Mediated Mitochondrial Membrane Permeabilization
2010 · External reference
The Mitochondrial Complex I Inhibitor Rotenone Induces Endoplasmic Reticulum Stress and Activation of GSK‐3β in Cultured Rat Retinal Cells
10.1167/iovs.14-14371 · 2014 · External reference
The ARTS of p53‐Dependent Mitochondrial Apoptosis
10.1093/jmcb/mjac074 · 2022 · External reference
The Long‐Term Effects of Organophosphates Poisoning as a Risk Factor of CVDs: A Nationwide Population‐Based Cohort Study
10.1371/journal.pone.0137632 · 2015 · External reference
Role of the Mitochondrial Membrane Permeability Transition (MPT) in Rotenone‐Induced Apoptosis in Liver Cells
10.1093/toxsci/53.2.340 · 2000 · External reference
Endothelial Dysfunction Driven by Hypoxia—The Influence of Oxygen Deficiency on NO Bioavailability
10.3390/biom11070982 · 2021 · External reference
Caspase Cascade Regulated Mitochondria Mediated Apoptosis in Monocrotophos Exposed PC12 Cells
10.1021/tx100234m · 2010 · External reference
Rotenone Induces Non‐Specific Central Nervous System and Systemic Toxicity
10.1096/fj.03-0677fje · 2004 · External reference
H2S Protects From Rotenone‐Induced Ferroptosis by Stabilizing Fe‐S Clusters in Rat Cardiac Cells
10.3390/cells13050371 · 2024 · External reference
The Roles of Lactate and Lactylation in Diseases Related to Mitochondrial Dysfunction
10.3390/ijms26157149 · 2025 · External reference
Rotenone Inhibits Autophagic Flux Prior to Inducing Cell Death
10.1021/cn300145z · 2012 · External reference
Induction of Cellular Senescence by Pesticide Exposure in Human Umbilical Vein Endothelial Cells (HUVECs): Impacts on Telomerase Length, Cellular Morphology, and mtDNA Variation
10.1002/jcp.70150 · 2026 · External reference
Mitochondrial Dysfunction and Oxidative Stress in Retinal Degeneration: Mechanisms, Biomarkers, and Therapeutic Perspectives
10.3390/cimb48060612 · 2026 · External reference
The Effect of Neuronal CoQ10 Deficiency and Mitochondrial Dysfunction on a Rotenone‐Induced Neuronal Cell Model of Parkinson's Disease
10.3390/ijms25126622 · 2024 · External reference
Rotenone Damages Striatal Organotypic Slice Culture
10.1196/annals.1410.009 · 2008 · External reference
Apoptosis: A Comprehensive Overview of Signaling Pathways, Morphological Changes, and Physiological Significance and Therapeutic Implications
10.3390/cells13221838 · 2024 · External reference
Environmental and Public Health Implications of Pesticide Residues: From Soil Contamination to Policy Interventions
10.15580/gjbs.2025.1.120424187 · 2025 · External reference
Pesticidal Suicide: Adult Fatal Rotenone Poisoning
10.1016/j.jflm.2011.06.014 · 2011 · External reference
Mitochondrial Oxidative Stress Corrupts Coronary Collateral Growth by Activating Adenosine Monophosphate Activated Kinase‐α Signaling
10.1161/atvbaha.113.301591 · 2013 · External reference
The Role of BCL‐2 Family Proteins in Regulating Apoptosis and Cancer Therapy
10.3389/fonc.2022.985363 · 2022 · External reference
Rotenone: From Modelling to Implication in Parkinson's Disease
10.5114/fn.2019.89857 · 2019 · External reference
Rotenone Induces Cell Death in Primary Dopaminergic Culture by Increasing ROS Production and Inhibiting Mitochondrial Respiration
10.1016/j.neuint.2006.02.003 · 2006 · External reference
Protection Against Cellular Toxicity From Rotenone Treatment by the Neuroprotective, Novel Multifunctional Antiparkinsonian Drug D‐512
10.3390/jpm16020115 · 2026 · External reference
Rotenone Analysis by Liquid Chromatography–Tandem Mass Spectrometry With Information‐Dependent Acquisition in a Fatal Case of Rotenone Poisoning With a Commercial Organic Insecticide Being Sold in Korea
10.1093/jat/bkw032 · 2016 · External reference
Rotenone‐Induced Mitochondrial Dysfunction, Neuroinflammation, Oxidative Stress, and Glial Activation in Parkinson's and Alzheimer's Diseases
10.32604/biocell.2025.066320 · 2025 · External reference
Unresolved reference
2025 · External reference
Changes of Lysosome by L‐Serine in Rotenone‐Treated Hippocampal Neurons
10.1186/s42649-022-00084-z · 2023 · External reference
Influence of Cytotoxic Doses of 4‐Hydroxynonenal on Selected Neurotransmitter Receptors in PC‐12 Cells
10.1016/j.tiv.2008.07.001 · 2008 · External reference
Nicotinamide Counteracts Rotenone‐Induced Mitochondrial and Neuronal Dysfunction in a Translational Early‐Life Model
10.1038/s41598-026-36651-7 · 2026 · External reference
The Gill Epithelial Cell Lines RTgill‐W1, From Rainbow Trout and ASG‐10, From Atlantic Salmon, Exert Different Toxicity Profiles Towards Rotenone
10.1007/s10616-022-00560-0 · 2023 · External reference
Environmental Toxins and Oxidative Stress: The Link to Cardiovascular Diseases
10.3390/antiox14050604 · 2025 · External reference
Rotenone‐Induced Apoptosis and Role of Calcium: A Study on Neuro‐2a Cells
10.1007/s00204-012-0853-z · 2012 · External reference
Astrocyte Activation: A Key Step in Rotenone Induced Cytotoxicity and DNA Damage
10.1007/s11064-012-0841-y · 2012 · External reference
Acute Rotenone Poisoning: A Scoping Review
10.1016/j.heliyon.2024.e28334 · 2024 · External reference
Rotenone‐Induced Cell Apoptosis via Endoplasmic Reticulum Stress and PERK‐eIF2α‐CHOP Signalling Pathways in TM3 Cells
10.1016/j.ecoenv.2024.116972 · 2024 · External reference
Loss of Caspase‐2‐Dependent Apoptosis Induces Autophagy After Mitochondrial Oxidative Stress in Primary Cultures of Young Adult Cortical Neurons
10.1074/jbc.m110.163824 · 2011 · External reference
Mitochondrial Formation of Reactive Oxygen Species
10.1113/jphysiol.2003.049478 · 2003 · External reference
Mitigation of Neuroinflammation and Oxidative Stress in Rotenone‐Induced Parkinson Mouse Model Through Liposomal Coenzyme‐Q10 Intervention: A Comprehensive In‐Vivo Study
10.1007/s10753-025-02237-0 · 2025 · External reference
Prostaglandin A1 Inhibits Rotenone‐Induced Apoptosis in SH‐SY5Y Cells
10.1046/j.1471-4159.2002.01224.x · 2002 · External reference
Mitochondrial Diseases: From Molecular Mechanisms to Therapeutic Advances
10.1038/s41392-024-02044-3 · 2025 · External reference
Rotenone‐Induced Impairment of Mitochondrial Electron Transport Chain Confers a Selective Priming Signal for NLRP3 Inflammasome Activation
10.1074/jbc.m115.667063 · 2015 · External reference
Fatality After Deliberate Ingestion of the Pesticide Rotenone: A Case Report
10.1186/cc3528 · 2005 · External reference
The Role of Autophagy in Parkinson's Disease: Rotenone‐Based Modeling
10.1186/1744-9081-9-13 · 2013 · External reference
Variation in Rotenone and Deguelin Contents Among Strains Across Four Tephrosia Species and Their Activities Against Aphids and Whiteflies
10.3390/toxins14050339 · 2022 · External reference
Emerging Mechanisms of Lipid Peroxidation in Regulated Cell Death and Its Physiological Implications
10.1038/s41419-024-07244-x · 2024 · External reference
Mitochondrial Reactive Oxygen Species (ROS) and ROS‐Induced ROS Release
10.1152/physrev.00026.2013 · 2014 · External reference
Mitochondrial Membrane Potential. Analytical Biochemistry
10.1016/j.ab.2017.07.009 · 2018 · External reference
