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References from BMSCs‐Derived Exosomal XPO7 Attenuates Osteoarthritis Progression by Targeting KDM2B to Ameliorate Chondrocyte Senescence. Local targets link to admitted publications; unresolved targets remain external evidence.
Osteoarthritis
10.1016/s0140-6736(24)02322-5 · 2025 · External reference
Global, Regional, and National Burden of Osteoarthritis, 1990–2020 and Projections to 2050: a Systematic Analysis for the Global Burden of Disease Study 2021
10.1016/s2665-9913(23)00163-7 · 2023 · External reference
Advances in the Pathology and Treatment of Osteoarthritis
10.1016/j.jare.2025.01.053 · 2025 · External reference
The Extracellular Matrix of Articular Cartilage Controls the Bioavailability of Pericellular Matrix‐Bound Growth Factors to Drive Tissue Homeostasis and Repair
10.3390/ijms23116003 · 2022 · External reference
The Role of Inflammatory Mediators and Matrix Metalloproteinases (MMPs) in the Progression of Osteoarthritis
10.1016/j.bbiosy.2024.100090 · 2024 · External reference
Mechanisms and Therapeutic Implications of Cellular Senescence in Osteoarthritis
10.1038/s41584-020-00533-7 · 2021 · External reference
Reactive Oxygen Species, Aging and Articular Cartilage Homeostasis
10.1016/j.freeradbiomed.2018.08.038 · 2019 · External reference
Cross‐Talk of Inflammation and Cellular Senescence: A New Insight into the Occurrence and Progression of Osteoarthritis
10.1038/s41413-024-00375-z · 2024 · External reference
Aging and the Emerging Role of Cellular Senescence in Osteoarthritis
10.1016/j.joca.2023.11.018 · 2024 · External reference
Osteoarthritis Pathophysiology
10.1016/j.cger.2021.11.015 · 2022 · External reference
Senescence in Osteoarthritis: From Mechanism to Potential Treatment
10.1186/s13075-022-02859-x · 2022 · External reference
Intraarticular Injection of Bone Marrow‐Derived Mesenchymal Stem Cells Enhances Regeneration in Knee Osteoarthritis
10.1007/s00167-020-05859-z · 2020 · External reference
Clinical Application of Bone Marrow Mesenchymal Stem/Stromal Cells to Repair Skeletal Tissue
10.3390/ijms21249759 · 2020 · External reference
Stem Cell‐Derived Exosomes: Emerging Therapeutic Opportunities for Wound Healing
10.1186/s13287-023-03345-0 · 2023 · External reference
Exosomes
10.1146/annurev-biochem-013118-111902 · 2019 · External reference
Exosomes Derived From Quercetin‐Treated Bone Marrow Derived Mesenchymal Stem Cells Inhibit the Progression of Osteoarthritis Through Delivering miR‐124‐3p to Chondrocytes
10.1089/dna.2023.0341 · 2024 · External reference
BMSC‐Derived Exosomes From Congenital Polydactyly Tissue Alleviate Osteoarthritis by Promoting Chondrocyte Proliferation
10.1038/s41420-020-00374-z · 2020 · External reference
Cinnamaldehyde‐Treated Bone Marrow Mesenchymal‐Stem‐Cell‐Derived Exosomes via Aqueous Two‐Phase System Attenuate IL‐1β‐Induced Inflammation and Catabolism via Modulation of Proinflammatory Signaling Pathways
10.3390/ijms25137263 · 2024 · External reference
Xpo7 Is a Broad‐Spectrum Exportin and a Nuclear Import Receptor
10.1083/jcb.201712013 · 2018 · External reference
Exportin 7 Defines a Novel General Nuclear Export Pathway
10.1038/sj.emboj.7600338 · 2004 · External reference
CRISPR‐Based Screening Identifies XPO7 as a Positive Regulator of Senescence
10.1093/procel/pwad012 · 2023 · External reference
XPO7 Is a Tumor Suppressor Regulating p21(CIP1)‐dependent Senescence
10.1101/gad.343269.120 · 2021 · External reference
Exosomes Derived From Bone Marrow Mesenchymal Stem Cells Alleviate Rheumatoid Arthritis Symptoms via Shuttling Proteins
10.1021/acs.jproteome.3c00697 · 2024 · External reference
Hypoxia‐Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age‐Related Diseases
10.14336/ad.2015.0929 · 2016 · External reference
The H3K36 Demethylase Jhdm1b/Kdm2b Regulates Cell Proliferation and Senescence Through P15(Ink4b)
10.1038/nsmb.1499 · 2008 · External reference
Bone Marrow Mesenchymal Stem Cell‐Derived Exosomes Prevent Osteoarthritis by Regulating Synovial Macrophage Polarization
10.18632/aging.104110 · 2020 · External reference
Bone Marrow Mesenchymal Stem Cell‐Derived Exosomal miR‐206 Promotes Osteoblast Proliferation and Differentiation in Osteoarthritis by Reducing Elf3
10.1111/jcmm.16654 · 2021 · External reference
Indole‐3‐propionic Acid Alleviates Chondrocytes Inflammation and Osteoarthritis via the AhR/NF‐κB Axis
10.1186/s10020-023-00614-9 · 2023 · External reference
10‐hydroxy‐2‐decenoic Acid Prevents Osteoarthritis by Targeting Aspartyl β Hydroxylase and Inhibiting Chondrocyte Senescence in Male Mice Preclinically
10.1038/s41467-024-51746-3 · 2024 · External reference
The OARSI Histopathology Initiative ‐ Recommendations for Histological Assessments of Osteoarthritis in the Rat
10.1016/j.joca.2010.05.030 · 2010 · External reference
Functional Proteins of Mesenchymal Stem Cell‐Derived Extracellular Vesicles
10.1186/s13287-019-1484-6 · 2019 · External reference
Exosomes as Mediators of Intercellular Crosstalk in Metabolism
10.1016/j.cmet.2021.08.006 · 2021 · External reference
CAV1 Protein Encapsulated in Mouse Bmsc‐Derived Extracellular Vesicles Alleviates Myocardial Fibrosis Following Myocardial Infarction by Blocking the TGF‐β1/SMAD2/c‐JUN Axis
10.1007/s12265-023-10472-9 · 2024 · External reference
HK1 From Hepatic Stellate Cell‐Derived Extracellular Vesicles Promotes Progression of Hepatocellular Carcinoma
10.1038/s42255-022-00642-5 · 2022 · External reference
Engineering Exosomes for Bone Defect Repair
10.3389/fbioe.2022.1091360 · 2022 · External reference
Nuclear Transport Proteins: Structure, Function, and Disease Relevance
10.1038/s41392-023-01649-4 · 2023 · External reference
Enhanced Activity of Exportin‐1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain
10.1155/2021/6682336 · 2021 · External reference
Senolytics and Senomorphics: Natural and Synthetic Therapeutics in the Treatment of Aging and Chronic Diseases
10.1016/j.freeradbiomed.2021.05.003 · 2021 · External reference
Senolytic Therapy Combining Dasatinib and Quercetin Restores the Chondrogenic Phenotype of Human Osteoarthritic Chondrocytes by the Release of Pro‐Anabolic Mediators
10.1111/acel.14361 · 2025 · External reference
Senolytics Cocktail Dasatinib and Quercetin Alleviate Chondrocyte Senescence and Facet Joint Osteoarthritis in Mice
10.1016/j.spinee.2024.09.017 · 2025 · External reference