Research graph
References from Genetic and Pharmacologic Inhibition of Myostatin Restores Muscle Mass in a Dynamin 2 ‐Related Centronuclear Myopathy Mouse Model. Local targets link to admitted publications; unresolved targets remain external evidence.
Common Pathogenic Mechanisms in Centronuclear and Myotubular Myopathies and Latest Treatment Advances
10.3390/ijms222111377 · 2021 · External reference
Myotubular Myopathy: Persistence of Fetal Muscle in an Adolescent Boy
10.1001/archneur.1966.00470070005001 · 1966 · External reference
Mutations in Dynamin 2 Cause Dominant Centronuclear Myopathy
10.1038/ng1657 · 2005 · External reference
A DNM2 Centronuclear Myopathy Mutation Reveals a Link Between Recycling Endosome Scission and Autophagy
2020 · External reference
A Novel DNM2 Variant Associated With Centronuclear Myopathy: A Case Report
10.3389/fgene.2025.1559773 · 2025 · External reference
Mild Functional Differences of Dynamin 2 Mutations Associated to Centronuclear Myopathy and Charcot‐Marie Tooth Peripheral Neuropathy
10.1371/journal.pone.0027498 · 2011 · External reference
An Integrated Modelling Methodology for Estimating the Prevalence of Centronuclear Myopathy
10.1016/j.nmd.2018.06.012 · 2018 · External reference
Regulation of Skeletal Muscle Mass in Mice by a New TGF‐p Superfamily Member
10.1038/387083a0 · 1997 · External reference
Down‐Regulation of Akt/Mammalian Target of Rapamycin Signaling Pathway in Response to Myostatin Overexpression in Skeletal Muscle
10.1210/en.2008-0959 · 2009 · External reference
Ectopic Expression of Myostatin Induces Atrophy of Adult Skeletal Muscle by Decreasing Muscle Gene Expression
10.1210/en.2006-1500 · 2007 · External reference
Myostatin: A Skeletal Muscle Chalone
10.1146/annurev-physiol-012422-112116 · 2023 · External reference
Myostatin Negatively Regulates Satellite Cell Activation and Self‐Renewal
10.1083/jcb.200207056 · 2003 · External reference
Myostatin Induces cachexia by Activating the Ubiquitin Proteolytic System Through an NF‐κB‐Independent, @1‐Dependent Mechanism
10.1002/jcp.20757 · 2006 · External reference
Antimyostatin Treatment in Health and Disease: The Story of Great Expectations and Limited Success
10.3390/cells10030533 · 2021 · External reference
Differential Muscle Hypertrophy Is Associated With Satellite Cell Numbers and Akt Pathway Activation Following Activin Type IIB Receptor Inhibition in Mtm1 p.R69C Mice
10.1016/j.ajpath.2014.03.003 · 2014 · External reference
Inhibition of Activin Receptor Type IIB Increases Strength and Lifespan in Myotubularin‐Deficient Mice
10.1016/j.ajpath.2010.10.035 · 2011 · External reference
A Centronuclear Myopathy‐Dynamin 2 Mutation Impairs Skeletal Muscle Structure and Function in Mice
10.1093/hmg/ddq413 · 2010 · External reference
Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer
10.1158/0008-5472.can-14-0057 · 2014 · External reference
Pharmacological Inhibition of Myostatin Improves Skeletal Muscle Mass and Function in a Mouse Model of Stroke
10.1038/s41598-017-13912-0 · 2017 · External reference
Specific Labelling of Myonuclei by an Antibody Against Pericentriolar Material 1 on Skeletal Muscle Tissue Sections
10.1111/apha.13034 · 2018 · External reference
Dynamic Properties of Mammalian Skeletal Muscles
10.1152/physrev.1972.52.1.129 · 1972 · External reference
Musculoskeletal Geometry, Muscle Architecture and Functional Specialisations of the Mouse Hindlimb
10.1371/journal.pone.0147669 · 2016 · External reference
Centronuclear myopathy Related to Dynamin 2 Mutations: Clinical, Morphological, Muscle Imaging and Genetic Features of an Italian Cohort
10.1016/j.nmd.2012.12.009 · 2013 · External reference
Increased Expression of Wild‐Type or a Centronuclear Myopathy Mutant of Dynamin 2 in Skeletal Muscle of Adult Mice Leads to Structural Defects and Muscle Weakness
10.1016/j.ajpath.2011.01.054 · 2011 · External reference
Myostatin Inhibits Myoblast Differentiation by Down‐Regulating MyoD Expression
10.1074/jbc.m204291200 · 2002 · External reference
Myostatin, a Negative Regulator of Muscle Growth, Functions by Inhibiting Myoblast Proliferation
10.1074/jbc.m004356200 · 2000 · External reference
Muscle Protein Synthesis, mTORC1/MAPK/Hippo Signaling, and Capillary Density Are Altered by Blocking of Myostatin and Activins
10.1152/ajpendo.00389.2012 · 2013 · External reference
Muscle‐Specific Function of the Centronuclear Myopathy and Charcot‐Marie‐Tooth Neuropathy‐Associated Dynamin 2 Is Required for Proper Lipid Metabolism, Mitochondria, Muscle Fibers, Neuromuscular Junctions, and Peripheral Nerves
10.1093/hmg/ddt292 · 2013 · External reference
Prepubertal Skeletal Muscle Growth Requires Pax7‐Expressing Satellite Cell‐Derived Myonuclear Contribution
10.1242/dev.167197 · 2018 · External reference
Nuclear Defects in Skeletal Muscle From a Dynamin 2‐Linked Centronuclear Myopathy Mouse Model
10.1038/s41598-018-38184-0 · 2019 · External reference
T‐Tubule Disorganization and Defective Excitation‐Contraction Coupling in Muscle Fibers Lacking Myotubularin Lipid Phosphatase
10.1073/pnas.0900705106 · 2009 · External reference
Downregulation of Myostatin Pathway in Neuromuscular Diseases May Explain Challenges of Anti‐Myostatin Therapeutic Approaches
10.1038/s41467-017-01486-4 · 2017 · External reference
Myostatin and Activin Blockade by Engineered Follistatin Results in Hypertrophy and Improves Dystrophic Pathology in mdx Mouse More Than Myostatin Blockade Alone
10.1186/s13395-018-0180-z · 2018 · External reference
Activin IIB Receptor Blockade Attenuates Dystrophic Pathology in a Mouse Model of Duchenne Muscular Dystrophy
10.1002/mus.21743 · 2010 · External reference
Targeting the Activin Type IIB Receptor to Improve Muscle Mass and Function in the mdx Mouse Model of Duchenne Muscular Dystrophy
10.1016/j.ajpath.2010.11.071 · 2011 · External reference
Activin Receptor Type IIB Inhibition Improves Muscle Phenotype and Function in a Mouse Model of Spinal Muscular Atrophy
10.1371/journal.pone.0166803 · 2016 · External reference
Treatment With ActRIIB‐mFc Produces Myofiber Growth and Improves Lifespan in the Acta1 H40Y Murine Model of Nemaline Myopathy
10.1016/j.ajpath.2016.02.008 · 2016 · External reference
Calcium Homeostasis Alterations in a Mouse Model of the Dynamin 2‐Related Centronuclear Myopathy
10.1242/bio.020263 · 2016 · External reference
Impaired Excitation‐Contraction Coupling in Muscle Fibres From the Dynamin2(R465W) Mouse Model of Centronuclear Myopathy
10.1113/jp274990 · 2017 · External reference
Disrupted Membrane Structure and Intracellular Ca2+ Signaling in Adult Skeletal Muscle With Acute Knockdown of Bin1
10.1371/journal.pone.0025740 · 2011 · External reference
Dynamin‐2 Mutations Associated With Centronuclear Myopathy Are Hypermorphic and Lead to T‐Tubule Fragmentation
10.1093/hmg/ddv285 · 2015 · External reference
Activin A More Prominently Regulates Muscle Mass in primates Than Does GDF8
10.1038/ncomms15153 · 2017 · External reference
