Research graph
References from Chemotherapy‐Induced Skeletal Muscle Dysfunction and Cognitive Impairment: A Muscle‐Brain Mechanistic Framework With Implications for Exercise Oncology. Local targets link to admitted publications; unresolved targets remain external evidence.
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Long‐Term Toxic Effects of Adjuvant Chemotherapy in Breast Cancer
10.1093/annonc/mdq683 · 2011 · External reference
Cancer Treatment and Survivorship Statistics, 2019
2019 · External reference
Skeletal Muscle Mass Change During Chemotherapy: A Systematic Review and Meta‐Analysis
10.21873/anticanres.14210 · 2020 · External reference
Sarcopenia and Loss of Muscle Mass in Patients With Lung Cancer Undergoing Chemotherapy Treatment: A Systematic Review and Meta‐Analysis
10.1080/0284186x.2023.2180660 · 2023 · External reference
Loss of Skeletal Muscle During Systemic Chemotherapy is Prognostic of Poor Survival in Patients With Foregut Cancer
10.1002/jcsm.12267 · 2018 · External reference
Impact of Skeletal Muscle Mass in Patients With Recurrent Gastric Cancer
10.1186/s12957-021-02283-6 · 2023 · External reference
Baseline Sarcopenia and Skeletal Muscle Loss During Chemotherapy Affect Survival Outcomes in Metastatic Gastric Cancer
10.21873/anticanres.12928 · 2018 · External reference
Longitudinal Assessment of Cognitive Changes Associated With Adjuvant Treatment for Breast Cancer: Impact of Age and Cognitive Reserve
10.1200/jco.2009.27.0827 · 2010 · External reference
Cancer‐Related Cognitive Outcomes Among Older Breast Cancer Survivors in the Thinking and Living With Cancer Study
10.1200/jco.18.00140 · 2018 · External reference
Prevalence of Cognitive Impairment Following Chemotherapy Treatment for Breast Cancer: A Systematic Review and Meta‐Analysis
10.1038/s41598-022-05682-1 · 2022 · External reference
Decline in Cognitive Function in Older Adults With Early‐Stage Breast Cancer After Adjuvant Treatment
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Doxorubicin‐Induced Elevated Oxidative Stress and Neurochemical Alterations in Brain and Cognitive Decline: Protection by MESNA and Insights Into Mechanisms of Chemotherapy‐Induced Cognitive Impairment (“Chemobrain”)
10.18632/oncotarget.25718 · 2018 · External reference
Rutin Protects Against Neuronal Damage In Vitro and Ameliorates Doxorubicin‐Induced Memory Deficits In Vivo in Wistar Rats
10.2147/dddt.s103511 · 2017 · External reference
Is 'chemo‐fog'/'chemo‐brain' Caused by Cancer Chemotherapy?
10.1111/j.1365-2710.2006.00726.x · 2006 · External reference
Unresolved reference
2022 · External reference
2‐Mercaptoethane Sulfonate Prevents Doxorubicin‐Induced Plasma Protein Oxidation and TNF‐Alpha Release: Implications for the Reactive Oxygen Species‐Mediated Mechanisms of Chemobrain
10.1016/j.freeradbiomed.2011.03.009 · 2011 · External reference
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10.1007/978-1-4419-6306-2_19 · 2010 · External reference
Alterations in Brain Antioxidant Enzymes and Redox Proteomic Identification of Oxidized Brain Proteins Induced by the Anti‐Cancer Drug Adriamycin: Implications for Oxidative Stress‐Mediated Chemobrain
10.1016/j.neuroscience.2010.01.021 · 2010 · External reference
Exercise is the Real Polypill
2013 · External reference
The Physiology of Optimizing Health With a Focus on Exercise as Medicine
10.1146/annurev-physiol-020518-114339 · 2019 · External reference
Role of Myokines in Exercise and Metabolism
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Skeletal Muscle: A Brief Review of Structure and Function
10.1007/s00223-014-9915-y · 2015 · External reference
The Ever‐Expanding Myokinome: Discovery Challenges and Therapeutic Implications
10.1038/nrd.2016.153 · 2016 · External reference
The Molecular Effects of BDNF Synthesis on Skeletal Muscle: A Mini‐Review
10.3389/fphys.2022.934714 · 2022 · External reference
FNDC5 and Irisin in Humans: I. Predictors of Circulating Concentrations in Serum and Plasma and II. mRNA Expression and Circulating Concentrations in Response to Weight Loss and Exercise
10.1016/j.metabol.2012.09.002 · 2012 · External reference
Muscle Wasting in Cancer: Opportunities and Challenges for Exercise in Clinical Cancer Trials
10.1002/rco2.56 · 2022 · External reference
The Emerging Role of Skeletal Muscle Oxidative Metabolism as a Biological Target and Cellular Regulator of Cancer‐Induced Muscle Wasting
10.1016/j.semcdb.2015.11.005 · 2016 · External reference
Loss of Muscle Mass During Chemotherapy is Predictive for Poor Survival of Patients With Metastatic Colorectal Cancer
10.1200/jco.2015.63.6043 · 2016 · External reference
Skeletal Muscle Loss During Neoadjuvant Chemotherapy Predicts Poor Prognosis in Patients With Breast Cancer
10.1186/s12885-022-09443-1 · 2022 · External reference
Exercise is Medicine in Oncology: Engaging Clinicians to Help Patients Move Through Cancer
2019 · External reference
Adverse Effects of Systemic Cancer Therapy on Skeletal Muscle: Myotoxicity Comes Out of the Closet
2023 · External reference
Anabolic Resistance in Cancer Cachexia: A Role for Sex and Chemotherapy
2026 · External reference
Prevalence of Cognitive Impairment and Change in Patients With Breast Cancer: A Systematic Review of Longitudinal Studies
10.1002/pon.5623 · 2021 · External reference
Promotion of Microtubule Assembly In Vitro by Taxol
10.1038/277665a0 · 1979 · External reference
Microtubules as a Target for Anticancer Drugs
10.1038/nrc1317 · 2004 · External reference
Mitosis Is Not a Key Target of Microtubule Agents in Patient Tumors
10.1038/nrclinonc.2010.228 · 2011 · External reference
Adriamycin‐Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II
10.1126/science.6093249 · 1984 · External reference
Anthracycline Cardiotoxicity: An Update on Mechanisms, Monitoring and Prevention
10.1136/heartjnl-2017-312103 · 2018 · External reference
A Critical Evaluation of the Mechanisms of Action Proposed for the Antitumor Effects of the Anthracycline Antibiotics Adriamycin and Daunorubicin
10.1016/s0006-2952(98)00307-4 · 1999 · External reference
Drug‐Induced Histone Eviction From Open Chromatin Contributes to the Chemotherapeutic Effects of Doxorubicin
10.1038/ncomms2921 · 2013 · External reference
Combination Platinum‐Based and DNA Damage Response‐Targeting Cancer Therapy: Evolution and Future Directions
10.2174/0929867323666161214114948 · 2017 · External reference
Cellular Pharmacology of Gemcitabine
10.1093/annonc/mdj941 · 2006 · External reference
Molecular Pathways: The Immunogenic Effects of Platinum‐Based Chemotherapeutics
10.1158/1078-0432.ccr-13-3141 · 2014 · External reference
Mitochondria: Inadvertent Targets in Chemotherapy‐Induced Skeletal Muscle Toxicity and Wasting?
10.1007/s00280-016-3045-3 · 2016 · External reference
Role of PGC‐1α in Sarcopenia: Etiology and Potential Intervention—A Mini‐Review
10.1159/000365947 · 2015 · External reference
Impaired cAMP‐PKA‐CREB1 Signalling Drives Mitochondrial Dysfunction in Skeletal Muscle During Cancer Cachexia
10.1038/s42255-025-01397-5 · 2025 · External reference
Integrative Study of Skeletal Muscle Mitochondrial Dysfunction in a Murine Pancreatic Cancer‐Induced Cachexia Model
10.7554/elife.93312 · 2024 · External reference
Chemotherapy‐Induced Loss of Bone and Muscle Mass in a Mouse Model of Breast Cancer Bone Metastases and Cachexia
2019 · External reference
The Anticancer Agent Doxorubicin Disrupts Mitochondrial Energy Metabolism and Redox Balance in Skeletal Muscle
10.1016/j.freeradbiomed.2013.08.191 · 2013 · External reference
Doxorubicin Caused Severe Hyperglycaemia and Insulin Resistance, Mediated by Inhibition in AMPk Signalling in Skeletal Muscle
10.1002/jcsm.12104 · 2016 · External reference
Doxorubicin Causes Lesions in the Electron Transport System of Skeletal Muscle Mitochondria That Are Associated With a Loss of Contractile Function
10.1074/jbc.ra119.008426 · 2019 · External reference
Doxorubicin Acts Through Tumor Necrosis Factor Receptor Subtype 1 to Cause Dysfunction of Murine Skeletal Muscle
10.1152/japplphysiol.00776.2009 · 1985 · External reference
Anthracycline‐Containing Chemotherapy Causes Long‐Term Impairment of Mitochondrial Respiration and Increased Reactive Oxygen Species Release in Skeletal Muscle
10.1038/srep08717 · 2015 · External reference
Chemotherapy‐Related Cachexia Is Associated With Mitochondrial Depletion and the Activation of ERK1/2 and p38 MAPKs
10.18632/oncotarget.9779 · 2016 · External reference
Mechanisms of Chemotherapy‐Induced Muscle Wasting in Mice With Cancer Cachexia
10.1002/rco2.50 · 2022 · External reference
Skeletal Muscle Atrophy and Dysfunction in Breast Cancer Patients: Role for Chemotherapy‐Derived Oxidant Stress
10.1152/ajpcell.00002.2018 · 2018 · External reference
Differences in Skeletal Muscle Loss Caused by Cytotoxic Chemotherapy and Molecular Targeted Therapy in Patients With Advanced Non‐Small Cell Lung Cancer
10.1111/1759-7714.12545 · 2018 · External reference
Sarcopenia During Neoadjuvant Therapy for Oesophageal Cancer: Characterising the Impact on Muscle Strength and Physical Performance
2018 · External reference
Prognostic Impact of CT‐Quantified Muscle and Fat Distribution Before and After First‐Line‐Chemotherapy in Lung Cancer Patients
10.1371/journal.pone.0169136 · 2017 · External reference
Impact on Postoperative Complications of Changes in Skeletal Muscle Mass During Neoadjuvant Chemotherapy for Gastro‐Oesophageal Cancer
10.1002/bjs5.50331 · 2020 · External reference
Association Between Body Composition, Survival, and Toxicity in Advanced Esophagogastric Cancer Patients Receiving Palliative Chemotherapy
10.1002/jcsm.12371 · 2019 · External reference
The Impact of Skeletal Muscle Wasting During Neoadjuvant Chemotherapy on Postoperative Anastomotic Leakage in Patients With Esophageal Cancer
10.1007/s10388-020-00774-1 · 2021 · External reference
Extreme Skeletal Muscle Loss During Induction Chemotherapy is an Independent Predictor of Poor Survival in Advanced Epithelial Ovarian Cancer Patients
10.1111/jog.14516 · 2020 · External reference
Loss of Skeletal Muscle Mass During Palliative Chemotherapy is a Poor Prognostic Factor in Patients With Advanced Gastric Cancer
10.1038/s41598-020-74765-8 · 2020 · External reference
Body Composition as a Prognostic Factor of Neoadjuvant Chemotherapy Toxicity and Outcome in Patients With Locally Advanced Gastric Cancer
10.5230/jgc.2017.17.e8 · 2017 · External reference
Characterization of Anthropometric Changes That Occur During Neoadjuvant Therapy for Potentially Resectable Pancreatic Cancer
10.1245/s10434-014-4285-2 · 2015 · External reference
A Single Chemotherapy Administration Induces Muscle Atrophy, Mitochondrial Alterations and Apoptosis in Breast Cancer Patients
10.1002/jcsm.13414 · 2024 · External reference
Changes in Skeletal Muscle Mass During Palliative Chemotherapy in Patients With Advanced Lung Cancer
10.3109/0284186x.2014.953259 · 2015 · External reference
Physical Exercise Mitigates Doxorubicin‐Induced Brain Cortex and Cerebellum Mitochondrial Alterations and Cellular Quality Control Signaling
10.1016/j.mito.2015.12.002 · 2016 · External reference
Chemotherapy‐Induced Cognitive Impairment is Associated With Increased Inflammation and Oxidative Damage in the Hippocampus
10.1007/s12035-019-1589-z · 2019 · External reference
Polydatin Ameliorates Chemotherapy‐Induced Cognitive Impairment (Chemobrain) by Inhibiting Oxidative Stress, Inflammatory Response, and Apoptosis in Rats
10.1080/09168451.2020.1722057 · 2020 · External reference
Endogenous Hydrogen Sulfide Alleviates Methotrexate‐Induced Cognitive Impairment by Attenuating Endoplasmic Reticulum Stress‐Induced Apoptosis via CHOP and Caspase‐12
10.1111/fcp.12543 · 2020 · External reference
Long‐Lasting Impairments in Adult Neurogenesis, Spatial Learning and Memory From a Standard Chemotherapy Regimen Used to Treat Breast Cancer
10.1016/j.bbr.2016.07.043 · 2016 · External reference
Self‐Perceived Cognitive Impairment in the First Year After Breast Cancer and the Identification of At‐Risk Patients
10.1016/j.ejon.2024.102685 · 2024 · External reference
Cognitive Impairment Following Chemotherapy for Breast Cancer: The Impact of Practice Effect on Results
10.1080/13803395.2018.1546381 · 2019 · External reference
Chemotherapy‐Induced Prospective Memory Impairment in Patients With Breast Cancer
10.1002/pon.3291 · 2013 · External reference
Prospective Memory Impairment in Chemotherapy‐Exposed Early Breast Cancer Survivors: Preliminary Evidence From a Clinical Test
10.1080/07347332.2016.1181133 · 2016 · External reference
Chemotherapy‐Related Cognitive Impairment in Patients With Breast Cancer Based on MRS and DTI Analysis
10.1007/s12282-020-01094-z · 2020 · External reference
Trajectories of Self‐Reported Cognitive Function in Postmenopausal Women During Adjuvant Systemic Therapy for Breast Cancer
10.1002/pon.4009 · 2017 · External reference
Perceived Cognitive Impairment in People With Colorectal Cancer Who Do and Do Not Receive Chemotherapy
10.1007/s11764-017-0656-6 · 2018 · External reference
A Prospective Study of Cognitive Complaints in Patients With Testicular Cancer
10.1016/j.clgc.2011.04.002 · 2011 · External reference
Cognitive Compensatory Processes of Older, Clinically Fit Patients With Hematologic Malignancies Undergoing Chemotherapy: A Longitudinal Cohort Study
10.1002/pon.4424 · 2017 · External reference
Muscle Mass Loss After Neoadjuvant Chemotherapy in Breast Cancer: Estimation on Breast Magnetic Resonance Imaging Using Pectoralis Muscle Area
10.1007/s00330-020-06799-5 · 2020 · External reference
Early Skeletal Muscle Deconditioning and Reduced Exercise Capacity During (Neo)Adjuvant Chemotherapy in Patients With Breast Cancer
10.1002/cncr.34533 · 2023 · External reference
Muscular Contraction's Therapeutic Potential for Cancer‐Induced Wasting
10.1152/ajpcell.00021.2022 · 2022 · External reference
Doxorubicin‐Induced Neurotoxicity is Attenuated by a 43‐kD Protein From the Leaves of Cajanus indicus L. via NF‐κB and Mitochondria Dependent Pathways
10.3109/10715762.2012.678841 · 2012 · External reference
The Blood‐Brain Barrier and Cancer: Transporters, Treatment, and Trojan Horses
10.1158/1078-0432.ccr-06-2854 · 2007 · External reference
Adriamycin‐Induced, TNF‐Alpha‐Mediated Central Nervous System Toxicity
10.1016/j.nbd.2006.02.013 · 2006 · External reference
Treadmill Exercise Ameliorates Chemotherapy‐Induced Muscle Weakness and Central Fatigue by Enhancing Mitochondrial Function and Inhibiting Apoptosis
10.5213/inj.1938046.023 · 2019 · External reference
Effects of Aerobic and Resistance Exercise in Breast Cancer Patients Receiving Adjuvant Chemotherapy: A Multicenter Randomized Controlled Trial
10.1200/jco.2006.08.2024 · 2007 · External reference
Effects of Exercise Dose and Type During Breast Cancer Chemotherapy: Multicenter Randomized Trial
10.1093/jnci/djt297 · 2013 · External reference
Subgroup Effects in a Randomised Trial of Different Types and Doses of Exercise During Breast Cancer Chemotherapy
10.1038/bjc.2014.466 · 2014 · External reference
High‐Intensity Exercise During Chemotherapy Induces Beneficial Effects 12 Months Into Breast Cancer Survivorship
10.1007/s11764-019-00747-z · 2019 · External reference
Exercise Training During Chemotherapy Preserves Skeletal Muscle Fiber Area, Capillarization, and Mitochondrial Content in Patients With Breast Cancer
10.1096/fj.201700968r · 2018 · External reference
Heavy Resistance Training in Breast Cancer Patients Undergoing Adjuvant Therapy
10.1249/mss.0000000000002260 · 2020 · External reference
Supervised Resistance Exercise for Women With Ovarian Cancer Who Have Completed First‐Line Treatment: A Pragmatic Study
10.1007/s00520-023-07754-y · 2023 · External reference
Exercise Improves Functional Capacity and Lean Body Mass in Patients With Gastrointestinal Cancer During Chemotherapy: A Single‐Blind RCT
10.1007/s00520-018-4478-5 · 2019 · External reference
Multimodal Prehabilitation During Neoadjuvant Therapy Prior to Esophagogastric Cancer Resection: Effect on Cardiopulmonary Exercise Test Performance, Muscle Mass and Quality of Life—A Pilot Randomized Clinical Trial
10.1245/s10434-021-11002-0 · 2022 · External reference
Multimodal Exercise Ameliorates Exercise Responses and Body Composition in Head and Neck Cancer Patients Receiving Chemotherapy
10.1007/s00520-019-04786-1 · 2019 · External reference
Effect of Exercise Training on Exercise Tolerance and Level of Oxidative Stress for Head and Neck Cancer Patients Following Chemotherapy
10.3389/fonc.2020.01536 · 2020 · External reference
Comparison of the Effects of a Supervised Exercise Program and Usual Care in Patients With Colorectal Cancer Undergoing Chemotherapy
10.1097/ncc.0b013e3182791097 · 2014 · External reference
Effects of Exercise on Inflammation in Patients Receiving Chemotherapy: A Nationwide NCORP Randomized Clinical Trial
10.1007/s00520-019-04772-7 · 2019 · External reference
Effect of a Multimodal High Intensity Exercise Intervention in Cancer Patients Undergoing Chemotherapy: Randomised Controlled Trial
10.1136/bmj.b3410 · 2009 · External reference
Physical Exercise Prevents Cognitive Impairment by Enhancing Hippocampal Neuroplasticity and Mitochondrial Function in Doxorubicin‐Induced Chemobrain
10.1016/j.neuropharm.2018.02.013 · 2018 · External reference
Treadmill Exercise Ameliorates Chemotherapy‐Induced Memory Impairment Through Wnt/β‐Catenin Signaling Pathway
10.12965/jer.2346594.297 · 2023 · External reference
Effects of Voluntary Wheel Running Exercise on Chemotherapy‐Impaired Cognitive and Motor Performance in Mice
10.3390/ijerph20075371 · 2023 · External reference
The Counter Effect of Exercise on Cisplatin‐Induced Cognitive and Proliferation Impairments
2024 · External reference
Effect of Physical Exercise on the Hippocampus and Global Grey Matter Volume in Breast Cancer Patients: A Randomized Controlled Trial (PAM Study)
10.1016/j.nicl.2022.103292 · 2023 · External reference
Effect of Aerobic Exercise on Cancer‐Associated Cognitive Impairment: A Proof‐of‐Concept RCT
10.1002/pon.4370 · 2018 · External reference
Does Walking Protect Against Decline in Cognitive Functioning Among Breast Cancer Patients Undergoing Chemotherapy? Results From a Small Randomised Controlled Trial
10.1371/journal.pone.0206874 · 2018 · External reference
Acute Aerobic Exercise Effects on Cognitive Function in Breast Cancer Survivors: A Randomized Crossover Trial
10.1186/s12885-019-5589-1 · 2019 · External reference
Cognition in Breast Cancer Survivors: A Pilot Study of Interval and Continuous Exercise
10.1016/j.jsams.2018.11.026 · 2019 · External reference
The Different Relationship of VO2max to Muscle Mitochondria in Humans and Quadrupedal Animals
10.1016/0034-5687(90)90077-c · 1990 · External reference
Effect of Physical Exercise on Cognitive Function After Chemotherapy in Patients With Breast Cancer: A Randomized Controlled Trial (PAM Study)
10.1186/s13058-022-01530-2 · 2022 · External reference
The Role of Cytokines in Cancer‐Related Fatigue
10.1002/1097-0142(20010915)92:6+<1684::aid-cncr1497>3.0.co;2-z · 2001 · External reference
How Does the Skeletal Muscle Communicate With the Brain in Health and Disease?
10.1016/j.neuropharm.2021.108744 · 2021 · External reference
Chemotherapy Impairs Skeletal Muscle Mitochondrial Homeostasis in Early Breast Cancer Patients
10.1002/jcsm.12991 · 2022 · External reference
