Research graph
References from Conserved and Tissue‐Specific RNA and Protein Cargos of Small Extracellular Vesicles From 120 Tissue Sites Across 34 Organs in a Single Pig. Local targets link to admitted publications; unresolved targets remain external evidence.
Survey of Organ‐Derived Small Extracellular Vesicles and Particles (sEVPs) to Identify Selective Protein Markers in Mouse Serum
10.1002/jex2.106 · 2023 · External reference
Cat RAPID Omics v2.0: Going Deeper and Wider in the Prediction of Protein–RNA Interactions
10.1093/nar/gkab393 · 2021 · External reference
Type 2 Alveolar Cells Are Stem Cells in Adult Lung
10.1172/jci68782 · 2013 · External reference
miRNA Cargo in Circulating Vesicles From Neurons is Altered in Individuals With Schizophrenia and Associated With Severe Disease
10.1126/sciadv.adi4386 · 2023 · External reference
Stem Cell Function and Stress Response are Controlled by Protein Synthesis
10.1038/nature18282 · 2016 · External reference
Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis
10.1161/circulationaha.122.063402 · 2023 · External reference
Trimmomatic: A Flexible Trimmer for Illumina Sequence Data
10.1093/bioinformatics/btu170 · 2014 · External reference
10.1002/pmic.70024>
10.1002/pmic.70024> · External reference
mRNAs, Proteins and the Emerging Principles of Gene Expression Control
10.1038/s41576-020-0258-4 · 2020 · External reference
Slingshot Homolog‐1 Mediates the Secretion of Small Extracellular Vesicles Containing Misfolded Proteins by Regulating Autophagy Cargo Receptors and Actin Dynamics
10.3389/fnagi.2022.933979 · 2022 · External reference
GtRNAdb 2.0: An Expanded Database of Transfer RNA Genes Identified in Complete and Draft Genomes
10.1093/nar/gkv1309 · 2016 · External reference
Ultrafast One‐Pass FASTQ Data Preprocessing, Quality Control, and Deduplication Using Fastp
10.1002/imt2.107 · 2023 · External reference
Therapeutically Harnessing Extracellular Vesicles
10.1038/s41573-022-00410-w · 2022 · External reference
Vesiclepedia 2024: An Extracellular Vesicles and Extracellular Particles Repository
10.1093/nar/gkad1007 · 2024 · External reference
MaxQuant Enables High Peptide Identification Rates, Individualized Ppb‐Range Mass Accuracies and Proteome‐Wide Protein Quantification
10.1038/nbt.1511 · 2008 · External reference
Recommendations for Studying In Situ Extracellular Vesicles From Solid Tissue
10.1002/jev2.70185 · 2025 · External reference
Subpopulations of Extracellular Vesicles From Human Metastatic Melanoma Tissue Identified by Quantitative Proteomics After Optimized Isolation
10.1080/20013078.2020.1722433 · 2020 · External reference
Isolation and Characterization of Extracellular Vesicle Subpopulations from Tissues
10.1038/s41596-020-00466-1 · 2021 · External reference
Proteomic Profiling of Tumour Tissue‐Derived Extracellular Vesicles in Colon Cancer
10.1002/jex2.127 · 2024 · External reference
Host and Microbiota Derived Extracellular Vesicles: Crucial Players in Iron Homeostasis
10.3389/fmed.2022.985141 · 2022 · External reference
Mitochondrial Extracellular Vesicles: A Promising Avenue for Diagnosing and Treating Lung Diseases
10.1021/acsnano.4c02940 · 2024 · External reference
Context‐Specific Regulation of Extracellular Vesicle Biogenesis and Cargo Selection
10.1038/s41580-023-00576-0 · 2023 · External reference
STAR: Ultrafast Universal RNA‐seq Aligner
10.1093/bioinformatics/bts635 · 2013 · External reference
Comprehensive Evaluation of Methods for Small Extracellular Vesicles Separation From Human Plasma, Urine and Cell Culture Medium
10.1002/jev2.12044 · 2020 · External reference
Adaptive Design of mRNA‐Loaded Extracellular Vesicles for Targeted Immunotherapy of Cancer
10.1038/s41467-023-42365-5 · 2023 · External reference
MicroRNA Targets in Drosophila
10.1186/gb-2003-5-1-r1 · 2003 · External reference
RNA Packaging Into Extracellular Vesicles: An Orchestra of RNA‐Binding Proteins?
10.1002/jev2.12043 · 2020 · External reference
Tau filaments are Tethered Within Brain Extracellular Vesicles in Alzheimer's Disease
10.1038/s41593-024-01801-5 · 2025 · External reference
Tissue Differences in the Exosomal/Small Extracellular Vesicle Proteome and Their Potential as Indicators of Altered Tissue Metabolism
10.1016/j.celrep.2021.110277 · 2022 · External reference
MicroRNA Sequence Codes for Small Extracellular Vesicle Release and Cellular Retention
10.1038/s41586-021-04234-3 · 2022 · External reference
Extracellular Vesicles From Normal Tissues Orchestrate the Homeostasis of Macrophages and Attenuate Inflammatory Injury of Sepsis
10.1002/btm2.10609 · 2024 · External reference
Transcriptome Variation in Human Tissues Revealed by Long‐Read Sequencing
10.1038/s41586-022-05035-y · 2022 · External reference
10.1093/gpbjnl/qzaf016
10.1093/gpbjnl/qzaf016 · External reference
Ensembl 2024
10.1093/nar/gkad1049 · 2024 · External reference
Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers
10.1016/j.cell.2020.07.009 · 2020 · External reference
Dynamic Lung Single‐Cell Atlas of Domesticated and Wild Pigs
10.1007/s11427-025-3150-6 · 2026 · External reference
Toward a human brain extracellular vesicle atlas: Characteristics of extracellular vesicles from different brain regions, including small RNA and protein profiles
10.1002/inmd.20230016 · 2023 · External reference
Adipose‐Derived Exosomes Block Muscular Stem Cell Proliferation in Aged Mouse by Delivering miRNA Let‐7d‐3p That Targets Transcription Factor HMGA2
10.1016/j.jbc.2022.102098 · 2022 · External reference
Mitochondrial Protein Enriched Extracellular Vesicles Discovered in Human Melanoma Tissues Can be Detected in Patient Plasma
10.1080/20013078.2019.1635420 · 2019 · External reference
Reassessment of Exosome Composition
10.1016/j.cell.2019.02.029 · 2019 · External reference
The Biology, Function, and Biomedical Applications of Exosomes
10.1126/science.aau6977 · 2020 · External reference
RNAInter v4.0: RNA Interactome Repository With Redefined Confidence Scoring System and Improved Accessibility
10.1093/nar/gkab997 · 2022 · External reference
Genome‐Wide Annotation of Protein‐Coding Genes in Pig
10.1186/s12915-022-01229-y · 2022 · External reference
ExoCarta: A Web‐Based Compendium of Exosomal Cargo
10.1016/j.jmb.2015.09.019 · 2016 · External reference
Graph‐Based Genome Alignment and Genotyping With HISAT2 and HISAT‐Genotype
10.1038/s41587-019-0201-4 · 2019 · External reference
miRBase: From microRNA Sequences to Function
10.1093/nar/gky1141 · 2019 · External reference
Quantitative Proteomics Identifies the Core Proteome of Exosomes With Syntenin‐1 as the Highest Abundant Protein and a Putative Universal Biomarker
10.1038/s41556-021-00693-y · 2021 · External reference
Visualization and Tracking of Tumour Extracellular Vesicle Delivery and RNA Translation Using Multiplexed Reporters
10.1038/ncomms8029 · 2015 · External reference
Cooperation Between β‐ and γ‐Cytoplasmic Actins in the Mechanical Regulation of Endothelial Microparticle Formation
10.1096/fj.12-216531 · 2013 · External reference
Prospects and Challenges of Tissue‐Derived Extracellular Vesicles
10.1016/j.ymthe.2024.06.025 · 2024 · External reference
Minimap2: Pairwise Alignment for Nucleotide Sequences
10.1093/bioinformatics/bty191 · 2018 · External reference
Interaction Between Astrocytes and Adult Subventricular Zone Precursors Stimulates Neurogenesis
10.1073/pnas.96.13.7526 · 1999 · External reference
Minimal Experimental Requirements for Definition of Extracellular Vesicles and Their Functions: A Position Statement From the International Society for Extracellular Vesicles
10.3402/jev.v3.26913 · 2014 · External reference
Robust and Rigorous Identification of Tissue‐Specific Genes by Statistically Extending Tau Score
10.1186/s13040-022-00315-9 · 2022 · External reference
Importance of the Pig as a Human Biomedical Model
10.1126/scitranslmed.abd5758 · 2021 · External reference
Cutadapt Removes Adapter Sequences From High‐Throughput Sequencing Reads
2011 · External reference
Comparison of Separation Methods for Tissue‐Derived Extracellular Vesicles in the Liver, Heart, and Skeletal Muscle
10.1002/2211-5463.13075 · 2021 · External reference
Exome‐Based Analysis for RNA Epigenome Sequencing Data
10.1093/bioinformatics/btt171 · 2013 · External reference
Effects of Trypsinization and of a Combined Trypsin, Collagenase, and DNase Digestion on Liberation and In Vitro Function of Satellite Cells Isolated From Juvenile Porcine Muscles
10.1007/s11626-018-0263-5 · 2018 · External reference
Evaluation of Circulating Small Extracellular Vesicles Derived miRNAs as Biomarkers of Early Colon Cancer: A Comparison With Plasma Total miRNAs
10.1080/20013078.2019.1643670 · 2019 · External reference
Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease
10.1016/j.cmet.2019.07.011 · 2019 · External reference
Scalable Production of Extracellular Vesicles and Its Therapeutic Values: A Review
10.3390/ijms23147986 · 2022 · External reference
R: A Language and Environment for Statistical Computing
2011 · External reference
RNA Delivery by Extracellular Vesicles in Mammalian Cells and Its Applications
10.1038/s41580-020-0251-y · 2020 · External reference
Profiling the Polyadenylated Transcriptome of Extracellular Vesicles With Long‐Read Nanopore Sequencing
10.1186/s12864-023-09552-6 · 2023 · External reference
Stringtie Enables Improved Reconstruction of a Transcriptome From RNA‐seq Reads
10.1038/nbt.3122 · 2015 · External reference
RNAcentral: A Comprehensive Database of Non‐Coding RNA Sequences
10.1093/nar/gkw1008 · 2017 · External reference
Accurate Isoform Discovery With IsoQuant Using Long Reads
10.1038/s41587-022-01565-y · 2023 · External reference
BEDTools: A Flexible Suite of Utilities for Comparing Genomic Features
10.1093/bioinformatics/btq033 · 2010 · External reference
Human Brain Small Extracellular Vesicles Contain Selectively Packaged, Full‐Length mRNA
10.1016/j.celrep.2024.114061 · 2024 · External reference
Single‐Cell Dynamics of Liver Development in Postnatal Pigs
10.1016/j.scib.2023.09.021 · 2023 · External reference
10.3390/cells9091955
10.3390/cells9091955 · External reference
exceRpt: A Comprehensive Analytic Platform for Extracellular RNA Profiling
10.1016/j.cels.2019.03.004 · 2019 · External reference
Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks
10.1101/gr.1239303 · 2003 · External reference
Genetically Encoding Multiple Functionalities Into Extracellular Vesicles for the Targeted Delivery of Biologics to T Cells
10.1038/s41551-023-01142-x · 2024 · External reference
A Compendium of Genetic Regulatory Effects Across Pig Tissues
10.1038/s41588-023-01585-7 · 2024 · External reference
Formation of a Protein Corona on the Surface of Extracellular Vesicles in Blood Plasma
10.1002/jev2.12140 · 2021 · External reference
SUPPA2: fast, Accurate, and Uncertainty‐Aware Differential Splicing Analysis Across Multiple Conditions
10.1186/s13059-018-1417-1 · 2018 · External reference
The Perseus Computational Platform for Comprehensive Analysis of (prote) Omics Data
10.1038/nmeth.3901 · 2016 · External reference
Proteomics. Tissue‐Based Map of the Human Proteome
10.1126/science.1260419 · 2015 · External reference
UniProt: The Universal Protein Knowledgebase in 2025
10.1093/nar/gkae1010 · 2025 · External reference
Shedding Light on the Cell Biology of Extracellular Vesicles
10.1038/nrm.2017.125 · 2018 · External reference
Proteomic Profiling of Tissue Extracellular Vesicles (EVs) Identifies Tissue EV Markers and Estimates the Abundance of Tissue EVs in the Circulation
10.1016/j.vesic.2025.100097 · 2025 · External reference
Minimal Information for Studies of Extracellular Vesicles (MISEV2023): From Basic to Advanced Approaches
10.1002/jev2.12404 · 2024 · External reference
circAtlas 3.0: A Gateway to 3 Million Curated Vertebrate Circular RNAs Based on a Standardized Nomenclature Scheme
2024 · External reference
Single‐Nucleus Transcriptome Profiling of Wild Boar and Domestic Pig Intestines Reveals the Spatiotemporal Dynamics of Immunity and Nutrient Absorption
10.1007/s11427-025-2993-2 · 2026 · External reference
Comparison of the Protein Composition of Isolated Extracellular Vesicles From Mouse Brain and Dissociated Brain Cell Culture Medium
10.1371/journal.pone.0309716 · 2024 · External reference
Genome‐Wide Midrange Transcription Profiles Reveal Expression Level Relationships in Human Tissue Specification
10.1093/bioinformatics/bti042 · 2005 · External reference
ABO Genotype Alters the Gut Microbiota by Regulating GalNAc Levels in Pigs
10.1038/s41586-022-04769-z · 2022 · External reference
A Cryostat‐Based Frozen Section Method to Increase the Yield of Extracellular Vesicles Extracted From Different Tissues
10.2144/btn-2022-0035 · 2022 · External reference
ATP1A3 as a Target for Isolating Neuron‐Specific Extracellular Vesicles From Human Brain and Biofluids
10.1126/sciadv.adi3647 · 2023 · External reference
Nano‐seq Analysis Reveals Different Functional Tendency Between Exosomes and Microvesicles Derived From hUMSC
10.1186/s13287-023-03491-5 · 2023 · External reference
10.1089/omi.2011.0118
10.1089/omi.2011.0118 · External reference
Identification of Distinct Nanoparticles and Subsets of Extracellular Vesicles by Asymmetric Flow Field‐Flow Fractionation
10.1038/s41556-018-0040-4 · 2018 · External reference
Comprehensive Characterization of Human Brain‐Derived Extracellular Vesicles Using Multiple Isolation Methods: Implications for Diagnostic and Therapeutic Applications
10.1002/jev2.12358 · 2023 · External reference
An Atlas of Expression Quantitative Trait Loci of microRNAs in Longissimus Muscle of Eight‐Way Crossbred Pigs
10.1016/j.jgg.2023.02.007 · 2023 · External reference
Metascape Provides a Biologist‐Oriented Resource for the Analysis of Systems‐Level Datasets
10.1038/s41467-019-09234-6 · 2019 · External reference