Research graph
References from Shear Stress‐Stimulated Trafficking of Endothelial Piezo1 to Splenic Capsule Boosts Spleen Contraction and Exercise Endurance. Local targets link to admitted publications; unresolved targets remain external evidence.
A Systems View of the Vascular Endothelium in Health and Disease
10.1016/j.cell.2024.07.012 · 2024 · External reference
Endothelial Fluid Shear Stress Sensing in Vascular Health and Disease
10.1172/jci83083 · 2016 · External reference
Endothelial Piezo1 Sustains Muscle Capillary Density and Contributes to Physical Activity
10.1172/jci141775 · 2022 · External reference
PIEZO Force Sensing in Vascular Biology: An Explosion of New Knowledge, Concepts and Opportunity
10.1002/advs.202511774 · 2025 · External reference
Visualizing PIEZO1 Localization and Activity in hiPSC‐Derived Single Cells and Organoids With HaloTag Technology
10.1038/s41467-025-59150-1 · 2025 · External reference
Platelets, Endothelial Cells and Leukocytes Contribute to the Exercise‐Triggered Release of Extracellular Vesicles Into the Circulation
10.1080/20013078.2019.1615820 · 2019 · External reference
The Roles of Extracellular Vesicles in the Immune System
10.1038/s41577-022-00763-8 · 2023 · External reference
Biophysical and Biochemical Roles of Shear Stress on Endothelium: A Revisit and New Insights
10.1161/circresaha.124.325685 · 2025 · External reference
Acute Exercise‐Induced Release of Innate Immune Proteins via Small Extracellular Vesicles Changes With Aerobic Fitness and Age
10.1111/apha.14095 · 2024 · External reference
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
10.1126/science.1193270 · 2010 · External reference
Context‐Specific Regulation of Extracellular Vesicle Biogenesis and Cargo Selection
10.1038/s41580-023-00576-0 · 2023 · External reference
Noradrenergic and Peptidergic Innervation of Lymphoid Tissue
10.4049/jimmunol.135.2.755 · 1985 · External reference
Exercise as Elixir to Combat Cardiovascular Ageing
10.1016/j.arr.2025.102848 · 2025 · External reference
The Body Hematocrit/Venous Hematocrit Ratio and the "Splenic Reservoir"
10.1182/blood.v17.1.71.71 · 1961 · External reference
Dysregulation of Extracellular Vesicle Protein Cargo in Female Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Cases and Sedentary Controls in Response to Maximal Exercise
10.1002/jev2.12403 · 2024 · External reference
Vascular Adaptation to Exercise in Humans: Role of Hemodynamic Stimuli
10.1152/physrev.00014.2016 · 2017 · External reference
Endothelial Shear Stress Signal Transduction and Atherogenesis: From Mechanisms to Therapeutics
10.1016/j.pharmthera.2022.108152 · 2022 · External reference
Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment
10.1016/j.molcel.2020.05.004 · 2020 · External reference
Longterm Exercise‐Derived Exosomal miR‐342‐5p
10.1161/circresaha.118.314635 · 2019 · External reference
Static Topographical Cue Combined With Dynamic Fluid Stimulation Enhances the Macrophage Extracellular Vesicle Yield and Therapeutic Potential for Bone Defects
10.1021/acsnano.4c15201 · 2025 · External reference
Reassessment of Exosome Composition
10.1016/j.cell.2019.02.029 · 2019 · External reference
Biodistribution of Extracellular Vesicles Following Administration Into Animals: A Systematic Review
10.1002/jev2.12085 · 2021 · External reference
Dissecting Exosome Inhibitors: Therapeutic Insights Into Small‐Molecule Chemicals Against Cancer
10.1038/s12276-022-00898-7 · 2022 · External reference
Comparison of Viral Inactivation Methods on the Characteristics of Extracellular Vesicles From SARS‐CoV‐2 Infected Human Lung Epithelial Cells
10.1002/jev2.12291 · 2022 · External reference
Piezo1 Integration of Vascular Architecture With Physiological Force
10.1038/nature13701 · 2014 · External reference
Effects of Panax Notoginseng Saponins on Alleviating Low Shear Induced Endothelial Inflammation and Thrombosis via Piezo1 Signalling
10.1016/j.jep.2024.118639 · 2024 · External reference
From Sweat to Hope: The Role of Exercise‐Induced Extracellular Vesicles in Cancer Prevention and Treatment
10.1002/jev2.12500 · 2024 · External reference
Exercise Promotes Angiogenesis by Enhancing Endothelial Cell Fatty Acid Utilization via Liver‐derived Extracellular Vesicle miR‐122‐5p
10.1016/j.jshs.2021.09.009 · 2022 · External reference
Moderate Exercise Enhances Endothelial Progenitor Cell Exosomes Release and Function
10.1249/mss.0000000000001672 · 2018 · External reference
Apoptotic Extracellular Vesicles Are Metabolized Regulators Nurturing the Skin and Hair
10.1016/j.bioactmat.2022.04.022 · 2023 · External reference
Specificities of Exosome Versus Small Ectosome Secretion Revealed by Live Intracellular Tracking of CD63 and CD9
10.1038/s41467-021-24384-2 · 2021 · External reference
Measurement of Splenic Hæmatocrit
10.1016/s0140-6736(68)92659-7 · 1968 · External reference
ARF6‐Regulated Shedding of Tumor Cell‐Derived Plasma Membrane Microvesicles
10.1016/j.cub.2009.09.059 · 2009 · External reference
A Beginner's Guide to Study Extracellular Vesicles in Human Blood Plasma and Serum
10.1002/jev2.12400 · 2024 · External reference
Mechanically Activated Ion Channel PIEZO1 Is Required for Lymphatic Valve Formation
10.1073/pnas.1817070115 · 2018 · External reference
Splenic Size and Volume Measurements in Patients With Chronic Lymphocytic Leukemia
10.1016/j.acra.2022.06.013 · 2023 · External reference
Enhanced Extracellular Vesicle Production and Ethanol‐Mediated Vascularization Bioactivity via a 3D‐Printed Scaffold‐Perfusion Bioreactor System
10.1016/j.actbio.2018.11.024 · 2019 · External reference
Piezo1, a Mechanically Activated Ion Channel, Is Required for Vascular Development in Mice
10.1073/pnas.1409233111 · 2014 · External reference
Piezo1 Channels Sense Whole Body Physical Activity to Reset Cardiovascular Homeostasis and Enhance Performance
10.1038/s41467-017-00429-3 · 2017 · External reference
Structure of the Mechanically Activated Ion Channel Piezo1
10.1038/nature25453 · 2018 · External reference
The Human Spleen During Physiological Stress
10.2165/00007256-200232060-00002 · 2002 · External reference
Flow‐Induced Reprogramming of Endothelial Cells in Atherosclerosis
10.1038/s41569-023-00883-1 · 2023 · External reference
The Role of Biomechanical Stress in Extracellular Vesicle Formation, Composition and Activity
10.1016/j.biotechadv.2023.108158 · 2023 · External reference
Shedding Light on the Cell Biology of Extracellular Vesicles
10.1038/nrm.2017.125 · 2018 · External reference
Measuring Particle Concentration of Multimodal Synthetic Reference Materials and Extracellular Vesicles With Orthogonal Techniques: Who Is Up to the Challenge?
10.1002/jev2.12052 · 2021 · External reference
Piezo1: Structural Pharmacology and Mechanotransduction Mechanisms
10.1016/j.tips.2025.06.009 · 2025 · External reference
Plasma Membrane‐Derived Extracellular Microvesicles Mediate Non‐Canonical Intercellular NOTCH Signaling
10.1038/s41467-017-00767-2 · 2017 · External reference
Adipocyte Piezo1 Mediates Obesogenic Adipogenesis Through the FGF1/FGFR1 Signaling Pathway in Mice
10.1038/s41467-020-16026-w · 2020 · External reference
Endothelial Cation Channel PIEZO1 Controls Blood Pressure by Mediating Flow‐Induced ATP Release
10.1172/jci87343 · 2016 · External reference
Mechanosensation by Endothelial PIEZO1 Is Required for Leukocyte Diapedesis
10.1182/blood.2021014614 · 2022 · External reference
Extracellular Vesicles Provide a Means for Tissue Crosstalk During Exercise
10.1016/j.cmet.2017.12.001 · 2018 · External reference
Minimal Information for Studies of Extracellular Vesicles (MISEV2023): From Basic to Advanced Approaches
10.1002/jev2.12404 · 2024 · External reference
Mechanisms of Mechanotransduction and Physiological Roles of PIEZO Channels
10.1038/s41580-024-00773-5 · 2024 · External reference
Extracellular Vesicle‐Based Drug Overview: Research Landscape, Quality Control and Nonclinical Evaluation Strategies
10.1038/s41392-025-02312-w · 2025 · External reference
Physiological Shear Stress Suppresses Apoptosis in Human Pulmonary Microvascular Endothelial Cells
10.14814/phy2.70269 · 2025 · External reference
Phosphorylation of Piezo1 at a Single Residue, Serine‐1612, Regulates Its Mechanosensitivity and In Vivo Mechanotransduction Function
10.1016/j.neuron.2024.08.009 · 2024 · External reference
Brain Control of Humoral Immune Responses Amenable to Behavioural Modulation
10.1038/s41586-020-2235-7 · 2020 · External reference
Ion Channel Piezo1 Activation Aggravates the Endothelial Dysfunction Under a High Glucose Environment
10.1186/s12933-024-02238-7 · 2024 · External reference
Structure and Mechanogating Mechanism of the Piezo1 Channel
10.1038/nature25743 · 2018 · External reference
