Research graph
References from <scp>SOX2</scp> Inhibits Cuproptosis to Affect Cisplatin Resistance in Non‐Small Cell Lung Cancer by Activating the Wnt/ <scp>ATP7B</scp> Signaling Pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Adjuvant Immunotherapy in Early‐Stage Resectable Non‐Small Cell Lung Cancer: A New Milestone
10.3389/fonc.2023.1063183 · 2023 · External reference
Baicalin Promotes the Sensitivity of NSCLC to Cisplatin by Regulating Ferritinophagy and Macrophage Immunity Through the KEAP1‐NRF2/HO‐1 Pathway
10.1186/s40001-024-01930-4 · 2024 · External reference
The Molecular Mechanism and Therapeutic Landscape of Copper and Cuproptosis in Cancer
10.1038/s41392-025-02192-0 · 2025 · External reference
Glucose Restriction Induces ROS‐AMPK‐Mediated CTR1 Expression and Increases Cisplatin Efficiency in NSCLC
10.1016/j.canlet.2022.215793 · 2022 · External reference
Combination of the Cuproptosis Inducer Disulfiram and Anti‐PD‐L1 Abolishes NSCLC Resistance by ATP7B to Regulate the HIF‐1 Signaling Pathway
10.3892/ijmm.2023.5343 · 2024 · External reference
Cuproptosis Inhibits Tumor Progression and Enhances Cisplatin Toxicity in Ovarian Cancer
10.1096/fj.202500047r · 2025 · External reference
Cuproptosis‐Related Gene—SLC31A1, FDX1 and ATP7B ‐ Polymorphisms Are Associated With Risk of Lung Cancer
10.2147/pgpm.s372824 · 2022 · External reference
MiR‐133a‐5p Facilitates Cuproptosis in Hepatocellular Carcinoma Through Targeting of ATP7B
10.2147/jir.s515647 · 2025 · External reference
ATPase Copper Transporting Beta (ATP7B) is a Novel Target for Improving the Therapeutic Efficacy of Docetaxel by Disulfiram/Copper in Human Prostate Cancer
10.1158/1535-7163.mct-23-0876 · 2024 · External reference
Dysregulated Wnt/Beta‐Catenin Signaling Confers Resistance to Cuproptosis in Cancer Cells
10.1038/s41418-024-01341-2 · 2024 · External reference
Development of a Prognostic Model for NSCLC Based on Differential Genes in Tumour Stem Cells
10.1038/s41598-024-71317-2 · 2024 · External reference
SOX2 Knockdown With siRNA Reverses Cisplatin Resistance in NSCLC by Regulating APE1 Signaling
10.1007/s12032-021-01626-3 · 2022 · External reference
Exosome‐Transmitted circVMP1 Facilitates the Progression and Cisplatin Resistance of Non‐Small Cell Lung Cancer by Targeting miR‐524‐5p‐METTL3/SOX2 Axis
10.1080/10717544.2022.2057617 · 2022 · External reference
SOX Transcription Factors Direct TCF‐Independent WNT/Beta‐Catenin Responsive Transcription to Govern Cell Fate in Human Pluripotent Stem Cells
10.1016/j.celrep.2022.111247 · 2022 · External reference
Up‐Regulation of microRNA‐200c‐3p Inhibits Invasion and Migration of Renal Cell Carcinoma Cells via the SOX2‐Dependent Wnt/Beta‐Catenin Signaling Pathway
10.1186/s12935-019-0944-5 · 2019 · External reference
TM4SF1 Promotes EMT and Cancer Stemness via the Wnt/Beta‐Catenin/SOX2 Pathway in Colorectal Cancer
10.1186/s13046-020-01690-z · 2020 · External reference
Copper Induces Cell Death by Targeting Lipoylated TCA Cycle Proteins
10.1126/science.abf0529 · 2022 · External reference
Dll1‐Mediated Notch Signaling Drives Tumor Cell Cross‐Talk With Cancer‐Associated Fibroblasts to Promote Radioresistance in Breast Cancer
10.1158/0008-5472.can-21-1225 · 2022 · External reference
Huangqin Qingre Qubi Capsule Inhibits RA Pathology by Binding FZD8 and Further Inhibiting the Activity of Wnt/Beta‐Catenin Signaling Pathway
10.1016/j.jep.2022.115886 · 2023 · External reference
Forkhead Box Protein M1 Promotes Nasopharyngeal Carcinoma Cell Tumorigenesis Possibly via the Wnt/Beta‐Catenin Signaling Pathway
2021 · External reference
Molecular Mechanisms of Chemoresistance Induced by Cisplatin in NSCLC Cancer Therapy
10.3390/ijms22168885 · 2021 · External reference
Metabolic Cell Death in Cancer: Ferroptosis, Cuproptosis, Disulfidptosis, and Beyond
10.1093/procel/pwae003 · 2024 · External reference
Intricate Relationship Between Cancer Stemness, Metastasis, and Drug Resistance
10.1002/mco2.710 · 2024 · External reference
Glioblastoma Functional Heterogeneity and Enrichment of Cancer Stem Cells With Tumor Recurrence
10.1016/j.neuron.2024.10.012 · 2024 · External reference
Cancer Stem Cells: Masters of All Traits
10.1016/j.bbadis.2024.167549 · 2025 · External reference
GJB2 Enhances Cancer Stem Cell Properties by Modulating SOX2 Expression via NF‐kappaB Pathway Activation in Lung Adenocarcinoma
10.21037/tcr-24-2075 · 2025 · External reference
Jmjd2c Maintains the ALDH(Bri+) Cancer Stemness With Transcription Factor SOX2 in Lung Squamous Cell Carcinoma
10.1080/15384047.2024.2373447 · 2024 · External reference
Long Non‐Coding RNA TDRG1 Aggravates Lung Cancer Stemness by Binding to Sox2 mRNA
10.1002/tox.23714 · 2023 · External reference
Baicalein Enhances Cisplatin Sensitivity in Cervical Cancer Cells by Promoting Cuproptosis Through the Akt Pathway
10.1016/j.biopha.2024.117415 · 2024 · External reference
Alterations in Astrocyte Subpopulations in Glioma and Identification of Cuproptosis‐Related Genes Using Single‐Cell RNA Sequencing
10.2147/jir.s473932 · 2024 · External reference
TTYH3 Promotes Cervical Cancer Progression by Activating the Wnt/Beta‐Catenin Signaling Pathway
10.1080/07357907.2024.2395014 · 2024 · External reference
SOX2 Gene Regulates the Transcriptional Network of Oncogenes and Affects Tumorigenesis of Human Lung Cancer Cells
10.1371/journal.pone.0036326 · 2012 · External reference
SOX2 Promotes Chemoresistance, Cancer Stem Cells Properties, and Epithelial‐Mesenchymal Transition by Beta‐Catenin and Beclin1/Autophagy Signaling in Colorectal Cancer
10.1038/s41419-021-03733-5 · 2021 · External reference
Signaling Pathways as the Pivotal Regulators of Cisplatin Resistance in Tumor Cells Through SOX2 Upregulation
10.1007/s12032-025-03004-9 · 2025 · External reference
C5a/C5aR Pathway Blocking Promoted CuS‐Mediated Cancer Therapy Effect by Inhibiting Cuproptosis Resistance
10.1136/jitc-2025-011472 · 2025 · External reference
Intricate Relationship Between Cancer Stemness, Metastasis, and Drug Resistance
10.1002/mco2.710 · ExternalCitation · doi-reference
Long Non‐Coding RNA TDRG1 Aggravates Lung Cancer Stemness by Binding to Sox2 mRNA
10.1002/tox.23714 · ExternalCitation · doi-reference
SOX2 Knockdown With siRNA Reverses Cisplatin Resistance in NSCLC by Regulating APE1 Signaling
10.1007/s12032-021-01626-3 · ExternalCitation · doi-reference
Signaling Pathways as the Pivotal Regulators of Cisplatin Resistance in Tumor Cells Through SOX2 Upregulation
10.1007/s12032-025-03004-9 · ExternalCitation · doi-reference
Cancer Stem Cells: Masters of All Traits
10.1016/j.bbadis.2024.167549 · ExternalCitation · doi-reference
Baicalein Enhances Cisplatin Sensitivity in Cervical Cancer Cells by Promoting Cuproptosis Through the Akt Pathway
10.1016/j.biopha.2024.117415 · ExternalCitation · doi-reference
Glucose Restriction Induces ROS‐AMPK‐Mediated CTR1 Expression and Increases Cisplatin Efficiency in NSCLC
10.1016/j.canlet.2022.215793 · ExternalCitation · doi-reference
SOX Transcription Factors Direct TCF‐Independent WNT/Beta‐Catenin Responsive Transcription to Govern Cell Fate in Human Pluripotent Stem Cells
10.1016/j.celrep.2022.111247 · ExternalCitation · doi-reference
Huangqin Qingre Qubi Capsule Inhibits RA Pathology by Binding FZD8 and Further Inhibiting the Activity of Wnt/Beta‐Catenin Signaling Pathway
10.1016/j.jep.2022.115886 · ExternalCitation · doi-reference
Glioblastoma Functional Heterogeneity and Enrichment of Cancer Stem Cells With Tumor Recurrence
10.1016/j.neuron.2024.10.012 · ExternalCitation · doi-reference
The Molecular Mechanism and Therapeutic Landscape of Copper and Cuproptosis in Cancer
10.1038/s41392-025-02192-0 · ExternalCitation · doi-reference
Dysregulated Wnt/Beta‐Catenin Signaling Confers Resistance to Cuproptosis in Cancer Cells
10.1038/s41418-024-01341-2 · ExternalCitation · doi-reference
SOX2 Promotes Chemoresistance, Cancer Stem Cells Properties, and Epithelial‐Mesenchymal Transition by Beta‐Catenin and Beclin1/Autophagy Signaling in Colorectal Cancer
10.1038/s41419-021-03733-5 · ExternalCitation · doi-reference
Development of a Prognostic Model for NSCLC Based on Differential Genes in Tumour Stem Cells
10.1038/s41598-024-71317-2 · ExternalCitation · doi-reference
TTYH3 Promotes Cervical Cancer Progression by Activating the Wnt/Beta‐Catenin Signaling Pathway
10.1080/07357907.2024.2395014 · ExternalCitation · doi-reference
Exosome‐Transmitted circVMP1 Facilitates the Progression and Cisplatin Resistance of Non‐Small Cell Lung Cancer by Targeting miR‐524‐5p‐METTL3/SOX2 Axis
10.1080/10717544.2022.2057617 · ExternalCitation · doi-reference
Jmjd2c Maintains the ALDH(Bri+) Cancer Stemness With Transcription Factor SOX2 in Lung Squamous Cell Carcinoma
10.1080/15384047.2024.2373447 · ExternalCitation · doi-reference
Metabolic Cell Death in Cancer: Ferroptosis, Cuproptosis, Disulfidptosis, and Beyond
10.1093/procel/pwae003 · ExternalCitation · doi-reference
Cuproptosis Inhibits Tumor Progression and Enhances Cisplatin Toxicity in Ovarian Cancer
10.1096/fj.202500047r · ExternalCitation · doi-reference
Copper Induces Cell Death by Targeting Lipoylated TCA Cycle Proteins
10.1126/science.abf0529 · ExternalCitation · doi-reference
C5a/C5aR Pathway Blocking Promoted CuS‐Mediated Cancer Therapy Effect by Inhibiting Cuproptosis Resistance
10.1136/jitc-2025-011472 · ExternalCitation · doi-reference
Dll1‐Mediated Notch Signaling Drives Tumor Cell Cross‐Talk With Cancer‐Associated Fibroblasts to Promote Radioresistance in Breast Cancer
10.1158/0008-5472.can-21-1225 · ExternalCitation · doi-reference
ATPase Copper Transporting Beta (ATP7B) is a Novel Target for Improving the Therapeutic Efficacy of Docetaxel by Disulfiram/Copper in Human Prostate Cancer
10.1158/1535-7163.mct-23-0876 · ExternalCitation · doi-reference
Up‐Regulation of microRNA‐200c‐3p Inhibits Invasion and Migration of Renal Cell Carcinoma Cells via the SOX2‐Dependent Wnt/Beta‐Catenin Signaling Pathway
10.1186/s12935-019-0944-5 · ExternalCitation · doi-reference
TM4SF1 Promotes EMT and Cancer Stemness via the Wnt/Beta‐Catenin/SOX2 Pathway in Colorectal Cancer
10.1186/s13046-020-01690-z · ExternalCitation · doi-reference
Baicalin Promotes the Sensitivity of NSCLC to Cisplatin by Regulating Ferritinophagy and Macrophage Immunity Through the KEAP1‐NRF2/HO‐1 Pathway
10.1186/s40001-024-01930-4 · ExternalCitation · doi-reference
SOX2 Gene Regulates the Transcriptional Network of Oncogenes and Affects Tumorigenesis of Human Lung Cancer Cells
10.1371/journal.pone.0036326 · ExternalCitation · doi-reference
GJB2 Enhances Cancer Stem Cell Properties by Modulating SOX2 Expression via NF‐kappaB Pathway Activation in Lung Adenocarcinoma
10.21037/tcr-24-2075 · ExternalCitation · doi-reference
Alterations in Astrocyte Subpopulations in Glioma and Identification of Cuproptosis‐Related Genes Using Single‐Cell RNA Sequencing
10.2147/jir.s473932 · ExternalCitation · doi-reference
MiR‐133a‐5p Facilitates Cuproptosis in Hepatocellular Carcinoma Through Targeting of ATP7B
10.2147/jir.s515647 · ExternalCitation · doi-reference
Cuproptosis‐Related Gene—SLC31A1, FDX1 and ATP7B ‐ Polymorphisms Are Associated With Risk of Lung Cancer
10.2147/pgpm.s372824 · ExternalCitation · doi-reference
Adjuvant Immunotherapy in Early‐Stage Resectable Non‐Small Cell Lung Cancer: A New Milestone
10.3389/fonc.2023.1063183 · ExternalCitation · doi-reference
Molecular Mechanisms of Chemoresistance Induced by Cisplatin in NSCLC Cancer Therapy
10.3390/ijms22168885 · ExternalCitation · doi-reference
Combination of the Cuproptosis Inducer Disulfiram and Anti‐PD‐L1 Abolishes NSCLC Resistance by ATP7B to Regulate the HIF‐1 Signaling Pathway
10.3892/ijmm.2023.5343 · ExternalCitation · doi-reference