Research graph
References from Posttranslational Modifications of p62/SQSTM1 in Health and Disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Molecular Cloning of a Phosphotyrosine‐independent Ligand of the p56lck SH2 Domain
10.1073/pnas.93.12.5991 · 1996 · External reference
Requirement for p62 Acetylation in the Aggregation of Ubiquitylated Proteins Under Nutrient Stress
10.1038/s41467-019-13718-w · 2019 · External reference
p62 is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway
10.1016/j.molcel.2011.06.038 · 2011 · External reference
K63 polyubiquitination and Activation of mTOR by the p62‐TRAF6 Complex in Nutrient‐activated Cells
10.1016/j.molcel.2013.06.020 · 2013 · External reference
The Adaptor Protein p62/SQSTM1 Targets Invading Bacteria to the Autophagy Pathway
10.4049/jimmunol.0900441 · 2009 · External reference
Listeria monocytogenes ActA‐mediated Escape From Autophagic Recognition
10.1038/ncb1967 · 2009 · External reference
Midbody Ring Disposal by Autophagy Is a Post‐abscission Event of Cytokinesis
10.1038/ncb1813 · 2009 · External reference
PINK1/Parkin‐mediated Mitophagy Is Dependent on VDAC1 and p62/SQSTM1
10.1038/ncb2012 · 2010 · External reference
Ubiquitin Signals Autophagic Degradation of Cytosolic Proteins and Peroxisomes
10.1073/pnas.0810611105 · 2008 · External reference
The Selective Autophagy Substrate p62 Activates the Stress Responsive Transcription Factor Nrf2 Through Inactivation of Keap1
10.1038/ncb2021 · 2010 · External reference
Phosphorylation of p62 Activates the Keap1‐Nrf2 Pathway During Selective Autophagy
10.1016/j.molcel.2013.08.003 · 2013 · External reference
PB1 domain‐mediated Heterodimerization in NADPH Oxidase and Signaling Complexes of atypical Protein Kinase C With Par6 and p62
10.1016/s1097-2765(03)00246-6 · 2003 · External reference
The Interaction of p62 With RIP Links the atypical PKCs to NF‐kappaB Activation
10.1093/emboj/18.11.3044 · 1999 · External reference
Crystal Structure of the Ubiquitin‐associated (UBA) Domain of p62 and Its Interaction With Ubiquitin
10.1074/jbc.m111.259630 · 2011 · External reference
Solution Structure of the Ubiquitin‐associated (UBA) Domain of human Autophagy Receptor NBR1 and Its Interaction With Ubiquitin and Polyubiquitin
10.1074/jbc.m114.555441 · 2014 · External reference
Teaching the Basics of Autophagy and Mitophagy to Redox Biologists–mechanisms and Experimental Approaches
10.1016/j.redox.2015.01.003 · 2015 · External reference
Molecular Determinants Regulating Selective Binding of Autophagy Adapters and Receptors to ATG8 Proteins
10.1038/s41467-019-10059-6 · 2019 · External reference
Nucleocytoplasmic Shuttling of p62/SQSTM1 and Its Role in Recruitment of Nuclear Polyubiquitinated Proteins to Promyelocytic Leukemia Bodies
10.1074/jbc.m109.039925 · 2010 · External reference
p62 in Cancer: Signaling Adaptor Beyond Autophagy
10.1016/j.cell.2016.09.030 · 2016 · External reference
p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators
10.1021/acs.jmedchem.9b02038 · 2020 · External reference
Control of Protein Stability by Post‐translational Modifications
10.1038/s41467-023-35795-8 · 2023 · External reference
Dynamics of Posttranslational Modification Systems: Recent Progress and Future Directions
10.1016/j.bpj.2017.11.3787 · 2018 · External reference
Post‐Translational Modifications of Proteins Orchestrate all Hallmarks of Cancer
10.3390/life15010126 · 2025 · External reference
Phosphorylation of Phase‐separated p62 Bodies by ULK1 Activates a Redox‐independent Stress Response
10.15252/embj.2022113349 · 2023 · External reference
Comprehensive PTM Profiling With SCASP‐PTM Uncovers Mechanisms of p62 Degradation and ALDOA‐mediated Tumor Progression
10.1016/j.celrep.2025.115500 · 2025 · External reference
Acetylation of p62 Regulates Base Excision Repair Through Interaction With APE1
10.1016/j.celrep.2022.111116 · 2022 · External reference
Phosphorylation of A170 Stress Protein by Casein Kinase II‐Like Activity in Macrophages
10.1006/bbrc.1997.7783 · 1997 · External reference
TBK1 controls Autophagosomal Engulfment of Polyubiquitinated Mitochondria Through p62/SQSTM1 Phosphorylation
10.1093/hmg/ddv179 · 2015 · External reference
TBK‐1 Promotes Autophagy‐mediated Antimicrobial Defense by Controlling Autophagosome Maturation
10.1016/j.immuni.2012.04.015 · 2012 · External reference
TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis
10.1016/j.molcel.2016.02.007 · 2016 · External reference
PRMT6‐mediated ADMA Promotes p62 Phase Separation to Form a Negative Feedback Loop in Ferroptosis
10.7150/thno.94789 · 2024 · External reference
The Proteomic Analysis of Endogenous FAT10 Substrates Identifies p62/SQSTM1 as a Substrate of FAT10ylation
2012 · External reference
Inhibition of Autophagic Flux by S‐nitrosylation of SQSTM1/p62 Promotes Neuronal Secretion and Cell‐to‐cell Transmission of SNCA/Alpha‐synuclein in Parkinson Disease and Lewy Body Dementia
10.1080/27694127.2022.2076770 · 2022 · External reference
S‐Nitrosylation of p62 Inhibits Autophagic Flux to Promote Alpha‐Synuclein Secretion and Spread in Parkinson's Disease and Lewy Body Dementia
10.1523/jneurosci.1508-21.2022 · 2022 · External reference
S‐acylation of p62 Promotes p62 Droplet Recruitment Into Autophagosomes in Mammalian Autophagy
10.1016/j.molcel.2023.09.004 · 2023 · External reference
SQSTM1/p62 Post‐Translational Modifications and Reverse Processes Modulate Disease Pathogenesis via KEAP1‐NRF2 Signaling and Selective Autophagy
10.1177/15230864251395963 · 2025 · External reference
Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th edition)(1)
10.1080/15548627.2020.1797280 · 2021 · External reference
Autophagy and Autophagy‐related Pathways in Cancer
10.1038/s41580-023-00585-z · 2023 · External reference
Mechanisms of Autophagosome Formation
10.2183/pjab.101.005 · 2025 · External reference
Love Laughs at Locksmiths: Ubiquitylation of p62 Unlocks Its Autophagy Receptor Potential
10.1038/cr.2017.56 · 2017 · External reference
p62/SQSTM1 binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy
10.1074/jbc.m702824200 · 2007 · External reference
Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates
10.1371/journal.pgen.1004987 · 2015 · External reference
Sestrin2 promotes Unc‐51‐Like Kinase 1 Mediated Phosphorylation of p62/Sequestosome‐1
10.1111/febs.12905 · 2014 · External reference
Sortase‐mediated Chemical Protein Synthesis Reveals the Bidentate Binding of Bisphosphorylated p62 With K63 Diubiquitin
10.1039/c7sc02937c · 2017 · External reference
Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins
10.1016/j.molcel.2011.07.039 · 2011 · External reference
Autophagic Degradation of the Androgen Receptor Mediated by Increased Phosphorylation of p62 Suppresses Apoptosis in Hypoxia
10.1016/j.cellsig.2015.07.009 · 2015 · External reference
TAK1 converts Sequestosome 1/p62 From an Autophagy Receptor to a Signaling Platform
2019 · External reference
Ubiquitylation of p62/sequestosome1 Activates Its Autophagy Receptor Function and Controls Selective Autophagy Upon Ubiquitin Stress
10.1038/cr.2017.40 · 2017 · External reference
Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination
10.1016/j.celrep.2017.03.030 · 2017 · External reference
Oxidation of SQSTM1/p62 Mediates the Link Between Redox state and Protein Homeostasis
10.1038/s41467-017-02746-z · 2018 · External reference
Ubiquitin‐mediated Recruitment of the ATG9A‐ATG2 Lipid Transfer Complex Drives Clearance of Phosphorylated p62 Aggregates
10.1091/mbc.e24-03-0101 · 2025 · External reference
The PB1 and the ZZ Domain of the Autophagy Receptor p62/SQSTM1 Regulate the Interaction of p62/SQSTM1 With the Autophagosome Protein LC3B
10.1002/pro.4840 · 2024 · External reference
PKA Phosphorylation of p62/SQSTM1 Regulates PB1 Domain Interaction Partner Binding
10.1016/j.bbamcr.2014.07.021 · 2014 · External reference
p62 Targeting to the Autophagosome Formation Site Requires Self‐Oligomerization But Not LC3 Binding
10.1083/jcb.201009067 · 2011 · External reference
Disruption of the EGFR‐SQSTM1 Interaction by a Stapled Peptide Suppresses Lung Cancer via Activating Autophagy and Inhibiting EGFR Signaling
10.1016/j.canlet.2020.01.004 · 2020 · External reference
TRIM38 Suppresses Breast Cancer Progression via Modulating SQSTM1 Ubiquitination and Autophagic Flux
10.1002/advs.202512725 · 2025 · External reference
Inhibition of SQSTM1 S403 Phosphorylation Facilitates the Aggresome Formation of Ubiquitinated Proteins During Proteasome Dysfunction
10.1186/s11658-023-00500-6 · 2023 · External reference
p38delta MAPK Regulates Aggresome Biogenesis by Phosphorylating SQSTM1 in Response to Proteasomal Stress
10.1242/jcs.216671 · 2018 · External reference
PLK2‐mediated Phosphorylation of SQSTM1 S349 Promotes Aggregation of Polyubiquitinated Proteins Upon Proteasomal Dysfunction
10.1080/15548627.2024.2361574 · 2024 · External reference
Physiological Insights Into ESCRT‐mediated Phagophore Closure: Potential Cytoprotective Roles for ATG8ylated Membranes
10.1080/15548627.2025.2468907 · 2025 · External reference
FIP200 controls the TBK1 Activation Threshold at SQSTM1/p62‐positive Condensates
10.1038/s41598-021-92408-4 · 2021 · External reference
USP13 deubiquitinates p62/SQSTM1 to Induce Autophagy and Nrf2 Release for Activating Antioxidant Response Genes
10.1016/j.freeradbiomed.2023.09.024 · 2023 · External reference
TRIM25 ubiquitinates and Degrades p62/SQSTM1 to Suppress Autophagy
10.3724/abbs.2025062 · 2025 · External reference
An Update on Oxidative Stress‐mediated Organ Pathophysiology
10.1016/j.fct.2013.09.026 · 2013 · External reference
Enhanced Liquidity of p62 Droplets Mediated by Smurf1 Links Nrf2 Activation and Autophagy
10.1186/s13578-023-00978-9 · 2023 · External reference
TAK1 Regulates the Nrf2 Antioxidant System through Modulating p62/SQSTM1
10.1089/ars.2016.6663 · 2016 · External reference
Ezetimibe, an NPC1L1 Inhibitor, Is a Potent Nrf2 Activator That Protects Mice From Diet‐induced Nonalcoholic Steatohepatitis
10.1016/j.freeradbiomed.2016.09.009 · 2016 · External reference
DNA Damage Response Pathway Regulates Nrf2 in Response to Oxidative Stress
10.1126/sciadv.adu9555 · 2025 · External reference
Role of Nrf2 and Exercise in Alleviating COPD‐induced Skeletal Muscle Dysfunction
10.1177/17534666231208633 · 2023 · External reference
Exercise Enhances Antioxidant Protein Levels in Oxidative Skeletal Muscle via IL‐1beta
10.1152/ajpregu.00052.2025 · 2026 · External reference
Activation of Macroautophagy and Chaperone‐mediated Autophagy in human Skeletal Muscle by High‐intensity Exercise in Normoxia and Hypoxia and After Recovery With or Without Post‐exercise Ischemia
10.1016/j.freeradbiomed.2024.07.012 · 2024 · External reference
TRIM21‐mediated Ubiquitination of SQSTM1/p62 Abolishes Its Ser403 Phosphorylation and Enhances Palmitic Acid Cytotoxicity
2024 · External reference
The Protein Kinase Activity of Fructokinase A Specifies the Antioxidant Responses of Tumor Cells by Phosphorylating p62
10.1126/sciadv.aav4570 · 2019 · External reference
P62/SQSTM1 is a Novel Leucine‐rich Repeat Kinase 2 (LRRK2) Substrate That Enhances Neuronal Toxicity
10.1042/bcj20170699 · 2018 · External reference
Serum Starvation Raises Turnover of Phosphorylated p62/SQSTM1 (Serine 349), Reveals Expression of Proteasome and N‐glycanase1 Interactive Protein RAD23B and Sensitizes human Synovial Fibroblasts to BAY 11‐7085‐induced Cell Death
10.18632/oncotarget.26295 · 2018 · External reference
Amino Acid Activation of mTORC1 by a PB1‐Domain‐Driven Kinase Complex Cascade
10.1016/j.celrep.2015.07.045 · 2015 · External reference
Dual‐specificity Kinase DYRK3 Phosphorylates p62 at the Thr‐269 Residue and Promotes Melanoma Progression
10.1016/j.jbc.2024.107206 · 2024 · External reference
Irradiation‐induced Increase in Nuclear p62 Levels Contributes to Chromosomal Fragmentation and Chromothripsis
10.1097/js9.0000000000002643 · 2025 · External reference
TRIM23 mediates Virus‐induced Autophagy via Activation of TBK1
10.1038/s41564-017-0017-2 · 2017 · External reference
Attenuation of cGAS‐STING Signaling Is Mediated by a p62/SQSTM1‐dependent Autophagy Pathway Activated by TBK1
10.15252/embj.201797858 · 2018 · External reference
CSNK1A1/CK1alpha suppresses Autoimmunity by Restraining the CGAS‐STING1 Signaling
10.1080/15548627.2023.2256135 · 2024 · External reference
Zebrafish TRIM2a Promotes Virus Replication via Ubiquitination of IRF3 and Autophagic Cargo Receptor p62
10.1093/jimmun/vkaf064 · 2025 · External reference
Enhancing Sirt1‐mediated Deacetylation of p62 With a Self‐assembling Nanopeptide and Resveratrol Hydrogel to Mitigate Sepsis‐induced Inflammation
10.1016/j.phymed.2025.157047 · 2025 · External reference
An ER‐Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport
10.1016/j.cell.2016.05.078 · 2016 · External reference
The ER‐embedded UBE2J1/RNF26 Ubiquitylation Complex Exerts Spatiotemporal Control Over the Endolysosomal Pathway
10.1016/j.celrep.2020.108659 · 2021 · External reference
VPS34 stimulation of p62 Phosphorylation for Cancer Progression
10.1038/onc.2017.295 · 2017 · External reference
Activation of Tumor‐promoting Pathways Implicated in Hepatocellular Adenoma/Carcinoma, a Long‐term Complication of Glycogen Storage Disease Type Ia
10.1016/j.bbrc.2019.11.061 · 2020 · External reference
Glucose Activates Lysine‐Specific Demethylase 1 Through the KEAP1/p62 Pathway
10.3390/antiox10121898 · 2021 · External reference
GPR30 Activation by 17beta‐Estradiol Promotes p62 Phosphorylation and Increases Estrogen Receptor Alpha Protein Expression by Inducing Its Release From a Complex Formed With KEAP1
10.3390/jpm11090906 · 2021 · External reference
Caspase‐8 Expression and Its Src Dependent Phosphorylation on Tyrosine 380 Triggers NRF2 Signaling Activation in Glioblastoma
10.1038/s41418-025-01542-3 · 2025 · External reference
Kaposi's Sarcoma‐associated Herpesvirus Induces Nrf2 Activation in Latently Infected Endothelial Cells Through SQSTM1 Phosphorylation and Interaction With Polyubiquitinated Keap1
10.1128/jvi.02742-14 · 2015 · External reference
p62/Sqstm1 promotes Malignancy of HCV‐positive Hepatocellular Carcinoma Through Nrf2‐dependent Metabolic Reprogramming
10.1038/ncomms12030 · 2016 · External reference
Phosphorylation of p62 by cdk1 Controls the Timely Transit of Cells Through Mitosis and Tumor Cell Proliferation
10.1128/mcb.00620-10 · 2011 · External reference
Enhanced Epithelial‐to‐mesenchymal Transition Associated With Lysosome Dysfunction in Podocytes: Role of p62/Sequestosome 1 as a Signaling Hub
10.1159/000373989 · 2015 · External reference
Identification and Validation of ATP6V1G1‐regulated Phosphorylated Proteins in Hepatocellular Carcinoma
10.1371/journal.pone.0310037 · 2024 · External reference
HOXA3 activates USP15 to Suppress Autophagy and Promote M2‐type Macrophage Polarization in Renal Cell Carcinoma via Facilitating the Deubiquitination of SQSTM1
10.1152/ajpcell.00712.2024 · 2025 · External reference
SERPINH1 modulates Apoptosis by Inhibiting P62 Ubiquitination Degradation to Promote Bone Metastasis of Prostate Cancer
10.1016/j.isci.2024.110427 · 2024 · External reference
Sirt1 deacetylates and Stabilizes p62 to Promote Hepato‐carcinogenesis
10.1038/s41419-021-03666-z · 2021 · External reference
TRIM44, a Novel Prognostic Marker, Supports the Survival of Proteasome‐Resistant Multiple Myeloma Cells
10.3390/cells13171431 · 2024 · External reference
The Expression of p‐p62 and Nuclear Nrf2 in Esophageal Squamous Cell Carcinoma and Association With Radioresistance
10.1111/1759-7714.13252 · 2020 · External reference
Inhibitors of the Protein‐protein Interaction Between Phosphorylated p62 and Keap1 Attenuate Chemoresistance in a human Hepatocellular Carcinoma Cell Line
10.1080/10715762.2020.1732955 · 2020 · External reference
Unveiling the Physiological Impact of ESCRT‐dependent Autophagosome Closure by Targeting the VPS37A Ubiquitin E2 Variant‐Like Domain
10.1016/j.celrep.2024.115016 · 2024 · External reference
Autophagic Sequestration of SQSTM1 Disrupts the Aggresome Formation of Ubiquitinated Proteins During Proteasome Inhibition
10.1038/s41419-022-05061-8 · 2022 · External reference
TBK1 is a Signaling Hub in Coordinating Stress‐adaptive Mechanisms in Head and Neck Cancer Progression
10.1080/15548627.2025.2481661 · 2025 · External reference
NAP1L1 degradation by FBXW7 Reduces the Deubiquitination of HDGF‐p62 Signaling to Stimulate Autophagy and Induce Primary Cisplatin Chemosensitivity in Nasopharyngeal Carcinoma
10.1186/s12943-025-02349-z · 2025 · External reference
PROCR Diminishes the Efficacy of Radiation by Impairing T‐cell‐mediated Antitumour Immunity
10.1038/s41467-025-62558-4 · 2025 · External reference
Targeting the HECTD3‐p62 Axis Increases the Radiosensitivity of Triple Negative Breast Cancer Cells
10.1038/s41420-024-02154-5 · 2024 · External reference
PTK2/FAK Regulates UPS Impairment via SQSTM1/p62 Phosphorylation in TARDBP/TDP‐43 Proteinopathies
10.1080/15548627.2019.1686729 · 2020 · External reference
ALS‐associated TBK1 Variant p.G175S Is Defective in Phosphorylation of p62 and Impacts TBK1‐mediated Signalling and TDP‐43 Autophagic Degradation
10.1016/j.mcn.2020.103539 · 2020 · External reference
Functional Characterization of a Familial ALS‐Associated Missense TBK1 (p‐Arg573Gly) Mutation in Patient‐Derived Lymphoblasts
10.3390/ijms24032847 · 2023 · External reference
ALS‐FTLD‐linked Mutations of SQSTM1/p62 Disrupt Selective Autophagy and NFE2L2/NRF2 Anti‐oxidative Stress Pathway
10.1080/15548627.2019.1644076 · 2020 · External reference
NS1 binding Protein Regulates Stress Granule Dynamics and Clearance by Inhibiting p62 Ubiquitination
10.1038/s41467-024-55446-w · 2024 · External reference
Cytosolic PINK1 Promotes the Targeting of Ubiquitinated Proteins to the Aggresome‐autophagy Pathway During Proteasomal Stress
10.1080/15548627.2016.1147667 · 2016 · External reference
Parkin Promotes Proteasomal Degradation of p62: Implication of Selective Vulnerability of Neuronal Cells in the Pathogenesis of Parkinson's Disease
10.1007/s13238-015-0230-9 · 2016 · External reference
Parkin Truncating Variants Result in a Loss‐of‐function Phenotype
10.1038/s41598-019-52534-6 · 2019 · External reference
Interplay Between Leucine‐Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM‐1 in Selective Autophagy
10.1371/journal.pone.0163029 · 2016 · External reference
Phosphorylation of Serine 349 of p62 in Alzheimer's disease Brain
10.1186/2051-5960-2-50 · 2014 · External reference
Mechanistic Insight Into Female Predominance in Alzheimer's Disease Based on Aberrant Protein S‐nitrosylation of C3
10.1126/sciadv.ade0764 · 2022 · External reference
Continued 26S Proteasome Dysfunction in Mouse Brain Cortical Neurons Impairs Autophagy and the Keap1‐Nrf2 Oxidative Defence Pathway
10.1038/cddis.2016.443 · 2017 · External reference
Sequestering Sequestosome 1 via S‐acylation in Autophagy, Huntington Disease, and Beyond
10.1080/27694127.2025.2547975 · 2025 · External reference
CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1‐Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis
10.1002/advs.202414550 · 2025 · External reference
Microbially Produced Imidazole Propionate Impairs Insulin Signaling Through mTORC1
10.1016/j.cell.2018.09.055 · 2018 · External reference
Humanized Monoacylglycerol Acyltransferase 2 Mice Develop Metabolic Dysfunction‐associated Steatohepatitis
10.1016/j.jlr.2024.100695 · 2024 · External reference
Lipotoxicity Induces Hepatic Protein Inclusions Through TANK Binding Kinase 1‐mediated p62/Sequestosome 1 Phosphorylation
10.1002/hep.29742 · 2018 · External reference
Tank‐Binding Kinase 1 Protects Against MASH Progression via Mitochondrial Quality Control
10.1038/s12276-026-01672-9 · 2026 · External reference
Deubiquitinase USP25 Alleviates Obesity‐Induced Cardiac Remodeling and Dysfunction by Downregulating TAK1 and Reducing TAK1‐Mediated Inflammation
2024 · External reference
OTUD7B deubiquitinates SQSTM1/p62 and Promotes IRF3 Degradation to Regulate Antiviral Immunity
10.1080/15548627.2022.2026098 · 2022 · External reference
Hepatitis B Surface Antigen Hijacks TANK‐binding Kinase 1 to Suppress Type I Interferon and Induce Early Autophagy
10.1038/s41419-025-07605-0 · 2025 · External reference
Coronavirus M Protein Promotes Mitophagy Over Virophagy by Recruiting PDPK1 to Phosphorylate SQSTM1 at T138
10.1038/s41467-024-53100-z · 2024 · External reference
Unc‐51‐Like Kinase 1 (ULK1) Regulates Bacterial Ubiquitylation and p62 Recruitment During Xenophagic Clearance of Listeria monocytogenes
10.1128/msphere.00308-25 · 2025 · External reference
A Detrimental Role of NLRP6 in Host Iron Metabolism During Salmonella Infection
10.1016/j.redox.2021.102217 · 2022 · External reference
Trichinella spiralis Inhibits Myoblast Differentiation by Targeting SQSTM1/p62 With a Secreted E3 Ubiquitin Ligase
10.1016/j.isci.2024.109102 · 2024 · External reference
TRIM21 promotes Type I Interferon by Inhibiting the Autophagic Degradation of STING via p62/SQSTM1 Ubiquitination in Systemic Lupus Erythematosus
10.3724/abbs.2025046 · 2025 · External reference
Myeloid‐specific Hdac10 Deletion Protects Against LPS‐induced Acute Lung Injury via P62 Acetylation at Lysine 165
10.1186/s12931-024-02891-2 · 2024 · External reference
IL‐1beta Restrains Its Own Apoptosis‐promoting Activity via NF‐kappaB (RelA) Ser276/p62‐mediated Elimination of Damaged Mitochondria in Chondrocytes
10.1093/bbb/zbaf119 · 2025 · External reference
Muscle‐derived IL‐1beta Regulates EcSOD Expression via the NBR1‐p62‐Nrf2 Pathway in Muscle During Cancer Cachexia
10.1113/jp286460 · 2024 · External reference
Muscle p62 Stimulates the Expression of Antioxidant Proteins Alleviating Cancer Cachexia
10.1096/fj.202300349r · 2023 · External reference
Hypoxic Postconditioning Restores Mitophagy Against Transient Global Cerebral Ischemia via Parkin‐induced Posttranslational Modification of TBK1
10.1016/j.nbd.2023.106043 · 2023 · External reference
Exosomal MiR‐653‐3p Alleviates Hypoxic‐Ischemic Brain Damage via the TRIM21/p62/Nrf2/CYLD Axis
10.1007/s12035-024-04507-8 · 2025 · External reference
Failure of Efficient Cardiac Proteostatic Adaptations to Chronic cAMP‐stress Is Associated With Accelerated Heart Aging
10.1007/s11357-025-01851-y · 2025 · External reference
TRIM21 knockout Alleviates Renal Fibrosis by Promoting Autophagic Degradation of Mature TGF‐beta1
10.1016/j.bcp.2025.116822 · 2025 · External reference
Deacetylation of GLUD1 Maintains the Survival of Lung Adenocarcinoma Cells Under Glucose Starvation by Inhibiting Autophagic Cell Death
10.1016/j.cellin.2024.100186 · 2024 · External reference
PIM Kinases Mediate Resistance of Glioblastoma Cells to TRAIL by a p62/SQSTM1‐dependent Mechanism
10.1038/s41419-018-1293-3 · 2019 · External reference
Mitochondrial Reactive Oxygen Species Trigger Metformin‐dependent Antitumor Immunity via Activation of Nrf2/mTORC1/p62 Axis in Tumor‐infiltrating CD8T Lymphocytes
10.1136/jitc-2021-002954 · 2021 · External reference
Genetic and Clinical Landscape of Chinese Frontotemporal Dementia: Dominance of TBK1 and OPTN Mutations
10.1186/s13195-024-01493-w · 2024 · External reference
Non‐canonical Function of FIP200 Is Required for Neural Stem Cell Maintenance and Differentiation by Limiting TBK1 Activation and p62 Aggregate Formation
10.1038/s41598-021-03404-7 · 2021 · External reference
Phosphorylation of p62 by AMP‐activated Protein Kinase Mediates Autophagic Cell Death in Adult Hippocampal Neural Stem Cells
10.1074/jbc.m117.780874 · 2017 · External reference
RNF166 Determines Recruitment of Adaptor Proteins During Antibacterial Autophagy
10.1016/j.celrep.2016.11.005 · 2016 · External reference
Tripartite Motif 25 Inhibits Protein Aggregate Degradation During PRRSV Infection by Suppressing p62‐mediated Autophagy
10.1128/jvi.01437-24 · 2024 · External reference
Tumor Necrosis Factor Receptor‐associated Factor 6 (TRAF6) Regulates Aeromonas Hydrophila‐induced Autophagy in Yellow Catfish (Pelteobagrus fulvidraco)
10.1016/j.fsi.2025.111066 · 2026 · External reference
Mink Enteritis Virus Infection Induced Cell Cycle Arrest and Autophagy for Its Replication
10.1016/j.vetmic.2025.110374 · 2025 · External reference
PRRSV Degrades MDA5 via Dual Autophagy Receptors P62 and CCT2 to Evade Antiviral Innate Immunity
10.1016/j.virs.2024.01.005 · 2024 · External reference
Vaccinia Virus Subverts Xenophagy Through Phosphorylation and Nuclear Targeting of p62
10.1083/jcb.202104129 · 2024 · External reference
CDKL5 regulates p62‐mediated Selective Autophagy and Confers Protection Against Neurotropic Viruses
10.1172/jci168544 · 2024 · External reference
The Autophagy Receptor SQSTM1/p62 Is a Restriction Factor of HCMV Infection
10.3390/v16091440 · 2024 · External reference
Serine Ubiquitination of SQSTM1 Regulates NFE2L2‐dependent Redox Homeostasis
2024 · External reference
An Intrinsic Host Defense Against HSV‐1 Relies on the Activation of Xenophagy With the Active Clearance of Autophagic Receptors
10.3390/cells13151256 · 2024 · External reference
Autophagy Suppresses Interleukin‐1beta (IL‐1beta) Signaling by Activation of p62 Degradation via Lysosomal and Proteasomal Pathways
10.1074/jbc.m111.280065 · 2012 · External reference
ACOD1, rather Than Itaconate, Facilitates p62‐mediated Activation of Nrf2 in Microglia Post Spinal Cord Contusion
10.1002/ctm2.1661 · 2024 · External reference
Prevention of Supercritical Carbon Dioxide Fluid Extract From Chrysanthemum Indicum Linnen on Cutaneous Squamous Cell Carcinomas Progression Following UV Irradiation in Mice
10.3892/etm.2024.12619 · 2024 · External reference
Synthesis of Keap1‐phosphorylated p62 and Keap1‐Nrf2 Protein‐protein Interaction Inhibitors and Their Inhibitory Activity
10.1016/j.bmcl.2016.10.083 · 2016 · External reference
Tiliroside Targets TBK1 to Induce Ferroptosis and Sensitize Hepatocellular Carcinoma to Sorafenib
10.1016/j.phymed.2023.154668 · 2023 · External reference
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Carnosol Attenuates Ang II‐induced Renal Injury by p62‐KEAP1‐NRF2 Signaling Pathway
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PEG‐23 Glyceryl Distearate, a Multifunctional Skin‐supporting Material, Upregulates the Expression of Factors Associated With Epidermal Barrier and Hydration
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