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References from Cholesterol 25‐Hydroxylase Deficiency Provides an Optimal and Durable Protective T Helper 1 Immunity via Interleukin‐12–Interleukin‐2 Axis in BCG‐Vaccinated Mice. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2025 · External reference
Key Advances in Vaccine Development for Tuberculosis‐Success and Challenges
10.1038/s41541-023-00750-7 · 2023 · External reference
Systematic Review and Meta‐Analysis of the Current Evidence on the Duration of Protection by bacillus Calmette‐Guerin Vaccination against Tuberculosis
10.3310/hta17370 · 2013 · External reference
10.1002/mco2.419
10.1002/mco2.419 · External reference
Effect of BCG Vaccination on Childhood Tuberculous Meningitis and Miliary Tuberculosis Worldwide: a Meta‐Analysis and Assessment of Cost‐Effectiveness
10.1016/s0140-6736(06)68507-3 · 2006 · External reference
The Success and Failure of BCG—Implications for a Novel Tuberculosis Vaccine
10.1038/nrmicro1211 · 2005 · External reference
Timing of Mycobacterium Tuberculosis Exposure Explains Variation in BCG Effectiveness: a Systematic Review and Meta‐Analysis
10.1136/thoraxjnl-2020-216794 · 2021 · External reference
Mucosal BCG Vaccination Induces Protective Lung‐Resident Memory T Cell Populations against Tuberculosis
10.1128/mbio.01686-16 · 2016 · External reference
Rv3615c is a Highly Immunodominant RD1 (Region of Difference 1)‐Dependent Secreted Antigen Specific for Mycobacterium Tuberculosis Infection
10.1073/pnas.1015153108 · 2011 · External reference
Safety and Efficacy of MVA85A, a New Tuberculosis Vaccine, in Infants Previously Vaccinated with BCG: a Randomised, Placebo‐Controlled Phase 2b Trial
10.1016/s0140-6736(13)60177-4 · 2013 · External reference
Next‐Generation TB Vaccines: Progress, Challenges, and Prospects
10.3390/vaccines11081304 · 2023 · External reference
Cholesterol Metabolism in Cancer: Mechanisms and Therapeutic Opportunities
10.1038/s42255-020-0174-0 · 2020 · External reference
Oxysterol‐EBI2 Signaling in Immune Regulation and Viral Infection
10.1002/eji.201444493 · 2014 · External reference
ATF3 and CH25H Regulate Effector Trogocytosis and Anti‐Tumor Activities of Endogenous and Immunotherapeutic Cytotoxic T Lymphocytes
10.1016/j.cmet.2022.08.007 · 2022 · External reference
Cholesterol 25‐Hydroxylase Inhibits SARS‐CoV‐2 and Other Coronaviruses by Depleting Membrane Cholesterol
10.15252/embj.2020106057 · 2020 · External reference
New Targets for Controlling Ebola Virus Disease
10.1093/nsr/nwv043 · 2015 · External reference
Cholesterol 25‐Hydroxylase Production by Dendritic Cells and Macrophages Is Regulated by Type I Interferons
10.1189/jlb.0610318 · 2010 · External reference
Listeria Monocytogenes Infection Induces Prosurvival Metabolic Signaling in Macrophages
10.1128/iai.01195-10 · 2011 · External reference
Role of Cholesterol 25‐Hydroxylase (Ch25h) in Mediating Innate Immune Responses to Streptococcus pneumoniae Infection
10.3390/cells12040570 · 2023 · External reference
Inflammation. 25‐Hydroxycholesterol Suppresses Interleukin‐1‐Driven Inflammation Downstream of Type I Interferon
10.1126/science.1254790 · 2014 · External reference
Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation
10.1016/j.cell.2017.09.029 · 2017 · External reference
25‐Hydroxycholesterol Contributes to Cerebral Inflammation of X‐Linked Adrenoleukodystrophy through Activation of the NLRP3 Inflammasome
10.1038/ncomms13129 · 2016 · External reference
25‐Hydroxycholesterol Amplifies Microglial IL‐1β Production in an apoE Isoform‐Dependent Manner
10.1186/s12974-020-01869-3 · 2020 · External reference
Cholesterol 25‐Hydroxylase Mediates Neuroinflammation and Neurodegeneration in a Mouse Model of Tauopathy
10.1084/jem.20232000 · 2024 · External reference
25‐Hydroxycholesterol Acts as an Amplifier of Inflammatory Signaling
10.1073/pnas.1404271111 · 2014 · External reference
Oxysterols Provide Innate Immunity to Bacterial Infection by Mobilizing Cell Surface Accessible Cholesterol
10.1038/s41564-020-0701-5 · 2020 · External reference
A Blunted GPR183/Oxysterol Axis during Dysglycemia Results in Delayed Recruitment of Macrophages to the Lung during Mycobacterium Tuberculosis Infection
10.1093/infdis/jiac102 · 2022 · External reference
Rapid GPR183‐Mediated Recruitment of Eosinophils to the Lung after Mycobacterium Tuberculosis Infection
10.1016/j.celrep.2022.111144 · 2022 · External reference
Pathogenic Mycobacterium Upregulates Cholesterol 25‐Hydroxylase to Promote Granuloma Development via Foam Cell Formation
10.1016/j.isci.2024.109204 · 2024 · External reference
Cholesterol 25‐Hydroxylase Is a Metabolic Switch to Constrain T Cell‐Mediated Inflammation in the Skin
10.1126/sciimmunol.abb6444 · 2021 · External reference
Regulating Innate and Adaptive Immunity for Controlling SIV Infection by 25‐Hydroxycholesterol
10.3389/fimmu.2018.02686 · 2018 · External reference
25‐Hydroxycholesterol Regulates Lysosome AMP Kinase Activation and Metabolic Reprogramming to Educate Immunosuppressive Macrophages
10.1016/j.immuni.2024.03.021 · 2024 · External reference
Th1 and Th17 Cells in Tuberculosis: Protection, Pathology, and Biomarkers
10.1155/2015/854507 · 2015 · External reference
The Cholesterol Metabolite 25‐hydroxycholesterol Restrains the Transcriptional Regulator SREBP2 and Limits Intestinal IgA Plasma Cell Differentiation
10.1016/j.immuni.2021.09.004 · 2021 · External reference
Pathological and Protective Roles of Dendritic Cells in Mycobacterium Tuberculosis Infection: Interaction between Host Immune Responses and Pathogen Evasion
10.3389/fcimb.2022.891878 · 2022 · External reference
Targeting Dendritic Cells to Accelerate T‐Cell Activation Overcomes a Bottleneck in Tuberculosis Vaccine Efficacy
10.1038/ncomms13894 · 2016 · External reference
Tumor Factors Stimulate Lysosomal Degradation of Tumor Antigens and Undermine Their Cross‐Presentation in Lung Cancer
10.1038/s41467-022-34428-w · 2022 · External reference
CD86 and IL‐12p70 Are Key Players for T Helper 1 Polarization and Natural Killer Cell Activation by Toll‐Like Receptor‐Induced Dendritic Cells
10.1371/journal.pone.0044266 · 2012 · External reference
Recombinant BCG Expressing the Subunit 1 of Pertussis Toxin Induces Innate Immune Memory and Confers Protection against Non‐Related Pathogens
10.3390/vaccines10020234 · 2022 · External reference
Bacillus Calmette‐Guerin‐Induced Trained Immunity Potentiates TH17 Responses in Vitro
10.1093/jleuko/qiaf123 · 2025 · External reference
High Production of IL‐12 by human Dendritic Cells Stimulated with Combinations of Pattern‐Recognition Receptor Agonists
10.1038/s41541-024-00869-1 · 2024 · External reference
Immunoregulation of Dendritic Cells by IL‐10 Is Mediated through Suppression of the PI3K/Akt Pathway and of IkappaB Kinase Activity
10.1182/blood-2003-12-4302 · 2004 · External reference
SREBP Transcription Factors: Master Regulators of Lipid Homeostasis
10.1016/j.biochi.2004.09.018 · 2004 · External reference
Mycobacterium Tuberculosis‐Specific CD4+ and CD8+ T Cells Differ in Their Capacity to Recognize Infected Macrophages
10.1371/journal.ppat.1007060 · 2018 · External reference
Mycobacterial Disease and Impaired IFN‐γ Immunity in Humans with Inherited ISG15 Deficiency
10.1126/science.1224026 · 2012 · External reference
Potential of the Dual IFN‐γ/IL‐2 Fluorescence‐Immunospot Assay to Distinguish Different Stages in Bovine Tuberculosis
10.1016/j.vetimm.2019.109930 · 2019 · External reference
IL‐2 Mediates Adjuvant Effect of Dendritic Cells
10.1016/s1471-4906(02)02187-7 · 2002 · External reference
Thoracic Injection of Low‐dose Interleukin‐2 as an Adjuvant Therapy Improves the Control of the Malignant Pleural Effusions: A Systematic Review and Meta‐analysis Base on Chinese Patients
10.1186/s12885-018-4581-5 · 2018 · External reference
Ki67 is a Promising Molecular Target in the Diagnosis of Cancer (Review)
10.3892/mmr.2014.2914 · 2015 · External reference
The Role of KLRG1: A Novel Biomarker and New Therapeutic Target
10.1186/s12964-024-01714-7 · 2024 · External reference
Delaying bacillus Calmette‐Guérin Vaccination from Birth to 4 1/2 Months of Age Reduces Postvaccination Th1 and IL‐17 Responses but Leads to Comparable Mycobacterial Responses at 9 Months of Age
10.4049/jimmunol.1000552 · 2010 · External reference
Potential Effect of Age of BCG Vaccination on Global Paediatric Tuberculosis Mortality: a Modelling Study
10.1016/s2214-109x(19)30444-9 · 2019 · External reference
Mycobacterium Bovis BCG‐Mediated Protection against W‐Beijing Strains of Mycobacterium Tuberculosis Is Diminished Concomitant with the Emergence of Regulatory T Cells
10.1128/cvi.05127-11 · 2011 · External reference
Lower Bacillus Calmette‐Guérin Protection against Mycobacterium Tuberculosis Infection after Exposure to Beijing Strains
10.1164/rccm.201912-2349le · 2020 · External reference
Cholesterol and 25‐Hydroxycholesterol Inhibit Activation of SREBPs by Different Mechanisms, Both Involving SCAP and Insigs
10.1074/jbc.m410302200 · 2004 · External reference
The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair
10.1016/j.immuni.2019.06.005 · 2019 · External reference
Cholesterol Homeostatic Regulator SCAP‐SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages
10.1016/j.immuni.2018.08.021 · 2018 · External reference
Activation of Liver X Receptor Suppresses the Production of the IL‐12 Family of Cytokines by Blocking Nuclear Translocation of NF‐κBp50
10.1177/1753425913501915 · 2014 · External reference
LXR Suppresses Inflammatory Gene Expression and Neutrophil Migration through Cis‐Repression and Cholesterol Efflux
10.1016/j.celrep.2018.11.100 · 2018 · External reference
Linking Lipid Metabolism to the Innate Immune Response in Macrophages through Sterol Regulatory Element Binding Protein‐1a
10.1016/j.cmet.2011.04.001 · 2011 · External reference
SREBP‐1a‐Stimulated Lipid Synthesis is Required for Macrophage Phagocytosis Downstream of TLR4‐directed mTORC1
2018 · External reference
Multifunctional, High‐Level Cytokine‐Producing Th1 Cells in the Lung, but Not Spleen, Correlate with Protection against Mycobacterium Tuberculosis Aerosol Challenge in Mice
10.4049/jimmunol.181.7.4955 · 2008 · External reference
Tuberculosis Subunit Vaccination Provides Long‐term Protective Immunity Characterized by Multifunctional CD4 Memory T Cells
10.4049/jimmunol.0801592 · 2009 · External reference
Polyfunctional CD4+ T Cells as Targets for Tuberculosis Vaccination
10.3389/fimmu.2017.01262 · 2017 · External reference
Testing the H56 Vaccine Delivered in 4 Different Adjuvants as a BCG‐Booster in a Non‐Human Primate Model of Tuberculosis
10.1371/journal.pone.0161217 · 2016 · External reference
Specific T Cell Frequency and Cytokine Expression Profile Do Not Correlate with Protection against Tuberculosis after bacillus Calmette‐Guérin Vaccination of Newborns
10.1164/rccm.201003-0334oc · 2010 · External reference
T‐cell Activation Is an Immune Correlate of Risk in BCG Vaccinated Infants
10.1038/ncomms11290 · 2016 · External reference
Signaling and Function of Interleukin‐2 in T Lymphocytes
10.1146/annurev-immunol-042617-053352 · 2018 · External reference
Interleukin‐2 Signaling in the Regulation of T Cell Biology in Autoimmunity and Cancer
10.1016/j.immuni.2024.02.001 · 2024 · External reference
Control of Chronic Mycobacterium Tuberculosis Infection by CD4 KLRG1‐ IL‐2‐Secreting Central Memory Cells
10.4049/jimmunol.1300248 · 2013 · External reference
Vaccine‐Elicited Memory CD4+ T Cell Expansion Is Impaired in the Lungs during Tuberculosis
10.1371/journal.ppat.1006704 · 2017 · External reference
Autocrine IL‐2 Is Required for Secondary Population Expansion of CD8(+) Memory T Cells
10.1038/ni.2079 · 2011 · External reference
The Quantity of Autocrine IL‐2 Governs the Expansion Potential of CD8+ T Cells
10.4049/jimmunol.1501083 · 2015 · External reference
Immunomodulatory Effects of IL‐2 and IL‐15; Implications for Cancer Immunotherapy
10.3390/cancers12123586 · 2020 · External reference
Cholesterol 25‐hydroxylase Protects against Experimental Colitis in Mice by Modulating Epithelial Gut Barrier Function
10.1038/s41598-020-71198-1 · 2020 · External reference
25‐Hydroxycholesterol Impairs Endothelial Function and Vasodilation by Uncoupling and Inhibiting Endothelial Nitric Oxide Synthase
10.1152/ajpendo.00218.2016 · 2016 · External reference
Protein‐energy Restriction‐induced Lipid Metabolism Disruption Causes Stable‐to‐progressive Disease Shift in Mycobacterium Avium‐infected Female Mice
10.1016/j.ebiom.2024.105198 · 2024 · External reference
Viral Coinfection Promotes Tuberculosis Immunopathogenesis by Type I IFN Signaling‐dependent Impediment of Th1 Cell Pulmonary Influx
10.1038/s41467-022-30914-3 · 2022 · External reference