Research graph
References from Colorectal Cancer: Epidemiology, Risk Factors, Signaling Pathways, Clinical Features, Screening, Diagnosis, and Management. Local targets link to admitted publications; unresolved targets remain external evidence.
Colorectal Cancer
10.1016/s0140-6736(24)00360-x · 2024 · External reference
Global Burden of Colorectal Cancer in 2020 and 2040: Incidence and Mortality Estimates From GLOBOCAN
10.1136/gutjnl-2022-327736 · 2023 · External reference
Colorectal Carcinogenesis in the Lynch Syndromes and Familial Adenomatous Polyposis: Trigger Events and Downstream Consequences
10.1186/s13053-025-00305-y · 2025 · External reference
Signaling Pathways Involved in Colorectal Cancer: Pathogenesis and Targeted Therapy
10.1038/s41392-024-01953-7 · 2024 · External reference
Recapitulating the Adenoma‐Carcinoma Sequence by Selection of Four Spontaneous Oncogenic Mutations in Mismatch‐Repair‐Deficient Human Colon Organoids
10.1038/s43018-024-00841-x · 2024 · External reference
The Genomic Landscape of 2,023 Colorectal Cancers
10.1038/s41586-024-07747-9 · 2024 · External reference
Mechanisms of Metastatic Colorectal Cancer
10.1038/s41575-024-00934-z · 2024 · External reference
Molecular Pathological Classification of Colorectal Cancer – An Update
10.1007/s00428-024-03746-3 · 2024 · External reference
Integrative Single‐Cell Analysis of Human Colorectal Cancer Reveals Patient Stratification With Distinct Immune Evasion Mechanisms
10.1038/s43018-024-00807-z · 2024 · External reference
Consistent Signatures in the Human Gut Microbiome of Old‐ and Young‐Onset Colorectal Cancer
10.1038/s41467-024-47523-x · 2024 · External reference
Reduction in Colorectal Cancer Incidence by Screening Endoscopy
10.1038/s41575-023-00847-3 · 2024 · External reference
Colorectal Cancer Incidence Trends in Younger Versus Older Adults: An Analysis of Population‐Based Cancer Registry Data
10.1016/s1470-2045(24)00600-4 · 2025 · External reference
Early‐Onset Colorectal Cancer as an Emerging Disease of Metabolic Dysregulation
10.1038/s41574-025-01159-z · 2025 · External reference
A Cell‐Free DNA Blood‐Based Test for Colorectal Cancer Screening
10.1056/nejmoa2304714 · 2024 · External reference
ctDNA‐Based Molecular Residual Disease and Survival in Resectable Colorectal Cancer
10.1038/s41591-024-03254-6 · 2024 · External reference
Late‐Line Options for Patients With Metastatic Colorectal Cancer: A Review and Evidence‐Based Algorithm
10.1038/s41571-024-00965-0 · 2025 · External reference
Unresolved reference
External reference
Cancer Organoids 2.0: Modelling the Complexity of the Tumour Immune Microenvironment
10.1038/s41568-024-00706-6 · 2024 · External reference
Toward Clinical Applications of Spatial‐Omics in Cancer Research
10.1038/s43018-024-00868-0 · 2024 · External reference
The Immune Microenvironment of Colorectal Cancer
10.1038/s41568-025-00872-1 · 2025 · External reference
An Integrated Tumor, Immune and Microbiome Atlas of Colon Cancer
10.1038/s41591-023-02324-5 · 2023 · External reference
Changing Epidemiology of Colorectal Cancer—Birth Cohort Effects and Emerging Risk Factors
10.1038/s41575-023-00841-9 · 2024 · External reference
AGA Clinical Practice Update on Current Role of Blood Tests for Colorectal Cancer Screening: Commentary
10.1016/j.cgh.2025.04.003 · 2025 · External reference
Colorectal Cancer Screening: An Update to the American Cancer Society Guideline, 2026
2026 · External reference
Clinical Validation of a Circulating Tumor DNA‐Based Blood Test to Screen for Colorectal Cancer
10.1001/jama.2025.7515 · 2025 · External reference
Implementation of Blood‐Based Colorectal Cancer Screening: Real‐World Adherence and Outcomes
10.1080/03007995.2025.2582257 · 2025 · External reference
Use of Artificial Intelligence Improves Colonoscopy Performance in Adenoma Detection: A Systematic Review and Meta‐Analysis
10.1016/j.gie.2024.08.033 · 2025 · External reference
Quality Assessment in Endoscopy “Artificial Intelligence in Endoscopy”
10.1016/j.bpg.2025.102006 · 2025 · External reference
AI‐Assisted Colonoscopy and Risk of Endoscopist Deskilling
10.1038/s41575-025-01122-3 · 2025 · External reference
Endoscopist Deskilling Risk After Exposure to Artificial Intelligence in Colonoscopy: A Multicentre, Observational Study
10.1016/s2468-1253(25)00133-5 · 2025 · External reference
Polyp Detection With Colonoscopy Assisted by the GI Genius Artificial Intelligence Endoscopy Module Compared With Standard Colonoscopy in Routine Colonoscopy Practice (Colo‐Detect): A Multicentre, Open‐Label, Parallel‐Arm, Pragmatic Randomised Controlled Trial
10.1016/s2468-1253(24)00161-4 · 2024 · External reference
Survival Benefit of Adjuvant Chemotherapy Based on Molecular Residual Disease Detection in Resected Colorectal Liver Metastases: Subgroup Analysis From Circulate‐Japan Galaxy
10.1016/j.annonc.2024.08.2240 · 2024 · External reference
Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer: 5‐Year Outcomes of the Randomized DYNAMIC Trial
10.1038/s41591-025-03579-w · 2025 · External reference
Circulating Tumor DNA‐Guided Adjuvant Therapy in Locally Advanced Colon Cancer: The Randomized Phase 2/3 DYNAMIC‐III Trial
10.1038/s41591-025-04030-w · 2025 · External reference
Post‐Adjuvant Chemotherapy in ctDNA‐Positive Patients With Resected Colorectal Cancer: A Randomized Phase 3 Trial
10.1038/s41591-026-04428-0 · 2026 · External reference
Immune Checkpoint Inhibitors for dMMR/MSI Localized Rectal Cancer: A Systematic Review of Treatment Strategies
10.1016/j.critrevonc.2025.104921 · 2025 · External reference
Nonoperative Management of Mismatch Repair‐Deficient Tumors
10.1056/nejmoa2404512 · 2025 · External reference
Neoadjuvant Immunotherapy in Locally Advanced Mismatch Repair‐Deficient Colon Cancer
10.1056/nejmoa2400634 · 2024 · External reference
Encorafenib, Cetuximab, and mFOLFOX6 in BRAF‐Mutated Colorectal Cancer
10.1056/nejmoa2501912 · 2025 · External reference
Trastuzumab Deruxtecan in Patients With HER2‐Positive Advanced Colorectal Cancer (DESTINY‐CRC02): Primary Results From a Multicentre, Randomised, Phase 2 Trial
10.1016/s1470-2045(24)00380-2 · 2024 · External reference
HER2‐Related Biomarkers Predict Clinical Outcomes With Trastuzumab Deruxtecan Treatment in Patients With HER2‐Expressing Metastatic Colorectal Cancer: Biomarker Analyses of DESTINY‐CRC01
10.1038/s41467-024-53223-3 · 2024 · External reference
Tucatinib plus Trastuzumab for Chemotherapy‐Refractory, HER2 + , RAS Wild‐Type Metastatic Colorectal Cancer (MOUNTAINEER): Final Analysis
10.1038/s41467-025-67824-z · 2026 · External reference
Efficacy and Safety of Adagrasib Plus Cetuximab in Patients With KRAS G12C‐Mutated Metastatic Colorectal Cancer
10.1158/2159-8290.cd-24-0217 · 2024 · External reference
Sotorasib Plus Panitumumab in Refractory Colorectal Cancer With Mutated KRAS G12C
10.1056/nejmoa2308795 · 2023 · External reference
Black‐White Disparities Across the Colorectal Cancer Care Continuum in the USA
10.1038/s41575-025-01087-3 · 2025 · External reference
Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2024 · External reference
Global Burden of Colorectal Cancer in 2022 and Projections to 2050: Incidence and Mortality Estimates From GLOBOCAN
10.1186/s12885-025-15138-0 · 2025 · External reference
Global Cancer Statistics 2024: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 34 Cancers in 186 Countries
2026 · External reference
Colorectal Cancer: Epidemiology, Risk Factors, and Public Health Strategies
10.1159/000543921 · 2025 · External reference
Global Colorectal Cancer Screening Programs and Coverage Rate Estimation: An Evidence Synthesis
10.1186/s12967-025-06887-4 · 2025 · External reference
Global Distribution of Colorectal Cancer Staging at Diagnosis: An Evidence Synthesis
10.1016/j.cgh.2024.11.019 · 2025 · External reference
Gender and Sex Differences in Colorectal Cancer Screening, Diagnosis and Treatment
10.1007/s12094-024-03801-0 · 2025 · External reference
Sex and Gender Perspectives in Colorectal Cancer
10.1016/j.esmoop.2023.101204 · 2023 · External reference
The Association Between Organised Colorectal Cancer Screening Strategies and Reduction of Its Related Mortality: A Systematic Review and Meta‐Analysis
10.1186/s12885-024-12054-7 · 2024 · External reference
Bridging the Equity Gap in Colorectal Cancer Screening: A Comparative Analysis Across High‐Income Countries
10.1016/j.jcpo.2025.100657 · 2025 · External reference
Racial and Ethnic Disparities in Use of Colorectal Cancer Screening Among Adults With Chronic Medical Conditions: BRFSS 2012–2020
10.5888/pcd21.230257 · 2024 · External reference
Challenges in the Management of Colorectal Cancer in Low‐ and Middle‐Income Countries
10.1016/j.ctarc.2023.100705 · 2023 · External reference
Uptake of Colorectal Cancer Screening in Low‐ and Middle‐Income Countries: A Systematic Review and Meta‐Analysis
10.1007/s12029-025-01274-0 · 2025 · External reference
Gut Microbiome‐Driven Colorectal Cancer via Immune, Metabolic, Neural, and Endocrine Axes Reprogramming
10.1038/s41522-025-00883-8 · 2026 · External reference
Direct and Indirect Effects of Estrogens, Androgens and Intestinal Microbiota on Colorectal Cancer
10.3389/fcimb.2024.1458033 · 2024 · External reference
Family History of Cancer as a Potential Risk Factor for Colorectal Cancer in EMRO Countries: A Systematic Review and Meta‐Analysis
10.1038/s41598-023-44487-8 · 2023 · External reference
Genetics, Genomics and Clinical Features of Adenomatous Polyposis
10.1007/s10689-025-00460-0 · 2025 · External reference
Therapeutic Targeting of Mismatch Repair‐Deficient Cancers
10.1038/s41571-025-01054-6 · 2025 · External reference
Association Between Red and Processed Meat Consumption and Colorectal Cancer Risk: A Comprehensive Meta‐Analysis of Prospective Studies
10.1007/s11357-025-01646-1 · 2025 · External reference
Diet‐Wide Analyses for Risk of Colorectal Cancer: Prospective Study of 12,251 Incident Cases Among 542,778 Women in the UK
10.1038/s41467-024-55219-5 · 2025 · External reference
Dietary Nitrosamines From Processed Meat Intake as Drivers of the Fecal Excretion of Nitrosocompounds
10.1021/acs.jafc.4c05751 · 2024 · External reference
Ultra‐Processed Food Consumption and Colorectal Cancer Risk: A Systematic Review and 2‐Stage Mediation Meta‐Analysis
10.1093/nutrit/nuaf283 · 2026 · External reference
Dietary‐Lifestyle Patterns and Colorectal Cancer Risk: Global Cancer Update Programme (Cup Global) Systematic Literature Review
10.1016/j.ajcnut.2025.01.014 · 2025 · External reference
Drinking Pattern and Time Lag of Alcohol Consumption With Colorectal Cancer Risk in US Men and Women
10.1093/jnci/djae330 · 2025 · External reference
The Biochemistry of the Carcinogenic Alcohol Metabolite Acetaldehyde
10.1016/j.dnarep.2024.103782 · 2024 · External reference
A Narrative Review on Alcohol and Alimentary Tract Cancer With Special Emphasis on Acetaldehyde and Oxidative Stress
10.1055/a-2588-6849 · 2025 · External reference
The Association Between Dietary Folate Intake and Risk of Colorectal Cancer Incidence: A Systematic Review and Dose‒Response Meta‐Analysis of Cohort Studies
10.1016/j.heliyon.2024.e33564 · 2024 · External reference
Smoking Habit and Long‐Term Colorectal Cancer Incidence by Exome‐Wide Mutational and Neoantigen Loads: Evidence Based on the Prospective Cohort Incident‐Tumour Biobank Method
10.1136/bmjonc-2025-000787 · 2025 · External reference
Conclusion About Colorectal Cancer Incidence in People Who Smoke
10.1136/bmjonc-2025-000855 · 2025 · External reference
Dissecting the Pathogenic Effects of Smoking and Its Hallmarks in Blood DNA Methylation on Colorectal Cancer Risk
10.1038/s41416-023-02397-6 · 2023 · External reference
The Role of Physical Activity and Epigenetic Changes in Colorectal Cancer Prevention
10.1186/s12935-025-03872-1 · 2025 · External reference
Exercise as a New Therapeutic Modality in Oncology: Challenge Trial Refines Survivorship Care
10.1038/s41571-025-01071-5 · 2025 · External reference
Do the Associations of Sedentary Time With Colorectal Cancer Risk Differ by Physical Activity Level and Vice Versa? A Cross‐Sectional Study of Two Large Population‐Based Surveys
10.1016/j.puhe.2025.106115 · 2026 · External reference
A Review Article: The Relationship Between Obesity and Colorectal Cancer
10.1007/s11892-024-01556-0 · 2024 · External reference
The Multifactorial Effect of Obesity on the Effectiveness and Outcomes of Cancer Therapies
10.1038/s41574-024-01032-5 · 2024 · External reference
Unlocking the Fat Factor: How Adiposity Shapes Survival in Colorectal Cancer – A Comprehensive Meta‐Analysis
10.1016/j.clnesp.2025.05.038 · 2025 · External reference
Hyperglycemia‐Driven Signaling Bridges Between Diabetes and Cancer
10.1016/j.bcp.2024.116450 · 2024 · External reference
Type 2 Diabetes and Colorectal Cancer: Genetic Causality Explored via Mendelian Randomization
10.1007/s12672-024-01621-w · 2024 · External reference
Early‐Onset Colorectal Cancer Is Associated With Metabolic Disorders: A Systematic Review and Meta‐Analysis
10.1007/s10654-025-01359-x · 2026 · External reference
Colorectal Cancer in Inflammatory Bowel Disease: A Review of the Role of Gut Microbiota and Bacterial Biofilms in Disease Pathogenesis
10.1093/ecco-jcc/jjae061 · 2024 · External reference
Advances in Molecular Mechanisms of Inflammatory Bowel Disease‑Associated Colorectal Cancer (Review)
10.3892/ol.2024.14390 · 2024 · External reference
Harnessing Gut Microbiota for Colorectal Cancer Therapy: From Clinical Insights to Therapeutic Innovations
10.1038/s41522-025-00818-3 · 2025 · External reference
Immune‐Microbiota Crosstalk in Colorectal Cancer: Mechanistic Pathways, Biomarkers, and Translational Therapeutics
10.1007/s12094-025-04197-1 · 2026 · External reference
Microbiome Confounders and Quantitative Profiling Challenge Predicted Microbial Targets in Colorectal Cancer Development
10.1038/s41591-024-02963-2 · 2024 · External reference
Early‐Onset Colorectal Cancer: From the Laboratory to the Clinic
10.1016/j.ctrv.2024.102821 · 2024 · External reference
Oral Antibiotic Use in Adulthood and Risk of Early‐Onset Colorectal Cancer: A Case‐Control Study
10.1016/j.cgh.2024.09.002 · 2025 · External reference
Antibiotic Therapy and Risk of Early‐Onset Colorectal Cancer: A National Case‐Control Study
10.14309/ctg.0000000000000437 · 2022 · External reference
Geographic and Age Variations in Mutational Processes in Colorectal Cancer
10.1038/s41586-025-09025-8 · 2025 · External reference
Early Onset Colorectal Cancer
10.1136/bmj-2024-082452 · 2025 · External reference
Red Flag Signs and Symptoms for Patients With Early‐Onset Colorectal Cancer: A Systematic Review and Meta‐Analysis
10.1001/jamanetworkopen.2024.13157 · 2024 · External reference
Colorectal Cancer Clocks in on Time
10.1038/s41590-024-01874-1 · 2024 · External reference
The Single‐Cell Spatial Landscape of Stage III Colorectal Cancers
10.1038/s41698-025-00853-5 · 2025 · External reference
From Subtypes to Solutions: Integrating CMS Classification With Precision Therapeutics in Colorectal Cancer
10.1007/s11864-024-01282-5 · 2024 · External reference
Multiregional Transcriptomics Identifies Congruent Consensus Subtypes With Prognostic Value Beyond Tumor Heterogeneity of Colorectal Cancer
10.1038/s41467-024-48706-2 · 2024 · External reference
Metastatic Colorectal Cancer: Mechanisms and Emerging Therapeutics
10.1016/j.tips.2023.01.003 · 2023 · External reference
Molecular Cartography Uncovers Evolutionary and Microenvironmental Dynamics in Sporadic Colorectal Tumors
10.1016/j.cell.2023.11.006 · 2023 · External reference
Serrated Colorectal Cancer: Preclinical Models and Molecular Pathways
10.1016/j.trecan.2023.09.011 · 2024 · External reference
Consensus Molecular Subtypes (CMS) Classification: A Progress Towards Subtype‐Driven Treatments in Colorectal Cancer
10.1186/s12957-025-04117-1 · 2025 · External reference
Clinical Challenges of Consensus Molecular Subtype CMS4 Colon Cancer in the Era of Precision Medicine
10.1158/1078-0432.ccr-23-3964 · 2024 · External reference
Integrating Spatial and Single‐Cell Transcriptomics Reveals Tumor Heterogeneity and Intercellular Networks in Colorectal Cancer
10.1038/s41419-024-06598-6 · 2024 · External reference
Exploring the Key Signaling Pathways and ncRNAs in Colorectal Cancer
10.3390/ijms25084548 · 2024 · External reference
TGF‐Β Modulated Pathways in Colorectal Cancer: New Potential Therapeutic Opportunities
10.3390/ijms25137400 · 2024 · External reference
Functional and Spatial Proteomics Profiling Reveals Intra‐ and Intercellular Signaling Crosstalk in Colorectal Cancer
10.1016/j.isci.2023.108399 · 2023 · External reference
Targeting the EGFR Signalling Pathway in Metastatic Colorectal Cancer
10.1016/s2468-1253(23)00479-x · 2024 · External reference
Current Advances in Targeted Therapy for Metastatic Colorectal Cancer—Clinical Translation and Future Directions
10.1016/j.ctrv.2024.102700 · 2024 · External reference
Biomarker Guided Combination Strategies and Perioperative Integration for Immune Cold Microsatellite Stable Colorectal Cancer
10.1007/s12672-026-04575-3 · 2026 · External reference
Wnt/Β‐Catenin Signalling, Epithelial‐Mesenchymal Transition and Crosslink Signalling in Colorectal Cancer Cells
10.1016/j.biopha.2024.116685 · 2024 · External reference
Cholesterol‐Targeting Wnt‐Β‐Catenin Signaling Inhibitors for Colorectal Cancer
10.1038/s41589-025-01870-y · 2025 · External reference
Wnt/Β‐Catenin Signaling Pathway in Carcinogenesis and Cancer Therapy
10.1186/s13045-024-01563-4 · 2024 · External reference
Current State and Future Prospects of Spatial Biology in Colorectal Cancer
10.3389/fonc.2024.1513821 · 2024 · External reference
MAPK‐Driven Epithelial Cell Plasticity Drives Colorectal Cancer Therapeutic Resistance
10.1038/s41586-025-09916-w · 2026 · External reference
Targeting the MAP Kinase Pathway in Colorectal Cancer: A Journey in Personalized Medicine
10.1158/1078-0432.ccr-25-0107 · 2025 · External reference
PI3K/AKT/mTOR Signaling Pathway as a Target for Colorectal Cancer Treatment
10.3390/ijms25063178 · 2024 · External reference
Targeting PI3K/AKT/mTOR Signaling to Overcome Drug Resistance in Cancer
10.1016/j.cbi.2024.111055 · 2024 · External reference
The Role of PIK3CA Gene Mutations in Colorectal Cancer and the Selection of Treatment Strategies
10.3389/fphar.2024.1494802 · 2024 · External reference
Recent Advances in Therapeutic Use of Transforming Growth Factor‐Beta Inhibitors in Cancer and Fibrosis
10.3389/fonc.2025.1489701 · 2025 · External reference
TGF‐Β Builds a Dual Immune Barrier in Colorectal Cancer by Impairing T Cell Recruitment and Instructing Immunosuppressive Spp1(+) Macrophages
10.1038/s41588-025-02380-2 · 2025 · External reference
TGFβ Signaling in Cancer‐Associated Fibroblasts Drives a Hepatic Gp130‐Dependent Pro‐Metastatic Inflammatory Program in Colorectal Cancer
10.1016/j.isci.2025.113696 · 2025 · External reference
68ga‐Fapi PET Imaging Monitors Response to Combined TGF‐Βr Inhibition and Immunotherapy in Metastatic Colorectal Cancer
10.1172/jci170490 · 2024 · External reference
Combination Immunotherapy for Colorectal Cancer: Clinical Applications, Rationale, Challenges, and Future Perspectives
10.1016/j.xcrm.2026.102728 · 2026 · External reference
Targeting the JAK‐STAT Pathway in Colorectal Cancer: Mechanisms, Clinical Implications, and Therapeutic Potential
10.3389/fcell.2024.1507621 · 2024 · External reference
Hippo/YAP Signaling Pathway in Colorectal Cancer: Regulatory Mechanisms and Potential Drug Exploration
10.3389/fonc.2025.1545952 · 2025 · External reference
Unveiling the Tumor Microenvironment in Colorectal Cancer Therapeutic Resistance
10.3389/fcell.2025.1753180 · 2025 · External reference
Notch Signaling in the Tumor Immune Microenvironment of Colorectal Cancer: Mechanisms and Therapeutic Opportunities
10.1186/s12967-025-06282-z · 2025 · External reference
Mechanisms and Therapeutic Potential of the Hedgehog Signaling Pathway in Cancer
10.1038/s41420-025-02327-w · 2025 · External reference
Intestinal Stem Cells in Intestinal Homeostasis and Colorectal Tumorigenesis
10.1093/lifemedi/lnae042 · 2024 · External reference
Notch Receptor/Ligand Diversity: Contribution to Colorectal Cancer Stem Cell Heterogeneity
10.3389/fcell.2023.1231416 · 2023 · External reference
Notch Signaling Pathway in Cancer: From Mechanistic Insights to Targeted Therapies
10.1038/s41392-024-01828-x · 2024 · External reference
Notch Signaling and Cancer: Insights Into Chemoresistance, Immune Evasion, and Immunotherapy
10.1016/j.gene.2025.149461 · 2025 · External reference
Myeloid‐Derived Suppressor Cells and Regulatory T Cells in Colorectal Cancer: A Synergistic Immunosuppressive Axis and Emerging Therapeutic Opportunities
10.3389/fimmu.2026.1757513 · 2026 · External reference
Targeting Crosstalk of Stat3 Between Tumor‐Associated M2 Macrophages and Tregs in Colorectal Cancer
10.1080/15384047.2023.2226418 · 2023 · External reference
Nf‐Κb and Apoptosis: Colorectal Cancer Progression and Novel Strategies for Treatment
10.1186/s40001-025-02734-w · 2025 · External reference
Targeting Stat3 With Sh‐4‐54 Suppresses Stemness and Chemoresistance in Cancer Stem‐Like Cells Derived From Colorectal Cancer
10.5306/wjco.v16.i2.97296 · 2025 · External reference
Immunotherapy Combination Approaches: Mechanisms, Biomarkers and Clinical Observations
10.1038/s41577-023-00973-8 · 2024 · External reference
The Emerging Roles of Hedgehog Signaling in Tumor Immune Microenvironment
10.3389/fonc.2023.1171418 · 2023 · External reference
Heterogeneity and Interplay: The Multifaceted Role of Cancer‐Associated Fibroblasts in the Tumor and Therapeutic Strategies
10.1007/s12094-024-03492-7 · 2024 · External reference
Cancer‐Associated Fibroblasts in the Tumor Microenvironment: Heterogeneity, Crosstalk Mechanisms, and Therapeutic Implications
10.1186/s12943-025-02533-1 · 2025 · External reference
The Multifaceted Role of YAP in the Tumor Microenvironment and Its Therapeutic Implications in Cancer
10.1038/s12276-025-01551-9 · 2025 · External reference
Hippo/YAP Signaling's Multifaceted Crosstalk in Cancer
10.3389/fcell.2025.1595362 · 2025 · External reference
The Key Role of Matrix Stiffness in Colorectal Cancer Immunotherapy: Mechanisms and Therapeutic Strategies
10.1016/j.bbcan.2024.189198 · 2024 · External reference
Targeting the Hippo Pathway in Cancer
10.1038/s41573-025-01234-0 · 2025 · External reference
The Mechanism of YAP/TAZ Transactivation and Dual Targeting for Cancer Therapy
10.1038/s41467-025-59309-w · 2025 · External reference
AMPK – A Key Factor in Crosstalk Between Tumor Cell Energy Metabolism and Immune Microenvironment?
10.1038/s41420-024-02011-5 · 2024 · External reference
The Role of AMPK in Cancer Metabolism and Its Impact on the Immunomodulation of the Tumor Microenvironment
10.3389/fimmu.2023.1114582 · 2023 · External reference
AMPK: The Energy Sensor at the Crossroads of Aging and Cancer
10.1016/j.semcancer.2024.08.002 · 2024 · External reference
Metformin in Colorectal Cancer: Epidemiological Evidence, Predictive Biomarkers, and Implications for Prevention and Treatment
10.3390/ijms26136040 · 2025 · External reference
Metformin's Multifaceted Role in Colorectal Cancer: Mechanisms of Action and Synergy With Standard Treatments
10.1007/s12672-025-03905-1 · 2025 · External reference
From Basics to Clinics: New Opportunities for Metformin in Tumor Metabolic Intervention and Treatment
10.1016/j.biopha.2025.118507 · 2025 · External reference
Network‐Based Elucidation of Colon Cancer Drug Resistance Mechanisms by Phosphoproteomic Time‐Series Analysis
10.1038/s41467-024-47957-3 · 2024 · External reference
Tumor‐Infiltrating Immune Cells in Colorectal Cancer
10.1016/j.neo.2024.101091 · 2025 · External reference
Spatial Landscapes of Cancers: Insights and Opportunities
10.1038/s41571-024-00926-7 · 2024 · External reference
Implementing Immunoscore in Colorectal Cancer: Lessons From Cohort Studies, Limitations and Barriers to Adoption
10.1002/2056-4538.70071 · 2026 · External reference
Cold and Hot Tumors: From Molecular Mechanisms to Targeted Therapy
10.1038/s41392-024-01979-x · 2024 · External reference
The Gut Microbiota in Cancer Immunity and Immunotherapy
10.1038/s41423-025-01326-2 · 2025 · External reference
Epidemiology, Pathogenesis, Biology and Evolving Management of MSI‐H/dMMR Cancers
10.1038/s41571-025-01015-z · 2025 · External reference
Predictors of Response to Immunotherapy in Colorectal Cancer
10.1093/oncolo/oyae152 · 2024 · External reference
The Characteristics of the Tumor Immune Microenvironment in Colorectal Cancer With Different MSI Status and Current Therapeutic Strategies
10.3389/fimmu.2024.1440830 · 2024 · External reference
Clinical Significance of Combined Tumour‐Infiltrating Lymphocytes and Microsatellite Instability Status in Colorectal Cancer: A Systematic Review and Network Meta‐Analysis
10.1016/s2468-1253(24)00091-8 · 2024 · External reference
PD‐L1 Positive Platelets Mediate Resistance to Immune Checkpoint Inhibitors in Patients With Colorectal Cancer
10.1186/s12964-025-02034-0 · 2025 · External reference
Mechanisms of Myeloid‐Derived Suppressor Cell‐Mediated Immunosuppression in Colorectal Cancer and Related Therapies
10.4251/wjgo.v16.i5.1690 · 2024 · External reference
Epigenetically Driven and Early Immune Evasion in Colorectal Cancer Evolution
10.1038/s41588-025-02349-1 · 2025 · External reference
Early Immune Evasion in Colorectal Cancer: Interplay Between Stem Cells and the Tumor Microenvironment
10.1016/j.trecan.2025.04.016 · 2025 · External reference
Myeloid‑Derived Suppressor Cells: Key Immunosuppressive Regulators and Therapeutic Targets in Colorectal Cancer (Review)
10.3892/ijo.2024.5673 · 2024 · External reference
Spatially Organized Tumor‐Stroma Boundary Determines the Efficacy of Immunotherapy in Colorectal Cancer Patients
10.1038/s41467-024-54710-3 · 2024 · External reference
Spatial Context of Immune Checkpoints as Predictors of Overall Survival in Patients With Resectable Colorectal Cancer Independent of Standard Tumor‐Node‐Metastasis Stages
10.1158/2767-9764.crc-24-0270 · 2024 · External reference
Cancer‐Associated Fibroblasts in Cancer Drug Resistance and Cancer Progression: A Review
10.1038/s41420-025-02566-x · 2025 · External reference
Cancer‐Associated Fibroblasts Enhance Colorectal Cancer Lymphatic Metastasis via Clec11a/Lgr5‐Mediated Wnt Pathway Activation
10.1172/jci194243 · 2025 · External reference
Insights Into the Relevance of Targeting Fibroblasts to Control Cancer
10.1016/j.xcrm.2025.102395 · 2025 · External reference
Immunotherapy in Microsatellite‐Stable Colorectal Cancer: Strategies to Overcome Resistance
10.1016/j.critrevonc.2025.104775 · 2025 · External reference
Gut Microbiota and Colorectal Cancer: Mechanistic Insights, Diagnostic Advances, and Microbiome‐Based Therapeutic Strategies
10.3389/fmicb.2025.1699893 · 2025 · External reference
Gut Microbiome in Colorectal Cancer: Metagenomics From Bench to Bedside
10.1093/jncics/pkaf026 · 2025 · External reference
Colorectal Cancer: The Immune Microenvironment and the Gut Microbiota—New Perspectives, Challenges, and Opportunities
10.1097/js9.0000000000002573 · 2025 · External reference
Dysbiosis and Colorectal Cancer: Conducive Factors, Biological and Molecular Role, and Therapeutic Prospectives
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