Research graph
References from G Protein‐Coupled Receptor in High‐Altitude Diseases: Mechanistic Insights and Therapeutic Opportunities. Local targets link to admitted publications; unresolved targets remain external evidence.
Altitude Illnesses
10.1038/s41572-024-00526-w · 2024 · External reference
Genome‐Wide Association Study Reveals Acute Mountain Sickness Susceptibility in Chinese Population
10.1007/s00438-026-02360-z · 2026 · External reference
Isolated High‐Altitude Cerebral Edema in the Himalayas: A Case Report
10.1097/ms9.0000000000004199 · 2025 · External reference
High‐Altitude Pulmonary Edema
10.1093/emph/eoaa052 · 2021 · External reference
Does This Patient Have Acute Mountain Sickness?: The Rational Clinical Examination Systematic Review
10.1001/jama.2017.16192 · 2017 · External reference
Chronic Mountain Sickness: Clinical Aspects, Etiology, Management, and Treatment
10.1089/ham.2016.0031 · 2016 · External reference
High‐Altitude Pulmonary Hypertension: A Pathophysiological Entity to Different Diseases
10.1183/09031936.03.00052403 · 2003 · External reference
Effect of High‐Altitude Exposure on the Heart
10.1097/cd9.0000000000000082 · 2023 · External reference
ARID1B, a Molecular Suppressor of Erythropoiesis, Is Essential for the Prevention of Monge's Disease
10.1038/s12276-022-00769-1 · 2022 · External reference
SNPs, Linkage Disequilibrium, and Chronic Mountain Sickness in Tibetan Chinese
10.2147/hp.s117967 · 2017 · External reference
Pathophysiology and Treatment of High‐Altitude Pulmonary Vascular Disease
10.1161/circulationaha.114.006977 · 2015 · External reference
Pathophysiology and Therapy of High‐Altitude Sickness: Practical Approach in Emergency and Critical Care
10.3390/jcm11143937 · 2022 · External reference
Dysregulation of Metabolites and High‐Altitude Illnesses Development Under Plateau Conditions
10.3389/fphys.2025.1600374 · 2025 · External reference
Molecular Mechanisms of High‐Altitude Acclimatization
10.3390/ijms24021698 · 2023 · External reference
G Protein‐Coupled Receptors (GPCRs): Advances in Structures, Mechanisms and Drug Discovery
10.1038/s41392-024-01803-6 · 2024 · External reference
Diversity and Modularity of G Protein‐Coupled Receptor Structures
10.1016/j.tips.2011.09.003 · 2012 · External reference
Trends in GPCR Drug Discovery: New Agents, Targets and Indications
10.1038/nrd.2017.178 · 2017 · External reference
G Protein‐Coupled Receptors: A Century of Research and Discovery
10.1161/circresaha.124.323067 · 2024 · External reference
Recent Advances on the Role of G Protein‐Coupled Receptors in Hypoxia‐Mediated Signaling
10.1208/s12248-016-9881-6 · 2016 · External reference
Role of G‐Protein Coupled Receptors in Cardiovascular Diseases
10.3389/fcvm.2023.1130312 · 2023 · External reference
A Review of the Role of Bradykinin and Nitric Oxide in the Cardioprotective Action of Angiotensin‐Converting Enzyme Inhibitors: Focus on Perindopril
10.1007/s40119-019-00150-w · 2019 · External reference
G‐Protein‐Coupled Receptor (GPCR) Signaling in the Carotid Body: Roles in Hypoxia and Cardiovascular and Respiratory Disease
10.3390/ijms21176012 · 2020 · External reference
GABA Function May be Related to the Impairment of Learning and Memory Caused by Systemic Prenatal Hypoxia‐Ischemia
10.1016/j.nlm.2018.01.004 · 2018 · External reference
GPCRs Identified on Mitochondrial Membranes: New Therapeutic Targets for Diseases
10.1016/j.jpha.2024.101178 · 2025 · External reference
Extreme Terrestrial Environments: Life in Thermal Stress and Hypoxia. A Narrative Review
10.3389/fphys.2018.00572 · 2018 · External reference
Altitude Hypoxia and Hypoxemia: Pathogenesis and Management
10.1038/s41392-025-02531-1 · 2026 · External reference
β2‐Adrenergic Receptor‐Dependent Attenuation of Hypoxic Pulmonary Vasoconstriction Prevents Progression of Pulmonary Arterial Hypertension in Intermittent Hypoxic Rats
10.1371/journal.pone.0110693 · 2014 · External reference
Flow‐Mediated Vasodilation Through Mechanosensitive G Protein‐Coupled Receptors in Endothelial Cells
10.1016/j.tcm.2020.12.010 · 2022 · External reference
A Current View of G Protein‐Coupled Receptor‐Mediated Signaling in Pulmonary Hypertension: Finding Opportunities for Therapeutic Intervention
10.20517/2574-1209.2018.44 · 2018 · External reference
Medical Conditions and High‐Altitude Travel
10.1056/nejmra2104829 · 2022 · External reference
Acute Mountain Sickness: Do Different Time Courses Point to Different Pathophysiological Mechanisms?
10.1152/japplphysiol.00305.2019 · 2020 · External reference
Symptom Progression in Acute Mountain Sickness During a 12‐Hour Exposure to Normobaric Hypoxia Equivalent to 4500 m
10.1089/ham.2014.1039 · 2014 · External reference
High‐Altitude Illnesses: Old Stories and New Insights Into the Pathophysiology, Treatment and Prevention
10.1016/j.smhs.2021.04.001 · 2021 · External reference
Recent Advances in Predicting Acute Mountain Sickness: From Multidimensional Cohort Studies to Cutting‐Edge Model Applications
10.3389/fphys.2024.1397280 · 2024 · External reference
Who Should Not Go High: Chronic Disease and Work at Altitude during Construction of the Qinghai‐Tibet Railroad
10.1089/ham.2007.1015 · 2007 · External reference
Children at High Altitude: An International Consensus Statement by an Ad Hoc Committee of the International Society for Mountain Medicine, March 12, 2001
10.1089/15270290152608561 · 2001 · External reference
High Altitude Pulmonary Edema, High Altitude Cerebral Edema, and Acute Mountain Sickness: An Enhanced Opinion From the High Andes – La Paz, Bolivia 3,500 m
10.1515/reveh-2021-0172 · 2023 · External reference
The Brain at High Altitude: From Molecular Signaling to Cognitive Performance
10.3390/ijms241210179 · 2023 · External reference
Altered Free Radical Metabolism in Acute Mountain Sickness: Implications for Dynamic Cerebral Autoregulation and Blood‐Brain Barrier Function
10.1113/jphysiol.2008.159855 · 2009 · External reference
Overactivation of Corticotropin‐Releasing Factor Receptor Type 1 and Aquaporin‐4 by Hypoxia Induces Cerebral Edema
10.1073/pnas.1404493111 · 2014 · External reference
Acute Mountain Sickness, Inflammation, and Permeability: New Insights From a Blood Biomarker Study
10.1152/japplphysiol.00391.2011 · 2011 · External reference
Cardiovascular Physiology and Pathophysiology at High Altitude
10.1038/s41569-023-00924-9 · 2024 · External reference
Physiological Risk Factors for Severe High‐Altitude Illness
10.1164/rccm.201108-1396oc · 2012 · External reference
Hypoxia‐Induced Acute Mountain Sickness Is Associated With Intracellular Cerebral Edema: A 3 T Magnetic Resonance Imaging Study
10.1038/sj.jcbfm.9600513 · 2008 · External reference
Roles of the Hypoximir MicroRNA‐424/322 in Acute Hypoxia and Hypoxia‐Induced Pulmonary Vascular Leakage
10.1096/fj.201900564rr · 2019 · External reference
Cardiovascular Medicine at High Altitude
10.1177/0003319713497086 · 2014 · External reference
TCA Cycle Rewiring Fosters Metabolic Adaptation to Oxygen Restriction in Skeletal Muscle From Rodents and Humans
10.1038/s41598-017-10097-4 · 2017 · External reference
Proteomic and Clinical Biomarkers for Acute Mountain Sickness in a Longitudinal Cohort
10.1038/s42003-022-03514-6 · 2022 · External reference
Cerebral Autoregulation in Subjects Adapted and Not Adapted to High Altitude
10.1161/01.str.31.10.2314 · 2000 · External reference
Research Advances in Pathogenesis and Prophylactic Measures of Acute High Altitude Illness
10.1016/j.rmed.2018.11.004 · 2018 · External reference
Abnormal Control of Ventilation in High‐Altitude Pulmonary Edema
10.1152/jappl.1988.64.3.1268 · 1988 · External reference
Ventilatory and Pulmonary Vascular Response to Hypoxia and Susceptibility to High Altitude Pulmonary Oedema
10.1183/09031936.95.08111825 · 1995 · External reference
Blunted Hypoxic Ventilatory Drive in Subjects Susceptible to High‐Altitude Pulmonary Edema
10.1152/jappl.1989.66.3.1152 · 1989 · External reference
Genetic Evidence for High‐Altitude Adaptation in Tibet
10.1126/science.1189406 · 2010 · External reference
Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude
10.1126/science.1190371 · 2010 · External reference
Identifying Signatures of Natural Selection in Tibetan and Andean Populations Using Dense Genome Scan Data
10.1371/journal.pgen.1001116 · 2010 · External reference
Higher Blood Flow and Circulating NO Products Offset High‐Altitude Hypoxia Among Tibetans
10.1073/pnas.0707462104 · 2007 · External reference
Polymorphisms of Angiotensin Converting Enzyme and Nitric Oxide Synthase 3 Genes as Risk Factors of High‐Altitude Pulmonary Edema: A Case‐Control Study and Meta‐Analysis
10.1620/tjem.229.255 · 2013 · External reference
Structural and Functional Alterations of Nitric Oxide Synthase 3 due to Missense Variants Associate With High‐Altitude Pulmonary Edema Through Dynamic Study
10.1080/07391102.2019.1711190 · 2021 · External reference
A Variant of the Endothelial Nitric Oxide Synthase Gene (NOS3) Associated With AMS Susceptibility Is Less Common in the Quechua, a High Altitude Native Population
10.1089/ham.2009.1054 · 2010 · External reference
Chronic Hypoxia Increases Endothelial Nitric Oxide Synthase Generation of Nitric Oxide by Increasing Heat Shock Protein 90 Association and Serine Phosphorylation
10.1161/01.res.0000031799.12850.1e · 2002 · External reference
Nitric Oxide and S‐Nitrosylation in Cardiac Regulation: G Protein‐Coupled Receptor Kinase‐2 and β‐Arrestins as Targets
10.3390/ijms22020521 · 2021 · External reference
Regulation of Endothelial Nitric Oxide Synthase Activity by Protein‐Protein Interaction
10.2174/13816128113196660752 · 2014 · External reference
HIF‐1–Dependent Repression of Equilibrative Nucleoside Transporter (ENT) in Hypoxia
10.1084/jem.20050177 · 2005 · External reference
Endothelin‐1 Mediates Hypoxia‐Induced Inhibition of Voltage‐Gated K+ Channel Expression in Pulmonary Arterial Myocytes
10.1152/ajplung.00091.2007 · 2008 · External reference
Regulation of Respiration
1978 · External reference
Sensory Processing and Integration at the Carotid Body Tripartite Synapse: Neurotransmitter Functions and Effects of Chronic Hypoxia
10.3389/fphys.2018.00225 · 2018 · External reference
Consequences of Peripheral Chemoreflex Inhibition With Low‐Dose Dopamine in Humans
10.1113/jphysiol.2013.266858 · 2014 · External reference
A Role for Dopamine in Control of the Hypoxic Ventilatory Response via D2 Receptors in the Zebrafish Gill
10.1002/cne.25548 · 2024 · External reference
Oxygen Chemoreceptor Inhibition by Dopamine D2 Receptors in Isolated Zebrafish Gills
10.1113/jp287824 · 2025 · External reference
Structural Genomics of the Human Dopamine Receptor System
10.1038/s41422-023-00808-0 · 2023 · External reference
Prospective Double‐Blinded Randomized Field‐Based Clinical Trial of Metoclopramide and Ibuprofen for the Treatment of High Altitude Headache and Acute Mountain Sickness
10.1016/j.wem.2019.11.005 · 2020 · External reference
Oxygen Regulation of Breathing Through an Olfactory Receptor Activated by Lactate
10.1038/nature15721 · 2015 · External reference
The Role of Olfr78 in the Breathing Circuit of Mice
10.1038/s41586-018-0545-9 · 2018 · External reference
Adenosine A2a Receptors and O2 Sensing in Development
10.1152/ajpregu.00664.2010 · 2011 · External reference
Ventilatory Effects of Adenosine Mediated by Carotid Body Chemoreceptors in the Rat
10.1007/bf00177715 · 1987 · External reference
The Effects of Intravenously Administered Aminophylline on Cerebral Circulation and Metabolism in Man
10.1172/jci102230 · 1950 · External reference
Adenosine Receptor‐Dependent Signaling Is Not Obligatory for Normobaric and Hypobaric Hypoxia‐Induced Cerebral Vasodilation in Humans
10.1152/japplphysiol.00840.2016 · 2017 · External reference
Sumatriptan for Prevention of Acute Mountain Sickness: Randomized Clinical Trial
10.1002/ana.21162 · 2007 · External reference
Progressive Disruption of Sphingosine‐1‐Phosphate Receptor 1 Correlates With Blood‐Brain Barrier Leakage in a Rat Model of Chronic Hypoxic Hypoperfusion
2024 · External reference
Endothelial Sphingosine‐1‐Phosphate Receptor 4 Regulates Blood‐Brain Barrier Permeability and Promotes a Homeostatic Endothelial Phenotype
10.1523/jneurosci.0188-21.2021 · 2022 · External reference
Adenosine A2A Receptor Involves in Neuroinflammation‐Mediated Cognitive Decline Through Activating Microglia Under Acute Hypobaric Hypoxia
10.1016/j.bbr.2018.02.038 · 2018 · External reference
A2A Adenosine Receptor Regulates the Human Blood‐Brain Barrier Permeability
10.1007/s12035-014-8879-2 · 2015 · External reference
A2B Adenosine Receptor Dampens Hypoxia‐Induced Vascular Leak
10.1182/blood-2007-10-117044 · 2008 · External reference
Role of Thromboxane A2 Signaling in Endothelium‐Dependent Contractions of Arteries
10.1016/j.prostaglandins.2017.11.004 · 2018 · External reference
Plasma Prostaglandins, Leukotrienes and Thromboxane in Acute High Altitude Hypoxia
10.1016/0034-5687(91)90062-n · 1991 · External reference
Hypoxia‐Induced Vascular Endothelial Growth Factor Expression Causes Vascular Leakage in the Brain
10.1093/brain/awf257 · 2002 · External reference
Bosentan Effects in Hypoxic Pulmonary Vasoconstriction: Preliminary Study in Subjects With or Without High Altitude Pulmonary Edema‐History
10.4103/2045-8932.94824 · 2012 · External reference
Synergistic Effect of the Genetic Polymorphisms of the Renin‐Angiotensin‐Aldosterone System on High‐Altitude Pulmonary Edema: A Study From Qinghai‐Tibet Altitude
10.1007/s10654-007-9208-0 · 2008 · External reference
Polymorphisms of Renin‐Angiotensin System Genes as a Risk Factor for High‐Altitude Pulmonary Oedema
10.1177/1470320310387177 · 2011 · External reference
The Role of Hypoxia‐Induced Modulation of Alveolar Epithelial Na+‐Transport in Hypoxemia at High Altitude
10.1177/2045894020936662 · 2020 · External reference
Salmeterol for the Prevention of High‐Altitude Pulmonary Edema
10.1056/nejmoa013183 · 2002 · External reference
Mechanisms of Impaired Alveolar Fluid Clearance
10.1002/ar.25166 · 2025 · External reference
High‐Altitude Pulmonary Vascular Diseases
10.21693/1933-088x-15.3.149 · 2017 · External reference
Hypoxic Ventilatory Response, Ventilation, Gas Exchange, and Fluid Balance in Acute Mountain Sickness
10.1089/15270290260512846 · 2002 · External reference
Plasma Proteomic Study of Acute Mountain Sickness Susceptible and Resistant Individuals
10.1038/s41598-018-19818-9 · 2018 · External reference
Physiology of the Carotid Body: From Molecules to Disease
10.1146/annurev-physiol-020518-114427 · 2020 · External reference
Adenosine Physiology and Pharmacology: How About A2 Receptors?
10.1016/s0163-7258(96)00094-0 · 1996 · External reference
International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update
10.1124/pr.110.003285 · 2011 · External reference
Blood Oxygen Regulation via P2Y12R Expressed in the Carotid Body
10.1186/s12931-024-02680-x · 2024 · External reference
Oxygen Sensing by the Carotid Body: Mechanisms and Role in Adaptation to Hypoxia
10.1152/ajpcell.00265.2015 · 2016 · External reference
Release of ATP by Pre‐Bötzinger Complex Astrocytes Contributes to the Hypoxic Ventilatory Response via a Ca2+‐Dependent P2Y1 Receptor Mechanism
10.1113/jp274727 · 2018 · External reference
Reduction of Hypoxic Ventilatory Drive by Dopamine
1982 · External reference
Brain Hemodynamic Changes Mediated by Dopamine Receptors: Role of the Cerebral Microvasculature in Dopamine‐Mediated Neurovascular Coupling
10.1016/j.neuroimage.2005.10.029 · 2006 · External reference
Hypoxia Sensing Through β‐Adrenergic Receptors
10.1172/jci.insight.90240 · 2025 · External reference
Role of Peripheral Chemoreceptors and Central Chemosensitivity in the Regulation of Respiration and Circulation
10.1242/jeb.100.1.23 · 1982 · External reference
Oxygen Sensing and Signal Transduction in Hypoxic Pulmonary Vasoconstriction
10.1183/13993003.00945-2015 · 2016 · External reference
Prevention of High‐Altitude Pulmonary Edema by Nifedipine
10.1056/nejm199110313251805 · 1991 · External reference
Pulmonary Hemodynamic Response to Exercise in Subjects With Prior High‐Altitude Pulmonary Edema
10.1152/jappl.1996.81.2.911 · 1996 · External reference
Stress Doppler Echocardiography for Identification of Susceptibility to High Altitude Pulmonary Edema
10.1016/s0735-1097(99)00633-6 · 2000 · External reference
Physiology in Medicine: A Physiologic Approach to Prevention and Treatment of Acute High‐Altitude Illnesses
10.1152/japplphysiol.00955.2014 · 2015 · External reference
Transpulmonary Plasma ET‐1 and Nitrite Differences in High Altitude Pulmonary Hypertension
10.1089/ham.2008.1053 · 2009 · External reference
Endothelin‐1 and Interleukin‐8 in High Altitude Pulmonary Oedema
10.1183/09031936.96.09091947 · 1996 · External reference
Cardiovascular Adjustments for Life at High Altitude
10.1016/j.resp.2007.05.006 · 2007 · External reference
Polymorphisms of Renin‐Angiotensin System Genes with High‐Altitude Pulmonary Edema in Japanese Subjects
10.1378/chest.126.3.825 · 2004 · External reference
Cooperative Oxygen Sensing by the Kidney and Carotid Body in Blood Pressure Control
10.3389/fphys.2017.00752 · 2017 · External reference
Prevention of Angiotensin II–Mediated Renal Oxidative Stress, Inflammation, and Fibrosis by Angiotensin‐Converting Enzyme 2
10.1161/hypertensionaha.110.164244 · 2011 · External reference
Association of AGTR1 Gene A1166C Polymorphism With the Risk of Heart Failure: A Meta‐Analysis
10.4238/2015.august.7.26 · 2015 · External reference
Excessive Erythrocytosis and Cardiovascular Risk in Andean Highlanders
10.1089/ham.2017.0123 · 2018 · External reference
Consensus Statement on Chronic and Subacute High Altitude Diseases
10.1089/ham.2005.6.147 · 2005 · External reference
Regulation of Cerebral Blood Flow in Humans: Physiology and Clinical Implications of Autoregulation
10.1152/physrev.00022.2020 · 2021 · External reference
Myogenic Vasoconstriction Requires G12/G13 and LARG to Maintain Local and Systemic Vascular Resistance
10.7554/elife.49374 · 2019 · External reference
Emerging Role of G Protein‐Coupled Receptors in Microvascular Myogenic Tone
10.1093/cvr/cvs152 · 2012 · External reference
Role of Adenosine A2 Receptors in Regulation of Cerebral Blood Flow During Induced Hypotension
10.1038/jcbfm.2009.244 · 2010 · External reference
Cerebral Blood Flow Response in Adenosine 2a Receptor Knockout Mice During Transient Hypoxic Hypoxia
10.1038/jcbfm.2008.57 · 2008 · External reference
Endothelial Response to Pathophysiological Stress
10.1161/atvbaha.119.312580 · 2019 · External reference
Endothelial Cell Dysfunction: Onset, Progression, and Consequences
10.31083/j.fbl2906223 · 2024 · External reference
Regulation of Alveolar Epithelial Function by Hypoxia
10.1183/09031936.00155507 · 2008 · External reference
The Role of Sphingosine 1‐Phosphate Metabolism in Brain Health and Disease
10.1016/j.pharmthera.2023.108381 · 2023 · External reference
Vascular and Immunobiology of the Circulatory Sphingosine 1‐Phosphate Gradient
10.1146/annurev-physiol-021014-071635 · 2017 · External reference
Critical Role of Hypoxia and A2A Adenosine Receptors in Liver Tissue‐Protecting Physiological Anti‐Inflammatory Pathway
10.2119/2007-00075.chouker · 2008 · External reference
Ureteral Calculi Associated With High‐Altitude Polycythemia: A Case Report
10.1097/md.0000000000024621 · 2021 · External reference
Prevalence of High‐Altitude Polycythemia and Hyperuricemia and Risk Factors for Hyperuricemia in High‐Altitude Immigrants
10.1089/ham.2022.0133 · 2023 · External reference
High‐Altitude Pulmonary Hypertension: A Comprehensive Review of Mechanisms and Management
10.1007/s10238-025-01577-3 · 2025 · External reference
EPAS1 Gene Polymorphisms Are Associated With High Altitude Polycythemia in Tibetans at the Qinghai‐Tibetan Plateau
10.1016/j.wem.2015.01.002 · 2015 · External reference
High Altitude Polycythemia and Its Maladaptive Mechanisms: An Updated Review
10.3389/fmed.2024.1448654 · 2024 · External reference
High‐Altitude Pulmonary Hypertension
10.1183/09059180.00011104 · 2009 · External reference
The G Protein‐Coupled Receptor 30 Is Up‐Regulated by Hypoxia‐Inducible Factor‐1α (HIF‐1α) in Breast Cancer Cells and Cardiomyocytes
10.1074/jbc.m110.172247 · 2011 · External reference
GPER‐Mediated Stabilization of HIF‐1α Contributes to Upregulated Aerobic Glycolysis in Tamoxifen‐Resistant Cells
10.1038/s41388-022-02506-4 · 2023 · External reference
The Contribution of the AT1 Receptor to Erythropoiesis
10.1016/j.bcp.2023.115805 · 2023 · External reference
Chapter Four—Erythropoietin Regulation by Angiotensin II
10.1016/bs.vh.2017.02.001 · 2017 · External reference
10.1016/b978-0-12-803247-3.00002-7
10.1016/b978-0-12-803247-3.00002-7 · 2018 · External reference
Metabolomic and Molecular Insights Into Sickle Cell Disease and Innovative Therapies
10.1182/bloodadvances.2018030619 · 2019 · External reference
Erythrocyte Adaptive Metabolic Reprogramming Under Physiological and Pathological Hypoxia
10.1097/moh.0000000000000574 · 2020 · External reference
Adenosine A2B Receptor Promotes Erythrocyte Oxygen Release to Counteract Tissue Hypoxia and Injury
10.1182/blood.v128.22.2424.2424 · 2016 · External reference
Elevated Adenosine Signaling via Adenosine A2B Receptor Induces Normal and Sickle Erythrocyte Sphingosine Kinase 1 Activity
10.1182/blood-2014-08-595751 · 2015 · External reference
Erythrocyte Adenosine A2B Receptor‐Mediated AMPK Activation: A Missing Component Counteracting CKD by Promoting Oxygen Delivery
10.1681/asn.2018080862 · 2019 · External reference
Beneficial Role of Erythrocyte Adenosine A2B Receptor–Mediated AMP‐Activated Protein Kinase Activation in High‐Altitude Hypoxia
10.1161/circulationaha.116.021311 · 2016 · External reference
Bosentan Therapy for Pulmonary Arterial Hypertension
10.1056/nejmoa012212 · 2002 · External reference
Bosentan Reduces Pulmonary Artery Pressure in High Altitude Residents
10.1089/ham.2011.1107 · 2012 · External reference
Smooth Muscle Proliferation and Role of the Prostacyclin (IP) Receptor in Idiopathic Pulmonary Arterial Hypertension
10.1164/rccm.201001-0011oc · 2010 · External reference
Prostacyclin Receptor‐Dependent Modulation of Pulmonary Vascular Remodeling
10.1164/ajrccm.164.2.2010150 · 2001 · External reference
GPCRs in Pulmonary Arterial Hypertension: Tipping the Balance
10.1111/bph.14172 · 2018 · External reference
Long‐Term Intravenous Epoprostenol Infusion in Primary Pulmonary Hypertension: Prognostic Factors and Survival
10.1016/s0735-1097(02)02012-0 · 2002 · External reference
Binding and Activity of the Prostacyclin Receptor (IP) Agonists, Treprostinil and Iloprost, at Human Prostanoid Receptors: Treprostinil Is a Potent DP1 and EP2 Agonist
10.1016/j.bcp.2012.03.012 · 2012 · External reference
Effects of Thromboxane A2 on Chronic Hypoxic Pulmonary Hypertension in the Rat
1996 · External reference
Role of Spm–cer‐S1P Signalling Pathway in MMP‐2 Mediated U46619‐Induced Proliferation of Pulmonary Artery Smooth Muscle Cells: Protective Role of Epigallocatechin‐3‐Gallate
10.1002/cbf.3136 · 2015 · External reference
Thromboxane A2‐Induced Inhibition of Voltage‐Gated K+ Channels and Pulmonary Vasoconstriction: Role of Protein Kinase Cζ
10.1161/01.res.0000095245.97945.fe · 2003 · External reference
EP3 receptor Deficiency Attenuates Pulmonary Hypertension Through Suppression of Rho/TGF‐β1 Signaling
10.1172/jci77656 · 2015 · External reference
Inhibition of CXCR4 Ameliorates Hypoxia‐Induced Pulmonary Arterial Hypertension in Rats
2021 · External reference
The Role of Inflammation in Hypoxic Pulmonary Hypertension: From Cellular Mechanisms to Clinical Phenotypes
10.1152/ajplung.00238.2014 · 2015 · External reference
PRX‐08066, a Novel 5‐Hydroxytryptamine Receptor 2B Antagonist, Reduces Monocrotaline‐Induced Pulmonary Arterial Hypertension and Right Ventricular Hypertrophy in Rats
10.1124/jpet.109.165001 · 2010 · External reference
Terguride Ameliorates Monocrotaline‐Induced Pulmonary Hypertension in Rats
10.1183/09031936.00126010 · 2011 · External reference
Development of a Peripherally Restricted 5‐HT2B Partial Agonist for Treatment of Pulmonary Arterial Hypertension
2023 · External reference
5‐HT2 Receptors and 5‐HIAA—Therapeutic Targets for Evaluation of Severity, Progression and Effectiveness of Treatment in Immature Male Rats in a Monocrotalin Model of Pulmonary Hypertension
10.1134/s0022093023040282 · 2023 · External reference
Function of the Serotonin 5‐Hydroxytryptamine 2B Receptor in Pulmonary Hypertension
10.1038/nm764 · 2002 · External reference
Endothelin Receptor Expression in Idiopathic Pulmonary Arterial Hypertension: Effect of Bosentan and Epoprostenol Treatment
10.1183/09031936.00167010 · 2011 · External reference
Endothelins
10.1056/nejm199508103330607 · 1995 · External reference
Both ETA and ETB Receptors Mediate Contraction to Endothelin‐1 in Human Blood Vessels
10.1161/01.cir.89.3.1203 · 1994 · External reference
BQ123, an ETA Receptor Antagonist, Inhibits Endothelin‐1‐Mediated Proliferation of Human Pulmonary Artery Smooth Muscle Cells
10.1165/ajrcmb/9.4.429 · 1993 · External reference
Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling
10.1164/rccm.201911-2137oc · 2020 · External reference
Adenosine a(2A) Receptor Activation Reverses Hypoxia‑Induced Rat Pulmonary Artery Smooth Muscle Cell Proliferation via Cyclic AMP‑Mediated Inhibition of the SDF1‑CXC4 Signaling Pathway
2018 · External reference
Absence of the Adenosine A2A Receptor Confers Pulmonary Arterial Hypertension and Increased Pulmonary Vascular Remodeling in Mice
10.1159/000316935 · 2011 · External reference
Disruption of the Apelin‐APJ System Worsens Hypoxia‐Induced Pulmonary Hypertension
10.1161/atvbaha.110.219980 · 2011 · External reference
The Biased Apelin Receptor Agonist, MM07, Reverses Sugen/Hypoxia‐Induced Pulmonary Arterial Hypertension as Effectively as the Endothelin Antagonist Macitentan
10.3389/fphar.2024.1369489 · 2024 · External reference
Pulmonary Apelin Levels and Effects in Rats With Hypoxic Pulmonary Hypertension
10.1016/j.rmed.2009.05.011 · 2009 · External reference
Structure‐Based Design of Non‐Hypertrophic Apelin Receptor Modulator
2024 · External reference
The Sphingosine Kinase 1/Sphingosine‐1‐Phosphate Pathway in Pulmonary Arterial Hypertension
10.1164/rccm.201401-0121oc · 2014 · External reference
S1PR (Sphingosine‐1‐Phosphate Receptor) Signaling in the Regulation of Vascular Tone and Blood Pressure
10.1161/hypertensionaha.117.09200 · 2017 · External reference
G‐Protein‐Coupled Receptor S1P1 Acts Within Endothelial Cells to Regulate Vascular Maturation
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S1PR1 (Sphingosine‐1‐Phosphate Receptor 1) Signaling Regulates Blood Flow and Pressure
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