Research graph
References from Both Genetic Manipulation and Acupuncture Alleviate Depressive‐Like Behavior Mediated by Astrocytic P2X7 Receptors. Local targets link to admitted publications; unresolved targets remain external evidence.
Reducing the Global Burden of Depression: A Lancet–World Psychiatric Association Commission
10.1016/s0140-6736(18)32408-5 · 2019 · External reference
Late‐Life Depression: A Narrative Review on Risk Factors and Prevention
10.1097/hrp.0000000000000240 · 2020 · External reference
Confronting Depression and Suicide in Physicians: A Consensus Statement
10.1001/jama.289.23.3161 · 2003 · External reference
Purinergic Signalling in the Nervous System: An Overview
10.1016/j.tins.2008.10.001 · 2009 · External reference
Ectonucleoside Triphosphate Diphosphohydrolases and Ecto‐5′‐Nucleotidase in Purinergic Signaling: How the Field Developed and Where We Are Now
10.1007/s11302-020-09755-6 · 2021 · External reference
Neuronal P2X7 Receptors Revisited: Do They Really Exist?
10.1523/jneurosci.3103-16.2017 · 2017 · External reference
P2X7 Receptors Amplify CNS Damage in Neurodegenerative Diseases
10.3390/ijms21175996 · 2020 · External reference
Neuronal P2X7 Receptor: Involvement in Neuronal Physiology and Pathology
10.1523/jneurosci.3104-16.2017 · 2017 · External reference
Opposing Effects of the Purinergic P2X7 Receptor on Seizures in Neurons and Microglia in Male Mice
10.1016/j.bbi.2024.05.023 · 2024 · External reference
Saikosaponins From Bupleurum scorzonerifolium Willd. Alleviates Microglial Pyroptosis in Depression by Binding and Inhibiting P2X7 Expression
10.1016/j.phymed.2024.156240 · 2025 · External reference
Microglia‐Derived Interleukin‐6 Triggers Astrocyte Apoptosis in the Hippocampus and Mediates Depression‐Like Behavior
10.1002/advs.202412556 · 2025 · External reference
Activation of P2X7 Receptor and NLRP3 Inflammasome Assembly in Hippocampal Glial Cells Mediates Chronic Stress‐Induced Depressive‐Like Behaviors
10.1186/s12974-017-0865-y · 2017 · External reference
Asymmetric Activation of Microglia in the Hippocampus Drives Anxiodepressive Consequences of Trigeminal Neuralgia in Rodents
10.1111/bph.15994 · 2023 · External reference
High, in Contrast to Low Levels of Acute Stress Induce Depressive‐Like Behavior by Involving Astrocytic, in Addition to Microglial P2X7 Receptors in the Rodent Hippocampus
10.3390/ijms23031904 · 2022 · External reference
P2X7 Receptor‐Mediated Depression‐Like Reactions Arising in the Mouse Medial Prefrontal Cortex
10.1093/cercor/bhad166 · 2023 · External reference
Purinergic Modulation of Major Depressive Disorder: Experimental Findings, Pathogenesis and Therapeutic Opportunities
10.1016/j.phrs.2025.107989 · 2025 · External reference
Implication of Cerebral Astrocytes in Major Depression: A Review of Fine Neuroanatomical Evidence in Humans
10.1002/glia.23994 · 2021 · External reference
Electroacupuncture Prevents Astrocyte Atrophy to Alleviate Depression
10.1038/s41419-023-05839-4 · 2023 · External reference
Stress‐Induced Dysfunction of Neurovascular Astrocytes in the Prefrontal Cortex Contributes to Sex‐Dependent Deficits in Cognition and Behavior
10.1038/s41380-025-02993-3 · 2025 · External reference
Astroglia‐Specific Contributions to the Regulation of Synapses, Cognition and Behaviour
10.1016/j.neubiorev.2020.07.039 · 2020 · External reference
Astrocyte‐Derived ATP Modulates Depressive‐Like Behaviors
10.1038/nm.3162 · 2013 · External reference
A Comparison of Side Effects of Selective Serotonin Reuptake Inhibitors and Tricyclic Antidepressants in Older Depressed Patients: A Meta‐Analysis
10.1002/gps.1156 · 2004 · External reference
Comparative Efficacy and Acceptability of 12 New‐Generation Antidepressants: A Multiple‐Treatments Meta‐Analysis
10.1016/s0140-6736(09)60046-5 · 2009 · External reference
The Effectiveness and Safety of Acupuncture Therapy in Depressive Disorders: Systematic Review and Meta‐Analysis
10.1016/j.jad.2009.07.005 · 2010 · External reference
Acupuncture for Depression
2018 · External reference
Clinical Evidence for Acupuncture‐Assisted Treatment of Depression: A Systematic Review and Meta‐Analysis With Meta‐Regression
10.1016/j.genhosppsych.2025.09.002 · 2025 · External reference
Acupuncture and Counselling for Depression in Primary Care: A Randomised Controlled Trial
10.1371/journal.pmed.1001518 · 2013 · External reference
The Efficacy and Cerebral Mechanism of Intradermal Acupuncture for Major Depressive Disorder: A Multicenter Randomized Controlled Trial
10.1038/s41386-024-02036-5 · 2025 · External reference
Efficacy and Safety of Acupuncture in the Treatment of Depression: A Systematic Review of Clinical Research
10.1002/ar.24783 · 2021 · External reference
Role of Purinergic Signaling in Acupuncture Therapeutics
10.1142/s0192415x21500294 · 2021 · External reference
The Open Field Test for Measuring Locomotor Activity and Anxiety‐Like Behavior
10.1007/978-1-4939-8994-2_9 · 2019 · External reference
Exploratory Rearing: A Context‐ and Stress‐Sensitive Behavior Recorded in the Open‐Field Test
10.1080/10253890.2018.1438405 · 2018 · External reference
Enzymes Involved in Metabolism of Extracellular Nucleotides and Nucleosides: Functional Implications and Measurement of Activities
10.3109/10409238.2014.953627 · 2014 · External reference
Astrocytes as Secretory Cells of the Central Nervous System: Idiosyncrasies of Vesicular Secretion
10.15252/embj.201592705 · 2016 · External reference
Erratum: Calhm2 Governs Astrocytic ATP Releasing in the Development of Depression‐Like Behaviors
10.1038/mp.2017.254 · 2018 · External reference
The Cytolytic P2Z Receptor for Extracellular ATP Identified as a P2X Receptor (P2X7)
10.1126/science.272.5262.735 · 1996 · External reference
Molecular Physiology of P2X Receptors
10.1152/physrev.00015.2002 · 2002 · External reference
Astrocytic P2X7 Receptor Regulates Depressive‐Like Behavioral Reactions of Mice in Response to Acute Stressful Stimulation
10.1007/s11302-024-10047-6 · 2025 · External reference
Gliotransmission in Physiologic and Pathologic Conditions
10.1016/b978-0-443-19104-6.00003-6 · 2025 · External reference
Novel Insight Into Astrocyte‐Mediated Gliotransmission Modulates the Synaptic Plasticity in Major Depressive Disorder
10.1016/j.lfs.2024.122988 · 2024 · External reference
Uncovering the Underlying Mechanisms of Ketamine as a Novel Antidepressant
10.3389/fphar.2021.740996 · 2021 · External reference
The Functional Neuroanatomy of Depression: Distinct Roles for Ventromedial and Dorsolateral Prefrontal Cortex
10.1016/j.bbr.2009.03.004 · 2009 · External reference
The Hippocampal–Prefrontal Pathway: The Weak Link in Psychiatric Disorders?
10.1016/j.euroneuro.2012.10.018 · 2013 · External reference
The Chronic Unpredictable Mild Stress (CUMS) Paradigm: Bridging the Gap in Depression Research From Bench to Bedside
10.1016/j.brainres.2024.149123 · 2024 · External reference
Chronic Unpredictable Mild Stress for Modeling Depression in Rodents: Meta‐Analysis of Model Reliability
10.1016/j.neubiorev.2018.12.002 · 2019 · External reference
New Roles for Old Glue: Astrocyte Function in Synaptic Plasticity and Neurological Disorders
10.5213/inj.1836214.107 · 2018 · External reference
New Roles for Astrocytes: Regulation of Synaptic Transmission
10.1016/s0166-2236(03)00237-6 · 2003 · External reference
Astrocyte Pathology in Major Depressive Disorder: Insights From Human Postmortem Brain Tissue
10.2174/13894501113149990156 · 2013 · External reference
Targeting Astrocytes in Major Depression
10.1586/14737175.2015.1095094 · 2015 · External reference
Cerebral Blood Flow in the Ventromedial Prefrontal Cortex Correlates With Treatment Response to Low‐Frequency Right Prefrontal Repetitive Transcranial Magnetic Stimulation in the Treatment of Depression
10.1111/j.1440-1819.2011.02312.x · 2012 · External reference
Cerebral Blood Flow Ratio of the Dorsolateral Prefrontal Cortex to the Ventromedial Prefrontal Cortex as a Potential Predictor of Treatment Response to Transcranial Magnetic Stimulation in Depression
10.1016/j.brs.2011.09.004 · 2012 · External reference
Mature Astrocytes as Source for Astrocyte Repopulation After Deletion in the Medial Prefrontal Cortex: Implications for Depression
10.1002/glia.24573 · 2024 · External reference
NLRP3 Inflammasome Mediates Chronic Mild Stress‐Induced Depression in Mice via Neuroinflammation
10.1093/ijnp/pyv006 · 2015 · External reference
Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor
10.1016/j.biopsych.2015.11.026 · 2016 · External reference
Serotonin Induces EPSCs Preferentially in Layer V Pyramidal Neurons of the Frontal Cortex in the Rat
10.1093/cercor/10.10.974 · 2000 · External reference
Stress Blunts Serotonin‐ and Hypocretin‐Evoked EPSCs in Prefrontal Cortex: Role of Corticosterone‐Mediated Apical Dendritic Atrophy
10.1073/pnas.0706679105 · 2008 · External reference
ATP Indirectly Stimulates Hippocampal CA1 and CA3 Pyramidal Neurons via the Activation of Neighboring P2X7 Receptor‐Bearing Astrocytes and NG2 Glial Cells, Respectively
10.3389/fphar.2022.944541 · 2022 · External reference
Astrocytic Rather Than Neuronal P2X7 Receptors Modulate the Function of the Tri‐Synaptic Network in the Rodent Hippocampus
10.1016/j.brainresbull.2018.07.016 · 2019 · External reference
Calcium‐Binding Proteins in the Nervous System
10.1016/0166-2236(92)90081-i · 1992 · External reference
Calcium Signalling and Psychiatric Disease: Bipolar Disorder and Schizophrenia
10.1007/s00441-014-1806-z · 2014 · External reference
Antidepressant Monotherapy and Combination Therapy With Acupuncture in Depressed Patients: A Resting‐State Functional Near‐Infrared Spectroscopy (fNIRS) Study
10.1007/s13311-021-01098-3 · 2021 · External reference
The Effectiveness and Safety of Acupuncture for Depression: An Overview of Meta‐Analyses
10.1016/j.ctim.2019.102202 · 2020 · External reference
Manual or Electroacupuncture as an Add‐On Therapy to SSRIs for Depression: A Randomized Controlled Trial
10.1016/j.jpsychires.2019.04.005 · 2019 · External reference
The Mechanism of Electroacupuncture for Depression on Basic Research: A Systematic Review
10.1186/s13020-020-00421-y · 2021 · External reference
Electroacupuncture Promotes Synaptic Plasticity in Rats With Chronic Inflammatory Pain‐Related Depression by Upregulating BDNF/TrkB/CREB Signaling Pathway
10.1002/brb3.3310 · 2023 · External reference
Electroacupuncture Alleviated Depression‐Like Behaviors in Ventromedial Prefrontal Cortex of Chronic Unpredictable Mild Stress‐Induced Rats: Increasing Synaptic Transmission and Phosphorylating Dopamine Transporter
10.1111/cns.14200 · 2023 · External reference
Acupuncture Alleviates CUMS‐Induced Depression‐Like Behaviors of Rats by Regulating Oxidative Stress, Neuroinflammation and Ferroptosis
10.1016/j.brainres.2023.148715 · 2024 · External reference
Electroacupuncture Ameliorates Chronic Unpredictable Mild Stress‐Induced Depression‐Like Behavior and Cognitive Impairment Through Suppressing Oxidative Stress and Neuroinflammation in Rats
10.1016/j.brainresbull.2023.110838 · 2024 · External reference
Antidepressant Effect of Electroacupuncture Regulates Signal Targeting in the Brain and Increases Brain‐Derived Neurotrophic Factor Levels
10.4103/1673-5374.193238 · 2016 · External reference
The Novel Imipramine–Magnesium Complex Exerts Antidepressant‐Like Activity in Mice Subjected to the Forced Swim Test and the Tail Suspension Test
10.3390/molecules30030519 · 2025 · External reference
Non‐Hallucinogenic Psychedelics for Mood and Anxiety Disorders: A Systematic Review
10.1016/j.psychres.2025.116532 · 2025 · External reference
Revisiting the Validity of the Mouse Tail Suspension Test: Systematic Review and Meta‐Analysis of the Effects of Prototypic Antidepressants
10.1016/j.neubiorev.2020.01.034 · 2020 · External reference
Revisiting the Validity of the Mouse Forced Swim Test: Systematic Review and Meta‐Analysis of the Effects of Prototypic Antidepressants
10.1016/j.neubiorev.2017.11.003 · 2018 · External reference
Effect of Acupuncture at ST36 on Motor Cortical Excitation and Inhibition
10.1002/brb3.1370 · 2019 · External reference
Brain Functional Changes Following Electroacupuncture in a Mouse Model of Comorbid Pain and Depression: A Resting‐State Functional Magnetic Resonance Imaging Study
10.1016/j.joim.2025.01.006 · 2025 · External reference
Acupuncture: A Novel Hypothesis for the Involvement of Purinergic Signalling
10.1016/j.mehy.2009.05.031 · 2009 · External reference
Suppressing PKC‐Dependent Membrane P2X3 Receptor Upregulation in Dorsal Root Ganglia Mediated Electroacupuncture Analgesia in Rat Painful Diabetic Neuropathy
10.1007/s11302-018-9617-4 · 2018 · External reference
Electroacupuncture Alleviates Neuropathic Pain in a Rat Model of CCD via Suppressing P2X3 Expression in Dorsal Root Ganglia
10.1186/s13020-024-01030-9 · 2024 · External reference
Increasing Efficiency of Repetitive Electroacupuncture on Purine‐ and Acid‐Induced Pain During a Three‐Week Treatment Schedule
10.3389/fphar.2021.680198 · 2021 · External reference
Electro‐Acupuncture Alleviates Chronic Unpredictable Stress‐Induced Depressive‐ and Anxiety‐Like Behavior and Hippocampal Neuroinflammation in Rat Model of Depression
10.3389/fnmol.2018.00149 · 2018 · External reference
Acupuncture Alleviates CUMS‐Induced Depression‐Like Behaviors by Restoring Prefrontal Cortex Neuroplasticity
10.1155/2023/1474841 · 2023 · External reference
Acupuncture Alleviates CSDS‐Induced Depressive‐Like Behaviors by Modulating Synaptic Plasticity in vCA1
10.7150/thno.106751 · 2025 · External reference
Microinjection of Reelin Into the mPFC Prevents MK‐801‐Induced Recognition Memory Impairment in Mice
10.1016/j.phrs.2021.105832 · 2021 · External reference
Hippocampal P2X7 and A2A Purinoceptors Mediate Cognitive Impairment Caused by Long‐Lasting Epileptic Seizures
10.7150/thno.100365 · 2025 · External reference
A Molecularly Defined mPFC‐BLA Circuit Specifically Regulates Social Novelty Preference
10.1126/sciadv.adt9008 · 2025 · External reference
Cytoarchitectonic and Chemoarchitectonic Characterization of the Prefrontal Cortical Areas in the Mouse
10.1007/s00429-010-0247-z · 2010 · External reference
