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References from Liver Metastases from Colorectal Cancer: From Pathogenesis to Current Treatment. Local targets link to admitted publications; unresolved targets remain external evidence.
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
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Disease Characteristics and Treatment Patterns of Chinese Patients with Metastatic Colorectal Cancer: a Retrospective Study Using Medical Records from China
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Cancer Statistics, 2024
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The Impact of Screening on Colorectal Cancer Mortality and Incidence: Has It Really Made a Difference?
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Understanding the Tumor Immune Microenvironment (TIME) for Effective Therapy
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Spatial Architecture of the Immune Microenvironment Orchestrates Tumor Immunity and Therapeutic Response
10.1186/s13045-021-01103-4 · 2021 · External reference
Nanomedicines Modulating Tumor Immunosuppressive Cells to Enhance Cancer Immunotherapy
10.1016/j.apsb.2020.08.010 · 2020 · External reference
Hepatic Surgical Anatomy
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Gut Liver Brain Axis in Diseases: the Implications for Therapeutic Interventions
10.1038/s41392-023-01673-4 · 2023 · External reference
Gut Vascular Barrier Impairment Leads to Intestinal Bacteria Dissemination and Colorectal Cancer Metastasis to Liver
10.1016/j.ccell.2021.03.004 · 2021 · External reference
Shedding Light on the EpCAM: an Overview
10.1002/jcp.28132 · 2019 · External reference
Angiocrine Signaling in Sinusoidal Homeostasis and Liver Diseases
10.1016/j.jhep.2024.05.014 · 2024 · External reference
Metastatic Colonization by Circulating Tumour Cells
10.1038/nature17038 · 2016 · External reference
Emerging Biological Principles of Metastasis
10.1016/j.cell.2016.11.037 · 2017 · External reference
Direct Signaling Between Platelets and Cancer Cells Induces an Epithelial‐Mesenchymal‐Like Transition and Promotes Metastasis
10.1016/j.ccr.2011.09.009 · 2011 · External reference
Platelets, Immune Cells and the Coagulation Cascade; Friend or Foe of the Circulating Tumour Cell?
10.1186/s12943-021-01347-1 · 2021 · External reference
Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis
10.1016/j.cell.2014.07.013 · 2014 · External reference
Liver Metastases
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EMT Transition States during Tumor Progression and Metastasis
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New Insights into the Mechanisms of Epithelial‐Mesenchymal Transition and Implications for Cancer
10.1038/s41580-018-0080-4 · 2019 · External reference
Immunity, Tolerance and Autoimmunity in the Liver: a Comprehensive Review
10.1016/j.jaut.2015.08.020 · 2016 · External reference
The Unique Immune Microenvironment of Liver Metastases: Challenges and Opportunities
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The Liver's Dilemma: Sensing Real Danger in a Sea of PAMPs: The (Arterial) Sinusoidal Segment Theory
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Nanoparticle‐Based Autoantigen Delivery to Treg‐Inducing Liver Sinusoidal Endothelial Cells Enables Control of Autoimmunity in Mice
10.1016/j.jhep.2015.01.006 · 2015 · External reference
TGF‐β‐dependent Induction of CD4+CD25+Foxp3+ Tregs by Liver Sinusoidal Endothelial Cells
10.1016/j.jhep.2014.04.027 · 2014 · External reference
Use of a Liver‐Targeting Immune‐Tolerogenic mRNA Lipid Nanoparticle Platform to Treat Peanut‐Induced Anaphylaxis by Single‐ and Multiple‐Epitope Nucleotide Sequence Delivery
10.1021/acsnano.2c12420 · 2023 · External reference
CD44 Expression on Murine Hepatic Stellate Cells Promotes the Induction of Monocytic and Polymorphonuclear Myeloid‐Derived Suppressor Cells
10.1093/jleuko/qiae053 · 2024 · External reference
CD44 in Myeloid Cells Is a Major Driver of Liver Inflammation and Injury in Alcohol‐Associated Liver Disease
2025 · External reference
Hepatic Stellate Cells: Balancing Homeostasis, Hepatoprotection and Fibrogenesis in Health and Disease
10.1038/s41575-025-01068-6 · 2025 · External reference
Hepatic Stellate Cells Undermine the Allostimulatory Function of Liver Myeloid Dendritic Cells via STAT3‐Dependent Induction of IDO
10.4049/jimmunol.1200819 · 2012 · External reference
The Role of Tumor‐Derived Exosomal LncRNA in Tumor Metastasis
10.1038/s41417-024-00852-x · 2025 · External reference
Tumor‐Derived Exosomal miR‐934 Induces Macrophage M2 Polarization to Promote Liver Metastasis of Colorectal Cancer
10.1186/s13045-020-00991-2 · 2020 · External reference
Exosome‐Encapsulated miRNAs Contribute to CXCL12/CXCR4‐induced Liver Metastasis of Colorectal Cancer by Enhancing M2 Polarization of Macrophages
10.1016/j.canlet.2020.01.005 · 2020 · External reference
Exosomal miR‐106a‐5p from Highly Metastatic Colorectal Cancer Cells Drives Liver Metastasis by Inducing Macrophage M2 Polarization in the Tumor Microenvironment
10.1186/s13046-024-03204-7 · 2024 · External reference
myCAF‐Derived Exosomal PWAR6 Accelerates CRC Liver Metastasis via Altering Glutamine Availability and NK Cell Function in the Tumor Microenvironment
10.1186/s13045-024-01643-5 · 2024 · External reference
The lncRNA MIR181A1HG in Extracellular Vesicles Derived from Highly Metastatic Colorectal Cancer Cells Promotes Liver Metastasis by Remodeling the Extracellular Matrix and Recruiting Myeloid‐Derived Suppressor Cells
10.1186/s13578-025-01365-2 · 2025 · External reference
Cancer‐Secreted Exosomal miR‐1246 Promotes Colorectal Cancer Liver Metastasis by Activating Hepatic Stellate Cells
10.1186/s10020-025-01112-w · 2025 · External reference
Hypoxia‐Inducible Exosomes Facilitate Liver‐Tropic Premetastatic Niche in Colorectal Cancer
10.1002/hep.32009 · 2021 · External reference
Extracellular Vesicles in Cancer´s Communication: Messages We Can Read and How to Answer
10.1186/s12943-025-02282-1 · 2025 · External reference
Cancer‐Secreted Exosomal miR‐1825 Induces Angiogenesis to Promote Colorectal Cancer Metastasis
10.1186/s12935-025-03674-5 · 2025 · External reference
Cancer‐Derived Exosomal miR‐25‐3p Promotes Pre‐Metastatic Niche Formation by Inducing Vascular Permeability and Angiogenesis
10.1038/s41467-018-07810-w · 2018 · External reference
Exosome‐Derived ADAM17 Promotes Liver Metastasis in Colorectal Cancer
10.3389/fphar.2021.734351 · 2021 · External reference
Hepatic Stellate Cells Activated by Cancer Cell‐Derived AMIGO2‐Containing Small Extracellular Vesicles Promote Cancer Cell Migration by Producing IL‐8
10.21873/anticanres.17528 · 2025 · External reference
ANXA1 Contained in EVs Regulates Macrophage Polarization in Tumor Microenvironment and Promotes Pancreatic Cancer Progression and Metastasis
10.3390/ijms222011018 · 2021 · External reference
Exosomal ANGPTL1 Attenuates Colorectal Cancer Liver Metastasis by Regulating Kupffer Cell Secretion Pattern and Impeding MMP9 Induced Vascular Leakiness
10.1186/s13046-020-01816-3 · 2021 · External reference
Tumor‐Secreted GRP78 Promotes the Establishment of a Pre‐Metastatic Niche in the Liver Microenvironment
10.3389/fimmu.2020.584458 · 2020 · External reference
Colon Cancer Exosome‐Associated HSP90B1 Initiates Pre‐Metastatic Niche Formation in the Liver by Polarizing M1 Macrophage into M2 Phenotype
10.1186/s13062-025-00623-0 · 2025 · External reference
Cancer‐Derived Exosomal HSPC111 Promotes Colorectal Cancer Liver Metastasis by Reprogramming Lipid Metabolism in Cancer‐Associated Fibroblasts
10.1038/s41419-022-04506-4 · 2022 · External reference
Jianpi Jiedu Recipe Inhibits Colorectal Cancer Liver Metastasis via Regulating ITGBL1‐rich Extracellular Vesicles Mediated Activation of Cancer‐Associated Fibroblasts
10.1016/j.phymed.2022.154082 · 2022 · External reference
Exosome‐Derived tRNA Fragments tRF‐GluCTC‐0005 Promotes Pancreatic Cancer Liver Metastasis by Activating Hepatic Stellate Cells
10.1038/s41419-024-06482-3 · 2024 · External reference
Colorectal Cancer‐Derived Small Extracellular Vesicles Induce TGFβ1‐Mediated Epithelial to Mesenchymal Transition of Hepatocytes
10.1186/s12935-023-02916-8 · 2023 · External reference
Tumor‐Derived Extracellular Vesicles Inhibit Natural Killer Cell Function in Pancreatic Cancer
10.3390/cancers11060874 · 2019 · External reference
Trapping of Lipopolysaccharide to Promote Immunotherapy against Colorectal Cancer and Attenuate Liver Metastasis
10.1002/adma.201805007 · 2018 · External reference
From the Colon to the Liver: How Gut Microbiota May Influence Colorectal Cancer Metastatic Potential
10.3390/jcm13020420 · 2024 · External reference
Gut Microbiota‐Mediated Bile Acid Metabolism Regulates Colorectal Cancer Liver Metastasis by Altering Neutrophil Recruitment
10.1158/0008-5472.can-24-4425 · 2025 · External reference
The Clonal Heterogeneity of Colon Cancer with Liver Metastases
10.1007/s00535-023-01989-6 · 2023 · External reference
The Clonal Evolution of Metastatic Colorectal Cancer
10.1126/sciadv.aay9691 · 2020 · External reference
Mapping the Spreading Routes of Lymphatic Metastases in human Colorectal Cancer
10.1038/s41467-020-15886-6 · 2020 · External reference
Whole Exome and Transcriptome Sequencing Reveal Clonal Evolution and Exhibit Immune‐related Features in Metastatic Colorectal Tumors
10.1038/s41420-021-00607-9 · 2021 · External reference
The Immune Contexture in Cancer Prognosis and Treatment
10.1038/nrclinonc.2017.101 · 2017 · External reference
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
10.1126/science.1129139 · 2006 · External reference
T Cells of Colorectal Cancer Patients' Stimulated by Neoantigenic and Cryptic Peptides Better Recognize Autologous Tumor Cells
10.1136/jitc-2022-005651 · 2022 · External reference
Tumor CEMIP Drives Immune Evasion of Colorectal Cancer via MHC‐I Internalization and Degradation
10.1136/jitc-2022-005592 · 2023 · External reference
SOX17 Enables Immune Evasion of Early Colorectal Adenomas and Cancers
10.1038/s41586-024-07135-3 · 2024 · External reference
Crosstalk Between Colorectal CSCs and Immune Cells in Tumorigenesis, and Strategies for Targeting Colorectal CSCs
10.1186/s40164-024-00474-x · 2024 · External reference
Proteogenomic Characterization of Primary Colorectal Cancer and Metastatic Progression Identifies Proteome‐Based Subtypes and Signatures
10.1016/j.celrep.2024.113810 · 2024 · External reference
Chromatin Accessibility Dynamics in Colorectal Cancer Liver Metastasis: Uncovering the Liver Tropism at Single Cell Resolution
10.1016/j.phrs.2023.106896 · 2023 · External reference
Hepatocyte‐Derived FGL1 Accelerates Liver Metastasis and Tumor Growth by Inhibiting CD8+ T and NK Cells
10.1172/jci.insight.173215 · 2024 · External reference
Immune Checkpoint HLA‐E:CD94‐NKG2A Mediates Evasion of Circulating Tumor Cells from NK Cell Surveillance
10.1016/j.ccell.2023.01.001 · 2023 · External reference
CD8(+) T Cells in the Cancer‐Immunity Cycle
10.1016/j.immuni.2023.09.005 · 2023 · External reference
Factors Contributing to the Potency of CD8(+) T Cells
10.1016/j.it.2023.07.005 · 2023 · External reference
An Early History of T Cell‐Mediated Cytotoxicity
10.1038/s41577-018-0009-3 · 2018 · External reference
A Critical Role for Fas‐Mediated Off‐Target Tumor Killing in T‐Cell Immunotherapy
10.1158/2159-8290.cd-20-0756 · 2021 · External reference
USP8‐Governed GPX4 Homeostasis Orchestrates Ferroptosis and Cancer Immunotherapy
10.1073/pnas.2315541121 · 2024 · External reference
ILC1‐Derived IFN‐γ Regulates Macrophage Activation in Colon Cancer
10.1186/s13062-023-00401-w · 2023 · External reference
Roles of IFN‐γ in Tumor Progression and Regression: A Review
10.1186/s40364-020-00228-x · 2020 · External reference
Interferon‐γ Drives T(reg) Fragility to Promote Anti‐Tumor Immunity
10.1016/j.cell.2017.05.005 · 2017 · External reference
Immune Phenotypic Linkage Between Colorectal Cancer and Liver Metastasis
10.1016/j.ccell.2022.02.013 · 2022 · External reference
Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single‐Cell Level
10.1158/2159-8290.cd-21-0316 · 2022 · External reference
Differential Phenotypic and Functional Properties of Liver‐Resident NK Cells and Mucosal ILC1s
10.1016/j.jaut.2015.09.004 · 2016 · External reference
Human NK Cells: Surface Receptors, Inhibitory Checkpoints, and Translational Applications
10.1038/s41423-019-0206-4 · 2019 · External reference
NK Cell Education: Physiological and Pathological Influences
10.3389/fimmu.2023.1087155 · 2023 · External reference
NK Cells and Solid Tumors: Therapeutic Potential and Persisting Obstacles
10.1186/s12943-022-01672-z · 2022 · External reference
Natural Killer Cells and Other Innate Lymphoid Cells in Cancer
10.1038/s41577-018-0061-z · 2018 · External reference
Natural Killer Cells and Type 1 Innate Lymphoid Cells in Cancer
10.1016/j.smim.2022.101709 · 2023 · External reference
NK Cells‐Directed Therapies Target Circulating Tumor Cells and Metastasis
10.1016/j.canlet.2020.09.021 · 2021 · External reference
Control of Metastasis by NK Cells
10.1016/j.ccell.2017.06.009 · 2017 · External reference
Resting Natural Killer Cells Promote the Progress of Colon Cancer Liver Metastasis by Elevating Tumor‐Derived Stem Cell Factor
10.7554/elife.97201.3 · 2024 · External reference
Hepatic Stellate Cells Suppress NK Cell‐Sustained Breast Cancer Dormancy
10.1038/s41586-021-03614-z · 2021 · External reference
Targeting the TGF‐β Signaling Axis in Metastatic Colorectal Cancer: Where Do We Stand?
10.3390/ijms242317101 · 2023 · External reference
Intricacies of TGF‐β Signaling in Treg and Th17 Cell Biology
10.1038/s41423-023-01036-7 · 2023 · External reference
Regulatory T Cells Induce Metastasis by Increasing Tgf‐β and Enhancing the Epithelial–Mesenchymal Transition
10.3390/cells8111387 · 2019 · External reference
TGF‐β Inhibits the Activation and Functions of NK Cells by Repressing the mTOR Pathway
10.1126/scisignal.aad1884 · 2016 · External reference
TGF‐β and IL‐15 Synergize Through MAPK Pathways to Drive the Conversion of Human NK Cells to an Innate Lymphoid Cell 1‐Like Phenotype
10.4049/jimmunol.1900866 · 2020 · External reference
Lactate‐Mediated Acidification of Tumor Microenvironment Induces Apoptosis of Liver‐Resident NK Cells in Colorectal Liver Metastasis
10.1158/2326-6066.cir-18-0481 · 2019 · External reference
Tumour Hypoxia Promotes Tolerance and Angiogenesis via CCL28 and T(reg) Cells
10.1038/nature10169 · 2011 · External reference
Requirement of RORα for Maintenance and Antitumor Immunity of Liver‐Resident Natural Killer Cells/ILC1s
10.1002/hep.32147 · 2022 · External reference
Elimination of Established Liver Metastases by Human Interleukin 2‐Activated Natural Killer Cells after Locoregional or Systemic Adoptive Transfer
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Tumor‐Infiltrating B Cells Affect the Progression of Oropharyngeal Squamous Cell Carcinoma via Cell‐to‐Cell Interactions with CD8(+) T Cells
10.1186/s40425-019-0726-6 · 2019 · External reference
Presence of B Cells in Tertiary Lymphoid Structures Is Associated with a Protective Immunity in Patients with Lung Cancer
10.1164/rccm.201309-1611oc · 2014 · External reference
Experimentally Induced Liver Metastases from Colorectal Cancer Can be Prevented by Mononuclear Phagocyte‐Mediated Monoclonal Antibody Therapy
10.1016/j.jhep.2010.04.023 · 2010 · External reference
Single‐Cell Landscape and Clinical Outcomes of Infiltrating B Cells in Colorectal Cancer
10.1111/imm.13568 · 2023 · External reference
A Single‐Cell Atlas of Liver Metastases of Colorectal Cancer Reveals Reprogramming of the Tumor Microenvironment in Response to Preoperative Chemotherapy
10.1038/s41421-021-00312-y · 2021 · External reference
Integrative Single‐Cell Transcriptomic Analyses Reveal the Cellular Ontological and Functional Heterogeneities of Primary and Metastatic Liver Tumors
10.1186/s12967-024-04947-9 · 2024 · External reference
Regulatory B Cell Production of IL‐10 Inhibits Lymphoma Depletion during CD20 Immunotherapy in Mice
10.1172/jci59266 · 2011 · External reference
Effect of IL‐10‐Producing B Cells in Peripheral Blood and Tumor Tissue on Gastric Cancer
10.1186/s12964-023-01174-5 · 2023 · External reference
B Cell Function in the Tumor Microenvironment
10.1146/annurev-immunol-101220-015603 · 2022 · External reference
Tumor‐Infiltrated Activated B Cells Suppress Liver Metastasis of Colorectal Cancers
10.1016/j.celrep.2022.111295 · 2022 · External reference
Tertiary Lymphoid Structures and B Lymphocytes: a Promising Therapeutic Strategy to Fight Cancer
10.3389/fimmu.2023.1231315 · 2023 · External reference
Peritumoral Immune‐Suppressive Mechanisms Impede Intratumoral Lymphocyte Infiltration into Colorectal Cancer Liver Versus Lung Metastases
10.1158/2767-9764.crc-23-0212 · 2023 · External reference
Tertiary Lymphoid Structures in Pulmonary Metastases of Microsatellite Stable Colorectal Cancer
10.1007/s00428-023-03577-8 · 2023 · External reference
Prediction Values of Tertiary Lymphoid Structures in the Prognosis of Patients with Left‐ and Right‐Sided Colon Cancer: A Multicenter Propensity Score‐Matched Study
10.1097/js9.0000000000000483 · 2023 · External reference
Localization and Density of Tertiary Lymphoid Structures Associate with Molecular Subtype and Clinical Outcome in Colorectal Cancer Liver Metastases
10.1136/jitc-2022-006425 · 2023 · External reference
Heterogeneity in Tertiary Lymphoid Structures Predicts Distinct Prognosis and Immune Microenvironment Characterizations of Clear Cell Renal Cell Carcinoma
10.1136/jitc-2023-006667 · 2023 · External reference
Spatial Multimodal Analysis Revealed Tertiary Lymphoid Structures as a Risk Stratification Indicator in Combined Hepatocellular‐cholangiocarcinoma
10.1016/j.canlet.2023.216513 · 2024 · External reference
Complete Pathological Remission and Tertiary Lymphoid Structures Are Associated with the Efficacy of Resectable NSCLC Receiving Neoadjuvant Chemoimmunotherapy: a Double‐Center Retrospective Study
10.1080/21645515.2023.2285902 · 2023 · External reference
Modeling Resistance of Colorectal Peritoneal Metastases to Immune Checkpoint Blockade in Humanized Mice
10.1136/jitc-2022-005345 · 2022 · External reference
Mature Tertiary Lymphoid Structures Are Key Niches of Tumour‐Specific Immune Responses in Pancreatic Ductal Adenocarcinomas
10.1136/gutjnl-2022-328697 · 2023 · External reference
Tertiary Lymphoid Structure‐Associated B Cells Enhance CXCL13(+)CD103(+)CD8(+) Tissue‐Resident Memory T‐Cell Response to Programmed Cell Death Protein 1 Blockade in Cancer Immunotherapy
10.1053/j.gastro.2023.10.022 · 2024 · External reference
Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment Within Human Melanoma
10.1016/j.cell.2018.11.043 · 2019 · External reference
Dynamics and Specificities of T Cells in Cancer Immunotherapy
10.1038/s41568-023-00560-y · 2023 · External reference
Phenotypic Signatures of Circulating Neoantigen‐Reactive CD8(+) T Cells in Patients with Metastatic Cancers
10.1016/j.ccell.2023.11.005 · 2023 · External reference
Neoantigen‐Specific CD4(+) T Cells in Human Melanoma Have Diverse Differentiation States and Correlate with CD8(+) T Cell, Macrophage, and B Cell Function
10.1016/j.ccell.2022.03.006 · 2022 · External reference
Prognostic Impact of Immune Response in Resectable Colorectal Liver Metastases Treated by Surgery Alone or Surgery with Perioperative FOLFOX in the Randomised EORTC Study 40983
10.1016/j.ejca.2015.08.014 · 2015 · External reference
Barriers to Immune Cell Infiltration in Tumors
10.1136/jitc-2022-006401 · 2023 · External reference
Visualizing Vasculature and Its Response to Therapy in the Tumor Microenvironment
10.7150/thno.84947 · 2023 · External reference
Runt Related Transcription Factor‐1 Plays a central Role in Vessel Co‐Option of Colorectal Cancer Liver Metastases
10.1038/s42003-021-02481-8 · 2021 · External reference
Targeting FAPα‐Expressing Hepatic Stellate Cells Overcomes Resistance to Antiangiogenics in Colorectal Cancer Liver Metastasis Models
10.1172/jci157399 · 2022 · External reference
Liver Sinusoidal Endothelial Cells—Gatekeepers of Hepatic Immunity
10.1038/s41575-018-0020-y · 2018 · External reference
Liver Sinusoidal Endothelial Cells: Physiology and Role in Liver Diseases
10.1016/j.jhep.2016.07.009 · 2017 · External reference
Cancer Cells Produce Liver Metastasis via Gap Formation in Sinusoidal Endothelial Cells through Proinflammatory Paracrine Mechanisms
10.1126/sciadv.abo5525 · 2022 · External reference
The Fibrotic and Immune Microenvironments as Targetable Drivers of Metastasis
10.1038/s41416-020-01172-1 · 2021 · External reference
Macrophage‐Derived Granulin Drives Resistance to Immune Checkpoint Inhibition in Metastatic Pancreatic Cancer
10.1158/0008-5472.can-17-3876 · 2018 · External reference
Phenotypic and Spatial Heterogeneity of CD8(+) Tumour Infiltrating Lymphocytes
10.1186/s12943-024-02104-w · 2024 · External reference
Spatial Transcriptome Mapping of the Desmoplastic Growth Pattern of Colorectal Liver Metastases by in Situ Sequencing Reveals a Biologically Relevant Zonation of the Desmoplastic Rim
10.1158/1078-0432.ccr-23-3461 · 2024 · External reference
Heterogeneity of PD‐L1 Expression and CD8 Lymphocyte Infiltration in Metastatic Colorectal Cancer and Their Prognostic Significance
10.1016/j.heliyon.2023.e13048 · 2023 · External reference
New Insights into T Cell Metabolism in Liver Cancer: from Mechanism to Therapy
10.1038/s41420-025-02397-w · 2025 · External reference
Navigating Metabolic Pathways to Enhance Antitumour Immunity and Immunotherapy
10.1038/s41571-019-0203-7 · 2019 · External reference
Small Extracellular Vesicles Containing Arginase‐1 Suppress T‐Cell Responses and Promote Tumor Growth in Ovarian Carcinoma
10.1038/s41467-019-10979-3 · 2019 · External reference
Melatonin Modulates L‐Arginine Metabolism in Tumor‐Associated Macrophages by Targeting Arginase 1 in Lymphoma
10.1007/s00210-023-02676-2 · 2024 · External reference
Immunometabolism: Crosstalk with Tumor Metabolism and Implications for Cancer Immunotherapy
10.1186/s12943-025-02460-1 · 2025 · External reference
Targeting MDSCs in Cancer: Emerging Immunotherapeutic and Metabolic Strategies
10.3389/fimmu.2026.1749965 · 2026 · External reference
NAFLD‐Associated Immune Remodeling in Colorectal Cancer Liver Metastasis: Mechanisms and Implications for Immunotherapy
10.3389/fimmu.2026.1863647 · 2026 · External reference
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10.1016/j.jaci.2007.06.016 · 2008 · External reference
T Cells in Health and Disease
10.1038/s41392-023-01471-y · 2023 · External reference
Regulating Lactate‐Related Immunometabolism and EMT Reversal for Colorectal Cancer Liver Metastases Using Shikonin Targeted Delivery
10.1186/s13046-023-02688-z · 2023 · External reference
Acidic Extracellular Microenvironment and Cancer
10.1186/1475-2867-13-89 · 2013 · External reference
ROS/PI3K/Akt and Wnt/β‐Catenin Signalings Activate HIF‐1α‐Induced Metabolic Reprogramming to Impart 5‐Fluorouracil Resistance in Colorectal Cancer
10.1186/s13046-021-02229-6 · 2022 · External reference
Inhibiting Glycolytic Metabolism Enhances CD8+ T Cell Memory and Antitumor Function
10.1172/jci69589 · 2013 · External reference
Mitochondrial Dysfunction Promotes the Transition of Precursor to Terminally Exhausted T Cells Through HIF‐1α‐Mediated Glycolytic Reprogramming
10.1038/s41467-023-42634-3 · 2023 · External reference
Bile Acids Produced by Gut Microbiota Activate TGR5 to Promote Colorectal Liver Metastasis Progression by Inducing MDSCs Infiltration in Liver
10.1016/j.intimp.2025.114829 · 2025 · External reference
A High Hepatic Uptake of Conjugated Bile Acids Promotes Colorectal Cancer‐Associated Liver Metastasis
10.3390/cells11233810 · 2022 · External reference
Cholestasis‐induced Phenotypic Transformation of Neutrophils Contributes to Immune Escape of Colorectal Cancer Liver Metastasis
10.1186/s12929-024-01052-3 · 2024 · External reference
Lipid Deposition Promotes YTHDF3‐mediated m6A Modification of PPARα to Facilitate Liver Metastasis of Colorectal Cancer
10.1093/procel/pwaf092 · 2025 · External reference
Deficiency of SDHC Promotes Metastasis by Reprogramming Fatty Acid Metabolism in Colorectal Cancer
10.1186/s12967-024-05361-x · 2024 · External reference
Targeting Human Acyl‐CoA:Cholesterol Acyltransferase as a Dual Viral and T Cell Metabolic Checkpoint
10.1038/s41467-021-22967-7 · 2021 · External reference
PTPRO Represses Colorectal Cancer Tumorigenesis and Progression by Reprogramming Fatty Acid Metabolism
10.1002/cac2.12341 · 2022 · External reference
Non‐Alcoholic Fatty Liver Disease Promotes Liver Metastasis of Colorectal Cancer via Fatty Acid Synthase Dependent EGFR Palmitoylation
10.1038/s41420-023-01770-x · 2024 · External reference
Integrative Single‐cell and Spatial Transcriptomic Analysis Reveals Lipid Metabolism‐Mediated Macrophage Heterogeneity during Colorectal Cancer Liver Metastasis Progression
10.1186/s12967-025-07581-1 · 2025 · External reference
DPP7 Promotes Fatty Acid β‐Oxidation in Tumor‐Associated Macrophages and Determines Immunosuppressive Microenvironment in Colorectal Cancer
10.7150/ijbs.117909 · 2025 · External reference
Glycerol‐3‐Phosphate Acyltransferase 3‐Mediated Lipid Droplets Accumulation Confers Chemoresistance of Colorectal Cancer
10.1002/mco2.486 · 2024 · External reference
Ferroptosis and Metastasis: Molecular Checkpoints, Microenvironmental Dynamics, and Therapeutic Opportunities
10.1186/s12943-025-02544-y · 2026 · External reference
AADAC Protects Colorectal Cancer Liver Colonization from Ferroptosis Through SLC7A11‐Dependent Inhibition of Lipid Peroxidation
10.1186/s13046-022-02493-0 · 2022 · External reference
Ferritinophagy: Multifaceted Roles and Potential Therapeutic Strategies in Liver Diseases
10.3389/fcell.2025.1551003 · 2025 · External reference
CD36‐mediated Ferroptosis Dampens Intratumoral CD8(+) T Cell Effector Function and Impairs Their Antitumor Ability
10.1016/j.cmet.2021.02.015 · 2021 · External reference
Ferroptosis Contributes to Immunosuppression
10.1007/s11684-024-1080-8 · 2025 · External reference
The Glutathione Peroxidase Gpx4 Prevents Lipid Peroxidation and Ferroptosis to Sustain Treg Cell Activation and Suppression of Antitumor Immunity
10.1016/j.celrep.2021.109235 · 2021 · External reference
Reprogramming Ferroptosis in MDSCs: for State‐Dependent Immunotherapy Combinations
10.1016/j.bbcan.2026.189571 · 2026 · External reference
Priming and Maintenance of Adaptive Immunity in the Liver
10.1146/annurev-immunol-090122-041354 · 2024 · External reference
Pancreatic Cancer Exosomes Initiate Pre‐Metastatic Niche Formation in the Liver
10.1038/ncb3169 · 2015 · External reference
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