Research graph
References from z‐VAD‐FMK triggers macrophage necroptosis during mycobacterial infection via a non‐canonical off‐target mechanism. Local targets link to admitted publications; unresolved targets remain external evidence.
Evasion of innate immunity by Mycobacterium tuberculosis: is death an exit strategy?
10.1038/nrmicro2387 · 2010 · External reference
Virulent Mycobacterium tuberculosis strains evade apoptosis of infected alveolar macrophages
10.4049/jimmunol.164.4.2016 · 2000 · External reference
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
10.1038/nchembio711 · 2005 · External reference
Identification of RIP1 kinase as a specific cellular target of necrostatins
10.1038/nchembio.83 · 2008 · External reference
Receptor interacting protein kinase‐3 determines cellular necrotic response to TNF‐α
10.1016/j.cell.2009.05.021 · 2009 · External reference
Phosphorylation‐driven assembly of the RIP1‐RIP3 complex regulates programmed necrosis and virus‐induced inflammation
10.1016/j.cell.2009.05.037 · 2009 · External reference
RIP3, an energy metabolism regulator that switches TNF‐induced cell death from apoptosis to necrosis
10.1126/science.1172308 · 2009 · External reference
Mixed lineage kinase domain‐like protein mediates necrosis signaling downstream of RIP3 kinase
10.1016/j.cell.2011.11.031 · 2012 · External reference
Mixed lineage kinase domain‐like is a key receptor interacting protein 3 downstream component of TNF‐induced necrosis
10.1073/pnas.1200012109 · 2012 · External reference
Molecular mechanisms of necroptosis: an ordered cellular explosion
10.1038/nrm2970 · 2010 · External reference
Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features
10.1038/cdd.2009.184 · 2010 · External reference
Shared principles in NF‐κB signaling
10.1016/j.cell.2008.01.020 · 2008 · External reference
Smac, a mitochondrial protein that promotes cytochrome c‐dependent caspase activation by eliminating IAP inhibition
10.1016/s0092-8674(00)00008-8 · 2000 · External reference
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
10.1016/s0092-8674(00)00009-x · 2000 · External reference
A small molecule smac mimic potentiates TRAIL‐ and TNFα‐mediated cell death
10.1126/science.1098231 · 2004 · External reference
Identification of a novel homotypic interaction motif required for the phosphorylation of receptor‐interacting protein (RIP) by RIP3
10.1074/jbc.m109488200 · 2002 · External reference
Translocation of mixed lineage kinase domain‐like protein to plasma membrane leads to necrotic cell death
10.1038/cr.2013.171 · 2014 · External reference
Mixed lineage kinase domain‐like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3
10.1016/j.molcel.2014.03.003 · 2014 · External reference
Direct activation of RIP3/MLKL‐dependent necrosis by herpes simplex virus 1 (HSV‐1) protein ICP6 triggers host antiviral defense
10.1073/pnas.1412767111 · 2014 · External reference
Toll‐like receptors activate programmed necrosis in macrophages through a receptor‐interacting kinase‐3‐mediated pathway
10.1073/pnas.1116302108 · 2011 · External reference
MLKL activates the cGAS‐STING pathway by releasing mitochondrial DNA upon necroptosis induction
10.1016/j.molcel.2025.06.005 · 2025 · External reference
Necroptosis in the pathophysiology of disease
10.1016/j.ajpath.2019.10.012 · 2020 · External reference
RIPK1‐RIPK3‐MLKL‐dependent necrosis promotes the aging of mouse male reproductive system
10.7554/elife.27692 · 2017 · External reference
Necroptosis in development and diseases
10.1101/gad.312561.118 · 2018 · External reference
Mixed lineage kinase domain‐like protein MLKL breaks down myelin following nerve injury
10.1016/j.molcel.2018.09.011 · 2018 · External reference
Bcl‐xL mediates RIPK3‐dependent necrosis in M. tuberculosis‐infected macrophages
10.1038/mi.2017.12 · 2017 · External reference
Necroptotic signaling is primed in Mycobacterium tuberculosis‐infected macrophages, but its pathophysiological consequence in disease is restricted
10.1038/s41418-017-0031-1 · 2018 · External reference
Is receptor‐interacting protein kinase 3 a viable therapeutic target for Mycobacterium tuberculosis infection?
10.3389/fimmu.2018.01178 · 2018 · External reference
NAD+ depletion triggers macrophage necroptosis, a cell death pathway exploited by Mycobacterium tuberculosis
10.1016/j.celrep.2018.06.042 · 2018 · External reference
An outer membrane channel protein of Mycobacterium tuberculosis with exotoxin activity
10.1073/pnas.1400136111 · 2014 · External reference
Type I interferon signaling mediates Mycobacterium tuberculosis–induced macrophage death
10.1084/jem.20200887 · 2021 · External reference
TNF induces pathogenic programmed macrophage necrosis in tuberculosis through a mitochondrial‐lysosomal‐endoplasmic reticulum circuit
10.1016/j.cell.2019.08.004 · 2019 · External reference
Toll‐like receptor 3‐mediated necrosis via TRIF, RIP3, and MLKL
10.1074/jbc.m113.462341 · 2013 · External reference
Cutting edge: Toll‐like receptor (TLR)2‐ and TLR4‐mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis
10.4049/jimmunol.169.7.3480 · 2002 · External reference
Toll‐like receptor 2‐deficient mice succumb to Mycobacterium tuberculosis infection
10.1016/s0002-9440(10)63095-7 · 2004 · External reference
Toll‐like receptor‐2 mediates mycobacteria‐induced proinflammatory signaling in macrophages
10.1073/pnas.96.25.14459 · 1999 · External reference
RIPK1 inhibits ZBP1‐driven necroptosis during development
10.1038/nature20559 · 2016 · External reference
Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons
10.7554/elife.67290 · 2021 · External reference
SP140‐RESIST pathway regulates interferon mRNA stability and antiviral immunity
10.1038/s41586-025-09152-2 · 2025 · External reference
ESCRT‐III acts downstream of MLKL to regulate necroptotic cell death and its consequences
10.1016/j.cell.2017.03.020 · 2017 · External reference
Mycobacterium kansasii
10.1128/microbiolspec.tnmi7-0011-2016 · 2017 · External reference
Population genomics provides insights into the evolution and adaptation to humans of the waterborne pathogen Mycobacterium kansasii
10.1038/s41467-021-22760-6 · 2021 · External reference
The genome of a pathogenic Rhodococcus: cooptive virulence underpinned by key gene acquisitions
10.1371/journal.pgen.1001145 · 2010 · External reference
The opportunistic intracellular bacterial pathogen Rhodococcus equi elicits type I interferon by engaging cytosolic DNA sensing in macrophages
10.1371/journal.ppat.1009888 · 2021 · External reference
Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally
10.1016/s1074-7613(00)80609-3 · 1998 · External reference
Caspase‐8 serves both apoptotic and nonapoptotic roles
10.4049/jimmunol.173.5.2976 · 2004 · External reference
Conditional deletion of caspase‐8 in macrophages alters macrophage activation in a RIPK‐dependent manner
10.1186/s13075-015-0794-z · 2015 · External reference
The role of caspase‐8 in inflammatory signalling and pyroptotic cell death
10.1016/j.smim.2023.101832 · 2023 · External reference
Pleiotropic defects in lymphocyte activation caused by caspase‐8 mutations lead to human immunodeficiency
10.1038/nature01063 · 2002 · External reference
Caspase‐8 deficiency presenting as late‐onset multi‐organ lymphocytic infiltration with granulomas in two adult siblings
10.1007/s10875-015-0150-8 · 2015 · External reference
Intestinal inflammation and dysregulated immunity in patients with inherited caspase‐8 deficiency
10.1053/j.gastro.2018.09.041 · 2019 · External reference
ACOD1‐mediated lysosomal membrane permeabilization contributes to Mycobacterium tuberculosis‐induced macrophage death
10.1073/pnas.2425309122 · 2025 · External reference
CYLD proteolysis protects macrophages from TNF‐mediated auto‐necroptosis induced by LPS and licensed by type I IFN
10.1016/j.celrep.2016.05.032 · 2016 · External reference
Staying alive: bacterial inhibition of apoptosis during infection
10.1016/j.tim.2008.02.001 · 2008 · External reference
Viral subversion of apoptotic enzymes: escape from death row
10.1146/annurev.micro.62.081307.163009 · 2008 · External reference
Inflammasome inhibition as a pathogenic stealth mechanism
10.1016/j.chom.2010.06.005 · 2010 · External reference
Bacterial secreted effectors and caspase‐3 interactions
10.1111/cmi.12368 · 2014 · External reference
Poxviruses utilize multiple strategies to inhibit apoptosis
10.3390/v9080215 · 2017 · External reference
Shigella evades pyroptosis by arginine ADP‐riboxanation of caspase‐11
10.1038/s41586-021-04020-1 · 2021 · External reference
Pathogen hijacks programmed cell death signaling by arginine ADPR‐deacylization of caspases
10.1016/j.molcel.2022.03.010 · 2022 · External reference
Non‐specific effects of methyl ketone peptide inhibitors of caspases
10.1016/s0014-5793(98)01640-8 · 1999 · External reference
Antiviral activity of caspase inhibitors: effect on picornaviral 2A proteinase
10.1016/s0014-5793(04)00069-9 · 2004 · External reference
z‐VAD‐fmk inhibits peptide:N‐glycanase and may result in ER stress
10.1038/sj.cdd.4401716 · 2006 · External reference
Cathepsin B‐like and cell death in the unicellular human pathogen Leishmania
10.1038/cddis.2010.51 · 2010 · External reference
Thermal proteome profiling identifies the membrane‐bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin
10.1016/j.chembiol.2021.02.017 · 2021 · External reference
The cellular thermal shift assay: a novel biophysical assay for in situ drug target engagement and mechanistic biomarker studies
10.1146/annurev-pharmtox-010715-103715 · 2016 · External reference
Target identification of small molecules using large‐scale CRISPR‐Cas mutagenesis scanning of essential genes
10.1038/s41467-017-02349-8 · 2018 · External reference
Cellular target deconvolution of small molecules using a selection‐based genetic screening platform
10.1021/acscentsci.2c00609 · 2022 · External reference
CRISPR approaches to small molecule target identification
10.1021/acschembio.7b00965 · 2018 · External reference
Diverse sequence determinants control human and mouse receptor interacting protein 3 (RIP3) and mixed lineage kinase domain‐like (MLKL) interaction in necroptotic signaling
10.1074/jbc.m112.435545 · 2013 · External reference
PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors
10.1073/pnas.1717190115 · 2018 · External reference
Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis
10.1038/s41418-018-0122-7 · 2019 · External reference
Mouse models of human TB pathology: roles in the analysis of necrosis and the development of host‐directed therapies
10.1007/s00281-015-0538-9 · 2016 · External reference
Concordant and discordant gene expression patterns in mouse strains identify best‐fit animal model for human tuberculosis
10.1038/s41598-017-11812-x · 2017 · External reference
Improved vectors and genome‐wide libraries for CRISPR screening
10.1038/nmeth.3047 · 2014 · External reference
