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References from Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network. Local targets link to admitted publications; unresolved targets remain external evidence.
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10.1016/j.wneu.2018.05.090 · 2018 · External reference
Primary hemorrhagic neurovascular diseases in Tibetans: a retrospective observational study
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More severe initial manifestations and worse short‐term functional outcome of intracerebral hemorrhage in the plateau than in the plain
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Experimental high‐altitude intracerebral hemorrhage in minipigs: histology, behavior, and intracranial pressure in a double‐injection model
10.1007/s00701-013-1618-z · 2013 · External reference
Clinical characteristics of spontaneous intracranial basal ganglia hemorrhage and risk factors for hematoma expansion in the plateaus of China
10.3389/fneur.2023.1183125 · 2023 · External reference
Clinical analysis of hypertensive cerebral hemorrhage in long‐term residents and sojourners in plateau area (in Chinese)
2023 · External reference
Long‐Term prognosis of spontaneous intracerebral hemorrhage on the Tibetan Plateau: a prospective cohort study at 2 hospitals
10.1016/j.wneu.2016.05.064 · 2016 · External reference
Emerging stroke risk factors: a focus on infectious and environmental determinants
10.3390/jcdd11010019 · 2024 · External reference
Characteristics of cerebral stroke in the tibet autonomous region of China
2020 · External reference
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Medical conditions and high‐altitude travel
10.1056/nejmra2104829 · 2022 · External reference
Global and country‐level estimates of human population at high altitude
10.1073/pnas.2102463118 · 2021 · External reference
Stroke in high‐altitude areas
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Prevalence of chronic mountain sickness in high altitude districts of Himachal Pradesh
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Adaptive responses to hypoxia and/or hyperoxia in humans
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High altitude is associated with pTau deposition, neuroinflammation, and myelin loss
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Whole‐genome sequencing uncovers the genetic basis of chronic mountain sickness in Andean highlanders
10.1016/j.ajhg.2013.07.011 · 2013 · External reference
Evidence for and against genetic predispositions to acute and chronic altitude illnesses
10.1089/ham.2016.0024 · 2016 · External reference
Short tandem repeats in populations of the Qinghai‐Tibet Plateau and adjacent regions provide insights into high‐altitude adaptation
10.1126/sciadv.adx1590 · 2025 · External reference
DNA methylation in adaptation to high‐altitude environments and pathogenesis of related diseases
10.1186/s40246-025-00794-x · 2025 · External reference
New insights into the genetic basis of Monge's disease and adaptation to high‐altitude
10.1093/molbev/msx239 · 2017 · External reference
Down‐regulation of EPAS1 transcription and genetic adaptation of Tibetans to high‐altitude hypoxia
2017 · External reference
New genetic and physiological factors for excessive erythrocytosis and chronic mountain sickness
10.1152/japplphysiol.00271.2015 · 2015 · External reference
Alternatively spliced NFKB1 transcripts enriched in Andean Aymara modulate inflammation, HIF and hemoglobin
10.1038/s41467-025-56848-0 · 2025 · External reference
Thrombotic, inflammatory, and HIF‐regulated genes and thrombosis risk in polycythemia vera and essential thrombocythemia
10.1182/bloodadvances.2019001379 · 2020 · External reference
A pleiotropic hypoxia‐sensitive EPAS1 enhancer is disrupted by adaptive alleles in Tibetans
10.1126/sciadv.ade1942 · 2022 · External reference
Altitude adaptation in Tibetans caused by introgression of Denisovan‐like DNA
10.1038/nature13408 · 2014 · External reference
Suppression of HIF2 signalling attenuates the initiation of hypoxia‐induced pulmonary hypertension
10.1183/13993003.00378-2019 · 2019 · External reference
Genetic variations in Tibetan populations and high‐altitude adaptation at the Himalayas
10.1093/molbev/msq290 · 2011 · External reference
Genetic evidence for high‐altitude adaptation in Tibet
10.1126/science.1189406 · 2010 · External reference
Genetic and immune changes in Tibetan high‐altitude populations contribute to biological adaptation to hypoxia
10.1265/ehpm.22-00040 · 2022 · External reference
LSD1 demethylates HIF1α to inhibit hydroxylation and ubiquitin‐mediated degradation in tumor angiogenesis
10.1038/onc.2017.158 · 2017 · External reference
The TIP60 complex is a conserved coactivator of HIF1A
10.1016/j.celrep.2016.05.082 · 2016 · External reference
Regulation of hypoxia‐inducible factor 2α signaling by the stress‐responsive deacetylase sirtuin 1
10.1126/science.1169956 · 2009 · External reference
DNMT3a epigenetic program regulates the HIF‐2α oxygen‐sensing pathway and the cellular response to hypoxia
10.1073/pnas.1322909111 · 2014 · External reference
EPAS1 resistance to miRNA‐based regulation contributes to prolonged expression of HIF‐2 during hypoxia in human endothelial cells
10.1016/j.gene.2023.147376 · 2023 · External reference
Protective role of estrogen against excessive erythrocytosis in Monge's disease
10.1038/s12276-020-00550-2 · 2021 · External reference
Estrogen via GPER downregulated HIF‐1a and MIF expression, attenuated cardiac arrhythmias, and myocardial inflammation during hypobaric hypoxia
10.1186/s10020-025-01144-2 · 2025 · External reference
Effect of estrogen receptor α on cardiopulmonary adaptation to chronic developmental hypoxia in a rat model
10.1152/ajplung.00161.2023 · 2024 · External reference
Are permanent residents of high altitude fully adapted to their hypoxic environment?
10.1089/ham.2016.0152 · 2017 · External reference
Physiological effects of chronic hypoxia
10.1056/nejmra1612008 · 2017 · External reference
Chronic mountain sickness in Chinese Han males who migrated to the Qinghai‐Tibetan plateau application and evaluation of diagnostic criteria for chronic mountain sickness
10.1186/1471-2458-14-701 · 2014 · External reference
Study of brain structure and function in chronic mountain sickness based on fMRI
10.3389/fneur.2021.763835 · 2021 · External reference
Exaggerated systemic oxidative‐inflammatory‐nitrosative stress in chronic mountain sickness is associated with cognitive decline and depression
10.1113/jp276898 · 2019 · External reference
DTI study on brain structure and cognitive function in patients with chronic mountain sickness
10.1038/s41598-019-55498-9 · 2019 · External reference
Global REACH 2018: high blood viscosity and hemoglobin concentration contribute to reduced flow‐mediated dilation in high‐altitude excessive erythrocytosis
10.1161/hypertensionaha.119.12780 · 2019 · External reference
Systemic vascular dysfunction in patients with chronic mountain sickness
10.1378/chest.11-0342 · 2012 · External reference
EPR spectroscopic evidence of iron‐catalysed free radical formation in chronic mountain sickness: dietary causes and vascular consequences
10.1016/j.freeradbiomed.2022.03.028 · 2022 · External reference
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10.1161/jaha.118.011104 · 2019 · External reference
Cerebral edema in chronic mountain sickness: a new finding
10.1038/srep43224 · 2017 · External reference
Chronic mountain sickness evolving over time
10.1016/j.chest.2022.01.024 · 2022 · External reference
High‐altitude erythrocytosis: mechanisms of adaptive and maladaptive responses
10.1152/physiol.00029.2021 · 2022 · External reference
Life destiny of erythrocyte in high altitude erythrocytosis: mechanisms underlying the progression from physiological (moderate) to pathological (excessive) high‐altitude erythrocytosis
10.3389/fgene.2025.1528935 · 2025 · External reference
The genetic basis of chronic mountain sickness
2014 · External reference
Integrated multiomics reveals inflammation‐driven excessive erythrocytosis in subjects with Monge's disease
2025 · External reference
Chronic mountain sickness: clinical aspects, etiology, management, and treatment
10.1089/ham.2016.0031 · 2016 · External reference
Chinese expert consensus on the diagnosis and treatment of high-altitude polycythemia (2025) (in Chinese)
2025 · External reference
Redefining chronic mountain sickness: insights from high‐altitude research and clinical experience
10.1515/mr-2024-0036 · 2025 · External reference
Impact of high altitude on the incidence of postoperative venous thromboembolism and its genetic susceptibility: a meta‐analysis and systematic review
10.1016/j.scitotenv.2022.156632 · 2022 · External reference
Features of thromboelastogram in populations exposed to or transferring from high altitude
10.1016/j.heliyon.2024.e25223 · 2024 · External reference
Hypoxia and low temperature upregulate transferrin to induce hypercoagulability at high altitude
10.1182/blood.2022016410 · 2022 · External reference
Clinical and prognostic characteristics of cerebral venous thrombosis at high altitude: a single‐center retrospective study of Tibet
10.1007/s00415-023-11597-2 · 2023 · External reference
Serum inflammatory factor profiles in the pathogenesis of high‐altitude polycythemia and mechanisms of acclimation to high altitudes
10.1155/2021/8844438 · 2021 · External reference
Proteomic analysis related to the mechanism of high‐altitude polycythemia in Tibetans
10.1016/j.bbrc.2025.152717 · 2025 · External reference
Cardiovascular physiology and pathophysiology at high altitude
10.1038/s41569-023-00924-9 · 2024 · External reference
Hemoglobin is associated with hypertension‐mediated cardiovascular damages in hypertensive patients with high‐altitude polycythemia
10.1007/s11739-024-03800-7 · 2025 · External reference
Hemoglobin concentration affects hypertensive basal ganglia hemorrhage after surgery: correlation analysis in a high‐altitude region
10.1016/j.wneu.2019.03.281 · 2019 · External reference
Elevated hemoglobin concentration affects acute severe head trauma after recovery from surgery of neurologic function in the Tibetan Plateau
10.1016/j.wneu.2015.09.070 · 2016 · External reference
Are coagulation profiles in Andean highlanders with excessive erythrocytosis favouring hypercoagulability?
10.1113/ep091670 · 2024 · External reference
Apoptosis is one cause of thrombocytopenia in patients with high‐altitude polycythemia
10.1080/09537104.2022.2157381 · 2023 · External reference
Platelets and high‐altitude exposure: a meta‐analysis
10.1089/ham.2021.0075 · 2022 · External reference
Correlation of platelet‐derived growth factor and thromboxane A2 expression with platelet parameters and coagulation indices in chronic altitude sickness patients
10.1113/ep089735 · 2022 · External reference
Medical problems of chronic hypoxia in highlanders living on the Tibetan Plateau
10.1089/ham.2024.0107 · 2025 · External reference
Erythrocytes display metabolic changes in high‐altitude polycythemia
10.1089/ham.2022.0151 · 2023 · External reference
Associations of high altitude polycythemia with polymorphisms in EPAS1, ITGA6 and ERBB4 in Chinese Han and Tibetan populations
10.18632/oncotarget.21420 · 2017 · External reference
Understanding the factors associated with hypertension in the Western Himalaya: a GIS integrated analysis
10.1186/s12889-025-24469-3 · 2025 · External reference
SMASH‐U: a proposal for etiologic classification of intracerebral hemorrhage
10.1161/strokeaha.112.661603 · 2012 · External reference
Global, regional, and national burden of intracerebral hemorrhage and its attributable risk factors from 1990 to 2021: results from the 2021 Global Burden of Disease Study
10.1186/s12889-024-19923-7 · 2024 · External reference
The association between altitude and the prevalence of hypertension among permanent highlanders
10.1038/s41440-022-00985-2 · 2022 · External reference
The U‐shaped association of altitudes with prevalence of hypertension among residents in Tibet, China
10.1038/s41371-020-0367-8 · 2021 · External reference
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10.1186/s12889-024-20891-1 · 2024 · External reference
Baroreflex control of sympathetic vasomotor activity and resting arterial pressure at high altitude: insight from Lowlanders and Sherpa
10.1113/jp277663 · 2019 · External reference
Association between hemoglobin concentration and hypertension risk in native Tibetans at high altitude
10.1111/jch.14726 · 2024 · External reference
Association between high‐altitude polycythemia and hypertension: a cross‐sectional study in adults at Tibetan ultrahigh altitudes
10.1038/s41371-024-00916-3 · 2024 · External reference
A sympathetic view of blood pressure control at high altitude: new insights from microneurographic studies
10.1113/ep089194 · 2021 · External reference
A retrospective cross‐sectional study on the clinicopathologic features of essential hypertension at high altitude in china
10.1155/cdr/8834620 · 2025 · External reference
Micro‐ and macrovascular function in the highest city in the world: a cross sectional study
2024 · External reference
Research on related factors of hyperuricemia in high altitude area migrant population
10.3389/fendo.2025.1559260 · 2025 · External reference
Serum metabolomic profiling uncovered metabolic shifts in individuals upon moderate‐altitude exposure and identified the potentiality of beta‐alanine to ameliorate hyperuricemia
10.1016/j.redox.2025.103546 · 2025 · External reference
Prevalence of high‐altitude polycythemia and hyperuricemia and risk factors for hyperuricemia in high‐altitude immigrants
10.1089/ham.2022.0133 · 2023 · External reference
Dysregulation of metabolites and high‐altitude illnesses development under plateau conditions
10.3389/fphys.2025.1600374 · 2025 · External reference
High altitude renal syndrome: four elements or one source?
10.1080/0886022x.2025.2482125 · 2025 · External reference
Association of exposure duration, modality, and polycythaemia with hyperuricaemia among Han male immigrants at high altitudes: a cross‐sectional study
10.1080/07853890.2025.2543065 · 2025 · External reference
Integration of metabolomics and proteomics reveals the molecular characterization of high‐altitude hyperuricemia
10.1021/acs.jproteome.5c00111 · 2025 · External reference
Serum uric acid levels and intracerebral hemorrhage: a two‐sample Mendelian randomization study
10.1016/j.jstrokecerebrovasdis.2024.108192 · 2025 · External reference
Serum urate as an independent predictor of poor outcome and future vascular events after acute stroke
10.1161/01.str.0000081983.34771.d2 · 2003 · External reference
Hyperuricemia as a risk factor for cerebral hemorrhage in young and middle‐aged hypertensive patients at high altitude
10.54029/2024jyx · 2024 · External reference
Gut microbiota's role in high‐altitude cognitive impairment: the therapeutic potential of Clostridium sp. supplementation
10.1007/s11427-024-2779-9 · 2025 · External reference
Disrupted gut microbiota aggravates spatial memory dysfunction induced by high altitude exposure: a link between plateau environment and microbiome‐gut‐brain axis
10.1016/j.ecoenv.2023.115035 · 2023 · External reference
The human brain in a high altitude natural environment: a review
10.3389/fnhum.2022.915995 · 2022 · External reference
A meta‐analysis of multidimensional cognitive functions changes in different intensities of high‐altitude hypoxia
10.1002/brb3.70883 · 2025 · External reference
Mechanism, prevention and treatment of cognitive impairment caused by high altitude exposure
10.3389/fphys.2023.1191058 · 2023 · External reference
Neurological biomarker profiles in Royal Canadian Air Force (RCAF) pilots and aircrew
10.3390/brainsci14121296 · 2024 · External reference
Insight into the effects of high‐altitude hypoxic exposure on learning and memory
10.1155/2022/4163188 · 2022 · External reference
High‐altitude hypoxia drives dentate gyrus neuronal vulnerability through an IL1α‐astrocyte‐SLC1A2 pathway
10.1186/s12974-026-03744-z · 2026 · External reference
High altitude hypoxia on brain ultrastructure of rats and Hsp70 expression changes
10.1080/02688697.2018.1519108 · 2019 · External reference
Relationship between blood‐brain barrier changes and drug metabolism under high‐altitude hypoxia: obstacle or opportunity for drug transport?
10.1080/03602532.2023.2180028 · 2023 · External reference
The impact of hypoxia on blood‐brain, blood‐CSF, and CSF‐brain barriers
10.1152/japplphysiol.00108.2020 · 2021 · External reference
Global Reach 2018: reduced flow‐mediated dilation stimulated by sustained increases in shear stress in high‐altitude excessive erythrocytosis
10.1152/ajpheart.00316.2019 · 2019 · External reference
The impact of hypoxaemia on vascular function in lowlanders and high altitude indigenous populations
10.1113/jp277191 · 2019 · External reference
Hypobaric hypoxia‐driven energy metabolism disturbance facilitates vascular endothelial dysfunction
10.1016/j.redox.2025.103675 · 2025 · External reference
Global reach 2018 heightened α‐Adrenergic signaling impairs endothelial function during chronic exposure to hypobaric hypoxia
10.1161/circresaha.119.316053 · 2020 · External reference
The impact of chronic mild hypoxia on cerebrovascular remodelling; uncoupling of angiogenesis and vascular breakdown
10.1186/s12987-021-00284-x · 2021 · External reference
Hypoxia inhibits cell cycle progression and cell proliferation in brain microvascular endothelial cells via the miR‐212‐3p/MCM2 axis
10.3390/ijms24032788 · 2023 · External reference
Multiomics analysis reveals role of ncRNA in hypoxia of mouse brain microvascular endothelial cells
10.3390/ijms26125629 · 2025 · External reference
Occludin degradation makes brain microvascular endothelial cells more vulnerable to reperfusion injury in vitro
10.1111/jnc.15102 · 2021 · External reference
Tight junction proteins at the blood‐brain barrier: far more than claudin‐5
10.1007/s00018-019-03030-7 · 2019 · External reference
Hypoxia‐enhanced Blood‐Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies
10.1038/s41467-019-10588-0 · 2019 · External reference
Brain pericytes acquire a microglial phenotype after stroke
10.1007/s00401-014-1295-x · 2014 · External reference
Molecular regulation of the response of brain pericytes to hypoxia
10.3390/ijms24065671 · 2023 · External reference
Neuronal and vascular deficits following chronic adaptation to high altitude
10.1016/j.expneurol.2018.10.007 · 2019 · External reference
Beyond barrier functions: roles of pericytes in homeostasis and regulation of neuroinflammation
10.1002/jnr.24715 · 2020 · External reference
Chronic exposure to high altitude: synaptic, astroglial and memory changes
10.1038/s41598-019-52563-1 · 2019 · External reference
Down‐regulation of inwardly rectifying K(+) currents in astrocytes derived from patients with Monge's disease
10.1016/j.neuroscience.2018.01.016 · 2018 · External reference
Intracellular pH regulation in iPSCs‐derived astrocytes from subjects with chronic mountain sickness
10.1016/j.neuroscience.2018.02.008 · 2018 · External reference
Enhanced BPGM/2,3‐DPG pathway activity suppresses glycolysis in hypoxic astrocytes via FIH‐1 and TET2
10.1016/j.brainresbull.2022.11.002 · 2023 · External reference
Stanniocalcin‐1 protected astrocytes from hypoxic damage through the AMPK pathway
10.1007/s11064-021-03393-z · 2021 · External reference
Monocarboxylate transporter‐dependent mechanism is involved in the adaptability of the body to exercise‐induced fatigue under high‐altitude hypoxia environment
10.1016/j.brainresbull.2023.02.007 · 2023 · External reference
Hypoxia inducible factor‐1α attenuates ischemic brain damage by modulating inflammatory response and glial activity
10.3390/cells10061359 · 2021 · External reference
Mechanism of aquaporin 4 (AQP 4) up‐regulation in rat cerebral edema under hypobaric hypoxia and the preventative effect of puerarin
10.1016/j.lfs.2017.10.021 · 2018 · External reference
Possible role of glymphatic system of the brain in the pathogenesis of high‐altitude cerebral edema
10.1089/ham.2018.0066 · 2018 · External reference
Pro‐inflammatory microglia exacerbate high‐altitude‐induced cognitive impairment by driving lipid droplet accumulation in astrocytes
2025 · External reference
Temporal and spatial changes in glial cells during chronic hypobaric hypoxia: role in neurodegeneration
10.1016/j.neuroscience.2018.04.026 · 2018 · External reference
Ferroptosis at high altitude: interplay between hypobaric hypoxia and iron balance alteration in cells
10.1016/j.lfs.2025.124148 · 2026 · External reference
High‐altitude hypoxia aggravated neurological deficits in mice induced by traumatic brain injury via BACH1 mediating astrocytic ferroptosis
10.1038/s41420-025-02337-8 · 2025 · External reference
Retarded astrogliogenesis in response to hypoxia is facilitated by downregulation of CIRBP
10.1016/j.ecoenv.2024.116710 · 2024 · External reference
Hypoxia‐inducible factor‐1 (HIF‐1) is involved in the regulation of hypoxia‐stimulated expression of monocyte chemoattractant protein‐1 (MCP‐1/CCL2) and MCP‐5 (Ccl12) in astrocytes
10.1186/1742-2094-4-12 · 2007 · External reference
Multiple roles of peripheral immune system in modulating ischemia/hypoxia‐induced neuroinflammation
10.3389/fmolb.2021.752465 · 2021 · External reference
Connection and communication between the nervous and immune systems
10.1038/s41577-025-01199-6 · 2025 · External reference
Distinct immune cell profiles associated with high‐altitude hypoxia and severe acute mountain sickness
10.1113/jp288584 · 2025 · External reference
Multi‐omics reveals immune response and metabolic profiles during high‐altitude mountaineering
10.1016/j.celrep.2024.115134 · 2025 · External reference
Immune sensitization during 1 year in the Antarctic high‐altitude concordia environment
10.1111/all.13545 · 2018 · External reference
Changes in immune cell populations during acclimatization to high altitude
10.14814/phy2.70024 · 2024 · External reference
Neuromodulation by the immune system: a focus on cytokines
10.1038/s41577-021-00508-z · 2021 · External reference
Comprehensive insight on immune landscape in intracerebral hemorrhage patients with single‐cell RNA sequencing: from blood to hematoma
10.1186/s12974-025-03518-z · 2025 · External reference
Systemic inflammatory response syndrome and long‐term outcome after intracerebral hemorrhage
10.1212/nxi.0000000000000588 · 2019 · External reference
Microglia regulate neuronal activity via structural remodeling of astrocytes
10.1016/j.neuron.2025.07.024 · 2025 · External reference
Microglia transcriptional states and their functional significance: context drives diversity
10.1016/j.immuni.2025.04.009 · 2025 · External reference
The role of microglia in neuronal and cognitive function during high altitude acclimatization
10.1038/s41598-024-69694-9 · 2024 · External reference
Nicotinamide riboside alleviates the neurotoxic injury of dendritic spine plasticity mediated by hypoxic microglial activation
10.3390/biom15101391 · 2025 · External reference
CX3CL1/CX3CR1 signal mediates M1‐type microglia and accelerates high‐altitude‐induced forgetting
10.3389/fncel.2023.1189348 · 2023 · External reference
Mitochondrial transplantation via magnetically responsive artificial cells promotes intracerebral hemorrhage recovery by supporting microglia immunological homeostasis
10.1002/adma.202500303 · 2025 · External reference
NRF1‐mediated microglial activation triggers high‐altitude cerebral edema
10.1093/jmcb/mjac036 · 2022 · External reference
Progress in the treatment of high altitude cerebral edema: targeting REDOX homeostasis
10.2147/jir.s415695 · 2023 · External reference
High‐altitude cerebral hypoxia promotes mitochondrial dysfunction and apoptosis of mouse neurons
10.3389/fnmol.2023.1216947 · 2023 · External reference
12/15–Lipoxygenase debilitates mitochondrial health in intermittent hypobaric hypoxia induced neuronal damage: an in vivo study
10.1016/j.redox.2021.102228 · 2022 · External reference
Altered iPSC‐derived neurons’ sodium channel properties in subjects with Monge's disease
10.1016/j.neuroscience.2014.12.039 · 2015 · External reference
Hypobaric hypoxia induces deficits in adult neurogenesis and social interaction via cyclooxygenase‐1/EP1 receptor pathway activating NLRP3 inflammasome
10.1007/s12035-022-02750-5 · 2022 · External reference
Mitochondrial dysfunction in iPSC‐derived neurons of subjects with chronic mountain sickness
10.1152/japplphysiol.00689.2017 · 2018 · External reference
Spontaneous intracerebral hemorrhage
10.1056/nejmra2201449 · 2022 · External reference
Hypoxia and inflammation: insights from high‐altitude physiology
10.3389/fphys.2021.676782 · 2021 · External reference
Molecular correlates of hemorrhage and edema volumes following human intracerebral hemorrhage implicate inflammation, autophagy, mRNA splicing, and T cell receptor signaling
10.1007/s12975-020-00869-y · 2021 · External reference
Oxidative stress and diseases associated with high‐altitude exposure
10.3390/antiox11020267 · 2022 · External reference
Oxidative‐nitrosative stress and systemic vascular function in highlanders with and without exaggerated hypoxemia
10.1378/chest.12-0728 · 2013 · External reference
High‐altitude medicine
10.1164/rccm.201207-1323ci · 2012 · External reference
The distinct role of HIF‐1α and HIF‐2α in hypoxia and angiogenesis
10.3390/cells14090673 · 2025 · External reference
The genomics and genetics of oxygen homeostasis
10.1146/annurev-genom-111119-073356 · 2020 · External reference
The brain at high altitude: from molecular signaling to cognitive performance
10.3390/ijms241210179 · 2023 · External reference
The potential role of hypoxia‐inducible factor‐1 in the progression and therapy of central nervous system diseases
10.2174/1570159x19666210729123137 · 2022 · External reference
The role of oxygen homeostasis and the HIF‐1 factor in the development of neurodegeneration
10.3390/ijms25094581 · 2024 · External reference
Hypoxia inducible factor‐1 as a target for neurodegenerative diseases
10.2174/092986711797200426 · 2011 · External reference
Impact of exposure duration to high‐altitude hypoxia on oxidative homeostasis in rat brain regions
10.3390/ijms26178714 · 2025 · External reference
Oxygen metabolism abnormalities and high‐altitude cerebral edema
10.3389/fimmu.2025.1555910 · 2025 · External reference
The role of oxidative stress and neuroinflammatory mediators in the pathogenesis of high‐altitude cerebral edema in rats
10.1016/j.resp.2024.104286 · 2024 · External reference
Effects of prolonged exposure to hypobaric hypoxia on oxidative stress: overwintering in antarctic concordia station
10.1155/2022/4430032 · 2022 · External reference
High‐altitude hypoxia induced reactive oxygen species generation, signaling, and mitigation approaches
10.1007/s00484-020-02037-1 · 2021 · External reference
Exosomes from high‐altitude cerebral edema patients induce cognitive dysfunction by altering oxidative stress responses in mice
10.1038/s41398-025-03469-2 · 2025 · External reference
High altitude hypoxia and oxidative stress: the new hope brought by free radical scavengers
10.1016/j.lfs.2023.122319 · 2024 · External reference
Impairment of autophagic flux after hypobaric hypoxia potentiates oxidative stress and cognitive function disturbances in mice
10.1007/s12264-023-01099-6 · 2024 · External reference
High altitude medicinal plants and their bioactive compounds for the prevention of oxidative stress‐induced diseases and disorders. Editorial Material
10.3389/fphar.2023.1257018 · 2023 · External reference
Rhodiola crenulate alleviates hypobaric hypoxia‐induced brain injury via adjusting NF‐κB/NLRP3‐mediated inflammation
10.1016/j.phymed.2022.154240 · 2022 · External reference
Rhodiola crenulata attenuates apoptosis and mitochondrial energy metabolism disorder in rats with hypobaric hypoxia‐induced brain injury by regulating the HIF‐1α/microRNA 210/ISCU1/2(COX10) signaling pathway
10.1016/j.jep.2019.03.028 · 2019 · External reference
Correlation between serum inflammatory factors and cognitive function in patients with high‐altitude polycythemia: a case‐control study
10.1097/md.0000000000037983 · 2024 · External reference
NMDA receptor‐mediated excitotoxicity is involved in neuronal apoptosis and cognitive impairment induced by chronic hypobaric hypoxia exposure at high altitude
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Hypoxia inducible factor‐1alpha expression correlates with inflammatory injury of blood‐brain barrier which influences perihaematomal edema after intracerebral hemorrhage
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Role of NADPH oxidase‐induced hypoxia‐induced factor‐1α increase in blood‐brain barrier disruption after 2‐hour focal ischemic stroke in rat
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Electroacupuncture enhances cerebral blood perfusion by inhibiting HIF‐1α in rat subarachnoid hemorrhage
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Inflammation and immune cell abnormalities in intracranial aneurysm subarachnoid hemorrhage (SAH): relevant signaling pathways and therapeutic strategies
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Potential role of serum hypoxia‐inducible factor 1alpha as a biomarker of delayed cerebral ischemia and poor clinical outcome after human aneurysmal subarachnoid hemorrhage: a prospective, longitudinal, multicenter, and observational study
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Serum hypoxia‐inducible factor 1alpha levels correlate with outcomes after intracerebral hemorrhage
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Early effects of acetazolamide on hemoglobin mass and plasma volume in chronic mountain sickness at 5100 m
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Carbonic anhydrase inhibitors and high altitude illnesses
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High‐altitude illnesses: old stories and new insights into the pathophysiology, treatment and prevention
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TRIOL attenuates intracerebral hemorrhage injury by bidirectionally modulating microglia‐ and neuron‐mediated hematoma clearance
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Oral antioxidant edaravone protects against cognitive deficits induced by chronic hypobaric hypoxia at high altitudes
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Single‐cell RNA sequencing and spatial transcriptomics reveal a novel mechanism of oligodendrocyte‐neuron interaction in cognitive decline after high‐altitude cerebral edema
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BMAL1 modulation alleviates inflammatory responses in monocytes by targeting the Fis1‐mediated mitochondrial unfolded protein response in high‐altitude hypoxia
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Pharmacological inhibition of mitochondrial division attenuates simulated high‐altitude exposure‐induced memory impairment in mice: involvement of inhibition of microglia‐mediated synapse elimination
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Promising natural medicines for the treatment of high‐altitude illness
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Exploring the neuroprotective properties of musk against high‐altitude cerebral edema: unveiling the mechanisms via TNF‐α/RIPK1 pathway regulation and necroptosis inhibition
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Hydroxychloroquine prevents high‐altitude cerebral edema by inhibiting endothelial claudin‐5 autophagic degradation
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Orexin A ameliorates high altitude induced memory retrieval impairment via BDNF/TrkB and PI3K/AKT/mTOR signaling pathways
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6‐Hydroxygenistein ameliorates high altitude brain injury via activating PI3K/AKT signaling pathway based on transcriptomic analysis and experimental validation
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Discovery of novel salidroside derivatives as potent hypoxia inducible factor 1α (HIF‐1α) signaling inhibitors to treat high altitude cerebral edema
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Ligustrazine hydrochloride prevents ferroptosis by activating the NRF2 signaling pathway in a high‐altitude cerebral edema rat model
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Traditional Chinese medicine use in the pathophysiological processes of intracerebral hemorrhage and comparison with conventional therapy
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Pathogenesis and treatments for high altitude pulmonary hypertension: an updated review
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Research progress on high‐concentration oxygen therapy after cerebral hemorrhage
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Hyperbaric oxygen therapy ameliorates acute brain injury after porcine intracerebral hemorrhage at high altitude
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The effect of hemoglobin concentration on hyperbaric oxygen and non‐hyperbaric oxygen in the treatment of hypertensive intracerebral hemorrhage after operation at the high altitude
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A study of survival strategies for improving acclimatization of lowlanders at high‐altitude
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Individual chronic mountain sickness symptom is an early warning sign of cognitive impairment
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Surgical management of intracerebral hemorrhage: new light on the horizon?
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Trial of early minimally invasive removal of intracerebral hemorrhage
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The effect of hematoma puncture drainage before decompressive craniectomy on the prognosis of hypertensive intracerebral hemorrhage with cerebral hernia at a high altitude
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