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References from A Quantitative Systems Pharmacology Model of Human Leucine Metabolism. Local targets link to admitted publications; unresolved targets remain external evidence.
Branched‐Chain Amino Acids: Catabolism in Skeletal Muscle and Implications for Muscle and Whole‐Body Metabolism
10.3389/fphys.2021.702826 · 2021 · External reference
Branched‐Chain Amino Acid Metabolism: Implications for Establishing Safe Intakes
10.1093/jn/135.6.1557s · 2005 · External reference
Branched‐Chain Amino Acids in Health and Disease: Metabolism, Alterations in Blood Plasma, and as Supplements
10.1186/s12986-018-0271-1 · 2018 · External reference
Branched‐Chain Amino Acids and Muscle Protein Synthesis in Humans: Myth or Reality?
10.1186/s12970-017-0184-9 · 2017 · External reference
A Branched‐Chain Amino Acid‐Related Metabolic Signature That Differentiates Obese and Lean Humans and Contributes to Insulin Resistance
10.1016/j.cmet.2009.02.002 · 2009 · External reference
Metabolite Profiles and the Risk of Developing Diabetes
10.1038/nm.2307 · 2011 · External reference
BDK Inhibition Acts as a Catabolic Switch to Mimic Fasting and Improve Metabolism in Mice
10.1016/j.molmet.2022.101611 · 2022 · External reference
Small Molecule Branched‐Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitors With Opposing Effects on BDK Protein Levels
10.1038/s41467-023-40536-y · 2023 · External reference
Branched‐Chain Amino Acid Restriction in Zucker‐Fatty Rats Improves Muscle Insulin Sensitivity by Enhancing Efficiency of Fatty Acid Oxidation and Acyl‐Glycine Export
10.1016/j.molmet.2016.04.006 · 2016 · External reference
The Critical Role of the Branched‐Chain Amino Acids (BCAAs) Catabolism‐Regulating Enzymes, Branched‐Chain Aminotransferase (BCAT) and Branched‐Chain Alpha‐Keto Acid Dehydrogenase (BCKD), in Human Pathophysiology
10.3390/ijms23074022 · 2022 · External reference
The Role of Leucine and Its Metabolites in Protein and Energy Metabolism
10.1007/s00726-015-2067-1 · 2016 · External reference
The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP‐Citrate Lyase
10.1016/j.cmet.2018.04.015 · 2018 · External reference
Quantitative Analysis of the Whole‐Body Metabolic Fate of Branched‐Chain Amino Acids
10.1016/j.cmet.2018.10.013 · 2019 · External reference
Protein Phosphatase 2Cm Is a Critical Regulator of Branched‐Chain Amino Acid Catabolism in Mice and Cultured Cells
10.1172/jci38151 · 2009 · External reference
A Molecular Model of Human Branched‐Chain Amino Acid Metabolism
10.1093/ajcn/68.1.72 · 1998 · External reference
Structure‐Based Design and Mechanisms of Allosteric Inhibitors for Mitochondrial Branched‐Chain Alpha‐Ketoacid Dehydrogenase Kinase
10.1073/pnas.1303220110 · 2013 · External reference
Discovery of First Branched‐Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF‐07328948
10.1021/acs.jmedchem.4c02230 · 2025 · External reference
Impaired Growth and Neurological Abnormalities in Branched‐Chain Alpha‐Keto Acid Dehydrogenase Kinase‐Deficient Mice
10.1042/bj20060869 · 2006 · External reference
Extra‐Cardiac BCAA Catabolism Lowers Blood Pressure and Protects From Heart Failure
10.1016/j.cmet.2022.09.008 · 2022 · External reference
Evaluation of Therapeutic Strategies Targeting BCAA Catabolism Using a Systems Pharmacology Model
10.3389/fphar.2022.993422 · 2022 · External reference
Branched‐Chain Amino Acids Differently Modulate Catabolic and Anabolic States in Mammals: A Pharmacological Point of View
10.1111/bph.13624 · 2017 · External reference
Amino Acid Metabolism, Transport and Signalling in the Liver Revisited
10.1016/j.bcp.2022.115074 · 2022 · External reference
Amino Acid Metabolism in Exercising Man
10.1172/jci106771 · 1971 · External reference
Splanchnic and Peripheral Glucose and Amino Acid Metabolism in Diabetes Mellitus
10.1172/jci106989 · 1972 · External reference
Influence of Leucine Infusion on Intracellular Amino Acids in Humans
10.1111/j.1365-2362.1990.tb01858.x · 1990 · External reference
Blood and Tissue Branched‐Chain Amino and Alpha‐Keto Acid Concentrations: Effect of Diet, Starvation, and Disease
10.1093/ajcn/34.2.173 · 1981 · External reference
Leucine and Protein Metabolism in Obese Zucker Rats
10.1371/journal.pone.0059443 · 2013 · External reference
Influence of Leucine on Arterial Concentrations and Regional Exchange of Amino Acids in Healthy Subjects
10.1042/cs0590173 · 1980 · External reference
Bolus Ingestion of Individual Branched‐Chain Amino Acids Alters Plasma Amino Acid Profiles in Young Healthy Men
10.1186/2193-1801-3-35 · 2014 · External reference
Pharmacokinetic and Metabolic Interrelationships Among Branched‐Chain Keto and Amino Acids in Humans
1985 · External reference
Effect of Starvation on the Turnover and Metabolic Response to Leucine
10.1172/jci109067 · 1978 · External reference
Dose‐Response Curves of Effects of Insulin on Leucine Kinetics in Humans
10.1152/ajpendo.1986.251.3.e334 · 1986 · External reference
Efficient Generation and Selection of Virtual Populations in Quantitative Systems Pharmacology Models
2016 · External reference
Improving the Generation and Selection of Virtual Populations in Quantitative Systems Pharmacology Models
10.1016/j.pbiomolbio.2018.06.002 · 2018 · External reference
The Valine Catabolic Pathway in Human Liver: Effect of Cirrhosis on Enzyme Activities
10.1002/hep.510240614 · 1996 · External reference
GlobalSensitivity.Jl: Performant and Parallel Global Sensitivity Analysis With Julia
10.21105/joss.04561 · 2022 · External reference
A Multiscale, Mechanism‐Driven, Dynamic Model for the Effects of 5alpha‐Reductase Inhibition on Prostate Maintenance
10.1371/journal.pone.0044359 · 2012 · External reference
Glutamine Transporters in Mammalian Cells and Their Functions in Physiology and Cancer
10.1016/j.bbamcr.2015.12.017 · 2016 · External reference
Amino Acid Transporters: Roles in Amino Acid Sensing and Signalling in Animal Cells
10.1042/bj20030405 · 2003 · External reference