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References from Ligustrazine Alleviates Nitroglycerin‐Induced Migraine by Regulating Mitochondrial Energy Metabolism Through the Concurrent Regulation of CypD, ANT, and PAR2. Local targets link to admitted publications; unresolved targets remain external evidence.
Migraine: A Review on Its History, Global Epidemiology, Risk Factors, and Comorbidities
10.3389/fneur.2021.800605 · 2021 · External reference
Protease‐Activated Receptors and Myocardial Infarction
10.1002/iub.441 · 2011 · External reference
Loss of Cyclophilin D Reveals a Critical Role for Mitochondrial Permeability Transition in Cell Death
10.1038/nature03434 · 2005 · External reference
Recent Development of Zolmitriptan Formulation in Migraine Therapy: Production, Metabolism and Pharmaceutical Aspects
10.2174/0118715273306929240820071521 · 2025 · External reference
TRPA1 and Other TRP Channels in Migraine
10.1186/1129-2377-14-71 · 2013 · External reference
Activation of PAR‐2 Elicits NO‐Dependent and CGRP‐Independent Dilation of the Dural Artery
10.1111/j.1526-4610.2010.01679.x · 2010 · External reference
PRDX6: A Protein Bridging S‐Palmitoylation and Diabetic Neuropathy
10.3389/fendo.2022.992875 · 2022 · External reference
Proteases and Protease‐Activated Receptors (PARs): Novel Signals for Pain
10.2174/1568026054367601 · 2005 · External reference
Blocking PAR2 Attenuates Oxaliplatin‐Induced Neuropathic Pain via TRPV1 and Releases of Substance P and CGRP in Superficial Dorsal Horn of Spinal Cord
10.1016/j.jns.2015.03.029 · 2015 · External reference
Cell Type‐Specific Gene Expression of Midbrain Dopaminergic Neurons Reveals Molecules Involved in Their Vulnerability and Protection
10.1093/hmg/ddi178 · 2005 · External reference
Molecular Mechanisms of Nitric Oxide Actions in the Brain
10.1111/j.1749-6632.1994.tb21792.x · 1994 · External reference
DAVID: Database for Annotation, Visualization, and Integrated Discovery
10.1186/gb-2003-4-5-p3 · 2003 · External reference
Ligustrazine Induces Viability, Suppresses Apoptosis and Autophagy of Retinal Ganglion Cells With Ischemia/Reperfusion Injury Through the PI3K/Akt/mTOR Signaling Pathway
10.1080/21655979.2021.1880060 · 2021 · External reference
Hyperglycaemic Impairment of PAR2‐Mediated Vasodilation: Prevention by Inhibition of Aortic Endothelial Sodium‐Glucose‐Co‐Transporter‐2 and Minimizing Oxidative Stress
10.1016/j.vph.2018.06.006 · 2018 · External reference
The Action of the Mast Cell Product Tryptase on Cyclooxygenase‐2 (COX2) and Subsequent Fibroblast Proliferation Involves Activation of the Extracellular Signal‐Regulated Kinase Isoforms 1 and 2 (erk1/2)
10.1016/j.cellsig.2004.09.017 · 2005 · External reference
Global, Regional, and National Incidence, Prevalence, and Years Lived With Disability for 354 Diseases and Injuries for 195 Countries and Territories, 1990–2017: A Systematic Analysis for the Global Burden of Disease Study 2017
10.1016/s0140-6736(18)32279-7 · 2018 · External reference
Nitric Oxide and Mitochondrial Function in Neurological Diseases
10.1016/j.neuroscience.2018.02.017 · 2018 · External reference
The Metabolic Face of Migraine—From Pathophysiology to Treatment
10.1038/s41582-019-0255-4 · 2019 · External reference
Small‐Molecule Inhibitors of Cyclophilin D as Potential Therapeutics in Mitochondria‐Related Diseases
10.1002/med.21892 · 2022 · External reference
Protease Activated Receptor 2 (PAR2) Activation Causes Migraine‐Like Pain Behaviors in Mice
10.1177/0333102418779548 · 2019 · External reference
Protease‐Activated Receptors (PARs): Mechanisms of Action and Potential Therapeutic Modulators in PAR‐Driven Inflammatory Diseases
10.1186/s12959-019-0194-8 · 2019 · External reference
Erastin Disrupts Mitochondrial Permeability Transition Pore (mPTP) and Induces Apoptotic Death of Colorectal Cancer Cells
10.1371/journal.pone.0154605 · 2016 · External reference
ROS/TRPA1/CGRP Signaling Mediates Cortical Spreading Depression
10.1186/s10194-019-0978-z · 2019 · External reference
Mitochondrial Reactive Oxygen Species: A Double Edged Sword in Ischemia/Reperfusion vs Preconditioning
10.1016/j.redox.2014.05.006 · 2014 · External reference
Inhibition of Protease Activated Receptor 2 Attenuates HBx‐Induced Inflammation and Mitochondria Oxidative Stress
10.2147/idr.s343864 · 2022 · External reference
Ferroptosis Inducer Erastin Sensitizes NSCLC Cells to Celastrol Through Activation of the ROS–Mitochondrial Fission–Mitophagy Axis
10.1002/1878-0261.12936 · 2021 · External reference
Regulatory Mechanisms of Tetramethylpyrazine on Central Nervous System Diseases: A Review
10.3389/fphar.2022.948600 · 2022 · External reference
PAR2 Activation in the Dura Causes Acute Behavioral Responses and Priming to Glyceryl Trinitrate in a Mouse Migraine Model
10.1186/s10194-023-01574-5 · 2023 · External reference
Riboflavin in Neurological Diseases: A Narrative Review
10.1007/s40261-021-01038-1 · 2021 · External reference
Relevance of Lactate Level Detection in Migrane and Fibromyalgia
10.4081/ejtm.2019.8202 · 2019 · External reference
The Voltage‐Dependent Anion Channel (VDAC): Function in Intracellular Signalling, Cell Life and Cell Death
10.2174/138161206777585111 · 2006 · External reference
Migraine Remains Second Among the World's Causes of Disability, and First Among Young Women: Findings From GBD2019
10.1186/s10194-020-01208-0 · 2020 · External reference
Effects of Ligustrazine on Energy Metabolism in Migraine Rats Based on Mitochondria‐Inflammation Pathway
10.1016/j.neulet.2024.138035 · 2024 · External reference
Detection of PPID‐Interacting Proteins in Migraine Rats by IP‐MS and Validation by Bioinformatics Analysis and Experiments
10.1016/j.brainres.2025.149854 · 2025 · External reference
Energy Metabolism Disturbance in Migraine: From a Mitochondrial Point of View
10.3389/fphys.2023.1133528 · 2023 · External reference
Inhibiting BDNF/TrkB.T1 Receptor Improves Resiniferatoxin‐Induced Postherpetic Neuralgia Through Decreasing ASIC3 Signaling in Dorsal Root Ganglia
10.1186/s12974-021-02148-5 · 2021 · External reference
Rutaecarpine Alleviates Migraine in Nitroglycerin‐Induced Mice by Regulating PTEN/PGK1 Signaling Pathway to Activate NRF2 Antioxidant System
10.1016/j.biopha.2023.115300 · 2023 · External reference
Xiongshao Zhitong Recipe Attenuates Nitroglycerin‐Induced Migraine‐Like Behaviors via the Inhibition of Inflammation Mediated by Nitric Oxide Synthase
10.3389/fphar.2022.920201 · 2022 · External reference
Combination of Danshen and Ligustrazine Has Dual Anti‐Inflammatory Effect on Macrophages and Endothelial Cells
10.1016/j.jep.2020.113425 · 2021 · External reference
VGLUT2 and APP Family: Unraveling the Neurobiochemical Mechanisms of Neurostimulation Therapy to STZ‐Induced Diabetes and Neuropathy
10.3389/fendo.2024.1336854 · 2024 · External reference
