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References from Multiple Sclerosis and Central Nervous System Demyelination. Local targets link to admitted publications; unresolved targets remain external evidence.
ICE/CED-3 family executes oligodendrocyte apoptosis by tumor necrosis factor
10.1046/j.1471-4159.1997.69010010.x · 1997 · External reference
Cell death and birth in multiple sclerosis brain
10.1016/s0022-510x(97)05213-1 · 1997 · External reference
Multiple sclerosis: oligodendrocytes display cell death-related molecules in situ but do not undergo apoptosis
10.1002/ana.410420113 · 1997 · External reference
Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice
10.1038/309356a0 · 1984 · External reference
Central nervous system demyelination and remyelination in multiple sclerosis and viral models of disease
10.1016/0165-5728(92)90141-7 · 1992 · External reference
Detailed in vivo analysis of interferon-gamma induced major histocompatibility complex expression in the the central nervous system: astrocytes fail to express major histocompatibility complex class I and II molecules
1999 · External reference
Long-term culture of human oligodendrocytes. Isolation, growth and identification
10.1016/0022-510x(83)90206-x · 1983 · External reference
Culture of glial cells from human brain biopsies
1997 · External reference
Expression of Ia antigens on the surface of human oligodendrocytes and astrocytes in culture
10.1016/0165-5728(85)90004-9 · 1985 · External reference
Immunohistochemical studies of adult human glial cells
10.1016/0165-5728(89)90166-5 · 1989 · External reference
Induction of human leukocyte antigen-A,B,C and -DR on cultured human oligodendrocytes and astrocytes by human gamma-interferon
10.1016/0304-3940(86)90543-4 · 1986 · External reference
In the presence of dexamethasone, gamma interferon induces rat oligodendrocytes to express major histocompatibility complex class II molecules
10.1073/pnas.89.19.9054 · 1992 · External reference
Human oligodendrocytes are susceptible to cytolysis by major histocompatibility complex class I-restricted lymphocytes
10.1016/0165-5728(90)90058-u · 1990 · External reference
10.1073/pnas.91.23.10859
10.1073/pnas.91.23.10859 · External reference
MHC class I-restricted lysis of human oligodendrocytes by myelin basic protein peptide-specific CD8 T lymphocytes
10.4049/jimmunol.160.6.3056 · 1998 · External reference
Oligodendrocyte lysis by CD4+T cells independent of tumor necrosis factor
10.1002/ana.410350315 · 1994 · External reference
A novel population of expanded human CD3+CD56+cells derived from T cells with potentin vivo antitumor activity in mice with severe combined immunodeficiency
10.4049/jimmunol.153.4.1687 · 1994 · External reference
Selective expansion of cytotoxic T lymphocytes with a CD4+CD56+surface phenotype and a T helper type 1 profile of cytokine secretion in the liver of patients chronically infected with Hepatitis B virus
10.4049/jimmunol.152.6.3074 · 1994 · External reference
Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule
10.1084/jem.169.6.2233 · 1989 · External reference
A novel population of CD4+CD56+myelin-reactive T cells lyses target cells expressing CD56/neural cell adhesion molecule
10.4049/jimmunol.157.2.679 · 1996 · External reference
Non-MHC-restricted cell-mediated lysis of human oligodendrocytes in vitro: relation with CD56 expression
10.4049/jimmunol.160.4.1606 · 1998 · External reference
Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis
10.1172/jci3568 · 1998 · External reference
Restricted use of VH4 germline segments in an acute multiple sclerosis brain
10.1002/ana.410430214 · 1998 · External reference
Cerebrospinal fluid-physiology, analysis and interpretation of protein patterns for diagnosis of neurological diseases
1998 · External reference
Antibodies to myelin-oligodendrocyte glycoprotein in cerebrospinal fluid from patients with multiple sclerosis and controls
10.1016/0165-5728(91)90014-x · 1991 · External reference
Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein
1998 · External reference
Antibody facilitation of multiple sclerosis-like lesions in a nonhuman primate
10.1172/jci118368 · 1995 · External reference
Distinct patterns of multiple sclerosis pathology indicates heterogeneity on pathogenesis
10.1111/j.1750-3639.1996.tb00854.x · 1996 · External reference
Complement activation by isolated myelin: activation of the classical pathway in the absence of myelin-specific antibodies
10.1073/pnas.79.10.3290 · 1982 · External reference
Antibody-independent complement activation by myelin via the classical complement pathway
10.1084/jem.155.2.587 · 1982 · External reference
Serum cytotoxicity to human and rat oligodendrocytes in culture
10.1016/0006-8993(90)91013-7 · 1990 · External reference
Serum-mediated oligodendrocyte cytotoxicity in multiple sclerosis patients and controls
10.1212/wnl.36.2.276 · 1986 · External reference
Serum cytotoxicity to oligodendrocytes in multiple sclerosis and controls: assessment by 51Cr release assay
10.1016/0165-5728(86)90115-3 · 1986 · External reference
Targeting of IgMkappa antibodies to oligodendrocytes promotes CNS remyelination
10.1523/jneurosci.18-19-07700.1998 · 1998 · External reference
Interferon-gamma potentiates antibody-mediated demyelination in vivo
10.1002/ana.410320212 · 1992 · External reference
Reactive microglia in multiple sclerosis lesions have an increased expression of receptors for the Fc part of IgG
10.1016/0022-510x(94)90340-9 · 1994 · External reference
Fc receptors for IgG on cultured human microglia mediate cytotoxicity and phagocytosis of antibody-coated targets
10.1097/00005072-199401000-00004 · 1994 · External reference
Oligodendrocyte-macrophage interactions in vitro triggered by specific antibodies
1991 · External reference
Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions
10.1073/pnas.89.10.4588 · 1992 · External reference
Clonal expansions of activated gamma/delta T cells in recent-onset multiple sclerosis
10.1073/pnas.90.3.923 · 1993 · External reference
Peripheral blood gamma/delta T cells lyse fresh human brain-derived oligodendrocytes
10.1002/ana.410300608 · 1991 · External reference
Mechanism of gamma/delta T cell-induced human oligodendrocyte cytotoxicity: relevance to multiple sclerosis
10.1016/s0165-5728(98)00047-2 · 1998 · External reference
Cytokine induction of heat shock protein expression in human oligodendrocytes: an interleukin-l-mediated mechanism
10.1016/0165-5728(94)90210-0 · 1994 · External reference
The small heat shock protein alpha B-crystallin as key autoantigen in multiple sclerosis
10.1016/s0079-6123(08)64031-5 · 1998 · External reference
Gamma/delta T-cell-human glial cell interactions. I. In vitro induction of gamma/delta T-cell expansion by human glial cells
10.1016/s0165-5728(96)00217-2 · 1997 · External reference
Reduced frequency of memory CD8+T lymphocytes in cerebrospinal fluid and blood of patients with multiple sclerosis
10.3109/08916939509001941 · 1995 · External reference
Multiple sclerosis: Fas signaling in oligodendrocyte cell death
10.1084/jem.184.6.2361 · 1996 · External reference
Involvement of the CD95 (APO-1/Fas) receptor/ligand system in multiple sclerosis brain
10.1084/jem.184.4.1513 · 1996 · External reference
CD40 engagement stimulates IL-12 P70 production by human microglial cells: bias fro Th1 polarization in the CNS
1998 · External reference
CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
10.1126/science.1698311 · 1990 · External reference
Scavenger receptor-mediated adhension of microglia to beta-amyloid fibrils
10.1038/382716a0 · 1996 · External reference
Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor
10.1016/s0896-6273(00)80187-7 · 1996 · External reference
Recognition of oxidatively damaged erythrocytes by a macrophage receptor with specificity for oxidized low density lipoprotein
10.1073/pnas.91.8.3265 · 1994 · External reference
HIV-1 entry into CD4+cells is mediated by the chemokine receptor CC-CKR-5
10.1038/381667a0 · 1996 · External reference
Soluble tumor necrosis factor receptor inhibits interleukin-12 production by stimulated human adult microglial cellsin vitro
10.1172/jci118946 · 1996 · External reference
Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions
10.1172/jci115102 · 1991 · External reference
Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta
10.4049/jimmunol.150.7.2659 · 1993 · External reference
Expression of tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) mRNA in adult human astrocytes: comparison with adult microglia and fetal astrocytes
10.1097/00005072-199605000-00003 · 1996 · External reference
Cooperation of both TNF receptors in inducing apoptosis: involvement of the TNF receptor-associated factor binding domain of the TNF receptor 75
10.4049/jimmunol.161.1.390 · 1998 · External reference
In vitro evidence for a dual role of tumor necrosis factor-alpha in human immunodeficiency virus type 1 encephalopathy
10.1002/ana.410370315 · 1995 · External reference
Multiple sclerosis: expression of molecules of the tumor necrosis factor ligand and receptor families in relationship to the demyelinated plaque
1998 · External reference
FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens
10.1074/jbc.272.5.2952 · 1997 · External reference
Oligodendrocyte cell death by caspase family proteases
10.1254/fpj.112.supplement_20 · 1998 · External reference
TNF-alpha transgenic and knockout models of CNS inflammation and degeneration
10.1016/s0165-5728(96)00184-1 · 1997 · External reference
Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha
10.1073/pnas.92.24.11294 · 1995 · External reference
Interferon-gamma in progression to chronic demyelination and neurological deficit following acute EAE
10.1006/mcne.1998.0725 · 1998 · External reference
TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination
10.1038/nm0198-078 · 1998 · External reference
Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy
10.1016/s0002-9440(10)65622-2 · 1998 · External reference
Severity of symptoms and demyelination in MOG-induced EAE depends on TNFR1
10.1002/(sici)1521-4141(199902)29:02<626::aid-immu626>3.0.co;2-a · 1999 · External reference
Myelin basic protein content of aggregating rat brain cell cultures treated with cytokines and/or demyelinating antibody: effects of macrophage enrichment
10.1002/jnr.490370512 · 1994 · External reference
Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes
10.4049/jimmunol.139.8.2593 · 1987 · External reference
CNTF protection of oligodendrocytes against natural and tumor necrosis factor-induced death
10.1126/science.8430320 · 1993 · External reference
Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin
10.4049/jimmunol.147.5.1522 · 1991 · External reference
Differential susceptibility of human CNS-derived cell populations to TNF-dependent and independent immune-mediated injury
10.1523/jneurosci.15-11-07293.1995 · 1995 · External reference
Effect of Theiler's murine encephalomyelitis virus and cytokines on cultured oligodendrocytes and astrocytes
10.1002/(sici)1097-4547(19960815)45:4<364::aid-jnr5>3.0.co;2-7 · 1996 · External reference
Effects of tumor necrosis factor on inward potassium current and cell morphology in cultured human oligodendrocytes
10.1002/glia.440090205 · 1993 · External reference
Signal transduction pathways in oligodendrocytes: role of tumor necrosis factor-alpha
10.1016/0736-5748(95)00019-d · 1995 · External reference
Tumor necrosis factor inhibits K+current expression in cultured oligodendrocytes
10.1007/bf01870457 · 1991 · External reference
TNF-alpha potentiates IFNgamma-induced cell death in oligodendrocyte progenitors
10.1002/(sici)1097-4547(19981201)54:5<574::aid-jnr2>3.0.co;2-0 · 1998 · External reference
p75 neurotrophin receptor expression on adult human oligodendrocytes: signaling without cell death in response to NGF
10.1523/jneurosci.18-04-01297.1998 · 1998 · External reference
JNKI, JNK2 and JNK3 are p53 N-terminal serine 34 kinases
10.1038/sj.onc.1201401 · 1997 · External reference
MEKK1/JNK signaling stabilizes and activates p53
10.1073/pnas.95.18.10541 · 1998 · External reference
Early activation of c-Jun N-terminal kinase and p38 kinase regulate cell survival in response to tumor necrosis factor alpha
10.1074/jbc.273.17.10232 · 1998 · External reference
An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
10.1126/science.274.5288.782 · 1996 · External reference
The Fas death factor
10.1126/science.7533326 · 1995 · External reference
Purification and characterization of the Fas-ligand that induces apoptosis
10.1084/jem.179.3.873 · 1994 · External reference
Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover
10.1083/jcb.133.2.335 · 1996 · External reference
Fas expression on human fetal astrocytes without susceptibility to fas-mediated cytotoxicity
10.1016/s0306-4522(97)00455-7 · 1998 · External reference
Localization of Fas antigen mRNA induced in postischemic murine forebrain by in situ hybridization
10.1016/0169-328x(95)00162-l · 1994 · External reference
Fas antigen expression in brains of patients with Alzheimer-type dementia
10.1016/0006-8993(95)00699-q · 1995 · External reference
CD95-CD95L: can the brain learn from the immune system?
10.1016/s0166-2236(97)01180-6 · 1998 · External reference
Soluble Fas (Apo-1) levels in cerebrospinal fluid of multiple sclerosis patients
10.1016/s0165-5728(97)00177-x · 1998 · External reference
MycN and IFNgamma cooperate in apoptosis of human neuroblastoma cells
10.1038/sj.onc.1200201 · 1998 · External reference
Anti-Fas/APO-1 antibody-mediated apoptosis of cultured human glioma cells. Induction and modulation of sensitivity by cytokines
10.1172/jci117462 · 1994 · External reference
Effects of IFNg on death receptor-medaited apoptosis in human adult oligodendrocytes
1999 · External reference
p75LNGFR regulates Trk signal transduction and NGF-induced neuronal differentiation in MAH cells
10.1016/0896-6273(94)90327-1 · 1994 · External reference
The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins
10.1016/0896-6273(94)90469-3 · 1994 · External reference
The Trk family of neurotrophin receptors
10.1002/neu.480251107 · 1994 · External reference
Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor
10.1126/science.8079174 · 1994 · External reference
Neurotrophins live or let die: does p75NTR decide?
10.1016/s0896-6273(00)80259-7 · 1997 · External reference
Multiple sclerosis patients express increased levels of beta-nerve growth factor in cerebrospinal fluid
10.1016/0304-3940(92)90762-v · 1992 · External reference
Expression of p75 neurotrophin receptor in multiple sclerosis brain
1997 · External reference
Gene expression of high-(p140trk) and low-affinity nerve growth factor receptor (LNGFR) in the adult and aged human peripheral nervous system
10.1016/0304-3940(93)90607-m · 1993 · External reference
Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75
10.1038/383716a0 · 1996 · External reference
Nerve growth factor and neurotrophin-3 differentially regulate the proliferation and survival of developing rat brain oligodendrocytes
10.1523/jneurosci.16-20-06433.1996 · 1996 · External reference
Oligodendrocyte apoptosis mediated by caspase activation
10.1523/jneurosci.19-08-03043.1999 · 1999 · External reference
Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme
10.1111/j.1749-6632.1998.tb08307.x · 1998 · External reference
The interleukin-1 system: receptors, ligands, and ICE in the brain and their involvement in the fever response
10.1111/j.1749-6632.1998.tb09548.x · 1998 · External reference
Proinflammatory and antiinflammatory cytokines in multiple sclerosis and central nervous system acquired immunodeficiency syndrome
10.1097/00002371-199210000-00004 · 1992 · External reference
Inflammatory mediators in demyelinating disorders of the CNS and PNS
10.1016/0165-5728(92)90134-7 · 1992 · External reference
Oligodendroglial response to the immune cytokine interferon gamma
10.1023/a:1022586726510 · 1999 · External reference
Interferon-gamma-induced oligodendrocyte cell death: implications for the pathogenesis of multiple sclerosis
10.1007/bf03401888 · 1995 · External reference
Primary demyelination in transgenic mice expressing interferon-gamma
10.1038/nm0997-1037 · 1997 · External reference
Recombinant human IL-2 is cytotoxic to oligodendrocytes after in vitro self aggregation
10.1006/cyto.1997.0228 · 1997 · External reference
A transglutaminase that converts interleukin-2 into a factor cytotoxic to oligodendrocytes
10.1126/science.8100369 · 1993 · External reference
Stimulation of oligodendroglial proliferation and maturation by interleukin-2
10.1038/321610a0 · 1986 · External reference
Increased cerebrospinal fluid and plasma levels of ultraweak chemiluminescence are associated with changes in the thiol pool and lipid-soluble fluorescence in multiple sclerosis: the pathogenic role of oxidative stress
1998 · External reference
Oligodendroglial cell death induced by oxygen radicals and its protection by catalase
10.1002/jnr.490290111 · 1991 · External reference
Astrocytes and catalase prevent the toxicity of catecholamines to oligodendrocytes
10.1016/0006-8993(94)91525-3 · 1994 · External reference
Antibody-dependent cellular cytotoxicity in antimyelin antibody-induced oligodendrocyte damage in vitro
10.1016/0165-5728(91)90058-f · 1991 · External reference
Reactive oxygen species are required for the phagocytosis of myelin by macrophages
10.1016/s0165-5728(98)00175-1 · 1998 · External reference
Species differences in the generation of reactive oxygen species by microglia
10.1007/bf02815200 · 1996 · External reference
The role of nitric oxide in multiple sclerosis
10.1007/s001090050102 · 1997 · External reference
Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide
10.4049/jimmunol.151.4.2132 · 1993 · External reference
Nitric oxide induces necrotic but not apoptotic cell death in oligodendrocytes
10.1016/0306-4522(94)00491-m · 1995 · External reference
Astrocytes and microglia express inducible nitric oxide synthase in mice with experimental allergic encephalomyelitis
10.1016/s0165-5728(96)00215-9 · 1997 · External reference
Inducible nitric oxide synthase expression is selectively induced in astrocytes isolated from adult human brain
10.1016/s0006-8993(98)01023-3 · 1998 · External reference
Immune regulatory and effector properties of human adult microglia studies in vitro and in situ
10.1016/s0960-5428(06)80267-6 · 1994 · External reference
Modulation of human microglial cell superoxide production by cytokines
10.1002/jlb.58.1.65 · 1995 · External reference
Inducible nitric-oxide synthase and nitric oxide production in human fetal astrocytes and microglia. A kinetic analysis
10.1074/jbc.272.17.11327 · 1997 · External reference
Species differences in the generation of reactive oxygen species by microglia
10.1007/bf02815200 · 1996 · External reference
Oligodendrocytes and microglia are selectively vulnerable to combined hypoxia and hypoglycemia injury in vitro
10.1097/00004647-199805000-00007 · 1998 · External reference
