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References from Tolerance Induction with Agonist Peptides Recognized by Autoaggressive Lymphocytes is Transient: Therapeutic Potential for Type 1 Diabetes is Limited and Depends on Time-point of Administration, Choice of Epitope and Adjuvant. Local targets link to admitted publications; unresolved targets remain external evidence.
Peptide-induced T cell tolerance to prevent autoimmune diabetes in a transgenic mouse model
10.1073/pnas.91.2.444 · 1994 · External reference
Systemic Antigen in the Treatment of T-Cell-Mediated Autoimmune Diseases
10.1016/s0167-5699(97)01171-7 · 1997 · External reference
Antigen specific immunotherapy: Is it a real possibility to combat T-cell medicated autoimmunity?
10.1073/pnas.91.2.437 · 1994 · External reference
Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy
10.1126/science.1279812 · 1992 · External reference
Induction of TH1 and TH2 immunity in neonatal mice
10.1126/science.271.5256.1728 · 1996 · External reference
The role of clonal deletion and anergy in oral tolerance
10.1016/s0923-2494(98)80147-8 · 1997 · External reference
Oral tolerance in the treatment of inflammatory autoimmune diseases
10.1007/s000110050433 · 1999 · External reference
Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens
10.1146/annurev.iy.12.040194.004113 · 1994 · External reference
Oral tolerance for the treatment of autoimmune diseases
10.1146/annurev.med.48.1.341 · 1997 · External reference
Induction of autoimmune diabetes by oral administration of autoantigen
10.1126/science.274.5293.1707 · 1996 · External reference
EAE: a model for immune intervention with synthetic peptides
10.3109/08830189209061792 · 1992 · External reference
Ablation of ‘tolerance’ and induction of diabetes by virus infection in viral antigen transgenic mice
10.1016/0092-8674(91)90164-t · 1991 · External reference
Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response
10.1016/0092-8674(91)90165-u · 1991 · External reference
How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model
10.1016/1074-7613(94)90101-5 · 1994 · External reference
Virus-induced autoimmune diabetes: Most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) CTL
10.2337/diabetes.49.11.1801 · 2000 · External reference
Pathological changes in the islet milieu precede infiltration of islets and destruction of beta-cells by autoreactive lymphocytes in a transgenic model of virus-induced IDDM
10.1006/jaut.1997.0131 · 1997 · External reference
Coexpression of B7.1 and viral (self) transgenes in pancreatic β-cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes
10.1016/1074-7613(95)90062-4 · 1995 · External reference
Dendritic cells induce autoimmune diabetes and maintain disease via De Novo formation of local lymphoid tissue
10.1084/jem.188.8.1493 · 1998 · External reference
Optimal lymphocytic choriomeningitis virus sequences restricted by H-2Dbmajor histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes
10.1128/jvi.69.4.2297-2305.1995 · 1995 · External reference
Comparison of activation versus induction of unresponsiveness of virus-specific CD4+ and CD8+ T cells upon acute versus persistent viral infection
10.1016/s1074-7613(00)80628-7 · 1998 · External reference
Neither B-lymphocytes nor antibodies directed against self antigens of the islets of Langerhans are required for development of virus-induced autoimmune diabetes
10.4049/jimmunol.165.10.5945 · 2000 · External reference
Autoreactive CD4+ lymphocytes protect from autoimmune diabetes via bystander suppression using the IL-4/STAT6 pathway
10.1016/s1074-7613(00)80121-1 · 1999 · External reference
DNA immunization to prevent autoimmune diabetes
10.1172/jci7209 · 1999 · External reference
Oral insulin treatment suppresses virus-induced antigen-specific destruction of beta cells and prevents autoimmune diabetes in transgenic mice
10.1172/jci118919 · 1996 · External reference
In vivo treatment with a MHC Class I-Restricted blocking peptide can prevent virus-induced autoimmune diabetes
10.4049/jimmunol.161.9.5087 · 1998 · External reference
Molecularly engineered vaccine which expresses an immunodominant T-cell epitope induces cytotoxic T lymphocytes that confer protection from lethal virus infection
10.1128/jvi.63.10.4311-4316.1989 · 1989 · External reference
Thymic tolerance to only one viral protein reduces lymphocytic choriomeningitis virus-induced immunopathology and increases survival in perforin-deficient mice
10.1128/jvi.73.7.5918-5925.1999 · 1999 · External reference
CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge
10.1128/jvi.70.2.1072-1079.1996 · 1996 · External reference
Peptide antigen treatment of naive and virus-immune mice: antigen-specific tolerance versus immunopathology
10.1016/s1074-7613(00)80340-4 · 1997 · External reference
Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses
10.1084/jem.179.6.1933 · 1994 · External reference
Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infection
10.1016/s1074-7613(00)80470-7 · 1998 · External reference
In vivo dynamics of anti-viral CD8 T cells responses to different epitopes. An evaluation of bystander activation in primary and secondary responses to viral infection
10.1007/978-1-4615-5355-7_14 · 1998 · External reference
Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection
10.1016/s1074-7613(00)80470-7 · 1998 · External reference
Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin
10.1073/pnas.88.22.10252 · 1991 · External reference