Research graph
References from Catalytic mechanism of action and substrate-binding sites. Local targets link to admitted publications; unresolved targets remain external evidence.
Crystal structure of human angiogenin reveals the structural basis for its functional divergence from ribonuclease.
10.1073/pnas.91.8.2915 · 1994 · External reference
Principles that govern the folding of protein chains.
10.1126/science.181.4096.223 · 1973 · External reference
A natural classification of ribonucleases.
10.1016/s0076-6879(01)41142-6 · 2001 · External reference
Crystal structures of eosinophil-derived neurotoxin (EDN) in complex with the inhibitors 5'-ATP, Ap3A, Ap4A, and Ap5A.
10.1021/bi0518592 · 2006 · External reference
Glycosylation of serum ribonuclease 1 indicates a major endothelial origin and reveals an increase in core fucosylation in pancreatic cancer
10.1093/glycob/cwm002 · 2007 · External reference
Differences in glycosylation pattern of human secretory ribonucleases.
1988 · External reference
The ribonuclease A superfamily: general discussion.
10.1007/s000180050211 · 1998 · External reference
The amino acid sequence of human pancreatic ribonuclease.
10.1016/0003-2697(84)90306-3 · 1984 · External reference
Atomic resolution structures of ribonuclease A at six pH values
10.1107/s0907444901021758 · 2002 · External reference
Crystallographic and modeling studies of RNase III suggest a mechanism for double-stranded RNA cleavage.
10.1016/s0969-2126(01)00685-2 · 2001 · External reference
Eosinophil cationic protein.
10.1016/s0076-6879(01)41159-1 · 2001 · External reference
Nucleotide binding architecture for secreted cytotoxic endoribonucleases.
10.1016/j.biochi.2012.12.015 · 2013 · External reference
Reverse transphosphorylation by ribonuclease A needs an intact p2-binding site. Point mutations at Lys-7 and Arg-10 alter the catalytic properties of the enzyme.
10.1016/s0021-9258(17)41977-6 · 1994 · External reference
Crystal structure of eosinophil cationic protein at 2.4 Å resolution,
10.1021/bi9919145 · 1999 · External reference
Kinetic and product distribution analysis of human eosinophil cationic protein indicates a subsite arrangement that favors exonuclease-type activity
10.1074/jbc.274.22.15605 · 1999 · External reference
Structural determinants of the eosinophil cationic protein antimicrobial activity.
10.1515/hsz-2012-0160 · 2012 · External reference
The sulfate-binding site structure of the human eosinophil cationic protein as revealed by a new crystal form
10.1016/j.jsb.2012.04.023 · 2012 · External reference
The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories.
10.1016/j.ygeno.2004.10.008 · 2005 · External reference
Beta-turns in proteins.
10.1016/0022-2836(77)90094-8 · 1977 · External reference
Bovine pancreatic ribonuclease: fifty years of the first enzymatic reaction mechanism.
10.1021/bi201075b · 2011 · External reference
Ribonuclease k6: chromosomal mapping and divergent rates of evolution within the RNase A gene superfamily.
10.1101/gr.8.6.599 · 1998 · External reference
In vitro biological activity of bovine milk ribonuclease-4.
2010 · External reference
Purification of human eosinophil-derived neurotoxin.
10.1073/pnas.78.8.5165 · 1981 · External reference
A Review of Ribonuclease 7's Structure, Regulation, and Contributions to Host Defense.
10.3390/ijms17030423 · 2016 · External reference
Exploring the RNase A scaffold to combine catalytic and antimicrobial activities. Structural characterization of RNase 3/1 chimeras.
10.3389/fmolb.2022.964717 · 2022 · External reference
Coulombic effects of remote subsites on the active site of ribonuclease A.
10.1021/bi981369s · 1998 · External reference
Tissue-specific expression of pancreatic-type RNases and RNase inhibitor in humans.
10.1089/dna.1997.16.413 · 1997 · External reference
Structural and functional importance of local and global conformational fluctuations in the RNase A superfamily.
10.1111/febs.12371 · 2013 · External reference
Emerging biological functions of ribonuclease 1 and angiogenin.
10.1080/10409238.2021.2004577 · 2022 · External reference
Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease.
10.1073/pnas.83.10.3146 · 1986 · External reference
The expansion and functional diversification of the mammalian ribonuclease a superfamily epitomizes the efficiency of multigene families at generating biological novelty.
10.1093/gbe/evt161 · 2013 · External reference
TLR8 Is a Sensor of RNase T2 Degradation Products.
10.1016/j.cell.2019.11.001 · 2019 · External reference
Structural analysis of an RNase T1 variant with an altered guanine binding segment.
10.1006/jmbi.1999.3324 · 1999 · External reference
Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily.
10.1016/0888-7543(90)90197-3 · 1990 · External reference
RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin
10.1074/jbc.m207587200 · 2002 · External reference
Angiogenin activates the astrocytic Nrf2/antioxidant-response element pathway and thereby protects murine neurons from oxidative stress.
10.1074/jbc.ra119.008491 · 2019 · External reference
New type of linkage between a carbohydrate and a protein: C-glycosylation of a specific tryptophan residue in human RNase Us
10.1021/bi00250a003 · 1994 · External reference
An angiogenin-binding protein from endothelial cells.
10.1073/pnas.88.6.2227 · 1991 · External reference
The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity.
10.1074/jbc.m607321200 · 2007 · External reference
Basic amino acid residues of human eosinophil derived neurotoxin essential for glycosaminoglycan binding.
10.3390/ijms140919067 · 2013 · External reference
Angiogenin-induced tRNA fragments inhibit translation initiation.
10.1016/j.molcel.2011.06.022 · 2011 · External reference
The action of boiled pancreas extract on yeast nucleic acid
10.1152/ajplegacy.1920.52.1.203 · 1920 · External reference
RNase 7 contributes to the cutaneous defense against Enterococcus faecium
10.1371/journal.pone.0006424 · 2009 · External reference
Bacterial RNase P: a new view of an ancient enzyme.
10.1038/nrmicro1491 · 2006 · External reference
Recognition signal for C-mannosylation of Trp-7 in RNase 2 consists of sequence Trp-x-x-Trp
10.1091/mbc.9.2.301 · 1998 · External reference
Human endothelial cells selectively express large amounts of pancreatic-type ribonuclease (RNase 1).
10.1002/jcb.10234 · 2002 · External reference
High-resolution crystal structures of ribonuclease A complexed with adenylic and uridylic nucleotide inhibitors. Implications for structure-based design of ribonucleolytic inhibitors.
10.1110/ps.03196603 · 2003 · External reference
Host Defence RNases as Antiviral Agents against Enveloped Single Stranded RNA Viruses.
10.1080/21505594.2021.1871823 · 2021 · External reference
Structural insights into EphA4 unconventional activation from prediction of the EphA4 and its complex with ribonuclease 1.
2022 · External reference
Structural determinants for tRNA selective cleavage by RNase 2/EDN.
10.1016/j.str.2023.12.012 · 2024 · External reference
Structural basis of substrate specificity in porcine RNase 4.
10.1111/febs.13646 · 2016 · External reference
In silico prediction and in vitro characterization of multifunctional human RNase3.
10.1155/2013/170398 · 2013 · External reference
Ribonuclease 7-driven activation of ROS1 is a potential therapeutic target in hepatocellular carcinoma
10.1016/j.jhep.2020.09.030 · 2021 · External reference
Structural mechanism of angiogenin activation by the ribosome.
10.1038/s41586-024-07508-8 · 2024 · External reference
Immune Modulation by Human Secreted RNases at the Extracellular Space
10.3389/fimmu.2018.01012 · 2018 · External reference
Selective cleavage of ncRNA and antiviral activity by RNase2/EDN in THP1-induced macrophages.
10.1007/s00018-022-04229-x · 2022 · External reference
T2 Family ribonucleases: ancient enzymes with diverse roles.
10.1016/j.tibs.2010.02.002 · 2010 · External reference
RNA biology of angiogenin: Current state and perspectives.
10.1080/15476286.2016.1272746 · 2017 · External reference
Three-dimensional crystal structure of human eosinophil cationic protein (RNase 3) at 1.75 A resolution
10.1006/jmbi.2000.3939 · 2000 · External reference
MicroRNA drop in the bloodstream and microRNA boost in the tumour caused by treatment with ribonuclease A leads to an attenuation of tumour malignancy
10.1371/journal.pone.0083482 · 2013 · External reference
The crystal structure of eosinophil cationic protein in complex with 2‘,5‘-ADP at 2.0 Å resolution reveals the details of the ribonucleolytic active site
10.1021/bi0264521 · 2002 · External reference
The expanding scope of antimicrobial peptide structures and their modes of action.
10.1016/j.tibtech.2011.05.001 · 2011 · External reference
The contribution of noncatalytic phosphate-binding subsites to the mechanism of bovine pancreatic ribonuclease A
10.1007/s000180050205 · 1998 · External reference
Bacterial RNA sensing by TLR8 requires RNase 6 processing and is inhibited by RNA 2'O-methylation.
10.1038/s44319-024-00281-9 · 2024 · External reference
Bacterial RNA sensing by TLR8 requires RNase 6 processing and is inhibited by RNA 2’O-methylation
10.1038/s44319-024-00281-9 · 2024 · External reference
Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2
10.1016/j.immuni.2020.03.009 · 2020 · External reference
Rare Angiogenin and Ribonuclease 4 variants associated with amyotrophic lateral sclerosis exhibit loss-of-function: a comprehensive in silico study.
10.1007/s11011-019-00473-6 · 2019 · External reference
Insights into RNA/DNA hybrid recognition and processing by RNase H from the crystal structure of a non-specific enzyme-dsDNA complex.
10.4161/cc.7.16.6461 · 2008 · External reference
Structure and function of ribonuclease A binding subsites.
1991 · External reference
Ribonuclease/angiogenin inhibitor 1 regulates stress-induced subcellular localization of angiogenin to control growth and survival.
2013 · External reference
Characterization of an RNase with two catalytic centers. Human RNase6 catalytic and phosphate-binding site arrangement favors the endonuclease cleavage of polymeric substrates.
10.1016/j.bbagen.2018.09.021 · 2019 · External reference
The first crystal structure of human RNase 6 reveals a novel substrate-binding and cleavage site arrangement.
10.1042/bcj20160245 · 2016 · External reference
Structure-Based Design of an RNase Chimera for Antimicrobial Therapy.
10.3390/ijms23010095 · 2021 · External reference
Insights into the Antimicrobial Mechanism of Action of Human RNase6: Structural Determinants for Bacterial Cell Agglutination and Membrane Permeation.
10.3390/ijms17040552 · 2016 · External reference
Positional scanning library applied to the human eosinophil cationic protein/RNase3 N-terminus reveals novel and potent anti-biofilm peptides
10.1016/j.ejmech.2018.05.012 · 2018 · External reference
Ribonuclease A.
10.1021/cr960427h · 1998 · External reference
Artificial Nucleases
2004 · External reference
Consequences of the endogenous N-glycosylation of human ribonuclease 1
10.1021/acs.biochem.8b01246 · 2019 · External reference
The anatomy and taxonomy of protein structure.
10.1016/s0065-3233(08)60520-3 · 1981 · External reference
Eosinophil-Derived Neurotoxin (EDN/RNase 2) and the Mouse Eosinophil-Associated RNases (mEars): Expanding Roles in Promoting Host Defense.
10.3390/ijms160715442 · 2015 · External reference
Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family.
10.1093/nar/24.18.3507 · 1996 · External reference
Eosinophil cationic protein and eosinophil-derived neurotoxin. Evolution of novel function in a primate ribonuclease gene family
10.1074/jbc.270.37.21539 · 1995 · External reference
Role of glutamine-117 in the ribonucleolytic activity of human angiogenin.
10.1073/pnas.91.8.2920 · 1994 · External reference
Role of glutamine-117 in the ribonucleolytic activity of human angiogenin.
10.1073/pnas.91.8.2920 · 1994 · External reference
Protein post-translational modification in host defense: the antimicrobial mechanism of action of human eosinophil cationic protein native forms.
10.1111/febs.13082 · 2014 · External reference
Generation of 2′,3′-cyclic phosphate-containing RNAs as a hidden layer of the transcriptome
10.3389/fgene.2018.00562 · 2018 · External reference
Human eosinophil-derived neurotoxin: involvement of a putative non-catalytic phosphate-binding subsite in its catalysis.
10.1007/s11010-007-9471-0 · 2007 · External reference
Promises of eukaryotic ribonucleases for cancer treatment: a systematic review
10.1186/s41231-022-00113-9 · 2022 · External reference
Structure-function relationships in human ribonucleases: main distinctive features of the major RNase types
10.1016/s0014-5793(97)00086-0 · 1997 · External reference
Human extracellular ribonucleases: multiplicity, molecular diversity and catalytic properties of the major RNase types.
10.1007/s000180050207 · 1998 · External reference
The eight human "canonical" ribonucleases: molecular diversity, catalytic properties, and special biological actions of the enzyme proteins.
10.1016/j.febslet.2010.04.018 · 2010 · External reference
A decade of protein engineering on Ribonuclease T1— atomic dissection of the enzyme-substrate interactions
10.1111/j.1432-1033.1997.t01-1-00001.x · 1997 · External reference
The role of human ribonuclease A family in health and diseases: A systematic review
10.1016/j.isci.2022.105284 · 2022 · External reference
The role of human ribonuclease A family in health and diseases: A systematic review
10.1016/j.isci.2022.105284 · 2022 · External reference
Atomic resolution (0.98 Å) structure of eosinophil-derived neurotoxin,
10.1021/bi015911f · 2002 · External reference
13 Ribonuclease T1
1982 · External reference
Ribonuclease T1, structure and function.
1970 · External reference
The three-dimensional structure of human RNase 4, unliganded and complexed with d(Up), reveals the basis for its uridine selectivity.
10.1006/jmbi.1998.2288 · 1999 · External reference
Structure and activity of the only human RNase T2
10.1093/nar/gks614 · 2012 · External reference
Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus.
10.1042/bj20130123 · 2013 · External reference
Bactericidal and membrane disruption activities of the eosinophil cationic protein are largely retained in an N-terminal fragment
10.1042/bj20082330 · 2009 · External reference
Comparison of human RNase 3 and RNase 7 bactericidal action at the Gram-negative and Gram-positive bacterial cell wall
10.1111/j.1742-4658.2010.07595.x · 2010 · External reference
Angiogenin/Ribonuclease 5 is an EGFR ligand and a serum biomarker for Erlotinib sensitivity in pancreatic cancer
10.1016/j.ccell.2018.02.012 · 2018 · External reference
Fractionation by lectin affinity chromatography indicates that the glycosylation of most ribonucleases in human viscera and body fluids is organ specific
10.1016/0003-9861(86)90725-3 · 1986 · External reference
Human ribonuclease A superfamily members, eosinophil-derived neurotoxin and pancreatic ribonuclease, induce dendritic cell maturation and activation.
10.4049/jimmunol.173.10.6134 · 2004 · External reference
Human RNase 7: a new cationic ribonuclease of the RNase A superfamily.
10.1093/nar/gkg157 · 2003 · External reference
The amino acid sequence of human ribonuclease 4, a highly conserved ribonuclease that cleaves specifically on the 3' side of uridine.
10.1111/j.1432-1033.1993.tb18259.x · 1993 · External reference
Coevolution of RNA and protein subunits in RNase P and RNase MRP, two RNA processing enzymes.
10.1016/j.jbc.2024.105729 · 2024 · External reference
Human endothelial cells selectively express large amounts of pancreatic-type ribonuclease (RNase 1).
10.1002/jcb.10234 · ExternalCitation · doi-reference
The three-dimensional structure of human RNase 4, unliganded and complexed with d(Up), reveals the basis for its uridine selectivity.
10.1006/jmbi.1998.2288 · ExternalCitation · doi-reference
Structural analysis of an RNase T1 variant with an altered guanine binding segment.
10.1006/jmbi.1999.3324 · ExternalCitation · doi-reference
Three-dimensional crystal structure of human eosinophil cationic protein (RNase 3) at 1.75 A resolution
10.1006/jmbi.2000.3939 · ExternalCitation · doi-reference
Selective cleavage of ncRNA and antiviral activity by RNase2/EDN in THP1-induced macrophages.
10.1007/s00018-022-04229-x · ExternalCitation · doi-reference
The contribution of noncatalytic phosphate-binding subsites to the mechanism of bovine pancreatic ribonuclease A
10.1007/s000180050205 · ExternalCitation · doi-reference
Human extracellular ribonucleases: multiplicity, molecular diversity and catalytic properties of the major RNase types.
10.1007/s000180050207 · ExternalCitation · doi-reference
The ribonuclease A superfamily: general discussion.
10.1007/s000180050211 · ExternalCitation · doi-reference
Human eosinophil-derived neurotoxin: involvement of a putative non-catalytic phosphate-binding subsite in its catalysis.
10.1007/s11010-007-9471-0 · ExternalCitation · doi-reference
Rare Angiogenin and Ribonuclease 4 variants associated with amyotrophic lateral sclerosis exhibit loss-of-function: a comprehensive in silico study.
10.1007/s11011-019-00473-6 · ExternalCitation · doi-reference
The amino acid sequence of human pancreatic ribonuclease.
10.1016/0003-2697(84)90306-3 · ExternalCitation · doi-reference
Fractionation by lectin affinity chromatography indicates that the glycosylation of most ribonucleases in human viscera and body fluids is organ specific
10.1016/0003-9861(86)90725-3 · ExternalCitation · doi-reference
Beta-turns in proteins.
10.1016/0022-2836(77)90094-8 · ExternalCitation · doi-reference
Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily.
10.1016/0888-7543(90)90197-3 · ExternalCitation · doi-reference
Characterization of an RNase with two catalytic centers. Human RNase6 catalytic and phosphate-binding site arrangement favors the endonuclease cleavage of polymeric substrates.
10.1016/j.bbagen.2018.09.021 · ExternalCitation · doi-reference
Nucleotide binding architecture for secreted cytotoxic endoribonucleases.
10.1016/j.biochi.2012.12.015 · ExternalCitation · doi-reference
Angiogenin/Ribonuclease 5 is an EGFR ligand and a serum biomarker for Erlotinib sensitivity in pancreatic cancer
10.1016/j.ccell.2018.02.012 · ExternalCitation · doi-reference
TLR8 Is a Sensor of RNase T2 Degradation Products.
10.1016/j.cell.2019.11.001 · ExternalCitation · doi-reference
Positional scanning library applied to the human eosinophil cationic protein/RNase3 N-terminus reveals novel and potent anti-biofilm peptides
10.1016/j.ejmech.2018.05.012 · ExternalCitation · doi-reference
The eight human "canonical" ribonucleases: molecular diversity, catalytic properties, and special biological actions of the enzyme proteins.
10.1016/j.febslet.2010.04.018 · ExternalCitation · doi-reference
Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2
10.1016/j.immuni.2020.03.009 · ExternalCitation · doi-reference
The role of human ribonuclease A family in health and diseases: A systematic review
10.1016/j.isci.2022.105284 · ExternalCitation · doi-reference
Coevolution of RNA and protein subunits in RNase P and RNase MRP, two RNA processing enzymes.
10.1016/j.jbc.2024.105729 · ExternalCitation · doi-reference
Ribonuclease 7-driven activation of ROS1 is a potential therapeutic target in hepatocellular carcinoma
10.1016/j.jhep.2020.09.030 · ExternalCitation · doi-reference
The sulfate-binding site structure of the human eosinophil cationic protein as revealed by a new crystal form
10.1016/j.jsb.2012.04.023 · ExternalCitation · doi-reference
Angiogenin-induced tRNA fragments inhibit translation initiation.
10.1016/j.molcel.2011.06.022 · ExternalCitation · doi-reference
Structural determinants for tRNA selective cleavage by RNase 2/EDN.
10.1016/j.str.2023.12.012 · ExternalCitation · doi-reference
T2 Family ribonucleases: ancient enzymes with diverse roles.
10.1016/j.tibs.2010.02.002 · ExternalCitation · doi-reference
The expanding scope of antimicrobial peptide structures and their modes of action.
10.1016/j.tibtech.2011.05.001 · ExternalCitation · doi-reference
The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories.
10.1016/j.ygeno.2004.10.008 · ExternalCitation · doi-reference
Structure-function relationships in human ribonucleases: main distinctive features of the major RNase types
10.1016/s0014-5793(97)00086-0 · ExternalCitation · doi-reference
Reverse transphosphorylation by ribonuclease A needs an intact p2-binding site. Point mutations at Lys-7 and Arg-10 alter the catalytic properties of the enzyme.
10.1016/s0021-9258(17)41977-6 · ExternalCitation · doi-reference
The anatomy and taxonomy of protein structure.
10.1016/s0065-3233(08)60520-3 · ExternalCitation · doi-reference
A natural classification of ribonucleases.
10.1016/s0076-6879(01)41142-6 · ExternalCitation · doi-reference
Eosinophil cationic protein.
10.1016/s0076-6879(01)41159-1 · ExternalCitation · doi-reference
Crystallographic and modeling studies of RNase III suggest a mechanism for double-stranded RNA cleavage.
10.1016/s0969-2126(01)00685-2 · ExternalCitation · doi-reference
Consequences of the endogenous N-glycosylation of human ribonuclease 1
10.1021/acs.biochem.8b01246 · ExternalCitation · doi-reference
New type of linkage between a carbohydrate and a protein: C-glycosylation of a specific tryptophan residue in human RNase Us
10.1021/bi00250a003 · ExternalCitation · doi-reference
Atomic resolution (0.98 Å) structure of eosinophil-derived neurotoxin,
10.1021/bi015911f · ExternalCitation · doi-reference
The crystal structure of eosinophil cationic protein in complex with 2‘,5‘-ADP at 2.0 Å resolution reveals the details of the ribonucleolytic active site
10.1021/bi0264521 · ExternalCitation · doi-reference
Crystal structures of eosinophil-derived neurotoxin (EDN) in complex with the inhibitors 5'-ATP, Ap3A, Ap4A, and Ap5A.
10.1021/bi0518592 · ExternalCitation · doi-reference
Bovine pancreatic ribonuclease: fifty years of the first enzymatic reaction mechanism.
10.1021/bi201075b · ExternalCitation · doi-reference
Coulombic effects of remote subsites on the active site of ribonuclease A.
10.1021/bi981369s · ExternalCitation · doi-reference
Crystal structure of eosinophil cationic protein at 2.4 Å resolution,
10.1021/bi9919145 · ExternalCitation · doi-reference
Ribonuclease A.
10.1021/cr960427h · ExternalCitation · doi-reference
Bacterial RNase P: a new view of an ancient enzyme.
10.1038/nrmicro1491 · ExternalCitation · doi-reference
Structural mechanism of angiogenin activation by the ribosome.
10.1038/s41586-024-07508-8 · ExternalCitation · doi-reference
Bacterial RNA sensing by TLR8 requires RNase 6 processing and is inhibited by RNA 2’O-methylation
10.1038/s44319-024-00281-9 · ExternalCitation · doi-reference
The first crystal structure of human RNase 6 reveals a novel substrate-binding and cleavage site arrangement.
10.1042/bcj20160245 · ExternalCitation · doi-reference
Bactericidal and membrane disruption activities of the eosinophil cationic protein are largely retained in an N-terminal fragment
10.1042/bj20082330 · ExternalCitation · doi-reference
Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus.
10.1042/bj20130123 · ExternalCitation · doi-reference
Purification of human eosinophil-derived neurotoxin.
10.1073/pnas.78.8.5165 · ExternalCitation · doi-reference
Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease.
10.1073/pnas.83.10.3146 · ExternalCitation · doi-reference
An angiogenin-binding protein from endothelial cells.
10.1073/pnas.88.6.2227 · ExternalCitation · doi-reference
Crystal structure of human angiogenin reveals the structural basis for its functional divergence from ribonuclease.
10.1073/pnas.91.8.2915 · ExternalCitation · doi-reference
Role of glutamine-117 in the ribonucleolytic activity of human angiogenin.
10.1073/pnas.91.8.2920 · ExternalCitation · doi-reference
Eosinophil cationic protein and eosinophil-derived neurotoxin. Evolution of novel function in a primate ribonuclease gene family
10.1074/jbc.270.37.21539 · ExternalCitation · doi-reference
Kinetic and product distribution analysis of human eosinophil cationic protein indicates a subsite arrangement that favors exonuclease-type activity
10.1074/jbc.274.22.15605 · ExternalCitation · doi-reference
RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin
10.1074/jbc.m207587200 · ExternalCitation · doi-reference
The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity.
10.1074/jbc.m607321200 · ExternalCitation · doi-reference
Angiogenin activates the astrocytic Nrf2/antioxidant-response element pathway and thereby protects murine neurons from oxidative stress.
10.1074/jbc.ra119.008491 · ExternalCitation · doi-reference
Emerging biological functions of ribonuclease 1 and angiogenin.
10.1080/10409238.2021.2004577 · ExternalCitation · doi-reference
RNA biology of angiogenin: Current state and perspectives.
10.1080/15476286.2016.1272746 · ExternalCitation · doi-reference
Host Defence RNases as Antiviral Agents against Enveloped Single Stranded RNA Viruses.
10.1080/21505594.2021.1871823 · ExternalCitation · doi-reference
Tissue-specific expression of pancreatic-type RNases and RNase inhibitor in humans.
10.1089/dna.1997.16.413 · ExternalCitation · doi-reference
Recognition signal for C-mannosylation of Trp-7 in RNase 2 consists of sequence Trp-x-x-Trp
10.1091/mbc.9.2.301 · ExternalCitation · doi-reference
The expansion and functional diversification of the mammalian ribonuclease a superfamily epitomizes the efficiency of multigene families at generating biological novelty.
10.1093/gbe/evt161 · ExternalCitation · doi-reference
Glycosylation of serum ribonuclease 1 indicates a major endothelial origin and reveals an increase in core fucosylation in pancreatic cancer
10.1093/glycob/cwm002 · ExternalCitation · doi-reference
Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family.
10.1093/nar/24.18.3507 · ExternalCitation · doi-reference
Human RNase 7: a new cationic ribonuclease of the RNase A superfamily.
10.1093/nar/gkg157 · ExternalCitation · doi-reference
Structure and activity of the only human RNase T2
10.1093/nar/gks614 · ExternalCitation · doi-reference
Ribonuclease k6: chromosomal mapping and divergent rates of evolution within the RNase A gene superfamily.
10.1101/gr.8.6.599 · ExternalCitation · doi-reference
Atomic resolution structures of ribonuclease A at six pH values
10.1107/s0907444901021758 · ExternalCitation · doi-reference
High-resolution crystal structures of ribonuclease A complexed with adenylic and uridylic nucleotide inhibitors. Implications for structure-based design of ribonucleolytic inhibitors.
10.1110/ps.03196603 · ExternalCitation · doi-reference
Structural and functional importance of local and global conformational fluctuations in the RNase A superfamily.
10.1111/febs.12371 · ExternalCitation · doi-reference
Protein post-translational modification in host defense: the antimicrobial mechanism of action of human eosinophil cationic protein native forms.
10.1111/febs.13082 · ExternalCitation · doi-reference
Structural basis of substrate specificity in porcine RNase 4.
10.1111/febs.13646 · ExternalCitation · doi-reference
The amino acid sequence of human ribonuclease 4, a highly conserved ribonuclease that cleaves specifically on the 3' side of uridine.
10.1111/j.1432-1033.1993.tb18259.x · ExternalCitation · doi-reference
A decade of protein engineering on Ribonuclease T1— atomic dissection of the enzyme-substrate interactions
10.1111/j.1432-1033.1997.t01-1-00001.x · ExternalCitation · doi-reference
Comparison of human RNase 3 and RNase 7 bactericidal action at the Gram-negative and Gram-positive bacterial cell wall
10.1111/j.1742-4658.2010.07595.x · ExternalCitation · doi-reference
Principles that govern the folding of protein chains.
10.1126/science.181.4096.223 · ExternalCitation · doi-reference
The action of boiled pancreas extract on yeast nucleic acid
10.1152/ajplegacy.1920.52.1.203 · ExternalCitation · doi-reference
In silico prediction and in vitro characterization of multifunctional human RNase3.
10.1155/2013/170398 · ExternalCitation · doi-reference
Promises of eukaryotic ribonucleases for cancer treatment: a systematic review
10.1186/s41231-022-00113-9 · ExternalCitation · doi-reference
RNase 7 contributes to the cutaneous defense against Enterococcus faecium
10.1371/journal.pone.0006424 · ExternalCitation · doi-reference
MicroRNA drop in the bloodstream and microRNA boost in the tumour caused by treatment with ribonuclease A leads to an attenuation of tumour malignancy
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Structural determinants of the eosinophil cationic protein antimicrobial activity.
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Generation of 2′,3′-cyclic phosphate-containing RNAs as a hidden layer of the transcriptome
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Immune Modulation by Human Secreted RNases at the Extracellular Space
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Exploring the RNase A scaffold to combine catalytic and antimicrobial activities. Structural characterization of RNase 3/1 chimeras.
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Basic amino acid residues of human eosinophil derived neurotoxin essential for glycosaminoglycan binding.
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Eosinophil-Derived Neurotoxin (EDN/RNase 2) and the Mouse Eosinophil-Associated RNases (mEars): Expanding Roles in Promoting Host Defense.
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A Review of Ribonuclease 7's Structure, Regulation, and Contributions to Host Defense.
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Insights into the Antimicrobial Mechanism of Action of Human RNase6: Structural Determinants for Bacterial Cell Agglutination and Membrane Permeation.
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Structure-Based Design of an RNase Chimera for Antimicrobial Therapy.
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Human ribonuclease A superfamily members, eosinophil-derived neurotoxin and pancreatic ribonuclease, induce dendritic cell maturation and activation.
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Insights into RNA/DNA hybrid recognition and processing by RNase H from the crystal structure of a non-specific enzyme-dsDNA complex.
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