Research graph
References from Human natural variants. Local targets link to admitted publications; unresolved targets remain external evidence.
Polymorphisms in the RNASE3 gene are associated with susceptibility to cerebral malaria in Ghanaian children
10.1371/journal.pone.0029465 · 2011 · External reference
A common polymorphism in RNASE6 impacts its antimicrobial activity toward uropathogenic Escherichia coli
10.3390/ijms25010604 · 2024 · External reference
Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract
10.1038/ki.2014.268 · 2015 · External reference
Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7 activation
10.1016/j.immuni.2024.04.010 · 2024 · External reference
Murine ribonuclease 6 limits bacterial dissemination during experimental urinary tract infection
2024 · External reference
Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection
10.1038/ng1842 · 2006 · External reference
Genetic variants of RNASE3 (ECP) and susceptibility to severe malaria in Senegalese population
10.1186/s12936-018-2205-9 · 2018 · External reference
The 434(G>C) polymorphism within the coding sequence of eosinophil cationic protein (ECP) correlates with the natural course of Schistosoma mansoni infection
10.1016/j.ijpara.2007.04.001 · 2007 · External reference
Expression and localisation of vascular ribonucleases in endothelial cells
10.1160/th10-06-0345 · 2011 · External reference
Effects of pathogenic mutants of the neuroprotective RNase 5-angiogenin in amyotrophic lateral sclerosis (ALS)
10.3390/genes15060738 · 2024 · External reference
A novel candidate region for ALS on chromosome 14q11.2
10.1212/01.wnl.0000144344.39103.f6 · 2004 · External reference
ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis
10.1038/ng1742 · 2006 · External reference
Defective removal of ribonucleotides from DNA promotes systemic autoimmunity
10.1172/jci78001 · 2015 · External reference
RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin
10.1074/jbc.m207587200 · 2002 · External reference
Hurlstone, rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA
10.1073/pnas.1009811107 · 2011 · External reference
RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection
10.1038/ng.398 · 2009 · External reference
The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity
10.1074/jbc.m607321200 · 2007 · External reference
Polymorphism of the eosinophil cationic protein-gene is related to the expression of allergic symptoms
10.1046/j.1365-2222.2002.01410.x · 2002 · External reference
The production of the eosinophil proteins ECP and EPX / EDN are regulated in a reciprocal manner
10.1111/apm.12142 · 2014 · External reference
A (G->C) transversion in the 3' UTR of the human ECP (eosinophil cationic protein) gene correlates to the cellular content of ECP
10.1189/jlb.0904517 · 2006 · External reference
Ribonuclease-1 treatment after traumatic brain injury preserves blood-brain barrier integrity and delays secondary brain damage in mice
10.1038/s41598-022-09326-2 · 2022 · External reference
Human endothelial cells selectively express large amounts of pancreatic-type ribonuclease (RNase 1)
10.1002/jcb.10234 · 2002 · External reference
The nuclear RNase III Drosha initiates microRNA processing
10.1038/nature01957 · 2003 · External reference
Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress
10.1007/s10456-012-9322-9 · 2013 · External reference
Human antimicrobial RNases inhibit intracellular bacterial growth and induce autophagy in mycobacteria-infected macrophages
10.3389/fimmu.2019.01500 · 2019 · External reference
Haplotype of RNASE 3 polymorphisms is associated with severe malaria in an Indian population
10.1007/s11033-020-05934-1 · 2020 · External reference
The genetics of amyotrophic lateral sclerosis
10.1097/wco.0000000000001294 · 2024 · External reference
The promoter polymorphism in the eosinophil cationic protein gene and its influence on the serum eosinophil cationic protein level
10.1164/rccm.200204-292oc · 2003 · External reference
Bacterial RNA sensing by TLR8 requires RNase 6 processing and is inhibited by RNA 2’O-methylation
10.1038/s44319-024-00281-9 · 2024 · External reference
Arginine rich cationic proteins of human eosinophil granules. Comparison of the constituents of eosinophilic and neutrophilic leukocytes
1977 · External reference
Immune sensing of synthetic, bacterial, and protozoan rna by toll-like receptor 8 requires coordinated processing by RNase T2 and RNase 2
10.1016/j.immuni.2020.03.009 · 2020 · External reference
Insights into the role of ribonuclease 4 polymorphisms in amyotrophic lateral sclerosis
10.1080/07391102.2017.1419147 · 2019 · External reference
The 434(G>C) polymorphism in the eosinophil cationic protein gene and its association with tissue eosinophilia in oral squamous cell carcinomas
10.1111/j.1600-0714.2009.00795.x · 2010 · External reference
Ribonuclease 7 polymorphism rs1263872 reduces antimicrobial activity and associates with pediatric urinary tract infections
10.1172/jci149807 · 2021 · External reference
Insights into the antimicrobial mechanism of action of human RNase6: structural determinants for bacterial cell agglutination and membrane permeation
10.3390/ijms17040552 · 2016 · External reference
, Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family
10.1093/nar/24.18.3507 · 1996 · External reference
Human ribonuclease 6 has a protective role during experimental urinary tract infection
10.1159/000534736 · 2023 · External reference
Protein post-translational modification in host defense: the antimicrobial mechanism of action of human eosinophil cationic protein native forms
10.1111/febs.13082 · 2014 · External reference
DICER1-related tumor predisposition: identification of at-risk individuals and recommended surveillance strategies
10.1158/1078-0432.ccr-24-1532 · 2024 · External reference
Biallelic DICER1 mutations in sporadic pleuropulmonary blastoma
10.1158/0008-5472.can-13-2470 · 2014 · External reference
Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma
10.1038/s41467-018-05029-3 · 2018 · External reference
Ribonuclease 7 is a potent antimicrobial peptide within the human urinary tract
10.1038/ki.2011.109 · 2011 · External reference
Nucleotide modifications enable rational design of TLR7-selective ligands by blocking RNase cleavage
10.1084/jem.20230341 · 2024 · External reference
The functional heterogeneity of eosinophil cationic protein is determined by a gene polymorphism and post-translational modifications
10.1111/j.1365-2222.2007.02644.x · 2007 · External reference
Development of genotyping methods for single nucleotide polymorphism in the human pancreatic ribonuclease gene (RNASE1) and their application to population studies
10.1007/s10528-007-9138-2 · 2008 · External reference
Biallelic dicer1 mutations in the gynecologic tract of mice drive lineage-specific development of DICER1 syndrome–associated cancer
10.1158/0008-5472.can-22-3620 · 2023 · External reference
Sequence variation at two eosinophil-associated ribonuclease loci in humans
10.1093/genetics/156.4.1949 · 2000 · External reference
Human endothelial cells selectively express large amounts of pancreatic-type ribonuclease (RNase 1)
10.1002/jcb.10234 · ExternalCitation · doi-reference
Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress
10.1007/s10456-012-9322-9 · ExternalCitation · doi-reference
Development of genotyping methods for single nucleotide polymorphism in the human pancreatic ribonuclease gene (RNASE1) and their application to population studies
10.1007/s10528-007-9138-2 · ExternalCitation · doi-reference
Haplotype of RNASE 3 polymorphisms is associated with severe malaria in an Indian population
10.1007/s11033-020-05934-1 · ExternalCitation · doi-reference
The 434(G>C) polymorphism within the coding sequence of eosinophil cationic protein (ECP) correlates with the natural course of Schistosoma mansoni infection
10.1016/j.ijpara.2007.04.001 · ExternalCitation · doi-reference
Immune sensing of synthetic, bacterial, and protozoan rna by toll-like receptor 8 requires coordinated processing by RNase T2 and RNase 2
10.1016/j.immuni.2020.03.009 · ExternalCitation · doi-reference
Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7 activation
10.1016/j.immuni.2024.04.010 · ExternalCitation · doi-reference
Ribonuclease 7 is a potent antimicrobial peptide within the human urinary tract
10.1038/ki.2011.109 · ExternalCitation · doi-reference
Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract
10.1038/ki.2014.268 · ExternalCitation · doi-reference
The nuclear RNase III Drosha initiates microRNA processing
10.1038/nature01957 · ExternalCitation · doi-reference
RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection
10.1038/ng.398 · ExternalCitation · doi-reference
ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis
10.1038/ng1742 · ExternalCitation · doi-reference
Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection
10.1038/ng1842 · ExternalCitation · doi-reference
Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma
10.1038/s41467-018-05029-3 · ExternalCitation · doi-reference
Ribonuclease-1 treatment after traumatic brain injury preserves blood-brain barrier integrity and delays secondary brain damage in mice
10.1038/s41598-022-09326-2 · ExternalCitation · doi-reference
Bacterial RNA sensing by TLR8 requires RNase 6 processing and is inhibited by RNA 2’O-methylation
10.1038/s44319-024-00281-9 · ExternalCitation · doi-reference
Polymorphism of the eosinophil cationic protein-gene is related to the expression of allergic symptoms
10.1046/j.1365-2222.2002.01410.x · ExternalCitation · doi-reference
Hurlstone, rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA
10.1073/pnas.1009811107 · ExternalCitation · doi-reference
RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin
10.1074/jbc.m207587200 · ExternalCitation · doi-reference
The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity
10.1074/jbc.m607321200 · ExternalCitation · doi-reference
Insights into the role of ribonuclease 4 polymorphisms in amyotrophic lateral sclerosis
10.1080/07391102.2017.1419147 · ExternalCitation · doi-reference
Nucleotide modifications enable rational design of TLR7-selective ligands by blocking RNase cleavage
10.1084/jem.20230341 · ExternalCitation · doi-reference
Sequence variation at two eosinophil-associated ribonuclease loci in humans
10.1093/genetics/156.4.1949 · ExternalCitation · doi-reference
, Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family
10.1093/nar/24.18.3507 · ExternalCitation · doi-reference
The genetics of amyotrophic lateral sclerosis
10.1097/wco.0000000000001294 · ExternalCitation · doi-reference
The production of the eosinophil proteins ECP and EPX / EDN are regulated in a reciprocal manner
10.1111/apm.12142 · ExternalCitation · doi-reference
Protein post-translational modification in host defense: the antimicrobial mechanism of action of human eosinophil cationic protein native forms
10.1111/febs.13082 · ExternalCitation · doi-reference
The functional heterogeneity of eosinophil cationic protein is determined by a gene polymorphism and post-translational modifications
10.1111/j.1365-2222.2007.02644.x · ExternalCitation · doi-reference
The 434(G>C) polymorphism in the eosinophil cationic protein gene and its association with tissue eosinophilia in oral squamous cell carcinomas
10.1111/j.1600-0714.2009.00795.x · ExternalCitation · doi-reference
Biallelic DICER1 mutations in sporadic pleuropulmonary blastoma
10.1158/0008-5472.can-13-2470 · ExternalCitation · doi-reference
Biallelic dicer1 mutations in the gynecologic tract of mice drive lineage-specific development of DICER1 syndrome–associated cancer
10.1158/0008-5472.can-22-3620 · ExternalCitation · doi-reference
DICER1-related tumor predisposition: identification of at-risk individuals and recommended surveillance strategies
10.1158/1078-0432.ccr-24-1532 · ExternalCitation · doi-reference
Human ribonuclease 6 has a protective role during experimental urinary tract infection
10.1159/000534736 · ExternalCitation · doi-reference
Expression and localisation of vascular ribonucleases in endothelial cells
10.1160/th10-06-0345 · ExternalCitation · doi-reference
The promoter polymorphism in the eosinophil cationic protein gene and its influence on the serum eosinophil cationic protein level
10.1164/rccm.200204-292oc · ExternalCitation · doi-reference
Ribonuclease 7 polymorphism rs1263872 reduces antimicrobial activity and associates with pediatric urinary tract infections
10.1172/jci149807 · ExternalCitation · doi-reference
Defective removal of ribonucleotides from DNA promotes systemic autoimmunity
10.1172/jci78001 · ExternalCitation · doi-reference
Genetic variants of RNASE3 (ECP) and susceptibility to severe malaria in Senegalese population
10.1186/s12936-018-2205-9 · ExternalCitation · doi-reference
A (G->C) transversion in the 3' UTR of the human ECP (eosinophil cationic protein) gene correlates to the cellular content of ECP
10.1189/jlb.0904517 · ExternalCitation · doi-reference
A novel candidate region for ALS on chromosome 14q11.2
10.1212/01.wnl.0000144344.39103.f6 · ExternalCitation · doi-reference
Polymorphisms in the RNASE3 gene are associated with susceptibility to cerebral malaria in Ghanaian children
10.1371/journal.pone.0029465 · ExternalCitation · doi-reference
Human antimicrobial RNases inhibit intracellular bacterial growth and induce autophagy in mycobacteria-infected macrophages
10.3389/fimmu.2019.01500 · ExternalCitation · doi-reference
Effects of pathogenic mutants of the neuroprotective RNase 5-angiogenin in amyotrophic lateral sclerosis (ALS)
10.3390/genes15060738 · ExternalCitation · doi-reference
Insights into the antimicrobial mechanism of action of human RNase6: structural determinants for bacterial cell agglutination and membrane permeation
10.3390/ijms17040552 · ExternalCitation · doi-reference
A common polymorphism in RNASE6 impacts its antimicrobial activity toward uropathogenic Escherichia coli
10.3390/ijms25010604 · ExternalCitation · doi-reference
