Research graph
References from Ribonucleases, cellular signaling and inflammation. Local targets link to admitted publications; unresolved targets remain external evidence.
Quantitative expression profiling in formalin-fixed paraffin-embedded samples by affymetrix microarrays
10.2353/jmoldx.2010.090155 · 2010 · External reference
S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells
10.1007/s10585-012-9532-y · 2013 · External reference
RNA-seq of tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics
10.1016/j.ccell.2015.09.018 · 2015 · External reference
Unresolved reference
External reference
Unresolved reference
External reference
Unresolved reference
External reference
Oxidation of sulfhydryl groups of ribonuclease inhibitor in epithelial cells is sufficient for its intracellular degradation
10.1074/jbc.271.31.18638 · 1996 · External reference
LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity
10.26508/lsa.202101226 · 2022 · External reference
A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma
10.1136/gutjnl-2012-304037 · 2014 · External reference
Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation
10.1172/jci94956 · 2018 · External reference
Induction of Interferon-γ and tissue inflammation by overexpression of eosinophil cationic protein in T cells and exosomes
10.1002/art.41920 · 2022 · External reference
Validating the genomic signature of pediatric septic shock
10.1152/physiolgenomics.00025.2008 · 2008 · External reference
Integrated ordination of miRNA and mRNA expression profiles
10.1186/s12864-015-1971-9 · 2015 · External reference
10.1016/s0079-6603(05)80009-1
10.1016/s0079-6603(05)80009-1 · External reference
Transcriptomic characterization of hepatocellular carcinoma with CTNNB1 mutation
10.1371/journal.pone.0095307 · 2014 · External reference
Insulin and the phosphatidylinositol 3-kinase signaling pathway regulate Ribonuclease 7 expression in the human urinary tract
10.1016/j.kint.2016.04.025 · 2016 · External reference
Transcriptomic landscape of breast cancers through mRNA sequencing
10.1038/srep00264 · 2012 · External reference
Inactivation of ribonuclease inhibitor by thiol-disulfide exchange
10.1016/s0021-9258(18)35814-9 · 1992 · External reference
Giuseppe D‧Alessio, the ribonuclease/angiogenin inhibitor is also present in mitochondria and nuclei
10.1016/j.febslet.2011.01.034 · 2011 · External reference
Expression Atlas update: insights from sequencing data at both bulk and single cell level
10.1093/nar/gkad1021 · 2024 · External reference
Progressive activation of TH2/TH22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis
10.1016/j.jaci.2012.07.012 · 2012 · External reference
Effect of eosinophil cationic protein (ECP) on Hodgkin lymphoma cell lines
10.1016/j.exphem.2011.05.006 · 2011 · External reference
Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature
10.1172/jci75436 · 2014 · External reference
Ribonuclease inhibitor 1 (RNH1) deficiency cause congenital cataracts and global developmental delay with infection-induced psychomotor regression and anemia
10.1038/s41431-023-01327-7 · 2023 · External reference
CXCL17 and ICAM2 Are associated with a potential anti-tumor immune response in early intraepithelial stages of human pancreatic carcinogenesis
10.1053/j.gastro.2010.10.009 · 2011 · External reference
RNase 7 inhibits uropathogenic Escherichia coli-induced inflammation in bladder cells under a high-glucose environment by regulating the JAK/STAT signaling pathway
10.3390/ijms23095156 · 2022 · External reference
Molecular basis for the autonomous promotion of cell proliferation by angiogenin
10.1093/nar/gkw1192 · 2017 · External reference
RNA-seq reveals more consistent reference genes for gene expression studies in human non-melanoma skin cancers
10.7717/peerj.3631 · 2017 · External reference
A human ribonuclease variant and ERK-pathway inhibitors exhibit highly synergistic toxicity for cancer cells
10.1158/1535-7163.mct-18-0724 · 2018 · External reference
Diagnosis of multisystem inflammatory syndrome in children by a whole-blood transcriptional signature
10.1093/jpids/piad035 · 2023 · External reference
Genomic landscape survey identifies SRSF1 as a key oncodriver in small cell lung cancer
10.1371/journal.pgen.1005895 · 2016 · External reference
miRNA signatures associate with pathogenesis and progression of osteosarcoma
10.1158/0008-5472.can-11-2663 · 2012 · External reference
Novel insight into mechanisms of ROS1 catalytic activation via loss of the extracellular domain
10.1038/s41598-024-71687-7 · 2024 · External reference
Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats
10.1038/366751a0 · 1993 · External reference
RNASE4 promotes malignant progression and chemoresistance in hypoxic glioblastoma via activation of AXL/AKT and NF-κB/cIAPs signaling pathways
10.62347/udbj5986 · 2024 · External reference
10.1016/s0079-6603(08)60215-9
10.1016/s0079-6603(08)60215-9 · External reference
Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation
10.1038/s41467-021-23075-2 · 2021 · External reference
Cell signaling by receptor tyrosine kinases
10.1016/j.cell.2010.06.011 · 2010 · External reference
Identification of ribonuclease 6 as an immunoinflammatory key gene associated with the glomerular injury in diabetic nephropathy
10.1038/s41598-022-24289-0 · 2022 · External reference
Copy number loss of the interferon gene cluster in melanomas is linked to reduced T cell infiltrate and poor patient prognosis
10.1371/journal.pone.0109760 · 2014 · External reference
Ribonuclease 7-driven activation of ROS1 is a potential therapeutic target in hepatocellular carcinoma
10.1016/j.jhep.2020.09.030 · 2021 · External reference
Targeting ALK averts ribonuclease 1-induced immunosuppression and enhances antitumor immunity in hepatocellular carcinoma
10.1038/s41467-024-45215-0 · 2024 · External reference
Human RNase3 immune modulation by catalytic-dependent and independent modes in a macrophage-cell line infection model
10.1007/s00018-020-03695-5 · 2021 · External reference
Novel aberrations uncovered in barrett's esophagus and esophageal adenocarcinoma using whole transcriptome sequencing
10.1158/1541-7786.mcr-17-0332 · 2017 · External reference
Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome
10.1038/ncomms7042 · 2015 · External reference
Mechanisms of activation of receptor tyrosine kinases: monomers or dimers
10.3390/cells3020304 · 2014 · External reference
Insulin receptor signaling regulates renal collecting duct and intercalated cell antibacterial defenses
10.1172/jci98595 · 2018 · External reference
Ribonuclease inhibitor 1 emerges as a potential biomarker and modulates inflammation and iron homeostasis in sepsis
10.1038/s41598-024-65778-8 · 2024 · External reference
Cationic proteins of human granulocytes: I. isolation of the cationic proteins from the granules of leukaemic myeloid cells
10.1111/j.1600-0609.1972.tb00932.x · 1972 · External reference
Cationic proteins of human granulocytes. II. separation of the cationic proteins of the granules of leukemic myeloid cells
10.1182/blood.v44.2.235.235 · 1974 · External reference
Angiogenin regulates PKD activation and COX-2 expression induced by TNF-α and bradykinin in the colonic myofibroblast
10.1016/j.bbrc.2020.02.169 · 2020 · External reference
Inhibition of RNase 7 by RNase inhibitor promotes inflammation and Staphylococcus aureus growth: implications for atopic dermatitis
10.1111/all.16125 · 2024 · External reference
5′-Diphosphoadenosine 3′-phosphate is a potent inhibitor of bovine pancreatic ribonuclease A
10.1006/bbrc.1997.6167 · 1997 · External reference
HPV related VIN: highly proliferative and diminished responsiveness to extracellular signals
10.1002/ijc.22769 · 2007 · External reference
Atrial myxomas arise from multipotent cardiac stem cells
10.1093/eurheartj/ehaa156 · 2020 · External reference
Analysis of the interactions of human ribonuclease inhibitor with angiogenin and ribonuclease A by mutagenesis: importance of inhibitor residues inside versus outside the C-terminal “hot spot” 1 1Edited by J. Wells
10.1006/jmbi.2000.4075 · 2000 · External reference
Analysis of the interactions of human ribonuclease inhibitor with angiogenin and ribonuclease A by mutagenesis: importance of inhibitor residues inside versus outside the C-terminal “hot spot” 1 1Edited by J. Wells
10.1006/jmbi.2000.4075 · 2000 · External reference
Biallelic variants in ribonuclease inhibitor (RNH1), an inflammasome modulator, are associated with a distinctive subtype of acute, necrotizing encephalopathy
10.1016/j.gim.2023.100897 · 2023 · External reference
Massive parallel sequencing uncovers actionable FGFR2–PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma
10.1038/ncomms7087 · 2015 · External reference
An endogenous ribonuclease inhibitor regulates the antimicrobial activity of ribonuclease 7 in the human urinary tract
10.1038/ki.2013.395 · 2014 · External reference
Mutational analysis of the complex of human RNase inhibitor and human eosinophil-derived neurotoxin (RNase 2)
10.1021/bi026852o · 2003 · External reference
Ribonuclease 4 is associated with aggressiveness and progression of prostate cancer
10.1038/s42003-022-03597-1 · 2022 · External reference
Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression
10.1016/j.ccr.2005.10.001 · 2005 · External reference
Eosinophil cationic protein (ECP): molecular and biological properties and the use of ECP as a marker of eosinophil activation in disease
10.1046/j.1365-2222.1999.00542.x · 1999 · External reference
Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice
10.1073/pnas.1204127109 · 2012 · External reference
Angiogenin/ribonuclease 5 Is an EGFR ligand and a serum biomarker for erlotinib sensitivity in pancreatic cancer
10.1016/j.ccell.2018.02.012 · 2018 · External reference
Ribonuclease 1 enhances antitumor immunity against breast cancer by boosting T cell activation
10.7150/ijbs.84592 · 2023 · External reference
Transcriptional and proteomic insights into the host response in fatal COVID-19 cases
10.1073/pnas.2018030117 · 2020 · External reference
Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells
10.1182/blood-2003-01-0151 · 2003 · External reference
Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2–MyD88 signal pathway in dendritic cells and enhances Th2 immune responses
10.1084/jem.20062027 · 2008 · External reference
Ribonuclease 1 induces T-cell dysfunction and impairs CD8+ T-cell cytotoxicity to benefit tumor growth through hijacking STAT1
10.1002/advs.202404961 · 2025 · External reference
Type I interferon: potential therapeutic target for psoriasis?
10.1371/journal.pone.0002737 · 2008 · External reference
Elucidating common pathogenic transcriptional networks in infective endocarditis and sepsis: integrated insights from biomarker discovery and single-cell RNA sequencing
10.3389/fimmu.2023.1298041 · 2024 · External reference
Eosinophil cationic protein stimulates TGF-β1 release by human lung fibroblasts in vitro
10.1007/s10753-007-9032-4 · 2007 · External reference
Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis in a murine model of polymicrobial sepsis
10.1172/jci.insight.131571 · 2020 · External reference
Ribonuclease 1 induces T-cell dysfunction and impairs CD8+ T-cell cytotoxicity to benefit tumor growth through hijacking STAT1
10.1002/advs.202404961 · ExternalCitation · doi-reference
Induction of Interferon-γ and tissue inflammation by overexpression of eosinophil cationic protein in T cells and exosomes
10.1002/art.41920 · ExternalCitation · doi-reference
HPV related VIN: highly proliferative and diminished responsiveness to extracellular signals
10.1002/ijc.22769 · ExternalCitation · doi-reference
5′-Diphosphoadenosine 3′-phosphate is a potent inhibitor of bovine pancreatic ribonuclease A
10.1006/bbrc.1997.6167 · ExternalCitation · doi-reference
Analysis of the interactions of human ribonuclease inhibitor with angiogenin and ribonuclease A by mutagenesis: importance of inhibitor residues inside versus outside the C-terminal “hot spot” 1 1Edited by J. Wells
10.1006/jmbi.2000.4075 · ExternalCitation · doi-reference
Human RNase3 immune modulation by catalytic-dependent and independent modes in a macrophage-cell line infection model
10.1007/s00018-020-03695-5 · ExternalCitation · doi-reference
S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells
10.1007/s10585-012-9532-y · ExternalCitation · doi-reference
Eosinophil cationic protein stimulates TGF-β1 release by human lung fibroblasts in vitro
10.1007/s10753-007-9032-4 · ExternalCitation · doi-reference
Angiogenin regulates PKD activation and COX-2 expression induced by TNF-α and bradykinin in the colonic myofibroblast
10.1016/j.bbrc.2020.02.169 · ExternalCitation · doi-reference
RNA-seq of tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics
10.1016/j.ccell.2015.09.018 · ExternalCitation · doi-reference
Angiogenin/ribonuclease 5 Is an EGFR ligand and a serum biomarker for erlotinib sensitivity in pancreatic cancer
10.1016/j.ccell.2018.02.012 · ExternalCitation · doi-reference
Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression
10.1016/j.ccr.2005.10.001 · ExternalCitation · doi-reference
Cell signaling by receptor tyrosine kinases
10.1016/j.cell.2010.06.011 · ExternalCitation · doi-reference
Effect of eosinophil cationic protein (ECP) on Hodgkin lymphoma cell lines
10.1016/j.exphem.2011.05.006 · ExternalCitation · doi-reference
Giuseppe D‧Alessio, the ribonuclease/angiogenin inhibitor is also present in mitochondria and nuclei
10.1016/j.febslet.2011.01.034 · ExternalCitation · doi-reference
Biallelic variants in ribonuclease inhibitor (RNH1), an inflammasome modulator, are associated with a distinctive subtype of acute, necrotizing encephalopathy
10.1016/j.gim.2023.100897 · ExternalCitation · doi-reference
Progressive activation of TH2/TH22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis
10.1016/j.jaci.2012.07.012 · ExternalCitation · doi-reference
Ribonuclease 7-driven activation of ROS1 is a potential therapeutic target in hepatocellular carcinoma
10.1016/j.jhep.2020.09.030 · ExternalCitation · doi-reference
Insulin and the phosphatidylinositol 3-kinase signaling pathway regulate Ribonuclease 7 expression in the human urinary tract
10.1016/j.kint.2016.04.025 · ExternalCitation · doi-reference
Inactivation of ribonuclease inhibitor by thiol-disulfide exchange
10.1016/s0021-9258(18)35814-9 · ExternalCitation · doi-reference
10.1016/s0079-6603(05)80009-1
10.1016/s0079-6603(05)80009-1 · ExternalCitation · doi-reference
10.1016/s0079-6603(08)60215-9
10.1016/s0079-6603(08)60215-9 · ExternalCitation · doi-reference
Mutational analysis of the complex of human RNase inhibitor and human eosinophil-derived neurotoxin (RNase 2)
10.1021/bi026852o · ExternalCitation · doi-reference
Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats
10.1038/366751a0 · ExternalCitation · doi-reference
An endogenous ribonuclease inhibitor regulates the antimicrobial activity of ribonuclease 7 in the human urinary tract
10.1038/ki.2013.395 · ExternalCitation · doi-reference
Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome
10.1038/ncomms7042 · ExternalCitation · doi-reference
Massive parallel sequencing uncovers actionable FGFR2–PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma
10.1038/ncomms7087 · ExternalCitation · doi-reference
Ribonuclease inhibitor 1 (RNH1) deficiency cause congenital cataracts and global developmental delay with infection-induced psychomotor regression and anemia
10.1038/s41431-023-01327-7 · ExternalCitation · doi-reference
Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation
10.1038/s41467-021-23075-2 · ExternalCitation · doi-reference
Targeting ALK averts ribonuclease 1-induced immunosuppression and enhances antitumor immunity in hepatocellular carcinoma
10.1038/s41467-024-45215-0 · ExternalCitation · doi-reference
Identification of ribonuclease 6 as an immunoinflammatory key gene associated with the glomerular injury in diabetic nephropathy
10.1038/s41598-022-24289-0 · ExternalCitation · doi-reference
Ribonuclease inhibitor 1 emerges as a potential biomarker and modulates inflammation and iron homeostasis in sepsis
10.1038/s41598-024-65778-8 · ExternalCitation · doi-reference
Novel insight into mechanisms of ROS1 catalytic activation via loss of the extracellular domain
10.1038/s41598-024-71687-7 · ExternalCitation · doi-reference
Ribonuclease 4 is associated with aggressiveness and progression of prostate cancer
10.1038/s42003-022-03597-1 · ExternalCitation · doi-reference
Transcriptomic landscape of breast cancers through mRNA sequencing
10.1038/srep00264 · ExternalCitation · doi-reference
Eosinophil cationic protein (ECP): molecular and biological properties and the use of ECP as a marker of eosinophil activation in disease
10.1046/j.1365-2222.1999.00542.x · ExternalCitation · doi-reference
CXCL17 and ICAM2 Are associated with a potential anti-tumor immune response in early intraepithelial stages of human pancreatic carcinogenesis
10.1053/j.gastro.2010.10.009 · ExternalCitation · doi-reference
Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice
10.1073/pnas.1204127109 · ExternalCitation · doi-reference
Transcriptional and proteomic insights into the host response in fatal COVID-19 cases
10.1073/pnas.2018030117 · ExternalCitation · doi-reference
Oxidation of sulfhydryl groups of ribonuclease inhibitor in epithelial cells is sufficient for its intracellular degradation
10.1074/jbc.271.31.18638 · ExternalCitation · doi-reference
Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2–MyD88 signal pathway in dendritic cells and enhances Th2 immune responses
10.1084/jem.20062027 · ExternalCitation · doi-reference
Atrial myxomas arise from multipotent cardiac stem cells
10.1093/eurheartj/ehaa156 · ExternalCitation · doi-reference
Diagnosis of multisystem inflammatory syndrome in children by a whole-blood transcriptional signature
10.1093/jpids/piad035 · ExternalCitation · doi-reference
Expression Atlas update: insights from sequencing data at both bulk and single cell level
10.1093/nar/gkad1021 · ExternalCitation · doi-reference
Molecular basis for the autonomous promotion of cell proliferation by angiogenin
10.1093/nar/gkw1192 · ExternalCitation · doi-reference
Inhibition of RNase 7 by RNase inhibitor promotes inflammation and Staphylococcus aureus growth: implications for atopic dermatitis
10.1111/all.16125 · ExternalCitation · doi-reference
Cationic proteins of human granulocytes: I. isolation of the cationic proteins from the granules of leukaemic myeloid cells
10.1111/j.1600-0609.1972.tb00932.x · ExternalCitation · doi-reference
A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma
10.1136/gutjnl-2012-304037 · ExternalCitation · doi-reference
Validating the genomic signature of pediatric septic shock
10.1152/physiolgenomics.00025.2008 · ExternalCitation · doi-reference
miRNA signatures associate with pathogenesis and progression of osteosarcoma
10.1158/0008-5472.can-11-2663 · ExternalCitation · doi-reference
A human ribonuclease variant and ERK-pathway inhibitors exhibit highly synergistic toxicity for cancer cells
10.1158/1535-7163.mct-18-0724 · ExternalCitation · doi-reference
Novel aberrations uncovered in barrett's esophagus and esophageal adenocarcinoma using whole transcriptome sequencing
10.1158/1541-7786.mcr-17-0332 · ExternalCitation · doi-reference
Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis in a murine model of polymicrobial sepsis
10.1172/jci.insight.131571 · ExternalCitation · doi-reference
Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature
10.1172/jci75436 · ExternalCitation · doi-reference
Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation
10.1172/jci94956 · ExternalCitation · doi-reference
Insulin receptor signaling regulates renal collecting duct and intercalated cell antibacterial defenses
10.1172/jci98595 · ExternalCitation · doi-reference
Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells
10.1182/blood-2003-01-0151 · ExternalCitation · doi-reference
Cationic proteins of human granulocytes. II. separation of the cationic proteins of the granules of leukemic myeloid cells
10.1182/blood.v44.2.235.235 · ExternalCitation · doi-reference
Integrated ordination of miRNA and mRNA expression profiles
10.1186/s12864-015-1971-9 · ExternalCitation · doi-reference
Genomic landscape survey identifies SRSF1 as a key oncodriver in small cell lung cancer
10.1371/journal.pgen.1005895 · ExternalCitation · doi-reference
Type I interferon: potential therapeutic target for psoriasis?
10.1371/journal.pone.0002737 · ExternalCitation · doi-reference
Transcriptomic characterization of hepatocellular carcinoma with CTNNB1 mutation
10.1371/journal.pone.0095307 · ExternalCitation · doi-reference
Copy number loss of the interferon gene cluster in melanomas is linked to reduced T cell infiltrate and poor patient prognosis
10.1371/journal.pone.0109760 · ExternalCitation · doi-reference
Quantitative expression profiling in formalin-fixed paraffin-embedded samples by affymetrix microarrays
10.2353/jmoldx.2010.090155 · ExternalCitation · doi-reference
LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity
10.26508/lsa.202101226 · ExternalCitation · doi-reference
Elucidating common pathogenic transcriptional networks in infective endocarditis and sepsis: integrated insights from biomarker discovery and single-cell RNA sequencing
10.3389/fimmu.2023.1298041 · ExternalCitation · doi-reference
Mechanisms of activation of receptor tyrosine kinases: monomers or dimers
10.3390/cells3020304 · ExternalCitation · doi-reference
RNase 7 inhibits uropathogenic Escherichia coli-induced inflammation in bladder cells under a high-glucose environment by regulating the JAK/STAT signaling pathway
10.3390/ijms23095156 · ExternalCitation · doi-reference
RNASE4 promotes malignant progression and chemoresistance in hypoxic glioblastoma via activation of AXL/AKT and NF-κB/cIAPs signaling pathways
10.62347/udbj5986 · ExternalCitation · doi-reference
Ribonuclease 1 enhances antitumor immunity against breast cancer by boosting T cell activation
10.7150/ijbs.84592 · ExternalCitation · doi-reference
RNA-seq reveals more consistent reference genes for gene expression studies in human non-melanoma skin cancers
10.7717/peerj.3631 · ExternalCitation · doi-reference
